Find Research Projects

Search results

• b - Ministry of Science and Technology

  Effects of Cafestol on Cardiac Hypertrophy.

  Liu, J.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Genetic Polymorphisms on Efficacy and Safety of Opioid Analgesics in Patients with Postoperative Pain in a Taiwanese Population

  Tai, Y.

  8/1/18 → 10/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Risk Analysis and Building of Risk Assessment Models for Postoperative Infectious Complications in Diabetic Patients – Big Data Analysis Using Data Mining Techniques

  Lin, C.

  8/1/18 → 10/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Prp: Platelet-Rich Plasma Effects in the Articular Chondrocytes and Synovial Fibroblasts with the Associated Mechanism---A Fibronectin Fragment Model

  Lee, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of a Cognitive Behavioral Self-Help Intervention on Immigrant Life Stress for Immigrant Women Who Are Divorced

  Kuo, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Association Study of Genetic Polymorphisms of Toll-Like Receptors on Ischemic Stroke (I)

  Chiou, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Cell Behaviors and Its Gene Analysis of Nerve-Like Cell on Three-Dimensional Fibrous Matrix

  Tseng, H. & Ho, Y.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of Nephrotoxicity-Induced Long-Term Mitochondrial Dysfunction in Chronic Kidney Disease of Unknown Etiology and Its Potential Therapeutic Strategy

  Hsu, Y.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 建立智慧神經加護病房資料庫(MiNiC)(2/3)

  Lin, M.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• ASPM-PAR-PCP訊息軸於侵犯性癌幹細胞造成癌轉移的角色與其標靶治療(2/3)

  Tsai, K. K.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 改質活性碳添加於新型微管陣列薄膜應用於中分子蛋白質吸附之高效率 血液淨化器研究

  Wu, M.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Urinary Total Arsenic Levels, Arsenic Methylation Capacity, Plasma Selenium Concentrations and Genetic Polymorphisms of Glutathione Peroxidase and Selenoprotein and Prostate Cancer

  Hsueh, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Molecular Basis of Senp2 in Regulating Smad4 Sumoylation and Its Functions in Triple Negative Breast Cancer(2/3)

  Chang, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Uncovering the Specific Interactions between DNA Mimic Proteins and Their Target DNA Binding Proteins by Structure-Based Studies(3/3)

  Wang, H.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Roles of Microrna Sponge-Like Long Non-Coding Rnas (Lncrnas) in Progression and Temozolomide Chemoresistance of Glioblastoma

  Chen, K.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Prediction of Cancer Metastasis Using SVM-Based Model with Quantification of Pathway Changes between Different Disease Statuses

  Chiu, H. & Chang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討HIV-1反轉錄酉每與新穎先導藥物之複合體結構以利優化作為抗HIV候選藥物

  Liu, C.

  8/1/14 → 10/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 大腸直腸癌已躍居世界上癌症死亡率第二名，屬於固體型腫瘤，缺氧常見於此類 腫瘤，並誘發HIF-1α 表現而導致抗藥性及預後較差，因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑，可殺死癌 細胞而不影響正常細胞，對小鼠也不具毒性。我們初步結果顯示，Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現，代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性，對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下，經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制；也有研究報導指出，藥物會誘導癌細胞產生autophagy，造成細胞過度吞噬其內容 物而死亡，因此，autophagy在癌細胞為保護或是引發毒殺作用，目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活，但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示，除抑制HIF-1α 表現外，Zeb 也可活化AMPK、UPR/ER stress、以及autophagy， 因此我們推測Zeb 可在缺氧狀態下，促進autophagic cell death。3 年內我們將執行4 項 目標： (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。（第一年） (2) 研究Zeb 抑制HIF-1α表現之分子機轉。（第一年到第二年） (3) 研究Zeb 誘發autophagy之分子機轉。（第二年到第三年） (4) 探討Zeb 對缺氧導致抗藥性之作用。（第三年）

  Yang, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Application of Hyaluronic Acid and Resveratrol Modified Carbon Nanotube Scaffolds for Tissue Engineering

  Sheu, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Study of the Involvement of Micrornas in Pressure-Induced Initial Renal Fibrosis

  Chen, T.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Cultural and Legal Factors in the Religious Disputes during the Late Imperial China and the Early Republican Period: a Weberian Comparative Sociology of Missionary Case, Temple Destruction and Confiscation Campaigns, and Confucian Church Movement

  Tsai, P.

  12/1/15 → 11/30/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Chitosan nanoparticle as a macrophage-targeting drug delivery carrier

  Mi, F.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Differential Expression of microRNAs in Osteoblasts and Their Roles in Regulation of Cell Survival and Metabolism

  Chen, R.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Study of the Relationships among Anti-Obesity Activity, Adipogenesis, and Adipose Angiogenesis of Vegetable Indolic Derivatives---Involvement of the Ah Receptor/Arnt ?(III)

  Chen, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Evaluation of an Early Detection Flu Information System

  Lo, Y.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Epigenetic Editing as a Novel Therapeutics for Gynecological Cancer

  Lai, H.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Oncogenic Role and Targeted Therapeutic Potential of Alpha 9 Nicotinic Acetylcholine Receptors on Breast Cancers: Emphasizing in Pre-Clinical Assessment of Biphasic Antibody Nano-Drugs in Xenografts( I )

  Chang, J.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Gender Analysis of Workplace Violence among Medical Care Personnel

  Chen, R.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Fish Oil on Alcoholic Liver Disease in Rats Based on Pathological Mechanisms

  Yang, S.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Further Investigation of Drugs Resistance Mechanism in Lung Cancer with Lung Fibrosis

  Chang, C.

  1/1/18 → 12/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigations of Corneal Endothelial Cells on Biomaterials

  Wang, T.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Promise of Prenatal Genetic Screening and Testing: Noninvasive Prenatal Diagnosis in Taiwan

  Shih, L.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Therapeutic Potentials of Exosomes from Mesenchymal Stem Cell on Mitigating Cardiac Alterations and Their Effects on Modulating Oxidation, Inflammation, Mitochondrial Dysfunction and Insulin Resistance in Obesity Mice and Obesity Mice with Sepsis

  Huang, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation the Possibility of Utilizing Linc01296 as a Precision Theranostic and Surveillance Biomarker for Oral Cancer and Its Mechanisms during Oral Carcinogenesis

  Tsai, L.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Basic Medical Properties of Atmospheric Plasma and Its Influence on Cell Behaviors

  Tseng, H.

  11/1/19 → 10/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以anti-FAP/anti-CD3雙功能抗體武裝之毒殺型T細胞搭配臨床化療藥物治療腫瘤纖維化之胰臟癌

  Lin, S.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 從前後及側位平面X光偵測脊椎釘位置異常

  Liaw, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effect of Rice Bran Oil and Frying Rice Bran Oil Combined with Exercise Training on Physical Performance, Gut Microbiota, Fatty Liver Disease and Insulin Resistance in Postmenopausal Condition

  Chiu, W.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Relationship of Job Related-Overtime, -Burnout, -Stress, and Foot Reflexology Massage-Based Walking and the Incidence, Progression and Immunity of Cervical Cancer

  Tsai, H.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Wearable Medical Modnles with Far Infrared Light and Microwave Pules Measurement (Emphasis Theme:A3)(3/3)

  Hsu, Y.

  5/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Mechanistic Insights into Scn5a Deficiency on Fibrogenesis: Implications in Channelopathy Induced Structure Remodeling

  Kao, Y.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Plasmon-Activated Water on the Microbiota of Inflammatory Bowel Disease, Crohn’S Disease and Ulcerative Colitis, by Drug-Induced and Transgenic Mouse Models

  Chang, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Cerebral Blood Flow Dysregulation in Aging, Mild Cognitive Impairment and Dementia--A Study of the Structure Integrity of Neurovascular Unit

  Hu, H.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 臨界點理論在醫師專業認同發展歷程的應用--成為好醫師路上的轉化歷程(1/2)

  Chiu, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 多重模式取向探討躁期與鬱期下精神運動之神經生物的變化(1/2)

  Martino, M.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Roles of Novel CCCH Zinc Finger Genes on the Regulation of Cell Proliferation and Inflammation

  Liang, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Application of Clinical Anti-Arthralgia Formulas of Traditional Chinese Medicine to Arthritis

  Wang, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Depression Trajectories in Women – a Developmental-Ecological Approach (Gm03)

  Kuo, S.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies of Folic Acid-Induced Anti-Tumor Growth Activity---Anti-Angiogensis and Anti-Cancer Cell Growth

  Lee, W.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

• Emerging and Reemerging Zoonotic Parasitosis Caused by Fish-Borne Parasites: Health Risks Associated with Consumption of Fish

  Fan, C.

  1/1/18 → 12/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology