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  腫瘤相關巨噬細胞在誘發產生表皮生長因子受器酪胺酸酉每抑制劑的抗藥性的角色

  Feng, P.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Multidisciplinary Study of the Pathophysiology of Blast-Induced Mild Traumatic Brain Injury

  Chiang, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Highly Reliable Surface-Enhanced Raman Scattering Sensors

  Liu, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Different Sources of n-3 Fatty Acids on Bone Loss, Body Fat and Inflammatory Markers in Osteoporotic Condition with Diabetes

  Chiu, W. & Fong, T.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Therapeutic Strategies for Traumatic Brain Injury with Novelly Desinged Drugs (III)

  Wang, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Chitosan Nanoparticle as a Macrophage-Targeting Drug Delivery Carrier

  Mi, F.

  8/1/14 → 8/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of HBX and IL-6 in Regulating SENP1/Stemness Properties of HBV-Related HCC under Hypoxia and Its Clinical Implication

  Huang, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Unraveling the Impact of Deletion of Androgen Receptor on Brain Trauma

  Yang, L.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Short-Chain Fatty Acids Act as Anti-Allergic Regulators on Immune Effector Cells and Exert Immune-Modulatory Effects on Ovalbumin-Induced Allergic Diseases in Mice

  Lee, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Functional Investigation of Heat Shock Protein in Esophageal Squamous Cell Cancer with Implications in Prognostic Prediction and Therapeutic Targeting

  Tzao, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation of Mechanisms of SSRI Antidepressants and GABAAR Modulators Inhibit High-Grade Glioma Invasion

  Shen, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Explore the Molecular Mechanisms and Application of microRNA-16 in In Acute Kidney Injury

  Chen, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Preclinical Evaluation of Application of Sclareol for Adjuvant Therapy of Cisplatin-Resistant Non-Small Cell Lung Cancer

  Wu, C.

  8/1/14 → 9/30/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effect of Endothelin-1 on Myofibroblast Transformation of Pleural Mesothelial Cells and Its Implications for Pleural and Pulmonary Fibrosis

  Chung, C. & Hsiao, G.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study of Nano-Size Memberane Tube for Tendon to Bone in Anterior Cruciate Ligament Reconstruction

  Chen, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Evaluate the Molecluar Mechanims and Clinical Application on Atf3 Regulated microRNAs

  Lin, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effect of RRM2 in Tumor Metastasis and Chemotherapy Response of Colorectal Cancer Patients with Different APC and K-Ras Status

  Cheng, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effect of RRM2 in Tumor Metastasis and Chemotherapy Response of Colorectal Cancer Patients with Different APC and K-Ras Status

  Cheng, Y.

  8/1/14 → 7/31/16

  Project: B - Project of TMU › i - Other (Funded by TMU)

• 乳癌是目前世界上女性癌症病患中為數最多的癌症之ㄧ。腺病毒蛋白type 5 E1A (E1A)和許多抗腫瘤作用有關，曾於多種癌症如乳癌、卵巢癌及頭頸癌之病患進行臨床基因治療試驗。許多的研究指出E1A具有多項抗腫瘤的功能，包括抑制腫瘤的發生、增加腫瘤細胞對於化療藥物的感受性以及減少腫瘤轉移的現象。腫瘤的轉移對於癌症患者的死亡率有極大的影響當然也包括了乳癌的患者。E1A於抑制腫瘤發展的過程中具有多重生物學上的意義，這也促使我們想要釐清E1A抑制癌症的機制。因此，我們對於了解E1A抑制癌症轉移相關的分子機制感到有興趣，並期望藉以作為未來改進乳癌病人臨床試驗的基石。我們初步的實驗結果顯示，E1A可以有效的抑制Glucose-regulated protein 78 (GRP78)這種已被廣泛報導和腫瘤惡化及轉移相關的蛋白的表現。 提出此研究計劃之目的在於詳細探討E1A所造成的抑制癌轉移作用中，GRP78所扮演的生物功能及其調控的機轉。為了達到此目的，我們將著重於E1A如何調控GRP78表現並進而展現對乳癌轉移的抑制作用。以下為此項研究計畫的四大主要目標： 目標一：探討GRP78在E1A所抑制之癌細胞移行及侵入作用中所扮演的角色 目標二：研究E1A抑制GRP78表現之分子機轉 目標三：於動物模式中驗證GRP78的表現對於E1A抗腫瘤作用的影響 目標四：探討GRP78及其相關分子的表現在乳癌病人的臨床重要性 完成以上的主要目標能夠幫助我們對於E1A之抗腫瘤轉移作用建立更加詳細的分子訊息傳遞機制。另外，藉由此研究計畫的新發現也許可以對未來發展癌症治療上提供更多具有潛力的標的物。

  Wang, W.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 103年度健康體適能檢測活動

  Kan, N.

  8/1/14 → 10/31/14

  Project: A - Government Institution › f - Other (Funded by Government)

• Determined the Role and the Mechanims of GRP94 in Mediating the Progression and Therapeutic Responses of HCC

  Huang, M.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study the Function and Regulation of miRNAs in Pancreatic Cancer Progression (I)

  Huang, M.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Anticancer Drug Discovery of New Tegafur-Derivatives for Colorectal Cancer Therapy

  Chen, M.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 臺蒙(MN)國合計畫－台灣及蒙古之洋蔥及蔥屬蔬菜對骨質疏鬆症的影響(2/3)

  Chen, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• To Investigate the Functions of Shikonin and Its Derivatives in Applied Age-Related Macular Degeneration and Wound Healining

  Cheng, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Application of Regioselective Substitution on 1,4-Benzoquinone Derivatives to Provide Potent Anticancer Agents

  Liou, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Translational Study to Confirm the Roles of Gata-DNA Binding Proteins in Bone Healing

  Chen, R.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Roles of Toll-Like Receptor-4 and Hif-1 in Propofol-Involved Protection against Traumatic Brain Injury-Induced Dysfunction of the Blood-Brain Barrier

  Chen, R.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 粒狀空氣污染物所產生的氧化壓力對慢性阻塞性肺疾病患者的泛素-蛋白酉每平衡系統之影響:探討氧化壓力，異常發炎以及蛋白質氧化之關係

  Chuang, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Fabrication of Degradable Biomedical Scaffold for Tissue Engineering with Pcl Mixed Different Kind of Graphene and Study on Its Biocompatibility

  Shen, Y.

  8/1/14 → 9/30/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Determinants of Dental Caries Service Utilization among Children under 12 Years-Old in Taiwan

  Teng, N.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Investigation of the Gutta Percha Temperature Change on Vertical Compaction of Warm Gutta Percha Technique

  Hsien, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Therapeutic Implications of Down-Regulation of Microglia Activation Following Repetitive Traumatic Brain Injury-Induced Chronic Traumatic Encephalopathy

  Chang, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 《Essence of Decision: Explaining the Cuban Missile Crisis》Translation and Annotation Project

  Chang, K.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Explore the Zhongshan District of impact on employee health behaviors of factors Tobacco Control intervention in large healthy workplace employee

  Chen, R. & Yeh, C.

  8/1/14 → 10/30/14

  Project: A - Government Institution › f - Other (Funded by Government)

• The Effect of Economic Recession on Health and Health Care Service Utilization of Elderly: Comparisons among Welfare State Regimes

  Chuang, K.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Construction and Application of Spatio-Temporal Database and Geography Information System for Emergency Medical Care (I)

  Lin, M.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Mixed Pharmceuticals Adsorption, Oxidation and Catalytic Chlorination by Metal Oxides

  Hu, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study the Therapeutic Effects and Novel Molecular Mechanisms of Resveratrol in Human Osteosarcoma---The Treatment of Metastatic Cancer

  Chien, M.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Saturated Fatty Acids from Animals and Vegetables on Alcoholic Liver Disease in Rats Based on Phathological Mechanism.

  Yang, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Explore of Toll-Like Receptors Associated miRNA Expression in Ischemic Stroke Patients (II)

  Wu, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Study of Antidepressive and Cognition Improvement Property of N-3 Fatty Acids on Metabolic Syndroms

  Huang, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Novel Therapeutic Agents for Herceptin Resistance Breast Cancer Cells through Targeting Nicotinic Acetylcholine Receptors

  Lee, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Wnt/Tenascin Regulates Neurotrophin-Induced Neuronal Transdifferentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells in 2d and 3d Cultures

  Lai, W.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effects of Neurofeedback and RSA Biofeedback on Quality of Sleep in Patients in the Chronic Phase of Traumatic Brain Injury

  Tsai, P.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 鐵質誘發巨噬細胞活化與遷移對胰島素耐受性的影響

  Chang, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Cortical Electrical Stimulation Technique for Improving Neuroplasticity and Motor Function in Parkinsonian Rats

  Hsieh, T.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Prognosis Analysis and Data Mining for Emergency Patients after Arriving Hospital

  Hsu, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Research on Development of Clound Computing Platform for Decision Support Systems Healthcare by Healthcare Big Data and Analytics

  Chiang, I.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of a Cognitive Behavioral Self-Help Intervention on Immigrant Life Stress for Immigrant Women Who Are Divorced

  Kuo, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology