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  The Role of Angiopoietin-Like Protein 1 in Sorafenib Resistance and Cancer Stemness of Hepatocellular Carcinoma Cells

  Huang, M.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Angiopoietin-like Proteins 100%
  • Sorafenib 97%
  • Hepatocellular Carcinoma 53%
  • Gastropoda 44%
  • Neoplasms 17%

• Anti-Aging Effect with the Associated Mechanism by PRP (Platelet-Rich Plasma) in Cartilage---A Fibronectin Fragment Model(3/3)

  Lee, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • fibronectins 100%
  • cartilage 63%
  • Toll-like receptor 2 58%
  • osteoarthritis 50%
  • chondrocytes 42%

• Design and Synthesis of Biaryl and Biphenylamino Sulfonamides as Novel Anticancer Agents

  Lai, M.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Biaryl 100%
  • Sulfonamide 88%
  • Antineoplastic Agent 76%
  • Antimitotic Agent 65%
  • Benzamide 51%

• ADAM9 調節 integrin b4 之轉換率以促使前列腺癌細胞移動及浸潤之研究(3/3)

  Sung, S.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • metastasis 100%
  • integrins 89%
  • neoplasm progression 42%
  • neoplasms 38%
  • neoplasm cells 32%

• 本研究擬探討高度糖化終產物及其前驅物甲基乙二醛誘發腎臟與內皮功能損傷之負 面效應，並釐清該損傷機轉是否與活化發炎體有關；此外，另探討白藜蘆醇之介入是否對 於上述損傷具有保護作用。第一部分實驗以高度糖化終產物接受器抑制劑釐清腎臟中高度 糖化終產物接受器的表現是否和發炎體路徑的活化有關，此外評估不同種高度糖化終產物 對於小鼠腎功能之影響。第二部分實驗則以高度糖化終產物接受器抑制劑證實抑制受器和 高度糖化中產物之交互作用是否可達到減少自由基產生進而抑制發炎體的活化以減緩發 炎反應所造成的腎損傷。第三部實驗分則觀察白藜蘆醇對於以高度糖化終產物前驅物MG 誘發腎損傷之影響並釐清白藜蘆醇是否可透過影響發炎體的活化達到延緩腎臟受損的作 用。研究預期長期高度糖化終產物和其前驅物‐甲基乙二醇的投與會使高度糖化終產堆積 在腎臟，也可能經由與其接受器結合進入細胞中活化發炎體路徑使腎臟發炎，使腎臟和內 皮功能損傷。因此減少暴露於高度糖化終產物的環境下或是抑制其接受器的作用皆可抑制 發炎體的活化達到延緩腎損傷的作用，且白藜蘆醇的介入對於上述損傷可能具有保護作用。

  Chen, J.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Receptor 100%
  • Activation 91%
  • Oxidative Stress 74%
  • Mouse 49%
  • Pathway 46%

• CXCL5/CXCR2/JNK Axis Is the Shared Pathway of Neuroinflammation and Microvascular Damage That Contributes to White Matter Injury in the Immature Brain(3/3)

  Huang, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • White Matter 100%
  • Brain Injuries 57%
  • Blood-Brain Barrier 40%
  • JNK Mitogen-Activated Protein Kinases 38%
  • Leukocytes 33%

• Preclinical Assessment of Cadherin11 Antagonists for Treating Drug-Resistant Breast Cancer through Modulating Tumor Immunity and Suppression of Cancer Stem Cells

  Chao, T.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • osteoblast cadherin 100%
  • Breast Neoplasms 37%
  • Neoplastic Stem Cells 31%
  • Neoplasm Metastasis 12%
  • Breast 7%

• Effect of Different Dietary Fats on Gut Microbiota, Fatty Liver and Insulin Resistance in Postmenopausal Condition

  Chiu, W.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • insulin resistance 100%
  • glucagon-like peptide 1 89%
  • dietary fat 83%
  • fatty liver 75%
  • intestinal microorganisms 61%

• The Role of Inflammatory Gene Polymorphisms on Risk of Post-Stroke Vascular Dementia( II )

  Chiou, H.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 幹細胞基礎研究與前臨床動物試驗

  Huang, Y.

  8/1/16 → 7/31/17

  Project: B - Project of TMU › i - Other (Funded by TMU)

• 實用半透明太陽電池之關鍵技術開發：以界面修 飾與元件工程提升元件效率、壽命及製程實用性

  Chang, C.

  8/1/16 → 7/31/17

  Project: D - Other Project

• The Effect of Wnt Signals and Programmed Cell Death on the Organization of Neural Circuit in Spinal Motor Neurons

  Kao, T.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Motor Neurons 100%
  • Wnt Receptors 73%
  • Ephrins 46%
  • Nerve Growth Factors 42%
  • Growth Cones 40%

• Studies on the Carcinogenic Mechanisms of Glucose Transporters in Gastrointestinal Cancer Cells and Its Clinical Therapeutic Applications(2/2)

  Chen, L.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Glucose 100%
  • Antitumor 19%
  • Occurrence in Nature 17%
  • Pharmacological Metabolism 11%
  • Biological Role 8%

• 可卡因促使Sig-1R局部化於核膜與emerin-HDACs抑制因子複合物結合來調節MAOB表達(3/3)

  Chuang, J.

  8/1/16 → 10/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • sigma-1 receptor 100%
  • Cocaine 59%
  • Monoamine Oxidase 42%
  • emerin 30%
  • Co-Repressor Proteins 23%

• The Evaluation of the Long-Term Effects of Interpersonal and Social Rhythm Therapy on Sleep and Social Functioning in Patients with Bipolar Disorder(3/3)

  Chung, M.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Sleep 100%
  • Bipolar Disorder 93%
  • Depression 42%
  • Periodicity 35%
  • Therapeutics 28%

• The Association between Improved Nutritional Care and the Prognosis of Cardiovascular Disease for Hemodialysis Patients

  Yang, S.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Renal Dialysis 100%
  • Diet 54%
  • Cardiovascular Diseases 38%
  • Nutrition Therapy 24%
  • Nutrition Assessment 21%

• The Association between Axonal Regeneration Inhibitors and Functional Neuroimage/ Prognosis in Stroke Patients

  Chi, N.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Stroke 100%
  • Executive Function 43%
  • Regeneration 35%
  • Rehabilitation 32%
  • Lacunar Stroke 27%

• Generate anti-Fibroblast growth factor receptor 2 (FGFR2) antibody drugs and study on their potential application against gastric cancer

  Lee, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Construction and Evaluation of Multi-Domain Attention Training for Older Adults with Mild Cognitive Impairment to Improve Intensity of Attention, Executive Attention, and Spatial Orienting Attention: a Randomized Controlled Study

  Chou, K.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Cognitive Dysfunction 100%
  • Taiwan 80%
  • Cognition 48%
  • Learning 44%
  • Memory 29%

• Application of Regioselective Substitution on 1,4-Benzoquinone Derivatives to Provide Potent Anticancer Agents(3/3)

  Liou, J.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • 1,4-benzoquinone 100%
  • Wittig Olefination 54%
  • Intramolecular Cyclization 40%
  • Nucleophilic Substitution 38%
  • Regioselectivity 35%

• 建立質譜定量分析策略以應用於癌症特定突變蛋白質之腫瘤蛋白質基因體學研究

  Han, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Mutation 100%
  • Mass Spectrometry 86%
  • Proteogenomics 68%
  • Peptides 43%
  • Neoplasms 35%

• Platelets and Platelet-Derived Microparticles for Trojan Horse Cancer Therapy (THCt)(2/3)

  Burnouf, T. P. R.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • doxorubicin 100%
  • microparticles 83%
  • cancer therapy 31%
  • drug carriers 16%
  • neoplasms 16%

• Multivariate Bioinformatics Analysis of Taiwanese Cancer RNA-seq data to Study Human Endogenous Retroviruses as Carcinogens(2/2)

  Lee, Y. G.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Establishing the Disease and Genetic Risk Prediction Score of Cognitive Impairment to Early Prevent the Threat of Dementia

  Hsieh, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Dementia 100%
  • Neurodegenerative Diseases 80%
  • Iron-Deficiency Anemias 78%
  • Taiwan 65%
  • Cognitive Dysfunction 65%

• Constructing an Assessment Model for Outcome after Carotid Stent Using National Health Insurance Database with Validation by Clinical Data

  Chiu, H.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Stroke 100%
  • Carotid Stenosis 82%
  • Stents 62%
  • Databases 58%
  • Health Insurance 51%

• Targeting Class III Phosphoinositide 3-Kinase (Pi3k) for Anticancer Drug Discovery

  Chen, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Phosphoinositide 100%
  • 3-Methyladenine 41%
  • Antineoplastic Agent 32%
  • Protein Synthesis 25%
  • LY294002 22%

• Combination Treatment of Tetrac- and Cetuximab-Induced Anti-Proliferation in Colorectal Cancer with Different Apc Status( III )

  Lin, H.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Identification of Osteoporosis Susceptibility Gene in Calcium Signaling Pathway -Second and Third Years

  Hung, K.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Osteoporosis 100%
  • Single Nucleotide Polymorphism 55%
  • Calcium Signaling 33%
  • Genes 22%
  • Genetic Polymorphisms 19%

• Biomechanical Comparison of Warm-Up Strategies for Preventing Achilles Tendon Injury

  Chen, H.

  8/1/16 → 8/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Achilles tendon 100%
  • tendons 65%
  • risk factors 18%
  • mechanical creep 17%
  • torque 10%

• Make a Portable/Wearable Kidney Possible – Development of Microtube Array Membrane (Mtam) Dialyzer – Study on Uremic Toxins Removal

  Wu, M.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Membranes 100%
  • Dialysis 95%
  • Equipment and Supplies 66%
  • Artificial Kidneys 55%
  • 4-cresol sulfate 34%

• Radiogenomics of Malignant Gliomas by Linking Physiological Mr Imaging, Histopathological Patterns, and Genetic Alternations: a Translational Study from Rat to Man(2/3)

  Chen, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Glioblastoma 100%
  • Glioma 51%
  • Biomarkers 36%
  • Multiparametric Magnetic Resonance Imaging 15%
  • Neoplasms 14%

• To Identify Whether Ion Conductance Dysfunction Is an Early Electrophsiological Biomarker of Polyneuropathy in Diabetic Patients: a Longitudinal Study of Nerve Excitability in Diabetic Patients(2/3)

  Sung, J.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Neural Conduction 100%
  • Diabetic Neuropathies 69%
  • Ions 24%
  • Biomarkers 19%
  • Polyneuropathies 17%

• Tmu Spark Taiwan-Anchor University Program

  Yen, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • industry 100%
  • Licensing of intellectual property 79%
  • budget plan 71%
  • expert 54%
  • basic research 47%

• The Role of Ddx3 in Cetuximab Resistance in Kras-Mutated and -Wild-Type Colorectal Cancer ( I )

  Lee, H.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Cetuximab 100%
  • Colorectal Neoplasms 18%
  • Animal Models 10%
  • Phosphatidylinositol 3-Kinases 9%
  • Tumor Burden 8%

• Roles of microRNA96 in TGF-beta-Mediated Tumor Progression(2/3)

  Tsai, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Transforming Growth Factors 100%
  • Neoplasms 26%
  • Prostatic Neoplasms 21%
  • Castration 15%
  • Androgen Receptors 14%

• Impact of Calcitriol on Fibroblast Growth Factor-23 (Fgf-23) Signaling in Diabetic Dysregulation in Cardiac Fatty Acid and Glucose Metabolism

  Lee, T.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • fibroblast growth factor 23 100%
  • Calcitriol 77%
  • Peroxisome Proliferator-Activated Receptors 33%
  • Fatty Acids 28%
  • Diabetes Mellitus 22%

• Crystal Structures and Functional Studies of Novel Glycosyltransferases from Staphylococcus aureus(2/3)

  Liu, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Glycosyltransferases 100%
  • Staphylococcus aureus 64%
  • Fibrin 30%
  • Cathepsin G 22%
  • Minisatellite Repeats 19%

• The Molecular Basis of Senp2 in Regulating Smad4 Sumoylation and Its Functions in Triple Negative Breast Cancer(2/3)

  Chang, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • SUMO-1 Protein 100%
  • Transforming Growth Factor beta 99%
  • Peptide Hydrolases 83%
  • Sumoylation 26%
  • Triple Negative Breast Neoplasms 23%

• The Role of Amyloid-Beta in the Late-Onset Post-Stroke Vascular Cognitive Impairment( II )

  Hu, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• A multi-modal investigation of the biochemical correlates of the temporal structure of neural activity

  Duncan, N. W.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 利用PLA2G6基因嵌入小鼠研究第十四型帕金森病分子病理機轉與治療(1/3)

  Yeh, T.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Clinical Effects of Deep Oscillation Massage in Treating Fibromyalgia

  Kang, J.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Fibromyalgia 100%
  • Massage 46%
  • Vibration 42%
  • Therapeutics 13%
  • Pain 13%

• A Polycrystalline Silicon Nanowire Field Effect Transistor Biosensor Using Lateral Oxidation of Silicon Technique and Its Improvement on Sensitivity

  Wu, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Efficiency of Complex Exercise Training on Body Composition and Functional Fitness after Total Knee Replacement in Overweight and Obese Patients with Knee Osteoarthritis

  Liou, T.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Knee Replacement Arthroplasties 100%
  • Knee Osteoarthritis 68%
  • Body Composition 48%
  • Rehabilitation 43%
  • Exercise 18%

• Contextualization of Acgme Milestone Project and Its Integration with Entrustable Professional Activities (Epas) in Taiwan – a 3-Stage Educational Implementation in Anesthesiology Based on 4 Teaching Hospitals

  Chen, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Taiwan 100%
  • educational reform 41%
  • learning 40%
  • content analysis 29%
  • expert 25%

• In Vi Vo and in Vi Tro Screening of the Dyslipidemic Antihypertensives, Studying the Mechanism to Modulate Signaling Srebp and Ppar in the Renal Cells, and Investigating the Cotherapy with Mountain Celery Seed Aqueous Extract in Reducing Worsen Renal F

  Chen, K.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Apium 100%
  • Seeds 63%
  • Kidney 55%
  • Antihypertensive Agents 47%
  • Sterol Regulatory Element Binding Proteins 31%

• Study of Reactive Dicarbonyl Species-Induced Epithelial to Mesenchymal Transition in Diabetes Exacerbating Pulmonary Fibrosis

  Hsieh, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Pulmonary Fibrosis 100%
  • Epithelial-Mesenchymal Transition 90%
  • Pyruvaldehyde 66%
  • Receptor for Advanced Glycation End Products 34%
  • Glyoxal 32%

• Exploiting Acridine Scaffold to Develop Novel Anticancer Agents Based on a Dual Target Strategy

  Huang, W.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Histone 100%
  • Topoisomerase Inhibitor 34%
  • Structure-Activity Relationship 26%
  • Antineoplastic Agent 18%
  • Camptothecin 13%

• Dissected the Role of Defensin 6 (Def 6),The Clinically Therapeutic Implication and Drug Development in Colon Cancer

  Wei, P.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • colorectal neoplasms 100%
  • neoplasms 37%
  • therapeutics 31%
  • metastasis 31%
  • death 25%

• Development a Risk Scoring System for Predicting the Risk of Poststroke Epilepsy to Improve the Quality of Care among Patients with Stroke

  Chien, L.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Epilepsy 100%
  • Stroke 45%
  • Anticonvulsants 24%
  • National Health Programs 20%
  • University Hospitals 15%