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The Roles of Novel CCCH Zinc Finger Genes on the Regulation of Cell Proliferation and Inflammation

Liang, Y.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

大腸直腸癌已躍居世界上癌症死亡率第二名,屬於固體型腫瘤,缺氧常見於此類 腫瘤,並誘發HIF-1α 表現而導致抗藥性及預後較差,因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑,可殺死癌 細胞而不影響正常細胞,對小鼠也不具毒性。我們初步結果顯示,Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現,代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性,對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下,經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制;也有研究報導指出,藥物會誘導癌細胞產生autophagy,造成細胞過度吞噬其內容 物而死亡,因此,autophagy在癌細胞為保護或是引發毒殺作用,目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活,但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示,除抑制HIF-1α 表現外,Zeb 也可活化AMPK、UPR/ER stress、以及autophagy, 因此我們推測Zeb 可在缺氧狀態下,促進autophagic cell death。3 年內我們將執行4 項 目標: (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。(第一年) (2) 研究Zeb 抑制HIF-1α表現之分子機轉。(第一年到第二年) (3) 研究Zeb 誘發autophagy之分子機轉。(第二年到第三年) (4) 探討Zeb 對缺氧導致抗藥性之作用。(第三年)

Yang, P.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Study of Nano-Size Memberane Tube for Tendon to Bone in Anterior Cruciate Ligament Reconstruction

Chen, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Smart Microtube Array Membrane Scaffold for Nerve Regeneration---Fabrication, in vitro and in vivo Evaluation

Chen, C.

8/1/1310/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Mechanism and Functional Study of Sumoylation in Mammalian System

Hwang, J.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Genomic and non-genomic estrogen effects on the spinal NR2B-related uterus-colon crosstalk in rats

Lin, T.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Research of Harmful Substances in Water on Human Reproductive and Neuronal Cells Toxicity Translation Assessment (I)

Mai, F.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Development of measurement technology of surface-enhanced Raman spectroscopy for detection of biomolecules

Liu, Y.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Molecular Mechanism Underlying Progesterone-Regulated p27 Gene Expression

Hsu, S.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Preparation and Application of New Type Matrix for Aligned Cell Sheet Engineering Use

Tseng, H.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Studies of Anti-Cancer Activity of Folic Acid

Lee, W.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Impact of Coping Skills Training on Stress, Symptom Distress in Children with Cancer

Chen, S.

8/1/1310/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

α9-型尼古丁乙醯膽鹼受體在乳癌幹細胞的角色與防治藥物的篩選

Lai, G.

8/1/137/31/14

Project: B - Project of TMUh - Other (Funded by TMU)

Glucagon-Like Peptide-1 in the Regulation of PPARs and Calcium Handling in Hyperglycemia or Hypertensive HL-1 Cells

Huang, J.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Studies on a Thermosensitive Hydrogel of Doxorubicin as Locally Controlled Delivery of Cancer Therapeutics

Ho, H.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Plant metabolomics (1. Agave sisalana, 2. Anoectochilus formosanus, 3. phalaenopsis spp.)

Lee, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Study on the Preventive Effect and Mechanism of Germinated Brown Rice and Its Components on Colorectal Cancer

Shih, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Renoprotective mechanisms of soy protein in rats with diabetic nephropathy 全文電子檔: 全文連結1

Chen, J.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Use the organometal catalytic reaction to synthesize the heterocycle-based anticancer agents

Liou, J.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

包載9α-型尼古丁乙醯膽鹼受體抑制劑之標靶性微脂體劑型設計與開發

Sheu, M.

8/1/137/31/14

Project: B - Project of TMUh - Other (Funded by TMU)

Design and Characterization of Multifunctional Self-Assembling Lecithin/Amphiphilic Polymers Mixed Micellar Delivery Systems

Sheu, M.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Dissected the role of Glucosed-regulated portein 78 in the progression, metastasis and therapy of colorectal cancer

Wei, P.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Biomarkers Associated with Toll-Like Receptors and Neuroimage Study in Ischemic Stroke Patients (I)

Hu, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Natural Product Hybrid and Ortho-Biaryl N-Hydroxycinnamide as Leads for Anticancer Agent Development

Huang, W.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Trade, Economic Factors, Envrionmental Hazards, and Risks of Infant and Child Mortality in Developing Countries

Chuang, Y.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

The Effects and Molecular Mechanisms of Phthalates (DEHP and DBP) and Primary Metabolite(MEHP and MEP) on Embryonic Development

Tzeng, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

The Epigenetic Control of IL-6-STAT3 Targeting Dnas in the Cell of Dihydropyridine-Induced Gingival Overgrowth

Lu, H.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Dietary Advanced Glycation Endproducts Are Associated with the Development of Polycystic Ovary Syndrome: The Mechanisms of Action

Hsia, S.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

An association study of arsenic exposure, inflammation, oxidative stress and the risk of developing cardiovascular diseases

Hsieh, F.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

The association of early-onset ischemic stroke and the aging of vascular system using the telomere length related genes

Hsieh, F.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Characterization of 5-Hydroxymethylcytosine and Ten-to-Eleven Translocation Gene (TET) in Cervical Cancer

Lai, H.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

The Effects of Sintered Dicalcium Pyrophosphate (SDCP) on Fracture Healing in Ovariectomized Rats

Kuo, Y.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Assessment of Iron Status in Overweight and Obese Adolescents

Chang, J.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

三陰性乳癌周邊微環境之研究平台建立:以玻尿酸合成酉每Ⅲ抑癌作用為例(1/3)

Ho, Y.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Motor Vehicle Injuries and Screening Tools of Unsafe Driving in Older Drivers

Lin, M.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Analyses the Role of ADAM9-Hemidesmosome Components Interaction in Malignant Cancer Metastasis and Future Therapeutic Strategy

Sung, S.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

TMU101-AE1-B68

Chiu, Y.

8/1/137/31/16

Project: B - Project of TMUh - Other (Funded by TMU)

A Multidisciplinary Study of the Pathophysiology of Blast-Induced Mild Traumatic Brain Injury

Chiang, Y.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

A Novel Porcine Bone Xenograft Development

Chang, W.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Distribution of the Number of False Discoveries in Genome-Wide Linkage Scan

Wang, W.

8/1/137/31/15

Project: A - Government Institutionb - Ministry of Science and Technology

The Anti-Tumor Mechanisms of a Novel Aliphatic Hydroxamate, WMJ-S-001---Targeting Tumor Angiogenesis and Lymphangiogenesis

Hsu, M.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology