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Mobile Phone Use and Walking: A Observational Field Study of Pedestrians' Risky Behaviours and Inattentional Blindness
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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抗氧化防禦基因標籤單核?酸多形性、氧化壓力生物標記與冠狀動脈心臟病之相關性(1/2)
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Huntingtin-Associated Protein-Regulated Biomarkers in Neurodegenerative Diseases
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Enhancement of immuno-modulatory capacity by shear stress in mesenchymal stem cells
Ho, J.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The role of DDX3 in human papillomavirus-infected lung tumorigenesis
Lee, H.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Study the Therapeutic Effects and Novel Molecular Mechanisms of Resveratrol in Human Osteosarcoma: the Treatment of Metastatic Cancer
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Effects of a program of mind-body interventions on psychological resilience, vagal tone, emotional states, and outcomes of heart failure
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Evaluations of Anti-Photoaging, Anti-Melanogenesis and Transdermal Delivery of Safflower Yellow
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Prediction of B-Cell Epitopes Using Propensity Scales and Correspondence Analysis
8/1/13 → 10/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Evaluation on Cervical Cancer Prevention and Treatment Policy in Taiwan
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Effects of Neurofeedback and Rsa Biofeedback on Quality of Sleep in Patients in the Chronic Phase of Traumatic Brain Injury
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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大腸直腸癌已躍居世界上癌症死亡率第二名,屬於固體型腫瘤,缺氧常見於此類 腫瘤,並誘發HIF-1α 表現而導致抗藥性及預後較差,因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑,可殺死癌 細胞而不影響正常細胞,對小鼠也不具毒性。我們初步結果顯示,Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現,代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性,對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下,經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制;也有研究報導指出,藥物會誘導癌細胞產生autophagy,造成細胞過度吞噬其內容 物而死亡,因此,autophagy在癌細胞為保護或是引發毒殺作用,目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活,但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示,除抑制HIF-1α 表現外,Zeb 也可活化AMPK、UPR/ER stress、以及autophagy, 因此我們推測Zeb 可在缺氧狀態下,促進autophagic cell death。3 年內我們將執行4 項 目標: (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。(第一年) (2) 研究Zeb 抑制HIF-1α表現之分子機轉。(第一年到第二年) (3) 研究Zeb 誘發autophagy之分子機轉。(第二年到第三年) (4) 探討Zeb 對缺氧導致抗藥性之作用。(第三年)
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Effects and Mechanisms of Pitx2c Modulation for Atrial Electrophysiological and Structural Remodelings in Heart Failure
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Molecular and cellular mechanism of adipocyte modulatory effects on pulmonary vein and atrium
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Effects of Exercise Training on Sleep Disturbances, Anxiety, and Depression among Newly Diagnosed Elderly Lung Cancer Patients
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Effect of Improved Nutrition Care on the Progress of Hemodialysis Patients
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Cellular and Molecular Mechanisms of Nicotine and Nitrosamines Promote Tumorigenic Behaviors in Renal Cell Carcinoma (Ii)
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Study the Klf10 alters metabolic pathways in genetic-deficient mice and human pancreatic ductal carcinomas
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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A series of studies analyzing exercise behavior and exploring the effects of interventions among pre-diabetes, type 1, and type 2 diabetes
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Investigation of the transcriptional and epigenetic mechanisms for the Nm23-H1 expression: An nm23-H1-promoter screening platform for novel metastasis-suppressing anticancer drugs
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Effect of Muscle Strength Training on Body Composition and Sarcopenic Obesity among the Female Overweight Elderly
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Studies on the anti-islet hypertrophy and anti-osteoporosis constituents from Formosan Fern
Hsu, F.
8/1/13 → 12/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Prp: Platelet-Rich Plasma Effects in the Articular Chondrocytes and Synovial Fibroblasts with the Associated Mechanism---A Fibronectin Fragment Model
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Characterization of 5-Hydroxymethylcytosine and Ten-to-Eleven Translocation Gene (TET) in Cervical Cancer
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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RNA-Seq Analysis of Transcriptome in Toxocara canis L3-Infected Host
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Fabricating Bioengineered Corneal Endothelium on Chitosan-Polycaprolactone Blends---Experiment, Mechanism, and Application
8/1/13 → 12/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Survey and Intervention of Health Literacy among Older Adults
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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End-of-Life Care for Elderly with Advanced Dementia in Long-Term Care Facilities
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Immature Testicular Tissue Engineering for Male Fertility Preservation---A Transgenic Mouse Model
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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支援在地老化之智慧生活實驗室規畫(3/3)
Tsai, D.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Preceptors’ perceptions of training programs and training needs, experienced barriers during precepting, and development and effectiveness evaluation of a preceptor intervention
Chang, W.
8/1/13 → 10/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Optimization of Human Meniscus Imaging and Its Clinical Application for Osteoarthritis
Tsai, P.
8/1/13 → 10/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Molecular Mechanism Underlying Progesterone-Regulated p27 Gene Expression
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Study of Therapeutic Effects for Stroke with Phenserine, an Amyloid Precursor Protein Inhibitor, in Rodent Focal Cerebral Ischemia Model
Chang, C.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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TMU101-AE1-B65
8/1/13 → 7/31/14
Project: C - Project of Alliance › p - Taipei Medical University Hospital
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Reflex Pelvic Floor Muscle Activities in Women with Urinary Incontinence (II)
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Research of Harmful Substances in Water on Human Reproductive and Neuronal Cells Toxicity Translation Assessment (I)
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Immune Alteration and Immunogenic Cell Death in Advanced Non-Small Cell Lung Cancer Patients
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Mechanism and Functional Study of Sumoylation in Mammalian System
Hwang, J.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Role of CISD2 in the Female Reproductive System of Mammal
Chang, H.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Degradation of nitrogen-containing PPCPs: kinetic study, application, and balancing the toxicity of N-DBP and intermediates through bioassay
Chang, E.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Design and Characterization of Multifunctional Self-Assembling Lecithin/Amphiphilic Polymers Mixed Micellar Delivery Systems
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The effect of endothelin-1 on myofibroblast transformation of pleural mesothelial cells and its implications for pleural and pulmonary fibrosis
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Chitosan nanoparticle as a macrophage-targeting drug delivery carrier
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Indoxyl Sulfate, Chronic Kidney Disease and Heat Shock Protein Modulate the Atrial Electrophysiological Characteristics
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Role of Organic Anion Transporter in Renal Tubular Injury---A Gateway to Hurt
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Glucagon-Like Peptide-1 in the Regulation of PPARs and Calcium Handling in Hyperglycemia or Hypertensive HL-1 Cells
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Proteomic Study of Metformin on Kidney Damage in Rats
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Translational studies of Mycobacterium tuberculosis-induced lung and pleural fibrosis
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Roles of Novel CCCH Zinc Finger Genes on the Regulation of Cell Proliferation and Inflammation
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology