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  Evaluations of Anti-Photoaging, Anti-Melanogenesis and Transdermal Delivery of Safflower Yellow

  Chien, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of the M-Learning Materials for Facilitating Nursing Students’ Basic Nursing Skills Competence and Self-Confidence

  Chuang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Design and Development of Antibody-Targetable and Self-Assembled Micelles of Anticancer Drug Conjugate and Complex of Hyaluronic Acid

  Sheu, M.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• RNA-Seq Analysis of Transcriptome in Toxocara canis L3-Infected Host

  Liao, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Therapeutic Strategies for Traumatic Brain Injury with Novelly Desinged Drugs (II)

  Wang, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 抽菸、α9-型尼古丁乙醯膽鹼受體、表皮生長因子受體及動情激素相關基因與乳癌之分子流行病學研究

  Chiou, H.

  8/1/13 → 7/31/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• The Epigenetic Control of IL-6-STAT3 Targeting Dnas in the Cell of Dihydropyridine-Induced Gingival Overgrowth

  Lu, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 抗發炎藥物與生物製劑藥物對類風濕性關節炎病人發生惡性腫瘤之影響：健保資料庫分析研究

  Chen, S. H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Assessing Risk and Progression of Knee Osteoarthritis via Loading Rate and T2 Mapping of Cartilage

  Chan, W. P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effects of Music Therapy on Psychological Distress and Functional Recovery in Patients With Stroke

  Chang, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Imapct of Oxidative Stress on the Pathogenesis of COPD---An Ivestigation into Its Relationship with Abnormal Inflammation, DNA Instability, Epigenetics and Cell Metabolism

  Lee, K.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Biomarkers Associated with Toll-Like Receptors and Neuroimage Study in Ischemic Stroke Patients (I)

  Hu, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• TMU101-AE1-B63

  Chen, C.

  8/1/13 → 7/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• A Clinical Correlation study of DNA Methyltransferases Alterations in Breast Cancer and Evaluation of DNA Methyltransferases as a Therapeutic Target in Cell and Animal Models

  Lin, R.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Prediction of B-Cell Epitopes Using Propensity Scales and Correspondence Analysis

  Su, E. C.

  8/1/13 → 10/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Sleep and Memory Consilidation in Alzheimer Disease

  Hu, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of ADAM 17 in Hypoxia-Induced CTGF Expression and Pulmonary Fibrosis (I)

  Chen, B.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• A study of diffusion tensor imaging as a potential surrogate marker for the management of acute ischemic cerebral stroke: A clinical and animal model at 7T

  Chen, C.

  8/1/13 → 10/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Motor Vehicle Injuries and Screening Tools of Unsafe Driving in Older Drivers

  Lin, M.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Huntingtin-Associated Protein-Regulated Biomarkers in Neurodegenerative Diseases

  Lin, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Trade, Economic Factors, Envrionmental Hazards, and Risks of Infant and Child Mortality in Developing Countries

  Chuang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Application of Functional Electrical Stimulation on the Study of Nerve Regeneration in the Rat with Diabetic Neuropathy

  Peng, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Dissected the role of alpha-7 nicotinic receptor in the prognosis and clinical therapy on gastric cancers

  Chang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Synthesis and Antihyperglycemic Evaluation of Isosteviol Derivatives

  Lin, M.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Chitosan nanoparticle as a macrophage-targeting drug delivery carrier

  Mi, F.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Gender Analysis of Workplace Violence among Medical Care Personnel

  Chen, R.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study the Klf10 alters metabolic pathways in genetic-deficient mice and human pancreatic ductal carcinomas

  Chang, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of CISD2 in the Female Reproductive System of Mammal

  Chang, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• TMU102-AE1-B20

  Hsieh, C.

  8/1/13 → 7/31/16

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• Evaluation of Therapeutic Correlation of Nanomedicine with Tea Polyphenol for Inhibition of Ocular Surface Inflammation in Rabbit Dry Eye Model

  Tseng, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The relationship and predictors of electrocardiography, inflammatory markers, clinical features in older bipolar and schizophrenia patients concurrent with coronary heart and cerebro-vascular diseases

  Tsai, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Molecular mechanisms of alpha9-nicotinic acetylcholine receptor (alpha 9-nAChR)-mediated Trastuzumab (HerceptinR) drug resistance in breast cancer cells

  Ho, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Indoxyl Sulfate, Chronic Kidney Disease and Heat Shock Protein Modulate the Atrial Electrophysiological Characteristics

  Hsieh, M.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Multidisciplinary Study of the Pathophysiology of Blast-Induced Mild Traumatic Brain Injury

  Chiang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of Autophagy in Membranous Glomerulonephropathy---From Animal to Human Model

  Lin, Y.

  8/1/13 → 12/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The association of early-onset ischemic stroke and the aging of vascular system using the telomere length related genes

  Hsieh, F.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討芳香烴受體(AhR)改變血管內皮細胞功能之新角色：經由表觀基因或後轉譯修飾(細胞週期蛋白/內皮細胞一氧化氮合成?)的調控與白蘆黎醇/史達汀臨床治療及應用(1/3)

  Juan, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Neuroendocrine-Immune Mechanisms of Physical Activity on Behavioral Symptoms in Lung Cancer Patients---A Comparison of Patients Receiving Active Treatments and Survivors

  Lin, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Combine anesthesia information system with artificial neural networks to develop the surgical complication pre-warning system

  Lin, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies on a Thermosensitive Hydrogel of Doxorubicin as Locally Controlled Delivery of Cancer Therapeutics

  Ho, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Vector-Borne Disease Forecasting Models Using Satellite Remote Sensing Techniques

  Chuang, T.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Association Study of Genetic Polymorphisms of Toll-Like Receptors on Ischemic Stroke (I)

  Chiou, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Pharmaceuticals Removal in Hospital wastwater and effluent by Electro-coagulation-flotation

  Hu, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Prp: Platelet-Rich Plasma Effects in the Articular Chondrocytes and Synovial Fibroblasts with the Associated Mechanism---A Fibronectin Fragment Model

  Lee, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 大腸直腸癌已躍居世界上癌症死亡率第二名，屬於固體型腫瘤，缺氧常見於此類 腫瘤，並誘發HIF-1α 表現而導致抗藥性及預後較差，因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑，可殺死癌 細胞而不影響正常細胞，對小鼠也不具毒性。我們初步結果顯示，Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現，代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性，對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下，經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制；也有研究報導指出，藥物會誘導癌細胞產生autophagy，造成細胞過度吞噬其內容 物而死亡，因此，autophagy在癌細胞為保護或是引發毒殺作用，目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活，但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示，除抑制HIF-1α 表現外，Zeb 也可活化AMPK、UPR/ER stress、以及autophagy， 因此我們推測Zeb 可在缺氧狀態下，促進autophagic cell death。3 年內我們將執行4 項 目標： (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。（第一年） (2) 研究Zeb 抑制HIF-1α表現之分子機轉。（第一年到第二年） (3) 研究Zeb 誘發autophagy之分子機轉。（第二年到第三年） (4) 探討Zeb 對缺氧導致抗藥性之作用。（第三年）

  Yang, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Application of Hyaluronic Acid and Resveratrol Modified Carbon Nanotube Scaffolds for Tissue Engineering

  Sheu, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Functional Electrical Stimulation Cycling and Central Neuromodulation on Motor Control in Stroke

  Chen, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Cultivation of Young Scholars: Philosophy of Consciousness

  Lane, T. J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Pulmonary effects of chorioamnionitis and postnatal hyperoxia in rat offspring

  Chen, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effect of Improved Nutrition Care on the Progress of Hemodialysis Patients

  Yang, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology