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Use the organometal catalytic reaction to synthesize the heterocycle-based anticancer agents

Liou, J.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

The association of early-onset ischemic stroke and the aging of vascular system using the telomere length related genes

Hsieh, F.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

An association study of arsenic exposure, inflammation, oxidative stress and the risk of developing cardiovascular diseases

Hsieh, F.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

The Effect of Improved Nutrition Care on the Progress of Hemodialysis Patients

Yang, S.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

臺蒙(MN)國合計畫-台灣及蒙古之洋蔥及蔥屬蔬菜對骨質疏鬆症的影響(1/3)

Chen, Y.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Design and Development of Antibody-Targetable and Self-Assembled Micelles of Anticancer Drug Conjugate and Complex of Hyaluronic Acid

Sheu, M.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

The exploitation of Taiwan native plants in promoting bone growth and establishment of the system biology platform

Lee, M.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Proteomic Study of Metformin on Kidney Damage in Rats

Lee, J.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

To Investigate the Functions of Shikonin and Its Derivatives in Applied Age-Related Macular Degeneration and Wound Healining

Cheng, Y.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Deferasirox Plasma Concentration Analysis and Effects of Potential Iron Chelators on Iron Overload and Safety Evaluation

Wu, T.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Natural Product Hybrid and Ortho-Biaryl N-Hydroxycinnamide as Leads for Anticancer Agent Development

Huang, W.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Biomarkers Associated with Toll-Like Receptors and Neuroimage Study in Ischemic Stroke Patients (I)

Hu, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

大腸直腸癌已躍居世界上癌症死亡率第二名,屬於固體型腫瘤,缺氧常見於此類 腫瘤,並誘發HIF-1α 表現而導致抗藥性及預後較差,因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑,可殺死癌 細胞而不影響正常細胞,對小鼠也不具毒性。我們初步結果顯示,Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現,代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性,對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下,經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制;也有研究報導指出,藥物會誘導癌細胞產生autophagy,造成細胞過度吞噬其內容 物而死亡,因此,autophagy在癌細胞為保護或是引發毒殺作用,目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活,但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示,除抑制HIF-1α 表現外,Zeb 也可活化AMPK、UPR/ER stress、以及autophagy, 因此我們推測Zeb 可在缺氧狀態下,促進autophagic cell death。3 年內我們將執行4 項 目標: (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。(第一年) (2) 研究Zeb 抑制HIF-1α表現之分子機轉。(第一年到第二年) (3) 研究Zeb 誘發autophagy之分子機轉。(第二年到第三年) (4) 探討Zeb 對缺氧導致抗藥性之作用。(第三年)

Yang, P.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

TMU101-AE1-B68

Chiu, Y.

8/1/137/31/16

Project: B - Project of TMUi - Other (Funded by TMU)

The Application of Fluoxetine and Its Related Medicines in Brain Tumor Treatment

Shen, S.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Contribution of Er Stress to Inhibit miR-19a/b and miR-26b-Mediated CTGF Expression in Lung Fibrosis (I)

Chen, Y.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

The Role of ADAM 17 in Hypoxia-Induced CTGF Expression and Pulmonary Fibrosis (I)

Chen, B.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Investigating of Transcranial Direct Current Stimulation and Robot-Assisted Gait Training Effects in Subjects with Stroke

Lai, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Investigation of the Functions of Brain Finger Protein, Znf179, in Embryo Development and in Adult Brain

Lee, Y.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Development of Novel Therapeutic Agents for Herceptin Resistance Breast Cancer Cells through Targeting Nicotinic Acetylcholine Receptors

Lee, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Analyses the Role of ADAM9-Hemidesmosome Components Interaction in Malignant Cancer Metastasis and Future Therapeutic Strategy

Sung, S.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Study on the Preventive Effect and Mechanism of Germinated Brown Rice and Its Components on Colorectal Cancer

Shih, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

抗氧化防禦基因標籤單核?酸多形性、氧化壓力生物標記與冠狀動脈心臟病之相關性(1/2)

Yeh, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

The Sumoylation of Histone Deacetylase 2 Contributes to CTGF Expression and Pulmonary Fibrosis in Chronic Obstructive Asthma (I)

Lin, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Studies of Anti-Cancer Activity of Folic Acid

Lee, W.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

利用基因工程誘導性潛能幹細胞治療巴金森氏症之研究

Chiang, Y.

8/1/137/31/14

Project: B - Project of TMUi - Other (Funded by TMU)

New Strategies of Parkinson’s Disease Treatment

Chiang, Y.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Immature Testicular Tissue Engineering for Male Fertility Preservation---A Transgenic Mouse Model

Chen, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Study the Role of GRP78 in E1A-Mediated Metastasis Suppression of Breast Cancer

Wang, W.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

102年度臺北市輻射屋居民健康照護需求評估工具建立

Chiu, C.

7/16/1312/31/13

Project: A - Government Institutionf - Other (Funded by Government)

健康促進國際政策及學術資料建置計畫

Chang, W.

7/3/1312/31/13

Project: A - Government Institutionc - Ministry of Health and Welfare

The Application of Biodegradable Nano-Enabled Drug Delivery in Treatemt of Brain Abscess

Tseng, Y.

7/1/139/30/14

Project: A - Government Institutionb - Ministry of Science and Technology

TMU101-AE1-B62

Chuang, T.

7/1/139/30/14

Project: B - Project of TMUi - Other (Funded by TMU)

TMU101-AE1-B61

Cheng, P.

7/1/136/30/14

Project: B - Project of TMUi - Other (Funded by TMU)

奈米金屬微粒暴露引發勞工心血管效應之細胞毒理評估

Chuang, K.

6/27/1312/20/13

Project: A - Government Institutionf - Other (Funded by Government)

行政院衛生署所屬醫院「102年度滿意度調查評估」勞務委託採購案

Kuo, N.

6/18/1310/28/13

Project: A - Government Institutionf - Other (Funded by Government)

102年癌症篩檢管理中心工作計畫之個管師考題研擬及閱卷

Chen, L.

6/13/138/31/13

Project: A - Government Institutionc - Ministry of Health and Welfare

職場生物氣膠暴露及建議值調查評估研究

Chao, H.

6/11/1312/13/13

Project: A - Government Institutionf - Other (Funded by Government)

建置健保法學知識數位平台

Yang, C.

6/7/1312/6/13

Project: A - Government Institutionc - Ministry of Health and Welfare

探討 GRP78 作為攝護腺癌化學治療之癒後因子之潛能

Chang, Y.

6/1/137/31/14

Project: C - Project of Alliancep - Taipei Medical University Hospital

牙科根管治療顯影材料之溶凝膠製備與改質研究

Lin, C.

6/1/135/31/14

Project: C - Project of Alliancep - Taipei Medical University Hospital