Find Research Projects

Search results

• Contribution of ER Stress to Inhibit miR-19a/b and miR-26b-Mediated CTGF Expression in Lung Fibrosis (II)

  Chen, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 氧化還原作用調控蛋白質去磷酸酉每羰基化和去羰基化反應對動脈血管內膜增生之影響(1/2)

  Hsieh, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Three Steps of Fluorescence Resonance Energy Transfer Observation of Complexation of DNA/Drug/Polymeric Micelles on Cornea Transport

  Liaw, J.

  8/1/14 → 12/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• An Investigation of the Effects of Tea Component on the Inhibition of Leukocyte Nicotinic Acetylcholine Receptor Expression on Breast Cancer Patients

  Tu, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies of Anti-Cancer Activity of Folic Acid

  Lee, W.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Lipid Raft Associated Signaling in Regulation of Osteoclast Activation in Inflammatory Arthritis

  Tsai, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of a Cognitive Behavioral Self-Help Intervention on Immigrant Life Stress for Immigrant Women Who Are Divorced

  Kuo, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Detecting Genetic Variants Based on a Random-Effects Model

  Cheng, K.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effects of Adipose-Derived Stem Cells on Denervated Rat Skeletal Muscle Atrophy

  Tsai, F.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Research on Development of Clound Computing Platform for Decision Support Systems Healthcare by Healthcare Big Data and Analytics

  Chiang, I.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討HIV-1反轉錄酉每與新穎先導藥物之複合體結構以利優化作為抗HIV候選藥物

  Liu, C.

  8/1/14 → 10/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Efficacy Studies of Tn-Directed Therapeutic Antibody and Immunotoxin in Syngeneic Mouse Tumor Models

  Hwang, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of CISD2 in the Female Reproductive System of Mammal

  Chang, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Expressing Membrane Antibody Reporter in the Islet Cells of Nonobese Diabetic Mice to Noninvasive Assess the Therapeutic Effects of Drugs or Transgenes for Autoimmune Diabetes

  Chuang, K.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 粒狀空氣污染物所產生的氧化壓力對慢性阻塞性肺疾病患者的泛素-蛋白酉每平衡系統之影響:探討氧化壓力，異常發炎以及蛋白質氧化之關係

  Chuang, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 組蛋白去甲基酉每JARID1B基因在肺腺癌之腫瘤形成與影響腫瘤生物行為機轉之探討(1/2)

  Kuo, K.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Structure-Based Design, Synthesis and Biological Evaluation of Novel 6-Substituted 10-Chloro-12h-Thiochromeno[2,3-C]Quinolin-12-One Derivatives as Potential Anticancer Agents

  Huang, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Anti-Aging Effect with the Associated Mechanism by PRP (Platelet-Rich Plasma) in Cartilage---A Fibronectin Fragment Model

  Lee, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Anticancer Drug Discovery of New Tegafur-Derivatives for Colorectal Cancer Therapy

  Chen, M.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討小泛素蛋白Sentrin-specific protease 2 參與轉型生長因子-beta訊息傳遞的作用機制(2/2)

  Chang, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Combination Treatment of Tetrac- and Cetuximab-Induced Anti-Proliferation in Colorectal Cancer with Different APC Status (I)

  Lin, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Dementia Care and Quality Improvement

  Chien, L.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation of the Transcriptional and Epigenetic Mechanisms for the Nm23-H1 Expression---An Nm23-H1-Promoter Screening Platform for Novel Metastasis-Suppressing Anticancer Drugs

  Wang, L.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Exploration and Development of Infection Control Model of Long-Term Care Facilities.

  Chi, M.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Functional Studies of ZNF179 in Neurons in vitro and in vvo

  Lee, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of CD24 in TNF-Alpha-Inhibited Erythroid Differentiation

  Huang, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Association of Physical Activity and Abstain from Smoking and Regression of Cervical Intraepithelial Neoplasia

  Tsai, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Evaluate the Radio-Biological Roles of miR-17-5P in Oral Cancer Cell Line OC3

  Wu, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Novel Roles of Aldose Reductase (AR) in Collagen GPVI- and Thrombin PAR4-Mediated Platelet Activation and Apoptosis---Regulatory Machinery of Arf-AR Signaling in Anucleate Cells

  Sheu, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Vector-Borne Disease Forecasting Models Using Satellite Remote Sensing Techniques

  Chuang, T.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effect of Endothelin-1 on Myofibroblast Transformation of Pleural Mesothelial Cells and Its Implications for Pleural and Pulmonary Fibrosis

  Chung, C. & Hsiao, G.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 乳癌是目前世界上女性癌症病患中為數最多的癌症之ㄧ。腺病毒蛋白type 5 E1A (E1A)和許多抗腫瘤作用有關，曾於多種癌症如乳癌、卵巢癌及頭頸癌之病患進行臨床基因治療試驗。許多的研究指出E1A具有多項抗腫瘤的功能，包括抑制腫瘤的發生、增加腫瘤細胞對於化療藥物的感受性以及減少腫瘤轉移的現象。腫瘤的轉移對於癌症患者的死亡率有極大的影響當然也包括了乳癌的患者。E1A於抑制腫瘤發展的過程中具有多重生物學上的意義，這也促使我們想要釐清E1A抑制癌症的機制。因此，我們對於了解E1A抑制癌症轉移相關的分子機制感到有興趣，並期望藉以作為未來改進乳癌病人臨床試驗的基石。我們初步的實驗結果顯示，E1A可以有效的抑制Glucose-regulated protein 78 (GRP78)這種已被廣泛報導和腫瘤惡化及轉移相關的蛋白的表現。 提出此研究計劃之目的在於詳細探討E1A所造成的抑制癌轉移作用中，GRP78所扮演的生物功能及其調控的機轉。為了達到此目的，我們將著重於E1A如何調控GRP78表現並進而展現對乳癌轉移的抑制作用。以下為此項研究計畫的四大主要目標： 目標一：探討GRP78在E1A所抑制之癌細胞移行及侵入作用中所扮演的角色 目標二：研究E1A抑制GRP78表現之分子機轉 目標三：於動物模式中驗證GRP78的表現對於E1A抗腫瘤作用的影響 目標四：探討GRP78及其相關分子的表現在乳癌病人的臨床重要性 完成以上的主要目標能夠幫助我們對於E1A之抗腫瘤轉移作用建立更加詳細的分子訊息傳遞機制。另外，藉由此研究計畫的新發現也許可以對未來發展癌症治療上提供更多具有潛力的標的物。

  Wang, W.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Assessing Trends and Influencing Factors of Medical Services Utilization and Expenditures and the Likelihood of Employment Status Change among Women with Postpartum Depression—A Ten-Year Retrospective Matched Case-Control Study with National Claims

  Huang, K.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Association between Lipid, Glucose Related Genes and Prognosis of Intra- and Extra-Cranial Stenosis in Stroke Patients

  Chiou, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Home-Based Exercise Training on Fatigue, Sleep Disturbance, Symptom Distress and Quality of Life in End-Stage Renal Disease Patients

  Lin, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation of the Intrinsic Molecular Mechanisms of ETV6 That Contribute to Suppression of Metastasis and Sensitivity of Chemotherapy in Prostate Cancer

  Liu, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Study on Trans-Neuronal Striato-Nigral Degeneration-Induced Movement Disorders after Stroke---Evaluation with Grey Matter Suppression Ir and Diffusion Tensor Imaging (III)

  Chen, C.

  8/1/14 → 10/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study the Therapeutic Role of Niemann-Pick Type C2 Protein in Liver Cancer

  Liao, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Saturated Fatty Acids from Animals and Vegetables on Alcoholic Liver Disease in Rats Based on Phathological Mechanism.

  Yang, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Biomarkers Associated with Toll-Like Receptors and Neuroimage Study in Ischemic Stroke Patients (II)

  Hu, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Chitosan Nanoparticle as a Macrophage-Targeting Drug Delivery Carrier

  Mi, F.

  8/1/14 → 8/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Pre-Clinical and Clinical Study for Multi-Nation Intelligent Medication Safety System

  Li, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Cultivation of Young Scholars: Philosophy of Consciousness

  Lane, T. J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study of Postoperative Adverse Outcomes of Surgical Patients Using Taiwan National Health Insurance Database

  Chen, T.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Evaluate the Molecluar Mechanims and Clinical Application on Atf3 Regulated microRNAs

  Lin, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Infant Feeding Information in the Internet and How the Information Influences the Infant Feeding Behavior

  Chen, Y. C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Uteroplacental Insufficiency and Hyperoxia on Lung Development and Epigenetic Alterations in the Rat Offspring

  Chen, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Pre- and Post-Operative Life Experience, Quality of Life and Physical Activity among Patients with Total Kneeand Hip Replacement

  Lin, P.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of CCR5/RANTES in Neurodegeneration

  Chou, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• An Association Study of Early Arsenic Exposure and Genes Related to Arsenic Metabolic Capacity on the Risk of Cardiovascular Disease (I)

  Hsieh, F.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology