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• b - Ministry of Science and Technology

  Phosphoproteome Analysis of Sperm during Capacitation and Modulations of Chinese Medicines

  Wu, T.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 台灣社區藥局藥師文化能力之探討

  Chang, E. H.

  7/1/18 → 2/28/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 社區藥局藥師對偽藥看法、經驗與防範策略之探討

  Chang, E. H.

  7/1/18 → 2/28/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Nuclear Phosphorylated Dicer Contributes to Metabolic Switch and Gemcitabine Resistance of Pancreatic Cancer

  Chiu, C.

  10/1/18 → 9/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Predictions of Therapeutic Effects of Zolpidem in Disorders of Consciousness Patients(3/3)

  Lane, T. J.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討粒線體因子C20orf7在大腸癌進程中對化療藥物抗藥性及上皮細胞間質轉化作用EMT之調控機轉及大腸癌合併治療策略研究

  Cho, E.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Dysmetabolic Iron Overload Syndrome and Testosterone Biosynthesis: Role of Fat and Iron Enriched Diet(2/3)

  Chang, J.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Evaluating the Long-Term Effect of Low-Dose Aspirin Use during Pregnancy on the Prevention of Cardiovascular Disease among Women after Delivery

  Wu, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Brain Function for Evaluating Post Stroke Recovery Following Robot-Assisted Gait Training and Transcranial Direct Current Stimulation

  Lai, C., Chen, C., Chen, S., Peng, C., Kang, J. & Lin, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• 子宮內膜異位症體外血清診斷試劑開發計畫(1/2)

  Yang, W.

  8/1/15 → 3/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Differential Analyses of Kidney Proteins and Uninary D-Lactate Concentration in Mice Nephritis

  Lee, J. & Chen, S.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study of Rich Platelets Plasma and Alginate Encapsulated Synovial Fluid Mesenchymal Stem Cells for Repairing the Partial Tear of Cruciate Ligament

  Chen, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation on the Role of Cytoskeleton Reorientation and Calcium Ion Transportation in Static Magnetic Field Induced Mesenchymal Stem Cells Proliferation

  Huang, H.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 計畫行為理論在決策輔助工具的做中學與藥師繼續教育

  Wang, L.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Evaluations of Apolipoprotein E on the Pathological Role in Lung Cancer and the Application in Early Prediction of Clinical Outcome

  Wu, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Deciphering the Mechanisms of Multiple Myeloma Tumor Driving Factor Whsc1 in Kras Mutated Colon Cancer Progression and Investigate the Whsc1 Targeting Combination Therapy

  Cho, E.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 時差對於大腦上視神經交叉核的丙胺基丁酸神經元網路結構之研究(2/2)

  Myung, J.

  3/1/19 → 10/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討不同選擇作用之組織蛋白去乙醯酶調節成分抑制神經發炎之機制及其對腦內出血與腦炎之治療特性評估(1/3)

  Hsiao, G.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study of Nano-Size Memberane Tube for Tendon to Bone in Anterior Cruciate Ligament Reconstruction

  Chen, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• To Study the Role of Multidrug Resistance Protein 4 on Induction of Aspirin Resistance in Type 2 Diabetes Mellitus

  Lu, W.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effect of RRM2 in Tumor Metastasis and Chemotherapy Response of Colorectal Cancer Patients with Different APC and K-Ras Status

  Cheng, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Functional Studies of ZNF179 in Neurons in vitro and in vvo

  Lee, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Clinical Correlation Study of Dna Methyltransferases Alterations in Breast Cancer and Evaluation of Dna Methyltransferases as a Therapeutic Target in Cell and Animal Models

  Lin, R.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies on the Role of ORMDL3 in Thrombin-Induced IL-8/CXCL8 Expression and Airway Inflammation

  Chen, B.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Novel Activities of Gamma-Aminobutyric Acid-Mediated Regulation of Platelet Activation, Apoptosis, and Autophagy: the Non-Genomic Functions of Nf-Kappab Signal in Anucleated Cells

  Sheu, J.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Protective Effect of PLZF Nuclear Translocation against Advanced Glycation End Product-Induced Endothelial Injury in Diabetes and Its Molecular Mechanism

  Chen, C. & Hsu, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討臺灣牛樟芝對多型性神經膠質瘤治療的角色、調控基因與開發新穎治療策略

  Lin, J.

  6/1/18 → 12/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigating the Dynamic Change of Genotype and Phenotype in Circulating Tumor Cells and Its Clinical Significance in Cancer Progression

  Lee, H.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study on the Immuno-Modulatory Effects of Notch Ligand Delta 4 on Immune Cells and in Ova-Induced Asthmatic Mice

  Lee, Y., Leu, S. & Liu, H.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of Micrornas in Cutaneous Wound Healing

  Shen, S.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Cafestol on Cardiac Hypertrophy.

  Liu, J.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Anti-Tumor Mechanisms of a Novel Aliphatic Hydroxamate, WMJ-S-001---Targeting Tumor Angiogenesis and Lymphangiogenesis

  Hsu, M.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of N-3 Polyunsaturated Fatty Acids on the Gut Microbiota in Depressive Disorder

  Huang, S.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 胃腸科相關癌症之差異蛋白質體與致病機轉之研究

  Lee, J.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 艾克曼嗜黏蛋白菌和電漿活化水對硫酸葡聚醣鈉誘導的潰瘍性結腸炎的保護作用：從微生物代謝產物和蛋白質以及細胞外泌體中的小分子核醣核酸觀點出發

  Chang, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以可量產之商用半導體製程建立奈米線場效電晶體血液產品病毒檢測平台 (重點主題:A2)(2/3)

  Lin, L. T.

  5/1/18 → 4/30/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study of the Mechanism of HPV Involved Tumorigenesis through Wnt Signaling Pathway Related microRNA Regulation

  Cheng, Y. & Lee, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Application of Clinical Anti-Arthralgia Formulas of Traditional Chinese Medicine to Arthritis

  Wang, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigating the Therapeutic Potential and Molecular Mechanism of Natural Products for Platinum-Resistant Bladder Cancer(1/3)

  Chen, M.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Melatoninergic Agonists and Omega-3 Fatty Acids in Circadian Rhythm and Neuroprotection: from Cellular, Animal, to Clinical Research

  Huang, S.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 病態性肥胖病人接受減重手術後改善非酒精性脂肪肝之預測因子

  Kao, W.

  3/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Deciphering the Molecular Regulatory Mechanisms of Ccl20-Ccr6 Chemokine Cascade in Epithelial-Mesenchymal Transition and Chemo-Resistance in Colon Cancer, and Also the Strategy for Cancer Treatment

  Cho, E.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Omega-3脂肪酸合併褪黑激素致效劑改善憂鬱症狀與生物日夜週期機制之探討： 一項營養與精神醫學之轉譯研究(2/3)

  Huang, S.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 建立國人電腦斷層脊椎椎體結構強度之預測模型

  Chen, H.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 分析TLK訊息傳遞網絡及其於染色質維護與防止腫瘤生成之功能

  Lee, S.

  4/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Impact of Coping Skills Training on Stress, Symptom Distress in Children with Cancer

  Chen, S.

  8/1/13 → 10/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 乳癌是目前世界上女性癌症病患中為數最多的癌症之ㄧ。腺病毒蛋白type 5 E1A (E1A)和許多抗腫瘤作用有關，曾於多種癌症如乳癌、卵巢癌及頭頸癌之病患進行臨床基因治療試驗。許多的研究指出E1A具有多項抗腫瘤的功能，包括抑制腫瘤的發生、增加腫瘤細胞對於化療藥物的感受性以及減少腫瘤轉移的現象。腫瘤的轉移對於癌症患者的死亡率有極大的影響當然也包括了乳癌的患者。E1A於抑制腫瘤發展的過程中具有多重生物學上的意義，這也促使我們想要釐清E1A抑制癌症的機制。因此，我們對於了解E1A抑制癌症轉移相關的分子機制感到有興趣，並期望藉以作為未來改進乳癌病人臨床試驗的基石。我們初步的實驗結果顯示，E1A可以有效的抑制Glucose-regulated protein 78 (GRP78)這種已被廣泛報導和腫瘤惡化及轉移相關的蛋白的表現。 提出此研究計劃之目的在於詳細探討E1A所造成的抑制癌轉移作用中，GRP78所扮演的生物功能及其調控的機轉。為了達到此目的，我們將著重於E1A如何調控GRP78表現並進而展現對乳癌轉移的抑制作用。以下為此項研究計畫的四大主要目標： 目標一：探討GRP78在E1A所抑制之癌細胞移行及侵入作用中所扮演的角色 目標二：研究E1A抑制GRP78表現之分子機轉 目標三：於動物模式中驗證GRP78的表現對於E1A抗腫瘤作用的影響 目標四：探討GRP78及其相關分子的表現在乳癌病人的臨床重要性 完成以上的主要目標能夠幫助我們對於E1A之抗腫瘤轉移作用建立更加詳細的分子訊息傳遞機制。另外，藉由此研究計畫的新發現也許可以對未來發展癌症治療上提供更多具有潛力的標的物。

  Wang, W.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study the Role of GRP78 in E1A-Mediated Metastasis Suppression of Breast Cancer

  Wang, W. & Wu, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討CDK4/6抑制劑在兒童惡性腦瘤治療的可行性(第二年)(2/3)

  Hsieh, T.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of Angiopoietin-Like Protein 1 in Sorafenib Resistance and Cancer Stemness of Hepatocellular Carcinoma Cells

  Huang, M.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology