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Use the organometal catalytic reaction to synthesize the heterocycle-based anticancer agents
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
Modifying the Impact of Maternal Psychopathology on Adverse Infant Health Outcomes---Effects of Paternal Involvement and a Trial on Positive Activity Intervention
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
The association of early-onset ischemic stroke and the aging of vascular system using the telomere length related genes
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
An association study of arsenic exposure, inflammation, oxidative stress and the risk of developing cardiovascular diseases
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
The Effect of Improved Nutrition Care on the Progress of Hemodialysis Patients
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
臺蒙(MN)國合計畫－台灣及蒙古之洋蔥及蔥屬蔬菜對骨質疏鬆症的影響(1/3)
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
The Study of the Relationships among Anti-Obesity Activity, Adipogenesis, and Adipose Angiogenesis of Vegetable Indolic Derivatives---Involvement of the Ah Receptor/Arnt ? (II)
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
Design and Development of Antibody-Targetable and Self-Assembled Micelles of Anticancer Drug Conjugate and Complex of Hyaluronic Acid
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
The exploitation of Taiwan native plants in promoting bone growth and establishment of the system biology platform
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
Proteomic Study of Metformin on Kidney Damage in Rats
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
To Investigate the Functions of Shikonin and Its Derivatives in Applied Age-Related Macular Degeneration and Wound Healining
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
A Clinical Correlation study of DNA Methyltransferases Alterations in Breast Cancer and Evaluation of DNA Methyltransferases as a Therapeutic Target in Cell and Animal Models
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
Deferasirox Plasma Concentration Analysis and Effects of Potential Iron Chelators on Iron Overload and Safety Evaluation
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
Natural Product Hybrid and Ortho-Biaryl N-Hydroxycinnamide as Leads for Anticancer Agent Development
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
Biomarkers Associated with Toll-Like Receptors and Neuroimage Study in Ischemic Stroke Patients (I)
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
大腸直腸癌已躍居世界上癌症死亡率第二名，屬於固體型腫瘤，缺氧常見於此類 腫瘤，並誘發HIF-1α 表現而導致抗藥性及預後較差，因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑，可殺死癌 細胞而不影響正常細胞，對小鼠也不具毒性。我們初步結果顯示，Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現，代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性，對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下，經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制；也有研究報導指出，藥物會誘導癌細胞產生autophagy，造成細胞過度吞噬其內容 物而死亡，因此，autophagy在癌細胞為保護或是引發毒殺作用，目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活，但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示，除抑制HIF-1α 表現外，Zeb 也可活化AMPK、UPR/ER stress、以及autophagy， 因此我們推測Zeb 可在缺氧狀態下，促進autophagic cell death。3 年內我們將執行4 項 目標： (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。（第一年） (2) 研究Zeb 抑制HIF-1α表現之分子機轉。（第一年到第二年） (3) 研究Zeb 誘發autophagy之分子機轉。（第二年到第三年） (4) 探討Zeb 對缺氧導致抗藥性之作用。（第三年）
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
Novel activities of gamma-aminobutyric acid-mediated regulation of platelet activation, apoptosis, and autophagy: the non-genomic functions of NF-kappaB signal in anucleated cells
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
The Application of Fluoxetine and Its Related Medicines in Brain Tumor Treatment
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
Contribution of Er Stress to Inhibit miR-19a/b and miR-26b-Mediated CTGF Expression in Lung Fibrosis (I)
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
The Role of ADAM 17 in Hypoxia-Induced CTGF Expression and Pulmonary Fibrosis (I)
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
Investigating of Transcranial Direct Current Stimulation and Robot-Assisted Gait Training Effects in Subjects with Stroke
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
晚期乳癌組織中尼古丁受體(α9-nAChR)表現與Trastuzumab (Herceptin®)產生抗藥性之分子機制探討
8/1/13 → 7/31/14
Project: B - Project of TMU › i - Other (Funded by TMU)
Molecular mechanisms of alpha9-nicotinic acetylcholine receptor (alpha 9-nAChR)-mediated Trastuzumab (HerceptinR) drug resistance in breast cancer cells
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
Investigation of the Functions of Brain Finger Protein, Znf179, in Embryo Development and in Adult Brain
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
Development of Novel Therapeutic Agents for Herceptin Resistance Breast Cancer Cells through Targeting Nicotinic Acetylcholine Receptors
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
Analyses the Role of ADAM9-Hemidesmosome Components Interaction in Malignant Cancer Metastasis and Future Therapeutic Strategy
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
Study on the Preventive Effect and Mechanism of Germinated Brown Rice and Its Components on Colorectal Cancer
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
抗氧化防禦基因標籤單核?酸多形性、氧化壓力生物標記與冠狀動脈心臟病之相關性(1/2)
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
The Sumoylation of Histone Deacetylase 2 Contributes to CTGF Expression and Pulmonary Fibrosis in Chronic Obstructive Asthma (I)
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
Studies of Anti-Cancer Activity of Folic Acid
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
The relationship and predictors of electrocardiography, inflammatory markers, clinical features in older bipolar and schizophrenia patients concurrent with coronary heart and cerebro-vascular diseases
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
Study the role of the endoplasmic reticulum stress related proteins, Glycoprotein 96(GP96), in liver cancer progression and metastasis and the clinically therapeutic implication
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
New Strategies of Parkinson’s Disease Treatment
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
Immature Testicular Tissue Engineering for Male Fertility Preservation---A Transgenic Mouse Model
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
Study the Role of GRP78 in E1A-Mediated Metastasis Suppression of Breast Cancer
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
A Study on Trans-Neuronal Striato-Nigral Degeneration-Induced Movement Disorders after Stroke---Evaluation with Grey Matter Suppression IR and Diffusion Tensor Imaging (II)
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
102年度臺北市輻射屋居民健康照護需求評估工具建立
7/16/13 → 12/31/13
Project: A - Government Institution › f - Other (Funded by Government)
健康促進國際政策及學術資料建置計畫
Chang, W.
7/3/13 → 12/31/13
Project: A - Government Institution › c - Ministry of Health and Welfare
The Application of Biodegradable Nano-Enabled Drug Delivery in Treatemt of Brain Abscess
7/1/13 → 9/30/14
Project: A - Government Institution › b - Ministry of Science and Technology
奈米金屬微粒暴露引發勞工心血管效應之細胞毒理評估
6/27/13 → 12/20/13
Project: A - Government Institution › f - Other (Funded by Government)
行政院衛生署所屬醫院「102年度滿意度調查評估」勞務委託採購案
6/18/13 → 10/28/13
Project: A - Government Institution › f - Other (Funded by Government)
102年癌症篩檢管理中心工作計畫之個管師考題研擬及閱卷
6/13/13 → 8/31/13
Project: A - Government Institution › c - Ministry of Health and Welfare
職場生物氣膠暴露及建議值調查評估研究
6/11/13 → 12/13/13
Project: A - Government Institution › f - Other (Funded by Government)
建置健保法學知識數位平台
6/7/13 → 12/6/13
Project: A - Government Institution › c - Ministry of Health and Welfare
探討 GRP78 作為攝護腺癌化學治療之癒後因子之潛能
6/1/13 → 7/31/14
Project: C - Project of Alliance › p - Taipei Medical University Hospital
牙科根管治療顯影材料之溶凝膠製備與改質研究
6/1/13 → 5/31/14
Project: C - Project of Alliance › p - Taipei Medical University Hospital