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• 牙科根管治療顯影材料之溶凝膠製備與改質研究

  Lin, C.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 血小板微粒特性及功能之體外研究

  Burnouf, T. P. R.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 以系統生物資訊方法分析策略發展頭頸癌治療藥物

  Chen, Y.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• TMU101-AE1-B58

  Liu, W.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › u - Taipei Medical University Shuang Ho Hospital

• 以新穎天線式結構之奈米線感測器偵測口腔癌症基因

  Wu, C.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• Ghrelin誘導人類大腸癌細胞增生與轉移機轉研究

  Chen, B.

  5/1/13 → 5/31/14

  Project: C - Project of Alliance › t - Taipei Municipal Wanfang Hospital

• 晶體性關節炎侵蝕骨頭(蝕骨細胞分化)的分子機制

  Liang, Y.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• TMU101-AE1-B56

  Wu, C.

  6/1/13 → 5/31/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• 脂肪幹細胞對於癌細胞移動調控機轉

  Tsai, F.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 探討SCUBE1在腎臟上皮間質化及癌症發展的角色

  Lin, H.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• MEKK1/JNK依賴SMAD3活化媒介CXCL12誘導肺部纖維母細胞CTGF表現之探討

  Chen, B.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 活體動物血管內膜平滑肌增生的機轉研究：含RGD的蛇毒蛋白triflavin和抗integrin β3抗體的相對作用活性比較

  Chang, N.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• TMU101-AE1-B60

  Lane, T. J.

  6/1/13 → 5/31/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• 由北市學童研究探討儲鐵蛋白質對巨噬細胞活化及移轉的營響

  Chang, J.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• TMU101-AE1-B25

  Yang, P.

  1/1/13 → 5/31/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• 臨床肝癌化療藥物與小麥粹取物整合處理對人類肝癌細胞抑制效果之評估與分子抑癌機制探討

  Tai, C.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 探討在parthanatos過程中細胞能量適應性之改變

  Lin, W.

  5/1/13 → 5/31/14

  Project: C - Project of Alliance › u - Taipei Medical University Shuang Ho Hospital

• 鈦坦銀合金應用於生醫植體之研究

  Huang, C.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• TMU101-AE1-B54

  Kao, Y.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › t - Taipei Municipal Wanfang Hospital

• 高純度具表面增強拉曼活性奈米貴金屬顆粒之製備與其生醫檢測策略

  Liu, Y.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• In vitro characterization of Salmonella virulence gene speG in human intestinal cells

  Fang, S.

  1/1/13 → 5/31/14

  Project: C - Project of Alliance › j - National Taipei University of Technology

• 子宮內膜異位症中乙式轉形生長因子在調控OCT4表現及上皮細胞/間葉細胞間轉型之角色探討

  Huang, Y.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 人類乳突病毒導致肺腫瘤化之可能機轉

  Cheng, Y.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 幼年期睡眠剝奪對褪黑激素生合成暨神經內分泌功能之影響：飛行式二次離子質譜儀之分子影像研究

  Chang, H.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• TMU101-AE1-B61

  Cheng, P.

  7/1/13 → 6/30/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• 探討糖尿病治劑MK0626對血管內皮前驅細胞與血管新生之影響

  Huang, C.

  1/1/13 → 6/30/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• 糖基-苯并咪唑衍生物對炎症淋巴水腫的影響

  Lin, C.

  5/1/13 → 6/30/14

  Project: C - Project of Alliance › t - Taipei Municipal Wanfang Hospital

• 奈米微粒物理化學特性與蛋白質反應之研究

  Chuang, H.

  5/1/13 → 6/30/14

  Project: C - Project of Alliance › u - Taipei Medical University Shuang Ho Hospital

• TMU101-AE1-B26

  Wu, C.

  1/1/13 → 6/30/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• TMU101-AE1-B34

  Lin, H.

  1/1/13 → 6/30/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Disjunctivism and Theories of Action

  Lin, C.

  8/1/12 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigating the Differential Effects and the Mechanisms of Flavonols on Osteogenic Differentiation of Human Dental Pulp Stem Cells

  Lee, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 《Understanding International Conflicts：An Introduction to Theory and History》Translation and Annotation Project

  Chang, K.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Novel Degradable Biomaterial for Dental Hemostatic Sponge Applications

  Lin, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study on the cancer and non-cancer, including cardovascular diseases, risks in cohort population with prolonged low-dose radiation exposure

  Chang, W.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Bullying Experience, Attitude and Suicide Attempts among Adolescents

  Chen, P.

  8/1/12 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Gender Analysis of Workplace Violence among Medical Care Personnel

  Chen, R.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Explore of Toll-Like Receptors Associated Mirna Expression in Ischemic Stroke Patients (I)

  Wu, C.

  8/1/13 → 7/31/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• 小客車路口闖紅燈、加速行為: 以kernel logit 模型估計行人倒數計時器之影響

  Pai, C.

  11/1/12 → 7/31/14

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• Saliva Alkaloids of Areca Nut or Tobacco, Inflammatory and Antioxidants Status and Oral Hygiene in Periodontitis Patients

  Huang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Moderating Effect of Welfare States on Health and Service Utilization - Comparison of Taiwan and European Countries

  Chuang, K.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 大腸直腸癌已躍居世界上癌症死亡率第二名，屬於固體型腫瘤，缺氧常見於此類 腫瘤，並誘發HIF-1α 表現而導致抗藥性及預後較差，因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑，可殺死癌 細胞而不影響正常細胞，對小鼠也不具毒性。我們初步結果顯示，Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現，代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性，對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下，經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制；也有研究報導指出，藥物會誘導癌細胞產生autophagy，造成細胞過度吞噬其內容 物而死亡，因此，autophagy在癌細胞為保護或是引發毒殺作用，目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活，但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示，除抑制HIF-1α 表現外，Zeb 也可活化AMPK、UPR/ER stress、以及autophagy， 因此我們推測Zeb 可在缺氧狀態下，促進autophagic cell death。3 年內我們將執行4 項 目標： (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。（第一年） (2) 研究Zeb 抑制HIF-1α表現之分子機轉。（第一年到第二年） (3) 研究Zeb 誘發autophagy之分子機轉。（第二年到第三年） (4) 探討Zeb 對缺氧導致抗藥性之作用。（第三年）

  Yang, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study the Therapeutic Effects and Novel Molecular Mechanisms of Resveratrol in Human Osteosarcoma: the Treatment of Metastatic Cancer

  Chien, M.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Real-Time Single-Cell Probing of the Action Mechanism of Amphotericin B Ion Channels---From Extracellular to Intracellular

  Yang, T.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 設計並評估新型含藥人工骨凝膠對齒槽骨缺損的修復作用

  Lee, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effect of Improved Nutrition Care on the Progress of Hemodialysis Patients

  Yang, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Assessment of Iron Status in Overweight and Obese Adolescents

  Chang, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Community-based Screening and Prevention Model for Periodontal Disease

  Chen, L.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of Sp-family in lung tumorigenesis

  Chang, W.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of fish oil on alcoholic liver disease in rats based on pathological mechanisms

  Yang, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology