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Lipid Raft Associated Signaling in Regulation of Osteoclast Activation in Inflammatory Arthritis

Tsai, H.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Effects of indoor air quality improvement on cardiovascular health in general population

Chuang, K.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Research of preparation and antibacterial mechanism on metal containing yttria-stabilized zirconia ceramics.

Ou, K.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Study on the Preventive Effect and Mechanism of Germinated Brown Rice and Its Components on Colorectal Cancer

Shih, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Proteomic Study of Metformin on Kidney Damage in Rats

Lee, J.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Contribution of Er Stress to Inhibit miR-19a/b and miR-26b-Mediated CTGF Expression in Lung Fibrosis (I)

Chen, Y.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Natural Product Hybrid and Ortho-Biaryl N-Hydroxycinnamide as Leads for Anticancer Agent Development

Huang, W.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

The effect of vascular endothelial growth factor gene polymorphism in the pathogenesis and therapeutic response of pterygium

Cheng, Y.

8/1/1312/31/14

Project: C - Project of Alliancer - Tung's Taichung MetroHarbor Hospital

抗發炎藥物與生物製劑藥物對類風濕性關節炎病人發生惡性腫瘤之影響:健保資料庫分析研究

Chen, S. H.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

臺蒙(MN)國合計畫-台灣及蒙古之洋蔥及蔥屬蔬菜對骨質疏鬆症的影響(1/3)

Chen, Y.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Effect of pacemaker current inhibitor (Ivabradine) on sinoatrial node function and pulmonary vein arrhythmogenesis

Lin, Y.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Gender Analysis of Workplace Violence among Medical Care Personnel

Chen, R.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Association of Epidermal Growth Factor Receptor mutations with HPV16/18 E6 Oncoprotein Expression in Non-Small Cell Lung Cancer

Lee, H.

8/1/137/31/14

Project: C - Project of Alliancer - Tung's Taichung MetroHarbor Hospital

TMU101-AE1-B64

Fang, S.

8/1/137/31/16

Project: C - Project of Allianceu - Taipei Medical University Shuang Ho Hospital

The role of microRNA let-7g in cytosolic Ca2+ regulation and COX-2 gene expression

Chang, W.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Mobile Phone Use and Walking: A Observational Field Study of Pedestrians' Risky Behaviours and Inattentional Blindness

Pai, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

大腸直腸癌已躍居世界上癌症死亡率第二名,屬於固體型腫瘤,缺氧常見於此類 腫瘤,並誘發HIF-1α 表現而導致抗藥性及預後較差,因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑,可殺死癌 細胞而不影響正常細胞,對小鼠也不具毒性。我們初步結果顯示,Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現,代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性,對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下,經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制;也有研究報導指出,藥物會誘導癌細胞產生autophagy,造成細胞過度吞噬其內容 物而死亡,因此,autophagy在癌細胞為保護或是引發毒殺作用,目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活,但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示,除抑制HIF-1α 表現外,Zeb 也可活化AMPK、UPR/ER stress、以及autophagy, 因此我們推測Zeb 可在缺氧狀態下,促進autophagic cell death。3 年內我們將執行4 項 目標: (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。(第一年) (2) 研究Zeb 抑制HIF-1α表現之分子機轉。(第一年到第二年) (3) 研究Zeb 誘發autophagy之分子機轉。(第二年到第三年) (4) 探討Zeb 對缺氧導致抗藥性之作用。(第三年)

Yang, P.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Pharmaceuticals Removal in Hospital wastwater and effluent by Electro-coagulation-flotation

Hu, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

The Effects and Regulation of Oxidize Low Density Lipoprotein and High Density Lipoprotein on Human Endothelial Progenitor Cells

Huang, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

The Effect of Blood Sugar Regulation and Molecular Mechanism by White Potato Extract

Li, S.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Study of Context Aware Knowledge Supporting Systems---A Case Study of Premature Neonates Care

Liu, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Analysis and Data Mining of Decision Characteristic of Prehospital Emergency Patients Transport

Hsu, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Study of the mechanism of HPV involved tumorigenesis through Wnt signaling pathway related microRNA regulation

Cheng, Y.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

探討小泛素蛋白酶Sentrin-specific protease 2 參與轉型生長因子-beta訊息傳遞的作用機制(1/2)

Chang, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Studies on a Thermosensitive Hydrogel of Doxorubicin as Locally Controlled Delivery of Cancer Therapeutics

Ho, H.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

榖胱甘月太硫轉移酉每參與乳癌致癌之分子機制探討(2/3)

Wu, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Association Study of Persistent Metabolic Syndrome, Inflammatory Markers and Mild Cognitive Decline

Bai, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Molecular mechanisms of propofol-involved protection against ischemia brain injuries

Chen, T.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Study the Therapeutic Effects and Novel Molecular Mechanisms of Resveratrol in Human Osteosarcoma: the Treatment of Metastatic Cancer

Chien, M.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

The influence of Porphyromonas gingivalis GroEL in vascular cells

Lin, F.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Study the Klf10 alters metabolic pathways in genetic-deficient mice and human pancreatic ductal carcinomas

Chang, H.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Research of Harmful Substances in Water on Human Reproductive and Neuronal Cells Toxicity Translation Assessment (I)

Mai, F.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Study the Role of GRP78 in E1A-Mediated Metastasis Suppression of Breast Cancer

Wang, W.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Functional Characterization of Niemann-Pick Type C2 Protein in Hepatocellular Carcinoma

Liao, Y.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Translational studies of Mycobacterium tuberculosis-induced lung and pleural fibrosis

Lin, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

The role and molecular mechanism of PPARα in acute kidney injury: focus on the protective effect in renal tubular cell

Hsu, Y.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Discovery of Rare and Common Variants in Genetic Association Studies

Cheng, K.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

A Methodology Study of Integrating Systems Thinking and Bayesian Network in Health Policy

Chuang, S.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Development of measurement technology of surface-enhanced Raman spectroscopy for detection of biomolecules

Liu, Y.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

The exploitation of Taiwan native plants in promoting bone growth and establishment of the system biology platform

Lee, M.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

三陰性乳癌周邊微環境之研究平台建立:以玻尿酸合成酉每Ⅲ抑癌作用為例(1/3)

Ho, Y.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Renoprotective mechanisms of soy protein in rats with diabetic nephropathy 全文電子檔: 全文連結1

Chen, J.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Investigation of the Effect of Androgen Receptor Knockout on Pathophysiology of Traumatic Brain Injury

Yang, L.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

TMU101-AE1-B66

Lin, J. A.

8/1/1312/31/14

Project: C - Project of Alliancep - Taipei Medical University Hospital

TMU101-AE1-B65

Wang, T.

8/1/137/31/14

Project: C - Project of Alliancep - Taipei Medical University Hospital