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• b - Ministry of Science and Technology

  Radiogenomics of Malignant Gliomas by Linking Physiological Mr Imaging, Histopathological Patterns, and Genetic Alternations: a Translational Study from Rat to Man

  Chen, C.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Glioblastoma 100%
  • Glioma 51%
  • Biomarkers 36%
  • Multiparametric Magnetic Resonance Imaging 15%
  • Neoplasms 14%

• 探討臺灣牛樟芝對多型性神經膠質瘤治療的角色、調控基因與開發新穎治療策略

  Lin, J.

  6/1/18 → 12/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Genetic Polymorphisms of Calcium Channel in the Risk of Breast Cancer

  Chang, W.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Calcium Channels 63%
  • Breast Neoplasms 60%
  • Genetic Polymorphisms 37%
  • Calcium 24%
  • Case-Control Studies 18%

• Construction and Application of Medical Image Database in Tmu Healthcare System( I )

  Huang, C.

  11/1/17 → 10/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Research of Biomedical Mg-Zr Alloys on Maxillofacial Reconstruction

  Peng, P., Ou, K. & Huang, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • bones 100%
  • orthopedics 91%
  • biodegradation 52%
  • Taguchi methods 51%
  • degradation 50%

• The Development and Clinical Application of a Miniature Transcranial Direct Current Stimulator in Rehabilitation Therapy (II)

  Peng, C.

  11/1/14 → 6/30/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Patient rehabilitation 100%
  • Animals 90%
  • Experiments 33%
  • Health insurance 20%
  • Research laboratories 14%

• Anti-Cancer and Anti-Inflammatory Properties of Novel Aliphatic Hydroxamate Derivatives: Hdacs- and Mirna-Mediated Post-Transcriptional and Post-Translational Mechanisms

  Hsu, M.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 脂肪激素內脂素對子宮肌瘤增生及微環境影響:分子機制探討及精準營養應用之研究(1/3)

  Hsia, S.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討運動對於粥狀動脈硬化脂質體學之影響

  Tung, Y.

  7/1/19 → 2/1/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Leukemia Based Precision Medicine Research Model on Non-Invasive Apoptosis Detection Platform – Application of Crispr/Cas9 Gene and Target Therapy on Philadelphia Chromosome of Chronic Myelogenous Leukemia as an Example

  Chen, S.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Precision Medicine 100%
  • Leukemia 88%
  • Heterografts 41%
  • Philadelphia Chromosome 39%
  • Myeloid Leukemia 37%

• 從前後及側位平面X光偵測脊椎釘位置異常

  Liaw, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation of the Functions of Brain Finger Protein, Znf179, in Embryo Development and in Adult Brain

  Lee, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Blood Vessels 100%
  • Embryonic Structures 92%
  • Knockout Mice 77%
  • Spatial Learning 68%
  • BFP ring finger protein 64%

• Effects of Different Oils Combined with Lycium Barbarum Extract on Chemical-Induced Liver Inflammation and Fibrosis in Rats

  Chao, J. C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Olive Oil 100%
  • Stellate Crystal 89%
  • Signal Transduction 47%
  • Antifibrotic 37%
  • Apoptotic 25%

• 氧化還原作用調控蛋白質去磷酸酉每羰基化和去羰基化反應對動脈血管內膜增生之影響(1/2)

  Hsieh, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Activation Autophagy by the Combination of a Histone Deacetylase Inhibitor and Radiation Limits BNIP3 Regulation in Triple-Negative Breast Cancer Cells and Orthotopic Mouse Model

  Chiu, H. & Ho, Y.

  8/1/15 → 6/30/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Triple Negative Breast Neoplasms 100%
  • Histone Deacetylase Inhibitors 97%
  • Ionizing Radiation 42%
  • Autophagy 39%
  • human ERBB2 protein 25%

• Contribution of ER Stress to Inhibit miR-19a/b and miR-26b-Mediated CTGF Expression in Lung Fibrosis (III)

  Chen, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Self, Consciousness, and Neurophilosophy

  Lane, T. J.

  1/1/15 → 6/30/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Molecular Model 100%
  • Neurophilosophy 96%
  • Applied Ethics 80%
  • Self-consciousness 68%
  • Philosophy of Science 60%

• The Role and Molecular Mechanism of Pparα in Acute Kidney Injury: Focus on the Protective Effect in Renal Tubular Cell

  Hsu, Y.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • MicroRNAs 100%
  • Type C Phospholipases 73%
  • Kidney 56%
  • Acute Kidney Injury 37%
  • Gentamicins 27%

• Endothelin-1 Mediates Fibrocyte Differentiation in Chronic Obstructive Asthma

  Lin, C.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Asthma 100%
  • Fibrosis 76%
  • Myofibroblasts 73%
  • Lung 61%
  • Connective Tissue Growth Factor 51%

• Micropatterned Substrate for the Cultivation of Glucose-Responsive Tissue Engineered Islet for Diabetic Research and Cell Therapy

  Yang, K.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • pancreas 100%
  • tissues 96%
  • cells 94%
  • insulin secretion 77%
  • therapeutics 61%

• The Further Investigation of Drugs Resistance Mechanism in Lung Cancer with Lung Fibrosis

  Chang, C.

  1/1/18 → 12/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Lung Neoplasms 100%
  • Lung 97%
  • Fibrosis 93%
  • Adenocarcinoma of Lung 60%
  • Proto-Oncogene Proteins c-met 38%

• Role of miR-21 in Regulating TET I-Hydroxymethylcytosine and Chemotherapeutic Response in Colorectal Cancer (I)

  Yang, P.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Colorectal Neoplasms 100%
  • 5-hydroxymethylcytosine 84%
  • APC Genes 58%
  • DNA Methylation 55%
  • Adenomatous Polyposis Coli 51%

• Potential of Capsaicin against Advanced Glycation Endproducts Formation

  Wu, C.

  12/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Capsaicin 100%
  • Glycation 34%
  • Protective 14%
  • Aminoguanidine 12%
  • Oxidative Stress 8%

• Effects of Different Sources of n-3 Fatty Acids on Bone Loss, Body Fat and Inflammatory Markers in Osteoporotic Condition with Diabetes

  Chiu, W. & Fong, T.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Fatty Acid 100%
  • Fat 66%
  • Ligand 24%
  • Deoxypyridinoline 20%
  • Marker 19%

• Dissected the Role of Thrombomodulin in the Clinical Diagnostic and Therapeutic Impacts for Breast Cancer and the Regulation Mechanisms(3/3)

  Hung, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Thrombomodulin 100%
  • Breast Neoplasms 90%
  • Therapeutics 20%
  • Neoplasms 12%
  • Steroid Receptors 11%

• To Study the Role of Sp1 in Cancer Drug Resistance(3/3)

  Chuang, J.

  8/1/18 → 10/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Interaction between Gut and Brain in High-Functioning Autism: from Phenotypes to Specific Imaging Endophenotypes

  Lo, Y.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Autistic Disorder 100%
  • Neuroimaging 45%
  • Brain 45%
  • Probiotics 44%
  • Biomarkers 38%

• Establishment of a Biophysical Effect-Based Platform for Rapid Expansion of Functional Mesenchymal Stem Cells(3/3)

  Ho, J.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • stromal cells 100%
  • stem cells 79%
  • cell transplantation 46%
  • microfluidic technology 39%
  • shear stress 32%

• Radiogenomic Mapping of Angiogenesis in Glioblastoma

  Hsieh, K. L.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Glioblastoma 100%
  • Phenotype 30%
  • Survival 28%
  • Multiparametric Magnetic Resonance Imaging 23%
  • Genetic Profile 21%

• The Effectiveness of Hormonal Therapy on Prostate Cancer Bone Metastasis Determined by Klf4

  Liu, Y.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• New Brain Cortical Electrical Stimulation Technology for the Neurorehabilitation Therapy of Bladder Dysfunction in the Parkinson’S Disease Animal Model(2/3)

  Peng, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 次發性副甲狀腺素亢進對於動靜脈廔管成熟率之角色

  Liu, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Predictors of Improvement of Nonalcoholic Fatty Liver Disease in Morbidly Obese Patients Undergoing Bariatric Surgery(III)

  Kao, W.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Electrophysiological Activity and Functional Correlates in Female Pelvic Floor Muscles

  Yang, J., Huang, W. & Yang, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • muscles 100%
  • urinary incontinence 51%
  • electromyography 38%
  • muscle contraction 36%
  • testing 5%

• The Publication of Journal of Biomedical Science

  Chang, W.

  1/1/15 → 3/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Scholarly Communication 100%
  • Taiwan 99%
  • Publications 83%
  • Biological Science Disciplines 62%
  • Information Dissemination 59%

• Application of Regioselective Substitution on 1,4-Benzoquinone Derivatives to Provide Potent Anticancer Agents

  Liou, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • 1,4-benzoquinone 100%
  • Wittig Olefination 54%
  • Intramolecular Cyclization 40%
  • Nucleophilic Substitution 38%
  • Regioselectivity 35%

• 設計並評估新型含藥人工骨凝膠對齒槽骨缺損的修復作用

  Lee, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • osteoblasts 100%
  • bones 83%
  • attachment 42%
  • stem cells 39%
  • healing 32%

• Use the organometal catalytic reaction to synthesize the heterocycle-based anticancer agents

  Liou, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Antineoplastic Agent 100%
  • Hydroxyl 93%
  • Antiproliferative 56%
  • Antitumor 52%
  • Structure-Activity Relationship 48%

• CXCL5/CXCR2/JNK Axis Is the Shared Pathway of Neuroinflammation and Microvascular Damage That Contributes to White Matter Injury in the Immature Brain

  Huang, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • White Matter 100%
  • Brain Injuries 57%
  • Blood-Brain Barrier 40%
  • JNK Mitogen-Activated Protein Kinases 38%
  • Leukocytes 33%

• Regulatory Mechanisms of Mitochondria Involved in Apoptosis, Necrosis and Autophagy in Anuclear Cells, Platelets

  Sheu, J.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Blood Platelets 100%
  • Mitochondrial Transmembrane Permeability-Driven Necrosis 53%
  • Mitochondria 40%
  • Cyclophilin D 39%
  • Apoptosis 35%

• Effects of Ultrafine Particles on Cardiopulmonary System: a Population-Based Approach

  Chuang, K.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Particulate Matter 100%
  • Air Pollution 68%
  • Taiwan 34%
  • United States Environmental Protection Agency 33%
  • Organized Financing 13%

• Development of Multifunctional Aminated Gelatin Nanoparticles as an Adjuvant Antigen-Carrier for Mucosal Immunization

  Liu, D.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • gelatins 100%
  • antigens 84%
  • nanoparticles 50%
  • delivery 23%
  • proteins 19%

• The Synergistic Function of Netrin-1 and Ephrin Signals in Spinal Motor Axon Guidance

  Kao, T. & Hsieh, T.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Netrin Receptors 100%
  • Netrins 82%
  • Ephrins 75%
  • Motor Neurons 50%
  • Netrin-1 40%

• The First Randomized Controlled Clinical Trial for Computerized Decision Support System

  Li, Y.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Contrast Media 100%
  • Drug-Related Side Effects and Adverse Reactions 60%
  • Clinical Decision Support Systems 56%
  • Physicians 54%
  • Randomized Controlled Trials 43%

• Combination Treatment of Tetrac- and Cetuximab-Induced Anti-Proliferation in Colorectal Cancer with Different APC Status (I)

  Lin, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • tetraiodothyroacetic acid 100%
  • Cetuximab 77%
  • Adenomatous Polyposis Coli 38%
  • Colorectal Neoplasms 28%
  • Integrins 16%

• Obesity and Cardiovascular Disease in Taiwan Women with Polycystic Ovary Syndrome

  Hsu, M., Liou, T., Chen, Y., Tzeng, C. & Hsu, C.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Polycystic Ovary Syndrome 100%
  • Obesity 13%
  • Metabolic Syndrome 13%
  • Endocrinologists 12%
  • Hirsutism 12%

• Improvement of Cryopreservative Effect of Natural Killer Cell by Increasing Membrane Rigidity Using Static Magnetic Field

  Huang, H.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • cells 100%
  • transfusion 62%
  • magnetic fields 55%
  • rigidity 38%
  • proposals 34%

• Renoprotective mechanisms of soy protein in rats with diabetic nephropathy 全文電子檔： 全文連結1

  Chen, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • diabetic nephropathy 100%
  • soy protein 62%
  • blood glucose 29%
  • blood pressure 28%
  • proteinuria 20%

• Development of 3d-Printing Dynamic Orthosis-For Hemiplegic Lower Limbs( II )

  Chen, S., Lai, C., Ou, K. & Peng, C.

  9/1/15 → 8/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Fish Oil on Alcoholic Liver Disease in Rats Based on Pathological Mechanisms

  Yang, S.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

  • liver diseases 100%
  • alcohol abuse 83%
  • fish oils 81%
  • liver function 46%
  • rats 39%