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Analysis and Data Mining of Decision Characteristic of Prehospital Emergency Patients Transport
Hsu, C.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Roles of toll-like receptor-4 and hif-1 in propofol-involved protection against traumatic brain injury-induced dysfunction of the blood-brain barrier
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Investigation of the Effect of Androgen Receptor Knockout on Pathophysiology of Traumatic Brain Injury
Yang, L.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Trends in Surgical Litigation and Media Coverage of Medical Malpractice: Implications for Medical Education
Lyu, S.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Synaptic Plasticity by Nogo-1 Receptor Overexpression and Exendin-4 Administration on Behavioral and Electrophysiological Recovery after Mild Traumatic Brain Injury (II)
8/1/13 → 7/31/14
Project: B - Project of TMU › i - Other (Funded by TMU)
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Study of Postoperative Adverse Outcomes of Surgical Patients Using Taiwan National Health Insurance Database
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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To Study the Correlation between Serum Markers of Oxidative Stress, Inflammation, and Endocrine-Disrupting Chemicals (Edcs) and Their Impact on the Menstrual Cycle and Reproductive Hormone in Taiwanese Women
Hsu, M.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Exploratory Study of Self-Identity and Medical Professionalism Among Medical Students
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Design and Characterization of Multifunctional Self-Assembling Lecithin/Amphiphilic Polymers Mixed Micellar Delivery Systems
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Anti-Tumor Mechanisms of a Novel Aliphatic Hydroxamate, WMJ-S-001---Targeting Tumor Angiogenesis and Lymphangiogenesis
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Expressing Membrane Antibody Reporter in the Islet Cells of Nonobese Diabetic Mice to Noninvasive Assess the Therapeutic Effects of Drugs or Transgenes for Autoimmune Diabetes
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Association Study of Genetic Polymorphisms of Toll-Like Receptors on Ischemic Stroke (I)
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Study of Therapeutic Effects for Stroke with Phenserine, an Amyloid Precursor Protein Inhibitor, in Rodent Focal Cerebral Ischemia Model
Chang, C.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Association between lipid, glucose related genes and prognosis of intra- and extra-cranial stenosis in stroke patients
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Dementia Care and Quality Improvement
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Real-Time Single-Cell Probing of the Action Mechanism of Amphotericin B Ion Channels---From Extracellular to Intracellular
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The influence of Porphyromonas gingivalis GroEL in vascular cells
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Design and Development of Antibody-Targetable and Self-Assembled Micelles of Anticancer Drug Conjugate and Complex of Hyaluronic Acid
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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A Clinical Correlation study of DNA Methyltransferases Alterations in Breast Cancer and Evaluation of DNA Methyltransferases as a Therapeutic Target in Cell and Animal Models
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Studies on a Thermosensitive Hydrogel of Doxorubicin as Locally Controlled Delivery of Cancer Therapeutics
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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TMU101-AE1-B65
8/1/13 → 7/31/14
Project: C - Project of Alliance › p - Taipei Medical University Hospital
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Role of Sp-family in lung tumorigenesis
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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探討芳香烴受體(AhR)改變血管內皮細胞功能之新角色:經由表觀基因或後轉譯修飾(細胞週期蛋白/內皮細胞一氧化氮合成?)的調控與白蘆黎醇/史達汀臨床治療及應用(1/3)
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Investigating the Differential Effects and the Mechanisms of Flavonols on Osteogenic Differentiation of Human Dental Pulp Stem Cells
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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New Strategies of Parkinson’s Disease Treatment
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Sleep and Memory Consilidation in Alzheimer Disease
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Effects of Electroconvulsive Therapy on Health Services Utilization, Positive and Negative Syndrome, and Sleep among Psychiatric Patients
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Use the organometal catalytic reaction to synthesize the heterocycle-based anticancer agents
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Role of ADAM 17 in Hypoxia-Induced CTGF Expression and Pulmonary Fibrosis (I)
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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大腸直腸癌已躍居世界上癌症死亡率第二名,屬於固體型腫瘤,缺氧常見於此類 腫瘤,並誘發HIF-1α 表現而導致抗藥性及預後較差,因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑,可殺死癌 細胞而不影響正常細胞,對小鼠也不具毒性。我們初步結果顯示,Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現,代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性,對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下,經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制;也有研究報導指出,藥物會誘導癌細胞產生autophagy,造成細胞過度吞噬其內容 物而死亡,因此,autophagy在癌細胞為保護或是引發毒殺作用,目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活,但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示,除抑制HIF-1α 表現外,Zeb 也可活化AMPK、UPR/ER stress、以及autophagy, 因此我們推測Zeb 可在缺氧狀態下,促進autophagic cell death。3 年內我們將執行4 項 目標: (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。(第一年) (2) 研究Zeb 抑制HIF-1α表現之分子機轉。(第一年到第二年) (3) 研究Zeb 誘發autophagy之分子機轉。(第二年到第三年) (4) 探討Zeb 對缺氧導致抗藥性之作用。(第三年)
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Effects of Exercise Training on Sleep Disturbances, Anxiety, and Depression among Newly Diagnosed Elderly Lung Cancer Patients
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Distribution of the Number of False Discoveries in Genome-Wide Linkage Scan
8/1/13 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Prp: Platelet-Rich Plasma Effects in the Articular Chondrocytes and Synovial Fibroblasts with the Associated Mechanism---A Fibronectin Fragment Model
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Effects of Music Listening on Pain, Heart Rate Variability and Joint Range of Motion for Patints Receving Total Knee Replacement
Lin, P.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Characterization of 5-Hydroxymethylcytosine and Ten-to-Eleven Translocation Gene (TET) in Cervical Cancer
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Role of ER stress in Evodiamine-induced apoptosis and G2/M arrest of human colorectal carcinoma cells
Chen, Y.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Translational studies of Mycobacterium tuberculosis-induced lung and pleural fibrosis
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Effects and Mechanisms of Pitx2c Modulation for Atrial Electrophysiological and Structural Remodelings in Heart Failure
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Electrophysiological and Molecular Insights into the Cardiac Regulations of ZFHX3 Gene---Implication in the Pathophysiology of Atrial Fibrillation
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Study the role of the endoplasmic reticulum stress related proteins, Glycoprotein 96(GP96), in liver cancer progression and metastasis and the clinically therapeutic implication
Huang, M.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Impact of Coping Skills Training on Stress, Symptom Distress in Children with Cancer
8/1/13 → 10/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Immune Alteration and Immunogenic Cell Death in Advanced Non-Small Cell Lung Cancer Patients
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Depression Trajectories in Women – A Developmental-ecological approach (GM03)
8/1/13 → 9/30/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Role of CISD2 in the Female Reproductive System of Mammal
Chang, H.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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A Novel Porcine Bone Xenograft Development
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Preclinical Assessment of the Potential Prognostic and Therapeutic Values of Hippo Signaling Cascade in Targeting Therapy-Resistant Cancer Stem Cells in Hepatocellular Carcinoma
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Ffects of Different Sources of n-3 Fatty Acids on Bone Loss, Body Fat and Inflammatory Markers in Osteoporotic Condition with Diabetes
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Genomic and non-genomic estrogen effects on the spinal NR2B-related uterus-colon crosstalk in rats
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Moderating Effect of Welfare States on Health and Service Utilization - Comparison of Taiwan and European Countries
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology