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• 委託辦理103年度「我國壓瘡(pressure sore)發生之影響因子及相關預防策略成效研究」

  Liu, F.

  7/13/14 → 11/30/14

  Project: A - Government Institution › c - Ministry of Health and Welfare

• 2014馬祖特用植物之開發應用

  Lee, M.

  7/25/14 → 7/30/15

  Project: A - Government Institution › f - Other (Funded by Government)

• Studies on the Teaching Model to Foster Mindfulness through Arts Performance in Medicine Students

  Lin, W.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Mindfulness 100%
  • Medicine 33%
  • Physicians 27%
  • Art 20%
  • Reflective Writing 20%

• A Study on the Influence of Classical Mathematics Reading Course on Medical Students$ Beliefs about Mathematics

  Ying, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • mathematics 100%
  • medical student 21%
  • university 18%
  • student 11%
  • subject of study 9%

• 中山區健康生活型態調查

  Chen, R.

  8/1/14 → 10/30/14

  Project: A - Government Institution › f - Other (Funded by Government)

• Using Cometing Risk Model for Death and Multi-State Stochastic Process for the Behaviour of Betel-Quid Chewing and Smoking to Estimate the Potential Years of Life Lost Due to Betel Quid and to Estiamte the Impact of Qutiing Betel-Quid Chewing

  Yen, M.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Mastication 100%
  • Smoking 34%
  • Habits 22%
  • Mouth Neoplasms 17%
  • Life Expectancy 15%

• Exploration and Development of Infection Control Model of Long-Term Care Facilities.

  Chi, M.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Long-Term Care 100%
  • Cross Infection 39%
  • Disease Outbreaks 35%
  • Infection Control 13%
  • Biomedical Research 13%

• Genomic and Non-Genomic Estrogen Effects on the Spinal NR2B-Related Uterus-Colon Crosstalk in Rats

  Lin, T.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • uterus 100%
  • colon 95%
  • estrogens 62%
  • irritable bowel syndrome 33%
  • comorbidity 31%

• An Investigation of the Effects of Tea Component on the Inhibition of Leukocyte Nicotinic Acetylcholine Receptor Expression on Breast Cancer Patients

  Tu, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Leukocytes 100%
  • Tea 92%
  • Breast Neoplasms 87%
  • Nicotine 31%
  • Capsules 28%

• Unraveling the Impact of Deletion of Androgen Receptor on Brain Trauma

  Yang, L.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Traumatic Brain Injury 100%
  • Androgen Receptors 63%
  • collapsin response mediator protein-2 45%
  • Phosphorylation 18%
  • Organized Financing 12%

• Molecular Epidemiological Study of Renal Cell Carcinoma---Arsenic Methylation Capability, 8-OHdG and Polymorphism of IRS and RAAS Exploration

  Hsueh, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Arsenic 100%
  • Renal Cell Carcinoma 62%
  • Methylation 54%
  • Insulin Receptor 26%
  • Enzymes 25%

• The Role of CISD2 in the Female Reproductive System of Mammal

  Chang, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • egg quality 100%
  • mammals 86%
  • eggs 70%
  • medicine 52%
  • sulfur 50%

• Mechanisms Underlying Airway Hypersensitivity Induced by Hydrogen Sulfide

  Lin, Y.

  8/1/14 → 10/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Unmyelinated Nerve Fibers 100%
  • Lung 65%
  • Hypersensitivity 50%
  • Reflex 39%
  • Ankyrins 37%

• Reflex Pelvic Floor Muscle Activities in Women with Urinary Incontinence (II)

  Yang, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • muscle contraction 100%
  • urinary incontinence 92%
  • reflexes 85%
  • muscles 36%
  • perineum 21%

• Efficacy Studies of Tn-Directed Therapeutic Antibody and Immunotoxin in Syngeneic Mouse Tumor Models

  Hwang, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • antibodies 100%
  • mice 94%
  • prostatic neoplasms 51%
  • neoplasms 48%
  • vaccines 21%

• Highly Reliable Surface-Enhanced Raman Scattering Sensors

  Liu, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Raman spectra 100%
  • augmentation 22%
  • noble metals 18%
  • preparation 17%
  • sensors 17%

• Assessing Trends and Influencing Factors of Medical Services Utilization and Expenditures and the Likelihood of Employment Status Change among Women with Postpartum Depression—A Ten-Year Retrospective Matched Case-Control Study with National Claims

  Huang, K.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • medical services 100%
  • expenditures 76%
  • Taiwan 72%
  • utilization 69%
  • incidence 55%

• Evaluation of the Mechanism of Post-Traumatic Immunosuppression---The Role of TLR4 Trafficking and microRNA

  Lin, J. A.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • immunosuppression 100%
  • bones 72%
  • monocytes 53%
  • inflammation 46%
  • orthopedics 45%

• Study of Mechanotransduction in Hair Cell

  Horng, J.

  8/1/14 → 12/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • hairs 100%
  • sodium-hydrogen antiporter 60%
  • mechanotransduction 35%
  • inner ear 29%
  • neomycin 28%

• 組蛋白去甲基酉每JARID1B基因在肺腺癌之腫瘤形成與影響腫瘤生物行為機轉之探討(1/2)

  Kuo, K.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Evaluation of Clinical Feasibility of Quantitative MR Perfusion Imaging and Its Calibration

  Tseng, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Magnetic Resonance Imaging 100%
  • Calibration 93%
  • Cerebrovascular Circulation 87%
  • Gray Matter 45%
  • Perfusion 45%

• Study on the Mechanism of Cross-Talk between Ahr and Autophagy, and Autophagy---Associated Physiological or Pathological Phenomenon on Vascular and Airway Systems (I)

  Li, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Aryl Hydrocarbon Receptors 100%
  • Autophagy 88%
  • Benzo(a)pyrene 17%
  • Fibrosis 15%
  • Endothelial Cells 15%

• Effects of Central Neuromodulation with Functional Electrical Stimulation on Bladder Functions in Traumatic Brain Injured Rats

  Peng, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Deep Brain Stimulation 100%
  • Traumatic Brain Injury 76%
  • Brain 29%
  • Urinary Bladder 27%
  • Urination 19%

• 乳癌是目前世界上女性癌症病患中為數最多的癌症之ㄧ。腺病毒蛋白type 5 E1A (E1A)和許多抗腫瘤作用有關，曾於多種癌症如乳癌、卵巢癌及頭頸癌之病患進行臨床基因治療試驗。許多的研究指出E1A具有多項抗腫瘤的功能，包括抑制腫瘤的發生、增加腫瘤細胞對於化療藥物的感受性以及減少腫瘤轉移的現象。腫瘤的轉移對於癌症患者的死亡率有極大的影響當然也包括了乳癌的患者。E1A於抑制腫瘤發展的過程中具有多重生物學上的意義，這也促使我們想要釐清E1A抑制癌症的機制。因此，我們對於了解E1A抑制癌症轉移相關的分子機制感到有興趣，並期望藉以作為未來改進乳癌病人臨床試驗的基石。我們初步的實驗結果顯示，E1A可以有效的抑制Glucose-regulated protein 78 (GRP78)這種已被廣泛報導和腫瘤惡化及轉移相關的蛋白的表現。 提出此研究計劃之目的在於詳細探討E1A所造成的抑制癌轉移作用中，GRP78所扮演的生物功能及其調控的機轉。為了達到此目的，我們將著重於E1A如何調控GRP78表現並進而展現對乳癌轉移的抑制作用。以下為此項研究計畫的四大主要目標： 目標一：探討GRP78在E1A所抑制之癌細胞移行及侵入作用中所扮演的角色 目標二：研究E1A抑制GRP78表現之分子機轉 目標三：於動物模式中驗證GRP78的表現對於E1A抗腫瘤作用的影響 目標四：探討GRP78及其相關分子的表現在乳癌病人的臨床重要性 完成以上的主要目標能夠幫助我們對於E1A之抗腫瘤轉移作用建立更加詳細的分子訊息傳遞機制。另外，藉由此研究計畫的新發現也許可以對未來發展癌症治療上提供更多具有潛力的標的物。

  Wang, W.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • glucose-regulated proteins 100%
  • Neoplasm Metastasis 25%
  • Neoplasms 23%
  • Breast Neoplasms 16%
  • Psychological Inhibition 12%

• Association between Lipid, Glucose Related Genes and Prognosis of Intra- and Extra-Cranial Stenosis in Stroke Patients

  Chiou, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Stroke 85%
  • Lipid Metabolism 84%
  • Homeostasis 64%
  • Glucose 63%
  • Antioxidants 46%

• Investigation of the Intrinsic Molecular Mechanisms of ETV6 That Contribute to Suppression of Metastasis and Sensitivity of Chemotherapy in Prostate Cancer

  Liu, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Prostatic Neoplasms 100%
  • Neoplasm Metastasis 28%
  • ras Genes 16%
  • Nuclear Receptor Co-Repressor 2 11%
  • Drug Therapy 11%

• A Study on Trans-Neuronal Striato-Nigral Degeneration-Induced Movement Disorders after Stroke---Evaluation with Grey Matter Suppression Ir and Diffusion Tensor Imaging (III)

  Chen, C.

  8/1/14 → 10/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of a Computerized Adaptive Testing of the Health Literacy in Stroke Rehabilitation

  Hou, W.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Health Literacy 100%
  • Stroke Rehabilitation 86%
  • Psychometrics 23%
  • Stroke 21%
  • Rehabilitation 19%

• Effects of Dietary Advanced Glycation Endproducts on Hypothalamic-Pituitary-Ovarian Axis in vitro and in vivo Study Are Associated with the Development of Polycystic Ovarian Syndrome: The Mechanisms of Action(1/3)

  Hsia, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Advanced Glycation End Products 100%
  • Polycystic Ovary Syndrome 69%
  • Granulosa Cells 14%
  • Diet 11%
  • Hormones 8%

• Evaluating the Effect of Migration Stimulating Factor on Wound Healing Behavior at the Cellular Level Using Nano-Biomedical Technologies

  Yang, T.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Wound Healing 100%
  • Biomedical Technology 61%
  • Raman Spectrum Analysis 42%
  • Cell Movement 39%
  • Extracellular Matrix 27%

• Effects of Saturated Fatty Acids from Animals and Vegetables on Alcoholic Liver Disease in Rats Based on Phathological Mechanism.

  Yang, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • saturated fatty acids 100%
  • liver diseases 78%
  • alcohol abuse 65%
  • lard 55%
  • ethanol 52%

• The Association Study of Genetic Polymorphisms of Toll-Like Receptors on Ischemic Stroke (II)

  Chiou, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Prostate Cancer Malignancy Is Enhanced by Glycotoxins

  Wu, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Receptor for Advanced Glycation End Products 100%
  • Prostatic Neoplasms 40%
  • Neoplasms 22%
  • Autophagy 16%
  • Amino Sugars 13%

• 肺纖維化之轉譯研究－組蛋白去乙醯酉每2的SUMO化修飾貢獻於慢性阻塞性氣喘的結締組織生長因子表現與肺部纖維化反應(2/3)

  Lin, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• End-of-Life Care for Elderly with Advanced Dementia in Long-Term Care Facilities

  Chang, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • dementia 100%
  • caregiver 30%
  • Taiwan 29%
  • nursing home 7%
  • interview 6%

• To Investigate the Role of SPNS2 in Determining Individual Susceptibility to Hypoxic Challenge

  Yang, C. H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Phenotype 100%
  • Pharmacology 55%
  • Physiological Adaptation 54%
  • Middle Cerebral Artery Infarction 45%
  • Neurodegenerative Diseases 36%

• CXCL5/CXCR2/JNK Axis Is the Shared Pathway of Neuroinflammation and Microvascular Damage That Contributes to White Matter Injury in the Immature Brain

  Huang, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • White Matter 100%
  • Brain Injuries 57%
  • Blood-Brain Barrier 40%
  • JNK Mitogen-Activated Protein Kinases 38%
  • Leukocytes 33%

• Cocaine Induces Sig-1R Nuclear Envelope Localization to Regulate MAOB Expression by Interacting with Emerin-HDACs Co-Repressor Complex

  Chuang, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • sigma-1 receptor 100%
  • Cocaine 63%
  • Monoamine Oxidase 42%
  • emerin 30%
  • Co-Repressor Proteins 29%

• Identifying Prostate Cancer Biosignature from Multi-Scale Mixture-Lineage Modeling of Tumor Cell Progression

  Jian, W.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Fibrosis 100%
  • Formal Social Control 33%
  • Thrombin 33%
  • Neoplasms 32%
  • Drug Development 31%

• Pre-Clinical and Clinical Study for Multi-Nation Intelligent Medication Safety System

  Li, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Decision support systems 100%
  • Security systems 98%
  • Health 71%
  • Automatic identification 58%
  • Health care 49%

• The Study of Neurotrophic and Neuroplastic Effects of Exercise and Environmental Enrichment in Mild Traumatic Brain Injury

  Chen, K.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Nerve Growth Factors 56%
  • Traumatic Brain Injury 51%
  • Exercise 34%
  • Neuropathology 29%
  • Global Health 25%

• A Clinical Correlation Study of DNA Methyltransferases Alterations in Breast Cancer and Evaluation of DNA Methyltransferases as a Therapeutic Target in Cell and Animal Models

  Lin, R.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Breast Neoplasms 100%
  • Tumor Suppressor Genes 95%
  • DNA (Cytosine-5-)-Methyltransferase 1 67%
  • Methyltransferases 40%
  • DNA Methylation 35%

• To Investigate the Functions of Shikonin and Its Derivatives in Applied Age-Related Macular Degeneration and Wound Healining

  Cheng, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • shikonin 100%
  • macular degeneration 20%
  • angiogenesis 17%
  • animal injuries 15%
  • tissue repair 15%

• Applications of Α-Galactosylceramide-Incorporated Liposome as a Targeting Antigen Carrier for Cancer Vaccine Therapy

  Liu, D.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • alpha-galactosylceramide 100%
  • Liposomes 55%
  • Natural Killer T-Cells 16%
  • Active Immunotherapy 12%
  • Antigens 12%

• The Effect of Muscle Strength Training on Body Composition and Sarcopenic Obesity among the Female Overweight Elderly

  Liou, T.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • medication 100%
  • study group 58%
  • Group 52%
  • Taiwan 48%
  • expert 36%

• Inhibitory Effect and Mechanism of Bioactivated Rice on Colorectal Carcinogenesis

  Shih, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • colorectal neoplasms 100%
  • health promotion 91%
  • rice 90%
  • carcinogenesis 88%
  • neoplasms 83%

• Antibody-Mediated Immune Suppression of Fetal and Neonatal Alloimmune Thrombocytopenia (FNAIT)

  Burnouf, T. P. R.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • thrombocytopenia 100%
  • immunoglobulin G 34%
  • antigens 26%
  • antibodies 23%
  • hemorrhage 14%

• Identification of Human Viral Micrornas and Its Targets by Using Small RNA Sequencing Data Based on RNA Sequence and Structure Features

  Chang, T.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • MicroRNAs 100%
  • Forensic Anthropology 14%
  • Databases 13%
  • Viruses 7%
  • Mammals 6%

• Effects of Different Oils Combined with Lycium Barbarum Extract on Chemical-Induced Liver Inflammation and Fibrosis in Rats

  Chao, J. C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Olive Oil 100%
  • Stellate Crystal 89%
  • Signal Transduction 47%
  • Antifibrotic 37%
  • Apoptotic 25%

• 氧化還原作用調控蛋白質去磷酸酉每羰基化和去羰基化反應對動脈血管內膜增生之影響(1/2)

  Hsieh, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology