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  The Roles of Novel CCCH Zinc Finger Genes on the Regulation of Cell Proliferation and Inflammation

  Liang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Prediction of B-Cell Epitopes Using Propensity Scales and Correspondence Analysis

  Su, E. C.

  8/1/13 → 10/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• TMU101-AE1-B67

  Wang, W.

  8/1/13 → 7/31/16

  Project: B - Project of TMU › i - Other (Funded by TMU)

• 大腸直腸癌已躍居世界上癌症死亡率第二名，屬於固體型腫瘤，缺氧常見於此類 腫瘤，並誘發HIF-1α 表現而導致抗藥性及預後較差，因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑，可殺死癌 細胞而不影響正常細胞，對小鼠也不具毒性。我們初步結果顯示，Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現，代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性，對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下，經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制；也有研究報導指出，藥物會誘導癌細胞產生autophagy，造成細胞過度吞噬其內容 物而死亡，因此，autophagy在癌細胞為保護或是引發毒殺作用，目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活，但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示，除抑制HIF-1α 表現外，Zeb 也可活化AMPK、UPR/ER stress、以及autophagy， 因此我們推測Zeb 可在缺氧狀態下，促進autophagic cell death。3 年內我們將執行4 項 目標： (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。（第一年） (2) 研究Zeb 抑制HIF-1α表現之分子機轉。（第一年到第二年） (3) 研究Zeb 誘發autophagy之分子機轉。（第二年到第三年） (4) 探討Zeb 對缺氧導致抗藥性之作用。（第三年）

  Yang, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study the Klf10 alters metabolic pathways in genetic-deficient mice and human pancreatic ductal carcinomas

  Chang, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 利用基因工程誘導性潛能幹細胞治療巴金森氏症之研究

  Chiang, Y.

  8/1/13 → 7/31/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• New Strategies of Parkinson’s Disease Treatment

  Chiang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Multidisciplinary Study of the Pathophysiology of Blast-Induced Mild Traumatic Brain Injury

  Chiang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigating the Differential Effects and the Mechanisms of Flavonols on Osteogenic Differentiation of Human Dental Pulp Stem Cells

  Lee, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Application of clinical anti-arthralgia formulas of traditional Chinese medicine to arthritis

  Wang, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Modifying the Impact of Maternal Psychopathology on Adverse Infant Health Outcomes---Effects of Paternal Involvement and a Trial on Positive Activity Intervention

  Chen, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• TMU101-AE1-B68

  Chiu, Y.

  8/1/13 → 7/31/16

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Association between lipid, glucose related genes and prognosis of intra- and extra-cranial stenosis in stroke patients

  Chiou, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Strontium-Impregnated Bioabsorbable Bone Screw for Fracture Fixation in Osteoporotic Bone

  Yang, K.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Immune Alteration and Immunogenic Cell Death in Advanced Non-Small Cell Lung Cancer Patients

  Feng, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 102年度臺北市輻射屋居民健康照護需求評估工具建立

  Chiu, C.

  7/16/13 → 12/31/13

  Project: A - Government Institution › f - Other (Funded by Government)

• 健康促進國際政策及學術資料建置計畫

  Chang, W.

  7/3/13 → 12/31/13

  Project: A - Government Institution › c - Ministry of Health and Welfare

• The Application of Biodegradable Nano-Enabled Drug Delivery in Treatemt of Brain Abscess

  Tseng, Y.

  7/1/13 → 9/30/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• TMU101-AE1-B61

  Cheng, P.

  7/1/13 → 6/30/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• TMU101-AE1-B62

  Chuang, T.

  7/1/13 → 9/30/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• 奈米金屬微粒暴露引發勞工心血管效應之細胞毒理評估

  Chuang, K.

  6/27/13 → 12/20/13

  Project: A - Government Institution › f - Other (Funded by Government)

• 行政院衛生署所屬醫院「102年度滿意度調查評估」勞務委託採購案

  Kuo, N.

  6/18/13 → 10/28/13

  Project: A - Government Institution › f - Other (Funded by Government)

• 102年癌症篩檢管理中心工作計畫之個管師考題研擬及閱卷

  Chen, L.

  6/13/13 → 8/31/13

  Project: A - Government Institution › c - Ministry of Health and Welfare

• 職場生物氣膠暴露及建議值調查評估研究

  Chao, H.

  6/11/13 → 12/13/13

  Project: A - Government Institution › f - Other (Funded by Government)

• 建置健保法學知識數位平台

  Yang, C.

  6/7/13 → 12/6/13

  Project: A - Government Institution › c - Ministry of Health and Welfare

• 鈦坦銀合金應用於生醫植體之研究

  Huang, C.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 探討 GRP78 作為攝護腺癌化學治療之癒後因子之潛能

  Chang, Y.

  6/1/13 → 7/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 高純度具表面增強拉曼活性奈米貴金屬顆粒之製備與其生醫檢測策略

  Liu, Y.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 102 年東南亞區域共同研究暨培訓型國際合作計畫—社區精神復健合作研究平台與專業人員培訓工作坊

  Tsai, D.

  6/1/13 → 12/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• 子宮內膜異位症中乙式轉形生長因子在調控OCT4表現及上皮細胞/間葉細胞間轉型之角色探討

  Huang, Y.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 人類乳突病毒導致肺腫瘤化之可能機轉

  Cheng, Y.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• MEKK1/JNK依賴SMAD3活化媒介CXCL12誘導肺部纖維母細胞CTGF表現之探討

  Chen, B.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 血小板微粒特性及功能之體外研究

  Burnouf, T. P. R.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• TMU101-AE1-B60

  Lane, T. J.

  6/1/13 → 5/31/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• 牙科根管治療顯影材料之溶凝膠製備與改質研究

  Lin, C.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 新型醫用鈦鍺合金材料之研究

  Peng, P.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• TMU101-AE1-B58

  Liu, W.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › u - Taipei Medical University Shuang Ho Hospital

• 香菸特異亞硝胺與代謝基因多形性於牙周炎個案治療成效

  Huang, Y.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• TMU101-AE1-B57

  Chien, L.

  6/1/13 → 5/31/15

  Project: B - Project of TMU › i - Other (Funded by TMU)

• 脂肪幹細胞對於癌細胞移動調控機轉

  Tsai, F.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 102 年東南亞區域共同研究暨培訓型國際合作計畫—亞洲 15 國衛生識能國際合作比較研究與研習教育計畫

  Chang, W.

  6/1/13 → 12/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• 由北市學童研究探討儲鐵蛋白質對巨噬細胞活化及移轉的營響

  Chang, J.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 奈米金鍵結標靶藥物afatinib用於治療HER2大量表現之癌症

  Chang, J.

  6/1/13 → 5/31/15

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 以系統生物資訊方法分析策略發展頭頸癌治療藥物

  Chen, Y.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 臨床肝癌化療藥物與小麥粹取物整合處理對人類肝癌細胞抑制效果之評估與分子抑癌機制探討

  Tai, C.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• TMU101-AE1-B56

  Wu, C.

  6/1/13 → 5/31/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• TMU101-AE1-B59

  Liao, C.

  6/1/13 → 12/31/15

  Project: B - Project of TMU › i - Other (Funded by TMU)

• 以新穎天線式結構之奈米線感測器偵測口腔癌症基因

  Wu, C.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 探討SCUBE1在腎臟上皮間質化及癌症發展的角色

  Lin, H.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 幼年期睡眠剝奪對褪黑激素生合成暨神經內分泌功能之影響：飛行式二次離子質譜儀之分子影像研究

  Chang, H.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital