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• Genetic Polymorphisms in microRNA and Risk of the Post-Thrombolytic Hyperglycemia in Acute Ischemic Stroke and Its Prognosis Study

  Hsieh, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Hyperglycemia 100%
  • MicroRNAs 92%
  • Stroke 80%
  • Single Nucleotide Polymorphism 42%
  • Small Untranslated RNA 10%

• Effects of Functional Electrical Stimulation Cycling and Central Neuromodulation on Motor Control in Stroke

  Chen, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Transcranial Direct Current Stimulation 100%
  • Rehabilitation 59%
  • Stroke 58%
  • Electric Stimulation 55%
  • Exercise 44%

• Development of Novel Therapeutic Agents for Herceptin Resistance Breast Cancer Cells through Targeting Nicotinic Acetylcholine Receptors

  Lee, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Breast Neoplasms 100%
  • Trastuzumab 88%
  • Neoplastic Stem Cells 39%
  • Drug Resistance 27%
  • Luciferases 20%

• 2014台北市立聯合醫院 (仁愛院區)員工體適能檢測暨體適能變化情形分析計畫

  Kan, N.

  8/1/14 → 2/28/15

  Project: A - Government Institution › f - Other (Funded by Government)

• Evaluating the Effect of Migration Stimulating Factor on Wound Healing Behavior at the Cellular Level Using Nano-Biomedical Technologies

  Yang, T.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Wound Healing 100%
  • Biomedical Technology 61%
  • Raman Spectrum Analysis 42%
  • Cell Movement 39%
  • Extracellular Matrix 27%

• Prostate Cancer Malignancy Is Enhanced by Glycotoxins

  Wu, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Receptor for Advanced Glycation End Products 100%
  • Prostatic Neoplasms 40%
  • Neoplasms 22%
  • Autophagy 16%
  • Amino Sugars 13%

• Effects of Uteroplacental Insufficiency and Hyperoxia on Lung Development and Epigenetic Alterations in the Rat Offspring

  Chen, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Fetal Growth Retardation 100%
  • Hyperoxia 99%
  • Receptor for Advanced Glycation End Products 74%
  • Epigenomics 69%
  • Lung 48%

• Pre- and Post-Operative Life Experience, Quality of Life and Physical Activity among Patients with Total Kneeand Hip Replacement

  Lin, P.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Life Change Events 100%
  • Joints 94%
  • Quality of Life 68%
  • Exercise 52%
  • Lysholm Knee Score 38%

• Analyses of ADAM9 on Integrin b4 Turnover to Facilitate Prostate Cancer Migration and Invasion

  Sung, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • metastasis 100%
  • integrins 89%
  • neoplasm progression 42%
  • prostatic neoplasms 38%
  • neoplasms 38%

• Contribution of ER Stress to Inhibit miR-19a/b and miR-26b-Mediated CTGF Expression in Lung Fibrosis (II)

  Chen, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Application and Mechanism of Novel Fluoro-Rutaecarpine on Inhibition of Inflammation Induced Endomt

  Lin, C.

  8/1/14 → 12/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Fibrosis 19%
  • Inflammation 15%
  • Sumoylation 5%

• 醫學與影像美學

  Chang, H.

  8/1/14 → 1/31/15

  Project: A - Government Institution › d - Ministry of Education

• 103年度健康體適能檢測活動

  Kan, N.

  8/1/14 → 10/31/14

  Project: A - Government Institution › f - Other (Funded by Government)

• Study the Function and Regulation of miRNAs in Pancreatic Cancer Progression (I)

  Huang, M.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • MicroRNAs 100%
  • Pancreatic Neoplasms 93%
  • Neoplastic Stem Cells 42%
  • Neoplasms 28%
  • Neoplasm Metastasis 12%

• Effects of Antrodia Camphorate Extract on Diet-Induced Steatohepatitis

  Chen, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Antrodia 100%
  • liver diseases 34%
  • inflammation 31%
  • extracts 27%
  • fatty liver 21%

• Evaluation on Cervical Cancer Prevention and Treatment Policy in Taiwan

  Tang, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Uterine Cervical Neoplasms 100%
  • Taiwan 83%
  • National Health Programs 63%
  • Early Detection of Cancer 34%
  • Hospice Care 31%

• Enhancement of Immuno-Modulatory Capacity by Shear Stress in Mesenchymal Stem Cells

  Ho, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Mesenchymal Stem Cells 100%
  • Mesenchymal Stem Cell Transplantation 21%
  • Aptitude 21%
  • Animal Disease Models 20%
  • Therapeutic Uses 13%

• Effect of RRM2 in Tumor Metastasis and Chemotherapy Response of Colorectal Cancer Patients with Different APC and K-Ras Status

  Cheng, Y.

  8/1/14 → 7/31/16

  Project: B - Project of TMU › i - Other (Funded by TMU)

  • Colorectal Neoplasms 100%
  • Drug Resistance 38%
  • ras Genes 37%
  • Taiwan 31%
  • Neoplasm Metastasis 25%

• Studies on Combination of Hydrophobic Anticancer Drugs Encapsulated in Nanocarriers and Hydrophilic Anticancer Drugs Loaded in Thermosensitive Hydrogels into Cancer Cell

  Ho, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Drug 100%
  • Nanocarrier 74%
  • Hydrogel 68%
  • Pharmacokinetics 12%
  • Nanoparticle 8%

• Application of Regioselective Substitution on 1,4-Benzoquinone Derivatives to Provide Potent Anticancer Agents

  Liou, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • 1,4-benzoquinone 100%
  • Wittig Olefination 54%
  • Intramolecular Cyclization 40%
  • Nucleophilic Substitution 38%
  • Regioselectivity 35%

• Effects of Different Sources of n-3 Fatty Acids on Bone Loss, Body Fat and Inflammatory Markers in Osteoporotic Condition with Diabetes

  Chiu, W. & Fong, T.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Fatty Acid 100%
  • Fat 66%
  • Ligand 24%
  • Deoxypyridinoline 20%
  • Marker 19%

• Antibody-Mediated Immune Suppression of Fetal and Neonatal Alloimmune Thrombocytopenia (FNAIT)

  Burnouf, T. P. R.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • thrombocytopenia 100%
  • immunoglobulin G 34%
  • antigens 26%
  • antibodies 23%
  • hemorrhage 14%

• Natural Product Hybrid and Ortho-Biaryl N-Hydroxycinnamide as Leads for Anticancer Agent Development

  Huang, W.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Histone 100%
  • Antineoplastic Agent 33%
  • Physiological Role 22%
  • Antiproliferative 18%
  • Structure-Activity Relationship 16%

• The Study of the Relationships among Anti-Obesity Activity, Adipogenesis, and Adipose Angiogenesis of Vegetable Indolic Derivatives---Involvement of the Ah Receptor/Arnt ?(III)

  Chen, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • angiogenesis 100%
  • adipogenesis 96%
  • indoles 88%
  • obesity 63%
  • receptors 62%

• 氧化還原作用調控蛋白質去磷酸酉每羰基化和去羰基化反應對動脈血管內膜增生之影響(1/2)

  Hsieh, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Indoor Air Quality Improvement on Cardiovascular Health in General Population

  Chuang, K.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Indoor Air Pollution 100%
  • Air Pollution 15%
  • Taiwan 13%
  • Cardiovascular System 13%
  • Quality Improvement 13%

• The Exploitation of Taiwan Native Plants in Promoting Bone Growth and Establishment of the System Biology Platform

  Lee, M.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Uraria crinita 100%
  • osteoblasts 67%
  • Taiwan 65%
  • bones 48%
  • Biological Sciences 27%

• Can Sesamin Alone or Cotheapy with Anti-DM Medicines Alleviate the Abnormal Intermediate Metabolites of Glucose and Fatty Acids, the Oxygen Consumption and Renal Fibrotic Progression?

  Peng, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • sesamin 100%
  • Oxygen Consumption 48%
  • Kidney 36%
  • Diabetic Nephropathies 20%
  • vascular factor 11%

• Emerging Mechanisms of Omega-3 Fatty Acids in Depression---The Effects of EPA and DHA on Chronic Stress, Neurogenesis and Neuroinflammation

  Huang, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Eicosapentaenoic Acid 100%
  • Docosahexaenoic Acids 95%
  • Depression 83%
  • Omega-3 Fatty Acids 63%
  • Antidepressive Agents 41%

• Determined the Role and the Mechanims of GRP94 in Mediating the Progression and Therapeutic Responses of HCC

  Huang, M.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • glucose-regulated proteins 100%
  • Heat-Shock Proteins 15%
  • Neoplasms 11%
  • Neoplasm Metastasis 8%
  • Preclinical Drug Evaluations 8%

• Identification of Rewired APC Mutation Signaling Network in Chemotherapy Resistant Response in Colorectal Cancer (I)

  Huang, T.

  8/1/14 → 10/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Adenomatous Polyposis Coli 100%
  • Colorectal Neoplasms 44%
  • Mutation 34%
  • Drug Resistance 28%
  • Fluorouracil 17%

• Dissected the Role of Glucosed-Regulated Portein 78 in the Progression, Metastasis and Therapy of Colorectal Cancer

  Wei, P.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • colorectal neoplasms 100%
  • metastasis 69%
  • neoplasms 55%
  • endoplasmic reticulum 32%
  • death 27%

• The Study of Therapeutic Effects for Stroke with Phenserine, an Amyloid Precursor Protein Inhibitor, in Rodent Focal Cerebral Ischemia Model(2/3)

  Chang, C. & Chiang, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › a - National Health Research Institutes

  • phenserine 100%
  • Stroke 75%
  • Amyloid beta-Protein Precursor 49%
  • pifithrin 40%
  • Stem Cells 31%

• Investigate the Molecular Mechanisms Involved in Enhancing Photodynamic Thetapy Using an Old Antibiotic Agent

  Tsai, T.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Doxycycline 100%
  • Protoporphyrin 37%
  • Light Irradiation 26%
  • Dosage Form 20%
  • Pharmaceutical 14%

• The Effect of Health Risk Behaviors on Recurrent Traffic Injury

  Chen, P.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Health risks 100%
  • Risk assessment 55%
  • Telephone 39%
  • Health insurance 28%
  • Telecommunication traffic 19%

• Construction and Application of Spatio-Temporal Database and Geography Information System for Emergency Medical Care (I)

  Lin, M.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Health care 100%
  • Big data 44%
  • Catchments 37%
  • Intensive care units 32%
  • Theaters 30%

• Investigation of the Transcriptional and Epigenetic Mechanisms for the Nm23-H1 Expression---An Nm23-H1-Promoter Screening Platform for Novel Metastasis-Suppressing Anticancer Drugs

  Wang, L.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Neoplasm Metastasis 100%
  • Genetic Promoter Regions 93%
  • Methylation 87%
  • Esophageal Neoplasms 66%
  • Tumor Suppressor Genes 63%

• 健康產業行銷與溝通

  Teng, N.

  8/1/14 → 1/31/15

  Project: A - Government Institution › d - Ministry of Education

• Study and Implementation of Patient Privacy Protection under the Framework for Electronic Medical Records Exchange in Taiwan

  Liu, C.

  8/1/14 → 10/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Electronic medical equipment 100%
  • Data privacy 38%
  • Health insurance 14%
  • Health 13%
  • Virtual private networks 13%

• ALA Photodynamic Therapy, Tumor Hypoxia, CSE1L Phosphorylation, and the Progression and Treatment of Skin Cancer

  Lee, W.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Skin Neoplasms 100%
  • Aminolevulinic Acid 31%
  • Tumor Hypoxia 25%
  • Neoplasms 24%
  • Photochemotherapy 20%

• Synaptic Plasticity by Nogo-1 Receptor Overexpression and Exendin-4 Administration on Behavioral and Electrophysiological Recovery after Mild Traumatic Brain Injury (III)

  Tsai, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Cortical Electrical Stimulation Technique for Improving Neuroplasticity and Motor Function in Parkinsonian Rats

  Hsieh, T.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Electric Stimulation 100%
  • Parkinson Disease 98%
  • Neuronal Plasticity 24%
  • Oxidopamine 19%
  • Therapeutics 13%

• 探討小泛素蛋白Sentrin-specific protease 2 參與轉型生長因子-beta訊息傳遞的作用機制(2/2)

  Chang, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Prognosis Analysis and Data Mining for Emergency Patients after Arriving Hospital

  Hsu, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Fires 100%
  • Health insurance 91%
  • Analytic hierarchy process 67%
  • Health care 61%
  • Data mining 50%

• The Investigation of the Gutta Percha Temperature Change on Vertical Compaction of Warm Gutta Percha Technique

  Hsien, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • thermography 100%
  • endodontics 69%
  • temperature 60%
  • methodology 54%
  • heat 42%

• Preclinical Evaluation of Application of Sclareol for Adjuvant Therapy of Cisplatin-Resistant Non-Small Cell Lung Cancer

  Wu, C.

  8/1/14 → 9/30/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • sclareol 100%
  • Cisplatin 49%
  • Non-Small Cell Lung Carcinoma 29%
  • A549 Cells 24%
  • Drug Resistance 20%

• 乳癌是目前世界上女性癌症病患中為數最多的癌症之ㄧ。腺病毒蛋白type 5 E1A (E1A)和許多抗腫瘤作用有關，曾於多種癌症如乳癌、卵巢癌及頭頸癌之病患進行臨床基因治療試驗。許多的研究指出E1A具有多項抗腫瘤的功能，包括抑制腫瘤的發生、增加腫瘤細胞對於化療藥物的感受性以及減少腫瘤轉移的現象。腫瘤的轉移對於癌症患者的死亡率有極大的影響當然也包括了乳癌的患者。E1A於抑制腫瘤發展的過程中具有多重生物學上的意義，這也促使我們想要釐清E1A抑制癌症的機制。因此，我們對於了解E1A抑制癌症轉移相關的分子機制感到有興趣，並期望藉以作為未來改進乳癌病人臨床試驗的基石。我們初步的實驗結果顯示，E1A可以有效的抑制Glucose-regulated protein 78 (GRP78)這種已被廣泛報導和腫瘤惡化及轉移相關的蛋白的表現。 提出此研究計劃之目的在於詳細探討E1A所造成的抑制癌轉移作用中，GRP78所扮演的生物功能及其調控的機轉。為了達到此目的，我們將著重於E1A如何調控GRP78表現並進而展現對乳癌轉移的抑制作用。以下為此項研究計畫的四大主要目標： 目標一：探討GRP78在E1A所抑制之癌細胞移行及侵入作用中所扮演的角色 目標二：研究E1A抑制GRP78表現之分子機轉 目標三：於動物模式中驗證GRP78的表現對於E1A抗腫瘤作用的影響 目標四：探討GRP78及其相關分子的表現在乳癌病人的臨床重要性 完成以上的主要目標能夠幫助我們對於E1A之抗腫瘤轉移作用建立更加詳細的分子訊息傳遞機制。另外，藉由此研究計畫的新發現也許可以對未來發展癌症治療上提供更多具有潛力的標的物。

  Wang, W.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • glucose-regulated proteins 100%
  • Neoplasm Metastasis 25%
  • Neoplasms 23%
  • Breast Neoplasms 16%
  • Psychological Inhibition 12%

• Studies on the Role of ORMDL3 in Thrombin-Induced IL-8/CXCL8 Expression and Airway Inflammation

  Chen, B.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Orosomucoid 100%
  • Thrombin 74%
  • Interleukin-8 34%
  • Transcription Factor AP-1 26%
  • Asthma 23%

• The Effect of Economic Recession on Health and Health Care Service Utilization of Elderly: Comparisons among Welfare State Regimes

  Chuang, K.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • recession 100%
  • economic crisis 76%
  • health 67%
  • welfare state 61%
  • welfare 49%

• Explore the Zhongshan District of impact on employee health behaviors of factors Tobacco Control intervention in large healthy workplace employee

  Chen, R. & Yeh, C.

  8/1/14 → 10/30/14

  Project: A - Government Institution › f - Other (Funded by Government)