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  Therapeutic Strategies for Traumatic Brain Injury with Novelly Desinged Drugs (III)

  Wang, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Ultrafine Particles on Cardiopulmonary System: a Population-Based Approach

  Chuang, K.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Mechanisms Underlying Airway Hypersensitivity Induced by Hydrogen Sulfide

  Lin, Y.

  8/1/14 → 10/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Multidisciplinary Study of the Pathophysiology of Blast-Induced Mild Traumatic Brain Injury

  Chiang, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effects of Adipose-Derived Stem Cells on Denervated Rat Skeletal Muscle Atrophy

  Tsai, F.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation of Glioblastoma Cell-Secreted microRNA Signatures and Their Functional Effects on Tumor Angiogenesis

  Chen, K.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Study of Therapeutic Effects for Stroke with Phenserine, an Amyloid Precursor Protein Inhibitor, in Rodent Focal Cerebral Ischemia Model(2/3)

  Chang, C. & Chiang, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › a - National Health Research Institutes

• Evaluation of Clinical Feasibility of Quantitative MR Perfusion Imaging and Its Calibration

  Tseng, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Translational Studies of Mycobacterium tuberculosis-Induced Lung and Pleural Fibrosis

  Lin, C.

  8/1/14 → 10/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation on Dental Implant Stability Detection Using Damping Factor as a Parameter

  Huang, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Functional Studies of ZNF179 in Neurons in vitro and in vvo

  Lee, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Genetic Polymorphisms in microRNA and Risk of the Post-Thrombolytic Hyperglycemia in Acute Ischemic Stroke and Its Prognosis Study

  Hsieh, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effect of Vasopressin Receptor Agonist and Antagonist on Pulmonary Vein and Atrial Arrhythmogenesis

  Huang, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 肝醣合成酉每激酉每3於登革病毒感染單核吞噬細胞的潛在角色(2/3)

  Lin, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Application and Mechanism of Novel Fluoro-Rutaecarpine on Inhibition of Inflammation Induced Endomt

  Lin, C.

  8/1/14 → 12/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Highly Reliable Surface-Enhanced Raman Scattering Sensors

  Liu, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of HBX and IL-6 in Regulating SENP1/Stemness Properties of HBV-Related HCC under Hypoxia and Its Clinical Implication

  Huang, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Kidney Injury and Heat Shock Protein Modulate the Atrial Electrophysiological Characterisitcs

  Hsieh, M.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Influence of Porphyromonas gingivalis Groel in Vascular Cells

  Lin, F.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role and Molecular Mechanism of PPARα in Acute Kidney Injury---Focus on the Protective Effect in Renal Tubular Cell

  Hsu, Y., Chen, T. & Chen, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 組蛋白去甲基酉每JARID1B基因在肺腺癌之腫瘤形成與影響腫瘤生物行為機轉之探討(1/2)

  Kuo, K.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Oncolytic Measles Virus for the Treatment of Breast Adenocarcinoma

  Lin, L. T.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Direct Renin Inhibitor on Visceral Adipose Tissue and Vascular Remodeling of Fructose-Fed Hypertensive Rats

  Fang, T.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Functional Investigation of Heat Shock Protein in Esophageal Squamous Cell Cancer with Implications in Prognostic Prediction and Therapeutic Targeting

  Tzao, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Clinical Correlation Study of DNA Methyltransferases Alterations in Breast Cancer and Evaluation of DNA Methyltransferases as a Therapeutic Target in Cell and Animal Models

  Lin, R.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 乳癌是目前世界上女性癌症病患中為數最多的癌症之ㄧ。腺病毒蛋白type 5 E1A (E1A)和許多抗腫瘤作用有關，曾於多種癌症如乳癌、卵巢癌及頭頸癌之病患進行臨床基因治療試驗。許多的研究指出E1A具有多項抗腫瘤的功能，包括抑制腫瘤的發生、增加腫瘤細胞對於化療藥物的感受性以及減少腫瘤轉移的現象。腫瘤的轉移對於癌症患者的死亡率有極大的影響當然也包括了乳癌的患者。E1A於抑制腫瘤發展的過程中具有多重生物學上的意義，這也促使我們想要釐清E1A抑制癌症的機制。因此，我們對於了解E1A抑制癌症轉移相關的分子機制感到有興趣，並期望藉以作為未來改進乳癌病人臨床試驗的基石。我們初步的實驗結果顯示，E1A可以有效的抑制Glucose-regulated protein 78 (GRP78)這種已被廣泛報導和腫瘤惡化及轉移相關的蛋白的表現。 提出此研究計劃之目的在於詳細探討E1A所造成的抑制癌轉移作用中，GRP78所扮演的生物功能及其調控的機轉。為了達到此目的，我們將著重於E1A如何調控GRP78表現並進而展現對乳癌轉移的抑制作用。以下為此項研究計畫的四大主要目標： 目標一：探討GRP78在E1A所抑制之癌細胞移行及侵入作用中所扮演的角色 目標二：研究E1A抑制GRP78表現之分子機轉 目標三：於動物模式中驗證GRP78的表現對於E1A抗腫瘤作用的影響 目標四：探討GRP78及其相關分子的表現在乳癌病人的臨床重要性 完成以上的主要目標能夠幫助我們對於E1A之抗腫瘤轉移作用建立更加詳細的分子訊息傳遞機制。另外，藉由此研究計畫的新發現也許可以對未來發展癌症治療上提供更多具有潛力的標的物。

  Wang, W.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Expressing Membrane Antibody Reporter in the Islet Cells of Nonobese Diabetic Mice to Noninvasive Assess the Therapeutic Effects of Drugs or Transgenes for Autoimmune Diabetes

  Chuang, K.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of Oxidative Stress-triggered Redox Adaptation Mechanism and Genetically Endowed Expression Profile of Antioxidant Enzymes in the modulation of Intrinsic and Acquired Chemoand Radio-resistance of Human Hepatocellular Carcinoma Cells

  Chiou, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Cocaine Induces Sig-1R Nuclear Envelope Localization to Regulate MAOB Expression by Interacting with Emerin-HDACs Co-Repressor Complex

  Chuang, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 臺蒙(MN)國合計畫－台灣及蒙古之洋蔥及蔥屬蔬菜對骨質疏鬆症的影響(2/3)

  Chen, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Genetic Polymorphisms of Calcium Channel in the Risk of Breast Cancer

  Chang, W.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Application of Regioselective Substitution on 1,4-Benzoquinone Derivatives to Provide Potent Anticancer Agents

  Liou, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Dementia Care and Quality Improvement

  Chien, L.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Red-Light Violations by Traditional/Electric Motorcycles/Bicycles: An Observational Field Study of Risk-Taking, Opportunistic, and Law-Obeying Behaviours

  Pai, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 2014馬祖特用植物之開發應用

  Lee, M.

  7/25/14 → 7/30/15

  Project: A - Government Institution › f - Other (Funded by Government)

• 委託辦理103年度「我國壓瘡(pressure sore)發生之影響因子及相關預防策略成效研究」

  Liu, F.

  7/13/14 → 11/30/14

  Project: A - Government Institution › c - Ministry of Health and Welfare

• The Empirical Study on Administrative Remedy Cases of National Health Insurance

  Lee, C. & Tsai, F.

  7/8/14 → 1/7/15

  Project: A - Government Institution › c - Ministry of Health and Welfare

• 心血管死因職災個案之風險因子及其保險給付申請比較分析

  Chung, M.

  7/7/14 → 12/20/14

  Project: A - Government Institution › f - Other (Funded by Government)

• TMU102-AE1-B44

  Liu, Y.

  7/1/14 → 6/30/16

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• TMU102-AE1-B43

  Chen, M.

  7/1/14 → 6/30/16

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• TMU102-AE1-B42

  Lin, Y.

  7/1/14 → 6/30/16

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• TMU102-AE1-B45

  Ho, S.

  7/1/14 → 7/31/15

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• 自組裝分子材料之開發及其在光電元件之應用

  Chang, C.

  7/1/14 → 10/31/14

  Project: A - Government Institution › f - Other (Funded by Government)

• The Construction of E-learning Materials for Processing of Chinese Medicine

  Wang, C.

  6/27/14 → 12/15/14

  Project: A - Government Institution › c - Ministry of Health and Welfare

• 養菇場及蔬菜園勞工生物氣膠暴露及健康影響初探研究

  Chao, H.

  6/23/14 → 5/31/15

  Project: A - Government Institution › f - Other (Funded by Government)

• 103年度「食品安全守護聯盟計畫」

  Chen, J.

  6/23/14 → 12/31/14

  Project: A - Government Institution › c - Ministry of Health and Welfare

• 衛生福利部所屬醫院「103年度滿意度調查評估」採購案

  Kuo, N.

  6/13/14 → 10/15/14

  Project: A - Government Institution › f - Other (Funded by Government)

• 103年至104年職場周全性健康促進模式之發展與成效評估研究計畫

  Chen, R. & Yeh, C.

  6/11/14 → 3/31/15

  Project: A - Government Institution › c - Ministry of Health and Welfare

• The Plan of Customer Protection and Risk Education

  Han, B.

  6/9/14 → 12/31/14

  Project: A - Government Institution › c - Ministry of Health and Welfare

• 建立癌症新診斷病人健康素養評量工具與評估計畫(103-104年)

  Bai, C. & Yang, K.

  6/4/14 → 6/3/15

  Project: A - Government Institution › c - Ministry of Health and Welfare