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• The Anti-Fibrotic Activity of Sodium Glucose Co-Transporters (Sglts) Inhibition: Therapeutic Potential in Diabetes Mellitus Cardiomyopathy

  Lee, T.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Cardiomyopathies 100%
  • Diabetes Mellitus 99%
  • 3-(3-(4-(3-(glucopyranosyloxy)-5-isopropyl-1H-pyrazol-4-ylmethyl)-3-methylphenoxy)propylamino)propionamide 82%
  • empagliflozin 70%
  • (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(methylthio)tetrahydro-2H-pyran-3,4,5-triol 69%

• Exploiting Acridine Scaffold to Develop Novel Anticancer Agents Based on a Dual Target Strategy

  Huang, W.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Histone 100%
  • Topoisomerase Inhibitor 34%
  • Structure-Activity Relationship 26%
  • Antineoplastic Agent 18%
  • Camptothecin 13%

• Investigation of a Novel Peptide-Nanoformulation as Eyedrop with Nox2 Inhibition Capacity for Prevent Sight-Threatening Blood Vessel Growth on the Surface of the Eye

  Tseng, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Epigenetic Editing as a Novel Therapeutics for Gynecological Cancer

  Lai, H.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Epigenomics 100%
  • Clustered Regularly Interspaced Short Palindromic Repeats 43%
  • Tumor Biomarkers 27%
  • Neoplasms 24%
  • Gene Editing 23%

• The Association of Training Process, Duty Hour, and Self-Identity Building of Young Physicians

  Chiu, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • physician 100%
  • working hours 31%
  • interview 16%
  • target group 13%
  • role play 13%

• New Brain Cortical Electrical Stimulation Technology for the Neurorehabilitation Therapy of Bladder Dysfunction in the Parkinson’S Disease Animal Model(2/3)

  Peng, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Targeting the Inflammation as a Novel Therapy for Neuroendocrine Prostate Cancer Determined by Zbtb46

  Chen, W.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Sterile Alpha Motif 100%
  • Androgens 99%
  • Prostatic Neoplasms 98%
  • Androgen Receptors 83%
  • Transcription Factors 46%

• Innovative Applications of Plasmon-Activated Water in Green Chemistry and Neuro-Related Medicine

  Liu, Y.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• In Vi Vo and in Vi Tro Screening of the Dyslipidemic Antihypertensives, Studying the Mechanism to Modulate Signaling Srebp and Ppar in the Renal Cells, and Investigating the Cotherapy with Mountain Celery Seed Aqueous Extract in Reducing Worsen Renal F(3/3)

  Chen, K.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Apium 100%
  • Seeds 63%
  • Kidney 60%
  • Antihypertensive Agents 47%
  • Sterol Regulatory Element Binding Proteins 31%

• Effects of Progressive Resistance Training and Isolated Soy Protein Supplementation on Body Composition and Physical Performance in Post Menopause Osteosarcopenia Elderly Women: Clinical Application Based on Ovx Mice Animal Model

  Huang, S.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Soybean Proteins 100%
  • Exercise 71%
  • Elderly 30%
  • Sports 22%
  • Prescriptions 21%

• Molecular Mechanisms of Secretory Rab Gtpase 3c in Promoting Colon Cancer Metastasis

  Chen, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 提升腦中風健康識能傳播策略規劃案

  Chan, L.

  4/10/19 → 7/10/19

  Project: A - Government Institution › c - Ministry of Health and Welfare

• 107年度新北市產業數位轉型推動計畫委託專業服務案

  Shia, B.

  10/18/18 → 7/18/19

  Project: A - Government Institution › f - Other (Funded by Government)

• Exploration of the Pharmacological Mechanisms of Hai-Fu-Rong as an Anti-Restenosis Remedy

  Wu, C.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Vascular Smooth Muscle 100%
  • Smooth Muscle Myocytes 89%
  • Cell Movement 83%
  • Coronary Balloon Angioplasty 83%
  • Pharmacology 67%

• Psychophysiological Effects of Lactobacillus Plantarum Ps128 in Patients with Major Depressive Disorder: a Pilot Study of 8-Week Open Trial

  Chen, C.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Lactobacillus plantarum 100%
  • Probiotics 77%
  • Gastrointestinal Microbiome 71%
  • Inflammation 53%
  • Permeability 46%

• Catalpol Acts as an Immunomodulator on Immune Cells and Exerts Anti-Allergic Effects on Ovalbumin-Induced Allergic Diseases in Mice

  Lee, Y.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • catalpol 100%
  • Mast Cells 16%
  • Asthma 15%
  • Immunoglobulin E 15%
  • Dendritic Cells 12%

• The Role of Txnip in Skewing Alveolar Macrophages towards M1/M2 Polarization: Implication for the Pathogenesis of Chronic Obstructive Pulmonary Disease(1/3)

  Chen, C.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• To Develop Novel Treatment Options for Hepatocellular Carcinoma via Drug Repurposing(1/2)

  Whang-Peng, J.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Transgenerational Epigenetic Reprogramming of Neuronal Maturation by Early-Life Maternal Sleep Deprivation(3/3)

  Yang, C. H.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Safety and Quality Assessment of Eggs Using Hyperspectral Imaging Technology

  Chuang, Y.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • egg shell 100%
  • fish roe 72%
  • image analysis 66%
  • egg contamination 41%
  • freshness 31%

• Investigated the Role of Mir-200 Family in the Prognostic and Therapeutic of Hcc and Dissected the Possible Mechanism

  Wang, W.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Hepatocellular Carcinoma 100%
  • MicroRNAs 22%
  • Hypoxia 20%
  • Neoplasms 14%
  • Hep G2 Cells 9%

• The Physiological Indicators of Early Cardiac Dysfunction in Patients with Schizophrenia

  Chen, P.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Schizophrenia 100%
  • Psychopathology 22%
  • Echocardiography 18%
  • Psychiatry 16%
  • Cardiovascular Diseases 16%

• Deciphering Molecular Biomarkers Governing Medulloblastoma Prognosis and Leptomeningeal Metastasis(2/2)

  Wong, T.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Medulloblastoma 100%
  • Neoplasm Metastasis 27%
  • Genes 10%
  • Heterografts 10%
  • Neoplasms 9%

• Investigation of the Cytotoxic Mechanism of Photorhabdus Luminescens Pirapl and Pirbpl Toxins by Using Structural and Proteomic Approaches

  Wang, H.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Photorhabdus 100%
  • Insecta 30%
  • Aedes 24%
  • toxin V 19%
  • Xenorhabdus 17%

• Effect of Maternal Food Safety-Related Risk Perceptions on Child Actual Mercury Exposure

  Chien, L.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Trajectory of Psychological Distress among Infertility Women: Efficacy and Mechanism of Mind-Body Intervention with Heart Rate Variability Biofeedback(1/3)

  Kuo, S.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Motor Signature, Falls Risk, and Home-Based Interventions in Older Adults with Mild Cognitive Impairment(2/3)

  Lin, M.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Design and Verification the Effects of an Innovative Interactive Game on Improving Cognition in Elderly

  Chang, C.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Aging of materials 100%
  • User experience 82%
  • Gamification 55%
  • Wearable technology 46%
  • Industry 18%

• Fragment-Based Discovery of First-In-Class Small-Molecule Kinase Inhibitors for Targeted Cancer Therapies(2/2)

  Huang, H.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Using Genome-Wide Linkage Analysis and Next Generation Sequencing Approaches to Identify the Genes Responsible for the Familial Colorectal Cancer Type X(2/3)

  Wang, W.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Evolution Haptoglobins as Protein Drugs for Coronary Artery Diseas

  Cheng, T.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Haptoglobins 100%
  • Coronary Artery Disease 52%
  • Inflammation 27%
  • Nanoparticles 20%
  • Monocytes 19%

• Need Assessment and Follow-Up of Discharge Planning Referral to Post-Acute Care for Aged Patients(2/2)

  Chi, M.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Subacute Care 100%
  • Needs Assessment 46%
  • Patient Discharge 44%
  • Taiwan 19%
  • Elderly 13%

• Study the Pathophysiological Role of Microrna in the Development of Emphysema(3/3)

  Su, B.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Emphysema 100%
  • prothymosin alpha 58%
  • Histone Deacetylase 2 44%
  • MicroRNAs 28%
  • Chronic Obstructive Pulmonary Disease 18%

• Decellularized Lymph Node Scaffold Vaccine Seeded with Dendritic Cells for Inducing Specific Antitumor Immunity

  Liu, D.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Dendritic Cells 100%
  • Lymph Nodes 61%
  • Immunity 30%
  • Neoplasms 28%
  • Neoplasm Antigens 26%

• To Study the Role of Multidrug Resistance Protein 4 on Induction of Aspirin Resistance in Type 2 Diabetes Mellitus

  Lu, W.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Subfamily B ATP Binding Cassette Transporter 100%
  • Aldehyde Reductase 68%
  • Aspirin 64%
  • Platelet Activation 25%
  • Blood Platelets 25%

• Targeting Hepatitis C Virus-Induced Hepatocellular Carcinoma with Precision Medicine-Tailored Oncolytic Measles Virus(1/3)

  Lin, L. T.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation of Long Noncoding Rna in Dicer-Mediated Micro-Rna Reprogramming and Sorafenib Resistance in Hepatocellular Carcinoma

  Chen, H.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Sorafenib 100%
  • Liver Neoplasms 80%
  • Long Noncoding RNA 75%
  • MicroRNAs 63%
  • Hepatocellular Carcinoma 23%

• Automated Design of Natural Products Laboratory(1/3)

  Lee, C.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Biomarkers and Polymorphisms Associated with Arterial Stiffness and Carotid Atherosclerosis in Healthy Community Dwelling Individuals in Taiwan

  Bai, C.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 新聘教師研究補助

  Huang, Y.

  8/1/18 → 7/31/19

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• Investigation of novel genetic mutations for antibiotic resistance, intracellular upregulated Salmonella genes within host cells, and the mechanisms of yqiC-induced host innate immunity for combating Salmonella infection (3/3)

  Fang, S.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Salmonella 100%
  • antibiotic resistance 37%
  • ciprofloxacin 34%
  • point mutation 33%
  • genes 26%

• Mechanistic Investigation of Linc00963 on Promoting Lymph Node Metastasis and Drug Resistance through Abcb5 Regulation and Its Potential Theranostic Value during Oral Carcinogenesis

  Tsai, L.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Marker 100%
  • Biological Marker 25%

• The New Therapeutic Strategy of 2, 3, 5, 4’-Tetrahydroxystilbene-2-O-Β-D-Glucoside (Thsg) Derivatives on Human Dental Pulp Stem Cells-Based Periodontal Treatment(3/3)

  Lee, S.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • resveratrol 100%
  • stem cells 59%
  • therapeutics 55%
  • tooth pulp 53%
  • cell proliferation 42%

• Two-Dimensional Oxide Crystals with Atomic Thickness for Energy Devices and Electronics(3/3)

  Li, S.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • oxides 100%
  • perovskites 80%
  • transistors 76%
  • solar cells 71%
  • carrier mobility 65%

• Targeting Kdm4a in Prostate Cancer(III)(3/3)

  Kung, H.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Bio-Inspired and Digital Design (Mgi+Ai) Driven Silk Protein Fibers in Design, Synthesis, Fabrication for Translational Researches(1/4)

  Yang, J.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Develop Integrated Diagnosis and Prediction Model of Parkinson'S Disease

  Chung, C.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Parkinson Disease 100%
  • Exosomes 35%
  • Artificial Intelligence 19%
  • Biomarkers 19%
  • Disease Progression 17%

• Hbx and Its Associated Epigenetic Regulators in Promoting Senp1 Expression and Cancer Stemness in Hbv-Related Hepatocellular Carcinoma: the Role of Hbx/Senp1 and Its Clinical Impact

  Wu, Y.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Disrupted Circadian Neurosynchrony: Physiological Interactions among Age, Circadian Rhythms and Resting-State Functional Connectivity(3/3)

  Wu, C.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• What Is an Insect? Genome Evolution of Insects Relative to Other Pancrustaceans(1/3)

  Chen, C.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology