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• The Pre-clinical Investigation of the Anticancer Effects of Polysaccharides Extracted from Ulva Prolifera on Colon Cancer

  Deng, W.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Polysaccharide 100%
  • Anticoagulant 14%
  • Nutrient 12%
  • Antineoplastic Agent 10%
  • Antioxidant Agent 8%

• The Inhibitory Effect of Fucoidan on Renal Fibrosis

  Chen, T. & Chen, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • fucoidan 100%
  • Fibrosis 40%
  • Kidney 38%
  • Chronic Renal Insufficiency 19%
  • Catenins 15%

• Estrogen Affects the Colon-Urethra Crosstalk via Spinal Kalirin/PSD-95-NR2B-Dependent NR2B Phosphorylation in Rats

  Lin, T.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • urethra 100%
  • colon 58%
  • estrogens 48%
  • mustard oil 48%
  • pain 27%

• Multifunctional Nanoparticles for Cancer Therapy

  Chiu, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Nanoparticle 100%
  • Drug 57%
  • Marker 31%
  • Inorganic Nanoparticle 22%
  • Fluorescence 20%

• The Physiological Predictors of Concurrent Cardiovascular Diseases in Bipolar Disorder

  Chen, P.

  8/1/15 → 10/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Bipolar Disorder 100%
  • Cardiovascular Diseases 85%
  • Mortality 22%
  • Psychiatry 21%
  • Hospitalization 21%

• The Potential Role of Glycogen Synthase Kinase-3 in Dengue Virus-Infected Mononuclear Phagocytes

  Lin, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Glycogen Synthase Kinase 3 100%
  • Dengue Virus 93%
  • Virus Diseases 47%
  • Interleukin-10 35%
  • Cellular Immunity 28%

• Neural and Glutamatergic Correlates of Resting State Activity and Stimulus-Induced Activity in Major Depressive Disorder---Can Multimodal Imaging (fMRI and MRS) Reveal Therapeutic Predictors?

  Chen, C., Lane, T. J., Hu, C., Tseng, Y. & Lee, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Major Depressive Disorder 100%
  • Magnetic Resonance Spectroscopy 53%
  • Magnetic Resonance Imaging 42%
  • Multimodal Imaging 42%
  • Gyrus Cinguli 33%

• Chemo-Sensitizer Conjugated Carbon Nanotubes as a Novel Cancer Therapeutical Delivery System

  Cho, E.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Carbon Nanotube 100%
  • Radiation Sensitizing Agent 38%
  • Ribonucleotide 28%
  • Water Soluble 17%
  • Drug 12%

• Antibody-Mediated Immune Suppression of Fetal and Neonatal Alloimmune Thrombocytopenia ( FNAIT)

  Burnouf, T. P. R.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • thrombocytopenia 100%
  • immunoglobulin G 34%
  • antigens 26%
  • antibodies 23%
  • hemorrhage 14%

• Investigation of Nuclear microRNA Signatures and Their Functional Effects on Glioblastoma Multiforme Pathology

  Chen, K. & Shih, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • MicroRNAs 100%
  • Glioblastoma 67%
  • Temozolomide 54%
  • Glioma 23%
  • Genes 12%

• A High Density and Nano-Sized ReRAM Crossbar Array Using Copper Chemical Displacement and Nanotip Array Techniques (I)

  Wu, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • random access memory 100%
  • diodes 21%
  • copper 13%
  • schedules 11%
  • nitrides 8%

• Applications of Α-Galactosylceramide-Incorporated Liposome as a Targeting Antigen Carrier for Cancer Vaccine Therapy

  Liu, D.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • alpha-galactosylceramide 100%
  • Liposomes 55%
  • Natural Killer T-Cells 16%
  • Active Immunotherapy 12%
  • Antigens 12%

• A Wearable Device Evaluation for Medication Management in Patients Taking Sleep Medicine via Cloud Platform Development( I )

  Li, Y., Jian, W. & Lee, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Sleep 100%
  • Wearable technology 35%
  • Health 28%
  • Education 19%
  • Oximeters 11%

• CXCL5/CXCR2/JNK Axis Is the Shared Pathway of Neuroinflammation and Microvascular Damage That Contributes to White Matter Injury in the Immature Brain

  Huang, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • White Matter 100%
  • Brain Injuries 57%
  • Blood-Brain Barrier 40%
  • JNK Mitogen-Activated Protein Kinases 38%
  • Leukocytes 33%

• Molecular Ivestigation of the Electron Transfer Flavoprotein Dehydrogenase Mutation Induced Mitochondrial Dysfunction and Metabolic Defects

  Kao, S. & Hsu, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • acyl-CoA dehydrogenase 100%
  • flavoproteins 97%
  • electron transfer 79%
  • droplets 39%
  • myoblasts 31%

• Activation of Adenosine A3 Receptors Suppresses Airway Hypersensitivity

  Lin, Y. & Hwang, L.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Adenosine A3 Receptor Agonists 100%
  • Adenosine A3 Receptors 80%
  • Hypersensitivity 72%
  • Unmyelinated Nerve Fibers 47%
  • Lung 37%

• Relationships of One-Carbon Cycle Pathways with Psychopathology and Metabolic Abnormalities in Patients with Schizophrenia and Potential Intervention Strategy with 5-Methyltetrahydrofolate and Vitamin B12

  Chen, C., Huang, S. & Lu, M.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Folic Acid 100%
  • Vitamin B 12 69%
  • Carbon Cycle 66%
  • Schizophrenia 51%
  • 5-methyltetrahydrofolate 48%

• 多元文化語境之英文學習革新課程計畫

  Lin, C., Chu, J. & Chang, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › d - Ministry of Education

• Effects of Regular Exercise on Emotional Control and Cognitive Function of Prefrontal-Limbic Pathway in Sleep-Deprived Rats---An Analysis by Behavior and Neurostructural Correlates

  Hsu, C. & Chang, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Sleep Deprivation 100%
  • Limbic System 76%
  • Cognition 47%
  • Blood-Brain Barrier 46%
  • Electrolytes 35%

• RRM2 在帶有不同APC 及k-ras 基因突變情形之大腸直腸癌轉移及治療效果所扮演的角色

  Cheng, Y.

  8/1/15 → 7/31/16

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Effects of Central Neuromodulation with Functional Electrical Stimulation on Bladder Functions in Traumatic Brain Injured Rats

  Peng, C., Chen, S. & Hsieh, T.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Deep Brain Stimulation 100%
  • Traumatic Brain Injury 76%
  • Brain 29%
  • Urinary Bladder 27%
  • Urination 19%

• Porcine Bone-Collagen Composite Graft Developement

  Chang, W. & Huang, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • bones 100%
  • dentistry 47%
  • collagen 44%
  • swine 43%
  • composite materials 28%

• Proteomics Study of Metformin on Lead Ion-Induced Rat Nephropathy

  Lee, J.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Lead 100%
  • Proteomics 82%
  • Ions 56%
  • Rats 54%
  • Blood 42%

• Development of Novel Tetracyclic and Heterocyclic Dual Topoisomerases Inhibitors as Anticancer Agents( I )

  Huang, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Topoisomerase Inhibitor 100%
  • Antineoplastic Agent 79%
  • Molecule 51%
  • Compound Mobility 45%
  • Anthraquinone 32%

• The Sumoylation of Histone Deacetylase 2 Contributes to CTGF Expression and Pulmonary Fibrosis in Chronic Obstructive Asthma (III)

  Lin, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• HMGA2, a New Target of Thyroid Hormone-Induced Progression in Colorectal Cancers

  Lin, H., Chang, T. & Yen, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • AT-Hook Motifs 100%
  • Thyroid Hormones 75%
  • tetraiodothyroacetic acid 70%
  • Colorectal Neoplasms 43%
  • Integrins 28%

• Drug Discovery and Pharmacological Study of Novel pan-HDAC Inhibitors as Anti-Angiogenic Drugs

  Pan, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Histone Deacetylase Inhibitors 100%
  • Histone Deacetylases 36%
  • Drug Discovery 23%
  • 3-(1-benzenesulfonyl-2,3-dihydro-1H-indol-5-yl)-N-hydroxyacrylamide 18%
  • Animal Models 16%

• Anticancer Drug Discovery of New Tegafur-Derivatives for Colorectal Cancer Therapy

  Chen, M.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Colorectal Neoplasms 47%
  • Survival Rate 15%
  • HCT116 Cells 12%
  • Neoplasms 11%
  • Prodrugs 11%

• Study on the Mechanism Involved in Nanoparticles-Induced Tight Junction and Aquaporins Damages in Endothelial Cells, as Well as the Effects on Physiological Function of Endothelial Barriers

  Li, C. & Cheng, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Nanoparticles 100%
  • Blood-Brain Barrier 69%
  • Aquaporins 65%
  • Tight Junction Proteins 39%
  • Permeability 35%

• Study on the Inhibitory Effect of Lactic Acid Bacteria and Germinated Brown Rice on Colorectal Carcinogenesis

  Shih, C., Li, S. & Chen, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Brown 100%
  • Short-Chain Fatty Acid 33%
  • Gamma-Aminobutyric Acid 28%
  • Tocotrienol 18%
  • Butyrate 14%

• Effects of Antrodia cinnamomea Extract on Fat Accumulation and Energy Expenditure

  Chen, J.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • metabolic syndrome 100%
  • insulin resistance 64%
  • blood pressure 51%
  • adipokines 46%
  • fatty liver 38%

• Neuroprotective Effects of Sig-1R-Znf179-Sp1 Pathway on Brain Injury

  Chang, W. & Chuang, J.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • sigma-1 receptor 100%
  • Traumatic Brain Injury 50%
  • Hydrogen Peroxide 31%
  • Neuroprotective Agents 19%
  • Wounds and Injuries 12%

• Study of Novel Genes Regulated by Aberrant DNA Methylation and Application in Colon Cancer Treatment

  Lin, R. & Ho, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Neoplasm Genes 100%
  • Methylation 83%
  • Taiwan 82%
  • DNA Methylation 81%
  • Colonic Neoplasms 66%

• Development of Novel Therapeutic Agents for Breast Cancer through Targeting Nicotinic Acetylcholine Receptors.

  Wu, C., Ho, Y. & Lee, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › c - Ministry of Health and Welfare

  • Resistance 100%
  • Nicotine 97%
  • Acute Toxicity 95%
  • Acetylcholine 85%
  • Drug 83%

• Construction of gene profiles and connectivity map for ER in a Taiwanese population(先期補助)

  Chang, W.

  8/1/15 → 7/31/16

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Activation Autophagy by the Combination of a Histone Deacetylase Inhibitor and Radiation Limits BNIP3 Regulation in Triple-Negative Breast Cancer Cells and Orthotopic Mouse Model

  Chiu, H. & Ho, Y.

  8/1/15 → 6/30/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Triple Negative Breast Neoplasms 100%
  • Histone Deacetylase Inhibitors 97%
  • Ionizing Radiation 42%
  • Autophagy 39%
  • human ERBB2 protein 25%

• Contribution of ER Stress to Inhibit miR-19a/b and miR-26b-Mediated CTGF Expression in Lung Fibrosis (III)

  Chen, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• 顱內靜脈血管系統異常與缺血性中風及皮質下血管性失智症的相關性研究

  Chiou, H.

  8/1/15 → 7/31/16

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Establish the Research Platform for Studying Triple-Negative Breast Tumor Microenvironment Regulation---The Hyaluronan Synthase-3 Mediated Antitumor Effects as an Example

  Ho, Y. & Wu, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Breast Neoplasms 100%
  • Gene Expression 46%
  • Tumor Microenvironment 40%
  • Hyaluronan Synthases 30%
  • Fibroblasts 29%

• Repositioning Drug Therapies for Traumatic Brain Injury

  Chiu, W., Chang, C. & Chiang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Traumatic Brain Injury 100%
  • Wounds and Injuries 37%
  • Dipeptidyl-Peptidase IV Inhibitors 33%
  • Incretins 33%
  • Acetylcysteine 28%

• A Multidisciplinary Study of the Pathophysiology of Blast-Induced Mild Traumatic Brain Injury

  Chiang, Y., Wu, C. & Lee, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Wounds and Injuries 100%
  • Dizziness 86%
  • N-nitrosoiminodiacetic acid 71%
  • Headache 70%
  • Animal Models 59%

• Development of Cortical Electrical Stimulation Technique for Improving Neuroplasticity and Motor Function in Parkinsonian Rats

  Hsieh, T., Chiang, Y. & Peng, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Study of Therapeutic Effects for Stroke with Phenserine, an Amyloid Precursor Protein Inhibitor, in Rodent Focal Cerebral Ischemia Model

  Chang, C. & Chiang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • phenserine 100%
  • Stroke 75%
  • Amyloid beta-Protein Precursor 49%
  • pifithrin 40%
  • Stem Cells 31%

• 族群健康促進之多元敘事力賦能課群

  Chiu, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › d - Ministry of Education

• The Effectiveness of Family-Based Participation Behavior Modification Program on Screen-Based Sedentary Behavior, Physical Activity, and Obesity in Children

  Chen, S., Chou, K. & Chang, W.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Sedentary Behavior 100%
  • Pediatric Obesity 59%
  • Exercise 41%
  • Behavior Therapy 33%
  • Screen Time 26%

• Whole Organ Decellularizationtrachea Scaffold Tissue Engineering for Whole Segment Tracheal Transplantation/Replacement

  Hung, S., Lee, F. & Tseng, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • trachea (vertebrates) 100%
  • cartilage 77%
  • sonication 70%
  • tissues 27%
  • skeleton 25%

• The Comparison of Complications and Mortality after Surgery between General Anesthesia and Regional Anesthesia in the Elderly

  Liao, C., Cherng, Y. & Chen, T.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Conduction Anesthesia 100%
  • General Anesthesia 89%
  • Elderly 42%
  • Mortality 35%
  • Postoperative Complications 30%

• A Mind-Body Approach to Study Irritable Bowel Syndrome---Role of Psychological Distress, Effectiveness and Mechanisms of Mindfulness Training

  Tsai, P., Chang, C. & Chen, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Mindfulness 100%
  • Depression 82%
  • Anxiety 79%
  • Self-Help Groups 49%
  • Urbanization 35%

• Study of C3H-Type Zinc-Finger Proteins on the Down-Regulation of Ubiquitination-Mediated Activation of Signal Transduction

  Liang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Ubiquitin 100%
  • Ubiquitination 71%
  • Lysine 32%
  • Zinc Fingers 28%
  • Signal Transduction 25%

• Systemic Analysis on Dynamic Mechanism of Actin Cytoskeleton Organization Regulated Physiological Changes Caused by Physical Stimuli in Mesenchymal Stem Cells

  Ho, J. & Chang, T.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Actins 100%
  • Mesenchymal Stem Cells 72%
  • Proteins 24%
  • Polymerization 22%
  • Microfilament Proteins 19%