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Hospital Patient Safety Culture-Comparison of Major Measurement Tools, Promotion Methods and Their Evaluation

Kuo, N.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Molecular and cellular mechanism of adipocyte modulatory effects on pulmonary vein and atrium

Chen, Y.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Antibody-Mediated Immune Suppression of Fetal and Neonatal Alloimmune Thrombocytopenia (FNAIT)

Burnouf, T. P. R.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Sleep and Memory Consilidation in Alzheimer Disease

Hu, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Discovery of Rare and Common Variants in Genetic Association Studies

Cheng, K.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Investigation of the Functions of Brain Finger Protein, Znf179, in Embryo Development and in Adult Brain

Lee, Y.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Association of Epidermal Growth Factor Receptor mutations with HPV16/18 E6 Oncoprotein Expression in Non-Small Cell Lung Cancer

Lee, H.

8/1/137/31/14

Project: C - Project of Allianceq - Tung's Taichung MetroHarbor Hospital

The Effects of Neurofeedback and Rsa Biofeedback on Quality of Sleep in Patients in the Chronic Phase of Traumatic Brain Injury

Tsai, P.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

The Sumoylation of Histone Deacetylase 2 Contributes to CTGF Expression and Pulmonary Fibrosis in Chronic Obstructive Asthma (I)

Lin, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Therapeutic Strategies for Traumatic Brain Injury with Novelly Desinged Drugs (II)

Wang, J.

8/1/137/31/15

Project: B - Project of TMUh - Other (Funded by TMU)

Deferasirox Plasma Concentration Analysis and Effects of Potential Iron Chelators on Iron Overload and Safety Evaluation

Wu, T.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Research of Harmful Substances in Water on Human Reproductive and Neuronal Cells Toxicity Translation Assessment (I)

Mai, F.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

TMU101-AE1-B65

Wang, T.

8/1/137/31/14

Project: C - Project of Allianceo - Taipei Medical University Hospital

Development of a Computerized Adaptive Testing of the Health Literacy in Stroke Rehabilitation.

Hou, W.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

TMU101-AE1-B66

Lin, J. A.

8/1/1312/31/14

Project: C - Project of Allianceo - Taipei Medical University Hospital

Molecular mechanisms of propofol-involved protection against ischemia brain injuries

Chen, T.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

大腸直腸癌已躍居世界上癌症死亡率第二名,屬於固體型腫瘤,缺氧常見於此類 腫瘤,並誘發HIF-1α 表現而導致抗藥性及預後較差,因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑,可殺死癌 細胞而不影響正常細胞,對小鼠也不具毒性。我們初步結果顯示,Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現,代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性,對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下,經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制;也有研究報導指出,藥物會誘導癌細胞產生autophagy,造成細胞過度吞噬其內容 物而死亡,因此,autophagy在癌細胞為保護或是引發毒殺作用,目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活,但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示,除抑制HIF-1α 表現外,Zeb 也可活化AMPK、UPR/ER stress、以及autophagy, 因此我們推測Zeb 可在缺氧狀態下,促進autophagic cell death。3 年內我們將執行4 項 目標: (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。(第一年) (2) 研究Zeb 抑制HIF-1α表現之分子機轉。(第一年到第二年) (3) 研究Zeb 誘發autophagy之分子機轉。(第二年到第三年) (4) 探討Zeb 對缺氧導致抗藥性之作用。(第三年)

Yang, P.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Smart Microtube Array Membrane Scaffold for Nerve Regeneration---Fabrication, in vitro and in vivo Evaluation

Chen, C.

8/1/1310/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Study of Nano-Size Memberane Tube for Tendon to Bone in Anterior Cruciate Ligament Reconstruction

Chen, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Assessing Risk and Progression of Knee Osteoarthritis via Loading Rate and T2 Mapping of Cartilage

Chan, W. P.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

The Role of CISD2 in the Female Reproductive System of Mammal

Chang, H.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Chitosan nanoparticle as a macrophage-targeting drug delivery carrier

Mi, F.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Investigation of the Effect of Androgen Receptor Knockout on Pathophysiology of Traumatic Brain Injury

Yang, L.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Proteomic Study of Metformin on Kidney Damage in Rats

Lee, J.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

A study on the evaluation of stromal stem cells and stromal fibroblasts in human tissue regenerative and cancer forming potentials

Shih, T.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

CAAT/enhancer binding protein beta訊息路徑參與thrombin誘導人類肺部上皮細胞IL-8/CXCL8表現之研究(3/3)

Chen, B.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

α9-型尼古丁乙醯膽鹼受體在乳癌幹細胞的角色與防治藥物的篩選

Lai, G.

8/1/137/31/14

Project: B - Project of TMUh - Other (Funded by TMU)

The Role of ADAM 17 in Hypoxia-Induced CTGF Expression and Pulmonary Fibrosis (I)

Chen, B.

8/1/139/30/14

Project: B - Project of TMUh - Other (Funded by TMU)

Effects of the M-Learning Materials for Facilitating Nursing Students’ Basic Nursing Skills Competence and Self-Confidence

Chuang, Y.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Synthesis and Antihyperglycemic Evaluation of Isosteviol Derivatives

Lin, M.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Design and Development of Antibody-Targetable and Self-Assembled Micelles of Anticancer Drug Conjugate and Complex of Hyaluronic Acid

Sheu, M.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Role of Activating Transcription Factor 3 in the Protective Effect of Resveratrol in Cardiomyocytes

Liu, J.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

The Effects and Regulation of Oxidize Low Density Lipoprotein and High Density Lipoprotein on Human Endothelial Progenitor Cells

Huang, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Indoxyl Sulfate, Chronic Kidney Disease and Heat Shock Protein Modulate the Atrial Electrophysiological Characteristics

Hsieh, M.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Study on the Preventive Effect and Mechanism of Germinated Brown Rice and Its Components on Colorectal Cancer

Shih, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Natural Product Hybrid and Ortho-Biaryl N-Hydroxycinnamide as Leads for Anticancer Agent Development

Huang, W.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Renoprotective mechanisms of soy protein in rats with diabetic nephropathy 全文電子檔: 全文連結1

Chen, J.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Role of HBX and IL-6 in Regulating SENP1/Stemness Properties of HBV-Related Hcc under Hypoxia and Its Clinical Implication

Huang, Y.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

102年度臺北市輻射屋居民健康照護需求評估工具建立

Chiu, C.

7/16/1312/31/13

Project: A - Government Institutionf - Other (Funded by Government)