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• b - Ministry of Science and Technology

  核糖核甘酸還原酉每抑制劑在人類乳突瘤病毒感染之非小細胞肺癌治療效果評估

  Hsu, N.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Regulation of Pml Degradation by Sentrin-Specific Protease 2

  Chang, C.

  11/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development and Validation of Mall Walking Program in Taiwan (2/2)

  Chang, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effect of Health Risk Behaviors on Recurrent Traffic Injury

  Chen, P. & Shu Kei Lam, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effects and Molecular Mechanisms of Phthalates (DEHP 和DBP) on the Mitochondrial Function and Genetic Regulation in Ovarian Granulosa Cells and Mouse Embryo

  Tzeng, C. & Kao, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• On risk governance and administrative law continued：A comparison of how law interacts with regulatory policy-making in Taiwan and the US (2/3)

  Liang, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of Aspm-Par-Pcp Signaling in Invasive-Cancer-Stem-Cell-Mediated Metastasis and Its Therapeutic Targeting(1/3)

  Tsai, K. K.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Characterization of Lncrna-Kdm4 Axis in Hypoxic Oral Cancer(1/3)

  Kung, H.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• On risk governance and administrative law continued：A comparison of how law interacts with regulatory policy-making in Taiwan and the US (1/3)

  Liang, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討慢性睡眠剝奪對口腔菌叢的影響，並闡明口腔菌叢引致認知功能失常的潛在機制

  Chang, H.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討TAGLN2 調控之 EMT 途徑參與 Parthenolide 誘導腦瘤幹細胞凋亡機制

  Chen, K.

  7/1/21 → 2/28/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Virus Detection Platform of Blood Products Using Nanowire Field Effect Transistor Prepared through Commercial Semiconductor Process with Mass Production Capability( II )

  Burnouf, T. P. R.

  5/1/18 → 4/30/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 隨機模型於精準健康科學之應用-應用隨機模式於不適健康照護之精準健康科學評估(3/3)

  Yen, M.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 長期尿道出口阻塞透過膠原蛋白 I 沉積而降低膀胱順應性-針灸治療的潛在標的

  Lin, T.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 罹患重大精神與生理疾病的病人之自殺風險性以及超額死亡的探討：嵌入型病例對照研究設計

  Huang, K.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 外籍看護工的照顧負荷：失能者、家屬與外籍看護的三方看法

  Hsu, H.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 開發混合型機器學習之代謝物滯留時間預測模型用於辨識液相層析串聯質譜儀實驗之代謝物(2/2)

  Wang, S.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 柴油引擎微粒在胚胎肺部發育的纖維母細胞Yap/Taz調控衰老機轉之研究

  Chuang, H.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Post-Stroke Vi Sual Dependence and Early Intervention of Multisensory Balance Rehabilitation (2/3)

  Lee, S.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討夜交藤萃取物合併Amoxicillin對於胃潰瘍的治療機制

  Lee, C.

  7/1/21 → 2/28/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• An Industry-University Alliance on Pilot-Type Animal Experimental Consultancy and Analytic Platforms( I )

  Chang, H.

  2/1/18 → 1/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• A High Density and Nano-Sized ReRAM Crossbar Array Using Copper Chemical Displacement and Nanotip Array Techniques (I)

  Wu, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• 奈米生物介面研究：中孔洞氧化矽奈米粒子性質及其蛋白質冠冕於抗聚乙二醇免疫性、腫瘤標靶效率及腎臟排泄的影響(2/2)

  Wu, S.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 尼古丁受體基因叢與認知障礙關聯性的探討

  Yeh, C.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Mobile Phone Use and Walking: A Observational Field Study of Pedestrians' Risky Behaviours and Inattentional Blindness

  Pai, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Therapeutic Implications of Down-Regulation of Microglia Activation Following Repetitive Traumatic Brain Injury-Induced Chronic Traumatic Encephalopathy

  Chang, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 生醫與醫材轉譯加值人才培訓-ANCHOR UNIVERSITY計畫(TMU)

  Wu, C.

  8/1/20 → 7/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Service for Sharing Precious Instruments of Taipei Medical University

  Lin, C.

  1/1/13 → 1/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study on the Expression and Regulatory Mechanism of Tumor Metastasis Suppressor Nm23-H1: Establishing Platforms for Studying and Screening Chemotherapeutic Agents Using Genomic Promoter Approaches

  Wang, L.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• 闡明Hiltonol為主的複合式用藥在肺癌生長，轉移和腫瘤微環境中的作用。

  Chang, S.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討HIV-1反轉錄酉每與新穎先導藥物之複合體結構以利優化作為抗HIV候選藥物

  Liu, C.

  8/1/14 → 10/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 中台灣跨校整合科研產業化平台計畫I

  Lin, C.

  10/1/20 → 12/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 大腸直腸癌已躍居世界上癌症死亡率第二名，屬於固體型腫瘤，缺氧常見於此類 腫瘤，並誘發HIF-1α 表現而導致抗藥性及預後較差，因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑，可殺死癌 細胞而不影響正常細胞，對小鼠也不具毒性。我們初步結果顯示，Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現，代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性，對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下，經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制；也有研究報導指出，藥物會誘導癌細胞產生autophagy，造成細胞過度吞噬其內容 物而死亡，因此，autophagy在癌細胞為保護或是引發毒殺作用，目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活，但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示，除抑制HIF-1α 表現外，Zeb 也可活化AMPK、UPR/ER stress、以及autophagy， 因此我們推測Zeb 可在缺氧狀態下，促進autophagic cell death。3 年內我們將執行4 項 目標： (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。（第一年） (2) 研究Zeb 抑制HIF-1α表現之分子機轉。（第一年到第二年） (3) 研究Zeb 誘發autophagy之分子機轉。（第二年到第三年） (4) 探討Zeb 對缺氧導致抗藥性之作用。（第三年）

  Yang, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 環境菌相、空氣污染及生活型態對學齡前兒童過敏性疾病之影響

  Chao, H. J.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 具抗纖維化效果之選擇性組蛋白去乙醯酶抑制劑：利用有機金屬耦合反應合成吡啶酮為骨架之系列衍生物

  Liu, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Social Economy and Indigenous Community Resilient Livelihood: A Case Study of Three Communities in Back Mountain of Jienshi District, Hsinchu County (3/3)

  Lin, Y.

  1/1/22 → 12/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Molecular Basis of Senp2 in Regulating Smad4 Sumoylation and Its Functions in Triple Negative Breast Cancer(2/3)

  Chang, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study the Effects and Regulation of Dicer in Gemcitabine Sensitivity of Pancreatic Cancer

  Su, Y.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Roles of Microrna Sponge-Like Long Non-Coding Rnas (Lncrnas) in Progression and Temozolomide Chemoresistance of Glioblastoma

  Chen, K.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• In Vivo and in Vitro Studies of Progesterone-Induced Anti-Angiogenesis

  Lee, W.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• Reactions of NSAIDs (Mefenamic Acid and Diclofenac) by O3/Gac Processes: Intermediates, Pathway and Kinetic Models

  Chang, E.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Use of RIA-Enabled Image Processing Techniques for Constructing Micro-to-Macro Personal Biomedical Atlas

  Chen, C.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以經顱交流電刺激治療思覺失調症的隨機對照試驗(1/3)

  Lu, M.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 從食安風險暴露之角度探討非營養性甜味劑對女性生殖狀況之影響-非營養性甜味劑對青春期早發育的影響及相關機轉探討(2/3)

  Chen, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Regular Exercise on Emotional Control and Cognitive Function of Prefrontal-Limbic Pathway in Sleep-Deprived Rats---An Analysis by Behavior and Neurostructural Correlates(2/2)

  Hsu, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Prevalence and Effect of Potentially Inappropriate Medication of Elderly in Long Term Care Facility

  Hung, Y.

  8/1/14 → 10/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 消費者購買保健食品之實證研究

  Chang, C.

  7/1/21 → 2/28/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Technology & Distrust: a Study on Biomed Research & Development Models and Legal Framework( I )

  Chia, W.

  2/1/20 → 1/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Study on Learning and Counselling Strategies of Dental Technology Students for the Dental Technician Examination

  Lin, C. & Huang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• ERK/p65及p300在Pref-1誘導肺部纖維母細胞CTGF表現之研究

  Chen, B.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology