Find Research Projects

Prediction of B-Cell Epitopes Using Propensity Scales and Correspondence Analysis

Su, E. C.

8/1/1310/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Effects of fish oil on alcoholic liver disease in rats based on pathological mechanisms

Yang, S.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

三陰性乳癌周邊微環境之研究平台建立:以玻尿酸合成酉每Ⅲ抑癌作用為例(1/3)

Ho, Y.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Immature Testicular Tissue Engineering for Male Fertility Preservation---A Transgenic Mouse Model

Chen, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Ffects of Different Sources of n-3 Fatty Acids on Bone Loss, Body Fat and Inflammatory Markers in Osteoporotic Condition with Diabetes

Chiu, W.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Association between lipid, glucose related genes and prognosis of intra- and extra-cranial stenosis in stroke patients

Chiou, H.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

運用凝血?作為基楚之癒合組織工程:與韌帶及肌腱組織癒合為例

Hsieh, M.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Development of Novel Degradable Biomaterial for Dental Hemostatic Sponge Applications

Lin, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Gender Analysis of Workplace Violence among Medical Care Personnel

Chen, R.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Development of Novel Therapeutic Agents for Herceptin Resistance Breast Cancer Cells through Targeting Nicotinic Acetylcholine Receptors

Lee, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

TMU101-AE1-B68

Chiu, Y.

8/1/137/31/16

Project: B - Project of TMUh - Other (Funded by TMU)

Exploring Biopathways Related to Cancer Based on Differences of Gene Expression between Cancer and Normal Situation

Chiu, H.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Studies on the anti-islet hypertrophy and anti-osteoporosis constituents from Formosan Fern

Hsu, F.

8/1/1312/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Hospital Patient Safety Culture-Comparison of Major Measurement Tools, Promotion Methods and Their Evaluation

Kuo, N.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Exploring the effects of an exercise program on female diabetic patients$ health

Liao, Y.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Survey and Intervention of Health Literacy among Older Adults

Chi, M.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

TMU101-AE1-B47

Liu, F.

8/1/137/31/16

Project: B - Project of TMUh - Other (Funded by TMU)

Study of Postoperative Adverse Outcomes of Surgical Patients Using Taiwan National Health Insurance Database

Chen, T.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Combine anesthesia information system with artificial neural networks to develop the surgical complication pre-warning system

Lin, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Study of the mechanism of HPV involved tumorigenesis through Wnt signaling pathway related microRNA regulation

Cheng, Y.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Development of a Computerized Adaptive Testing of the Health Literacy in Stroke Rehabilitation.

Hou, W.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Discovery of Rare and Common Variants in Genetic Association Studies

Cheng, K.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

The Effects of LED Light on Porphyromonas gingivalis in Periodontitis for Anti-Inflammation and Alveolar Bone Regeneration

Deng, W.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

The Effects of Neurofeedback and Rsa Biofeedback on Quality of Sleep in Patients in the Chronic Phase of Traumatic Brain Injury

Tsai, P.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

大腸直腸癌已躍居世界上癌症死亡率第二名,屬於固體型腫瘤,缺氧常見於此類 腫瘤,並誘發HIF-1α 表現而導致抗藥性及預後較差,因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑,可殺死癌 細胞而不影響正常細胞,對小鼠也不具毒性。我們初步結果顯示,Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現,代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性,對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下,經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制;也有研究報導指出,藥物會誘導癌細胞產生autophagy,造成細胞過度吞噬其內容 物而死亡,因此,autophagy在癌細胞為保護或是引發毒殺作用,目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活,但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示,除抑制HIF-1α 表現外,Zeb 也可活化AMPK、UPR/ER stress、以及autophagy, 因此我們推測Zeb 可在缺氧狀態下,促進autophagic cell death。3 年內我們將執行4 項 目標: (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。(第一年) (2) 研究Zeb 抑制HIF-1α表現之分子機轉。(第一年到第二年) (3) 研究Zeb 誘發autophagy之分子機轉。(第二年到第三年) (4) 探討Zeb 對缺氧導致抗藥性之作用。(第三年)

Yang, P.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Association Study of Persistent Metabolic Syndrome, Inflammatory Markers and Mild Cognitive Decline

Bai, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

TMU101-AE1-B66

Lin, J. A.

8/1/1312/31/14

Project: C - Project of Allianceo - Taipei Medical University Hospital

Effects and Mechanisms of Pitx2c Modulation for Atrial Electrophysiological and Structural Remodelings in Heart Failure

Kao, Y.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Research of Harmful Substances in Water on Human Reproductive and Neuronal Cells Toxicity Translation Assessment (I)

Mai, F.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Genomic and non-genomic estrogen effects on the spinal NR2B-related uterus-colon crosstalk in rats

Lin, T.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Molecular Mechanism Underlying Progesterone-Regulated p27 Gene Expression

Hsu, S.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Design and Development of Antibody-Targetable and Self-Assembled Micelles of Anticancer Drug Conjugate and Complex of Hyaluronic Acid

Sheu, M.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

榖胱甘月太硫轉移酉每參與乳癌致癌之分子機制探討(2/3)

Wu, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

包載9α-型尼古丁乙醯膽鹼受體抑制劑之標靶性微脂體劑型設計與開發

Sheu, M.

8/1/137/31/14

Project: B - Project of TMUh - Other (Funded by TMU)

Application of Hyaluronic Acid and Resveratrol Modified Carbon Nanotube Scaffolds for Tissue Engineering

Sheu, S.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Role of Organic Anion Transporter in Renal Tubular Injury---A Gateway to Hurt

Wu, M.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

利用人類血清白蛋白作為反譯寡核?酸及化療藥物載體之研究

Chiu, S.

8/1/137/31/14

Project: B - Project of TMUh - Other (Funded by TMU)

Proteomic Study of Metformin on Kidney Damage in Rats

Lee, J.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology