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  Study the Interactive Functions of Decoy Receptor 3 and Galectin-3 in Keratinocytes and Macrophages

  Lin, W.

  10/1/14 → 9/30/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• TMU103-AE1-B03

  Lin, C.

  10/1/14 → 9/30/15

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• Differential Machinery of Pluripotency Regulation in Stem Cells in Embryonic Stage and Somatic Cancers and Its Clinical Implications in Human Diseases---Crosstalk among Niche Growth Factor/Cytokine Signaling, Extracellular Matrix, and Epigenetic Netw (I)

  Huang, Y.

  10/1/14 → 9/30/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 103年度國民體適能檢測站設置實施計畫

  Kan, N.

  9/24/14 → 3/30/15

  Project: A - Government Institution › d - Ministry of Education

• 103年度「103-104年國民長期照護需要調查訪視控管作業」

  Huang, Y.

  9/11/14 → 6/30/15

  Project: A - Government Institution › c - Ministry of Health and Welfare

• 103年度「含中藥材創意商品開發」

  Hou, W.

  9/1/14 → 4/30/15

  Project: A - Government Institution › c - Ministry of Health and Welfare

• Development of 3d-Printing Dynamic Orthosis-For Hemiplegic Lower Limbs( I )

  Chen, S.

  9/1/14 → 11/30/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 北區高階生醫產業聚落及產業規劃-台灣遠距健康產業聚落發展先導計畫

  Yen, Y. & Chen, R.

  9/1/14 → 8/31/15

  Project: A - Government Institution › c - Ministry of Health and Welfare

• Novel Strategies to Target Long-Lived Plasma Cells for Treating Hemophilia a Inhibitors

  Liu, C.

  9/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Phase I, First-In-Human, Dose-Seeking Study Evaluating the Safety, Pharmacokinetics, and Pharmacodynamics of Orally Administered MPT0E028 in Subjects with Advanced Solid Malignancies without Standard Treatment (I)

  Liou, J.

  9/1/14 → 9/30/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Long-term follow-up study of health behaviors among adolescent cohort.

  Chiou, H., Chen, P., Chen, Y., Chang, H., Yang, S. & Chen, Y. C.

  9/1/14 → 12/31/14

  Project: A - Government Institution › c - Ministry of Health and Welfare

• Application of resilience engineering in emergent health care services

  蘇, 清., Chuang, S., 馬, 漢. & 蔡, 哲.

  8/7/14 → 8/6/15

  Project: A - Government Institution › a - National Health Research Institutes

• Valproate治療腦外傷病人的臨床研究

  Chang, C., Chiang, Y., Liao, K., Yang, S., Wu, C. & Chen, K.

  8/7/14 → 8/6/16

  Project: A - Government Institution › c - Ministry of Health and Welfare

• 國人口腔健康監測調查企劃案

  Tsai, H.

  8/4/14 → 12/31/14

  Project: A - Government Institution › c - Ministry of Health and Welfare

• 山藥儲藏性蛋白質功能性月生月太之延緩衰老功能評估與機制探討(2/3)

  Hou, W.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Mobile Phone Use and Walking: An Observational Field Study of Pedestrians’ Risky Behaviours and Inattentional Blindness

  Pai, C.

  8/1/14 → 10/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Therapeutic Implications of Down-Regulation of Microglia Activation Following Repetitive Traumatic Brain Injury-Induced Chronic Traumatic Encephalopathy

  Chang, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• To Study the Correlation between Serum Markers of Oxidative Stress, Inflammation, and Endocrine-Disrupting Chemicals (Edcs) and Their Impact on the Menstrual Cycle and Reproductive Hormone in Taiwanese Women.

  Hsu, M.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation of Glioblastoma Cell-Secreted microRNA Signatures and Their Functional Effects on Tumor Angiogenesis

  Chen, K.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Neurotrophic/Neuroprotective Role of GIP in Cellular and Rodent Models of Mild Traumatic Brain Injury (III)

  Lin, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Highly Reliable Surface-Enhanced Raman Scattering Sensors

  Liu, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 榖胱甘月太硫轉移酉每參與乳癌致癌之分子機制探討(3/3)

  Wu, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Drug Discovery and Pharmacological Study of Novel pan-HDAC Inhibitors as Anti-Angiogenic Drugs

  Pan, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of Oxidative Stress-triggered Redox Adaptation Mechanism and Genetically Endowed Expression Profile of Antioxidant Enzymes in the modulation of Intrinsic and Acquired Chemoand Radio-resistance of Human Hepatocellular Carcinoma Cells

  Chiou, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Analyses of ADAM9 on Integrin b4 Turnover to Facilitate Prostate Cancer Migration and Invasion

  Sung, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Can Sesamin Alone or Cotheapy with Anti-DM Medicines Alleviate the Abnormal Intermediate Metabolites of Glucose and Fatty Acids, the Oxygen Consumption and Renal Fibrotic Progression?

  Peng, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Identifying Prostate Cancer Biosignature from Multi-Scale Mixture-Lineage Modeling of Tumor Cell Progression

  Jian, W.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effect of Vasopressin Receptor Agonist and Antagonist on Pulmonary Vein and Atrial Arrhythmogenesis

  Huang, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Explore the Molecular Mechanisms and Application of microRNA-16 in In Acute Kidney Injury

  Chen, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 103年度健康體適能檢測活動

  Kan, N.

  8/1/14 → 10/31/14

  Project: A - Government Institution › f - Other (Funded by Government)

• Exploration and Development of Infection Control Model of Long-Term Care Facilities.

  Chi, M.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Relationship between Lumbar Vertebral Perfusion and Fat Marrow Content in Normal Subjects, Osteoporosis and Bone Metastases Using DCE-MRI and Fat-Water Separation

  Chan, W. P.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Combination Treatment of Tetrac- and Cetuximab-Induced Anti-Proliferation in Colorectal Cancer with Different APC Status (I)

  Lin, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Clinical Correlation Study of DNA Methyltransferases Alterations in Breast Cancer and Evaluation of DNA Methyltransferases as a Therapeutic Target in Cell and Animal Models

  Lin, R.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Molecular and Cellular Mechanism of Adipocyte Modulatory Effects on Pulmonary Vein and Atrium

  Chen, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study the Function and Regulation of miRNAs in Pancreatic Cancer Progression (I)

  Huang, M.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effect of RRM2 in Tumor Metastasis and Chemotherapy Response of Colorectal Cancer Patients with Different APC and K-Ras Status

  Cheng, Y.

  8/1/14 → 7/31/16

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Relationships of One-Carbon Cycle Pathways with Psychopathology and Metabolic Abnormalities in Patients with Schizophrenia and Potential Intervention Strategy with 5-Methyltetrahydrofolate and Vitamin B12

  Chen, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 乳癌是目前世界上女性癌症病患中為數最多的癌症之ㄧ。腺病毒蛋白type 5 E1A (E1A)和許多抗腫瘤作用有關，曾於多種癌症如乳癌、卵巢癌及頭頸癌之病患進行臨床基因治療試驗。許多的研究指出E1A具有多項抗腫瘤的功能，包括抑制腫瘤的發生、增加腫瘤細胞對於化療藥物的感受性以及減少腫瘤轉移的現象。腫瘤的轉移對於癌症患者的死亡率有極大的影響當然也包括了乳癌的患者。E1A於抑制腫瘤發展的過程中具有多重生物學上的意義，這也促使我們想要釐清E1A抑制癌症的機制。因此，我們對於了解E1A抑制癌症轉移相關的分子機制感到有興趣，並期望藉以作為未來改進乳癌病人臨床試驗的基石。我們初步的實驗結果顯示，E1A可以有效的抑制Glucose-regulated protein 78 (GRP78)這種已被廣泛報導和腫瘤惡化及轉移相關的蛋白的表現。 提出此研究計劃之目的在於詳細探討E1A所造成的抑制癌轉移作用中，GRP78所扮演的生物功能及其調控的機轉。為了達到此目的，我們將著重於E1A如何調控GRP78表現並進而展現對乳癌轉移的抑制作用。以下為此項研究計畫的四大主要目標： 目標一：探討GRP78在E1A所抑制之癌細胞移行及侵入作用中所扮演的角色 目標二：研究E1A抑制GRP78表現之分子機轉 目標三：於動物模式中驗證GRP78的表現對於E1A抗腫瘤作用的影響 目標四：探討GRP78及其相關分子的表現在乳癌病人的臨床重要性 完成以上的主要目標能夠幫助我們對於E1A之抗腫瘤轉移作用建立更加詳細的分子訊息傳遞機制。另外，藉由此研究計畫的新發現也許可以對未來發展癌症治療上提供更多具有潛力的標的物。

  Wang, W.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Dietary Advanced Glycation Endproducts on Hypothalamic-Pituitary-Ovarian Axis in vitro and in vivo Study Are Associated with the Development of Polycystic Ovarian Syndrome: The Mechanisms of Action(1/3)

  Hsia, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Nutrients Supplementation on Damaged Mitochondria and Their Biogenesis and Turnover

  Hsieh, R.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Genetic Polymorphisms in microRNA and Risk of the Post-Thrombolytic Hyperglycemia in Acute Ischemic Stroke and Its Prognosis Study

  Hsieh, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Home-Based Exercise Training on Fatigue, Sleep Disturbance, Symptom Distress and Quality of Life in End-Stage Renal Disease Patients

  Lin, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation on Dental Implant Stability Detection Using Damping Factor as a Parameter

  Huang, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Resveratol on Proliferation of Leiomyoma: in Vitro and in Vivo Study (A09)

  Hsia, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Application of Clinical Anti-Arthralgia Formulas of Traditional Chinese Medicine to Arthritis

  Wang, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Application of Scaffold in Ovarian Transplantation for Female Fertility Preservation---An in vivo Transgenic Mouse Model (I)

  Chen, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effects of Neurofeedback and RSA Biofeedback on Quality of Sleep in Patients in the Chronic Phase of Traumatic Brain Injury(2/3)

  Tsai, P.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Evaluate the Molecluar Mechanims and Clinical Application on Atf3 Regulated microRNAs

  Lin, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effect of Endothelin-1 on Myofibroblast Transformation of Pleural Mesothelial Cells and Its Implications for Pleural and Pulmonary Fibrosis

  Chung, C. & Hsiao, G.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology