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• To Study the Role of Sp1 in Cancer Drug Resistance( I )

  Chuang, J.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of Angiopoietin-Like Protein 1 in Sorafenib Resistance and Cancer Stemness of Hepatocellular Carcinoma Cells

  Huang, M.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Design and Synthesis of Biaryl and Biphenylamino Sulfonamides as Novel Anticancer Agents

  Lai, M.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 本研究擬探討高度糖化終產物及其前驅物甲基乙二醛誘發腎臟與內皮功能損傷之負 面效應，並釐清該損傷機轉是否與活化發炎體有關；此外，另探討白藜蘆醇之介入是否對 於上述損傷具有保護作用。第一部分實驗以高度糖化終產物接受器抑制劑釐清腎臟中高度 糖化終產物接受器的表現是否和發炎體路徑的活化有關，此外評估不同種高度糖化終產物 對於小鼠腎功能之影響。第二部分實驗則以高度糖化終產物接受器抑制劑證實抑制受器和 高度糖化中產物之交互作用是否可達到減少自由基產生進而抑制發炎體的活化以減緩發 炎反應所造成的腎損傷。第三部實驗分則觀察白藜蘆醇對於以高度糖化終產物前驅物MG 誘發腎損傷之影響並釐清白藜蘆醇是否可透過影響發炎體的活化達到延緩腎臟受損的作 用。研究預期長期高度糖化終產物和其前驅物‐甲基乙二醇的投與會使高度糖化終產堆積 在腎臟，也可能經由與其接受器結合進入細胞中活化發炎體路徑使腎臟發炎，使腎臟和內 皮功能損傷。因此減少暴露於高度糖化終產物的環境下或是抑制其接受器的作用皆可抑制 發炎體的活化達到延緩腎損傷的作用，且白藜蘆醇的介入對於上述損傷可能具有保護作用。

  Chen, J.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Synthesis and Clinical Investigations of Novel Bismuth (Or Zirconium) Hafnium Oxide for Dental Filling and Radiopacifying Application

  Lin, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Molecular Mechanism of the Effect of Cafestol on Growth Factor-Induced Cardiomyocyte Hypertrophy

  Liu, J.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Developing an Intelligent Assessment and Rehabilitation System for Bilateral Upper Limb Coordination Control of Upper Extremity in Hemiparetic Subjects-Ii

  Lin, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Evaluation of Computerized Vi Rtual Reality on Functional Ability and Quality of Life in Elderly

  Chang, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Vi Sualization of Cancer Comorbidity “Disease Graph”

  Jian, W.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study of Aging Effect on the Progression of Restenosis: Establishment of the Platform for Screening the Drugs Targets with Suppressing Effect on Platelet-Derived Growth Factor Receptor-Beta

  Wu, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 糖尿病與巴金森症之風險: 探討胰島素阻抗與巴金森症機轉之關聯

  Hong, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• ADAM9 調節 integrin b4 之轉換率以促使前列腺癌細胞移動及浸潤之研究(3/3)

  Sung, S.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Targeting Class III Phosphoinositide 3-Kinase (Pi3k) for Anticancer Drug Discovery

  Chen, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role and Molecular Mechanisms of N-Α-Acetyltransferase in Driving Tumor Invasion and Metastasis of Osteosarcoma

  Chien, M.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Glutamate Receptor as a Therapeutic Target in Recurrent Glioma: Patient-Derived Glioma Xenograft Model

  Shen, S.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Nanocarriers for Drug Delivery Conjugated with Specific Aptamer for Potential Use in Membranous Nephropathy

  Lin, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 溶瘤麻疹病毒抗乳腺癌治療之開發研究(3/3)

  Lin, L. T.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• To Study the Role of Sp1 in Cancer Metastatic Progression( I )

  Chang, W.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studying on the Mechanism and Translational Application of Blocking the Protein-Protein Interaction between Galpha-h and PLC-delta1 in Combating Drug-Resistance and Metastasis of Triple-Negative Breast Cancer

  Lin, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Application of Hdac Inhibitors in Keloid Treatment

  Lee, W.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Epigenetic Role of Pitx2c in Atrial Myocyte and Fibroblast: Therapeutic Implications of Atrial Fibrillation Mechanisms

  Kao, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Interactions between Female Sex Hormones and Folic Acid(2/3)

  Lee, W.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of Amyloid-Beta in the Late-Onset Post-Stroke Vascular Cognitive Impairment( II )

  Hu, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 臺美(US)國合計畫－腦傷害的新診斷和新治療之轉譯研究－Thalidomide新衍生藥與p53新抑制劑用於治療急性腦創傷:投藥 途徑、劑量效果及多重機制之探討(2/3)

  Wang, J.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 犬蛔蟲胜?抗伺機性與多重耐藥性金黃色葡萄球菌與鮑氏不動桿菌之機轉、表現、特化與應用

  Fan, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Protective Effect of Plzf and Annexin A1 on Diabetic Tubulopathy in the Pparα Signaling Pathway

  Hsu, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Protective Effect of PLZF Nuclear Translocation against Advanced Glycation End Product-Induced Endothelial Injury in Diabetes and Its Molecular Mechanism(2/3)

  Chen, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of Inflammatory Gene Polymorphisms on Risk of Post-Stroke Vascular Dementia( II )

  Chiou, H.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Impacts of Sirtuin Related Genes and Aging Related Factors on the Risk of Early-Onset Ischemic Stroke

  Hsieh, F.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Disease trajectories and its association with metabolic dysfunction of prostate cancer men following androgen deprivation therapy and the potential of pharmacological medication in preventing metastatic diseases.(2/3)

  Shao, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 顱內靜脈血管系統異常與缺血性中風及皮質下血管性失智症的相關性研究

  Chiou, H.

  8/1/16 → 7/31/17

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Spatio-Temporal Variations of Dengue Outbreaks in Taiwan

  Chuang, T.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 肺部炎症暨纖維化之轉譯研究

  Lin, C.

  8/1/16 → 7/31/17

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Application of Regioselective Substitution on 1,4-Benzoquinone Derivatives to Provide Potent Anticancer Agents(3/3)

  Liou, J.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Exploration and Investigation of Brown Adipogenesis-Associated Alternative Splicing Network by Transcriptome Analyses

  Lin, J.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Toxicological Assessment of Air Pollution in the Vicinity of a Petrochemical Complex

  Chuang, H.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Application of High-Throughput Sequencing Approaches in Immunogenomic Research : Diversity and Clonal Selection in the Human T-Cell Repertoire for Colonrectal Cancers

  Chang, W.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Anticancer Drug Discovery of New Tegafur-Derivatives for Colorectal Cancer Therapy(3/3)

  Chen, M.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• HMGA2, a New Target of Thyroid Hormone-Induced Progression in Colorectal Cancers(2/3)

  Lin, H.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 建立質譜定量分析策略以應用於癌症特定突變蛋白質之腫瘤蛋白質基因體學研究

  Han, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以胜肽為基礎之細胞激素結合誘餌療法於治療敗血症之療效及其調控發炎、氧化、凋亡、自嗜與發炎小體之作用探討(1/3)

  Huang, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 105學年度多元文化語境之英文學習革新課程計畫

  Chou, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › d - Ministry of Education

• Relationships between Admission Channels and Medical Career Fitness of Medical Students in Their Third Year

  Han, D.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 鑑定癌症幹細胞抑制劑(2/3)

  Whang-Peng, J.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 失調的大腦時鐘？探討老化歷程如何改變大腦網路的晝夜節律(1/3)

  Wu, C. W.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Predictions of Therapeutic Effects of Zolpidem in Disorders of Consciousness Patients

  Lane, T. J.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Mechanisms by Which Enterovirus-Host Interactions Form Viral Replication Organelles and Regulate Viral Replication

  Lin, J.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Series of Study in Lifestyle Analysis and Exploration of the Effect of Cognitive-Behavioral Intervention among High Risk Subjects with Family History of Colorectal Cancer

  Jeng, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Prostate Cancer Malignancy Is Enhanced by Glycotoxins(3/3)

  Wu, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Engineering Chimeric Antigen Receptor T-Cells against Immune Checkpoint Inhibitor Pd1 and Pd-L1 for Treating Pancreatic Cancer

  Liu, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology