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Assessing Risk and Progression of Knee Osteoarthritis via Loading Rate and T2 Mapping of Cartilage
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Molecular mechanisms of propofol-involved protection against ischemia brain injuries
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Indoxyl Sulfate, Chronic Kidney Disease and Heat Shock Protein Modulate the Atrial Electrophysiological Characteristics
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Sleep and Memory Consilidation in Alzheimer Disease
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Chitosan nanoparticle as a macrophage-targeting drug delivery carrier
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Preceptors’ perceptions of training programs and training needs, experienced barriers during precepting, and development and effectiveness evaluation of a preceptor intervention
Chang, W.
8/1/13 → 10/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Effects of Music Therapy on Psychological Distress and Functional Recovery in Patients With Stroke
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Molecular and Clinical Role of microRNA in Obesity Induced Nephropathy
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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To Study the Correlation between Serum Markers of Oxidative Stress, Inflammation, and Endocrine-Disrupting Chemicals (Edcs) and Their Impact on the Menstrual Cycle and Reproductive Hormone in Taiwanese Women
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Effects of fish oil on alcoholic liver disease in rats based on pathological mechanisms
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Use the organometal catalytic reaction to synthesize the heterocycle-based anticancer agents
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Roles of Novel CCCH Zinc Finger Genes on the Regulation of Cell Proliferation and Inflammation
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Optimization of Human Meniscus Imaging and Its Clinical Application for Osteoarthritis
Tsai, P.
8/1/13 → 10/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Effects of LED Light on Porphyromonas gingivalis in Periodontitis for Anti-Inflammation and Alveolar Bone Regeneration
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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End-of-Life Care for Elderly with Advanced Dementia in Long-Term Care Facilities
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Association between lipid, glucose related genes and prognosis of intra- and extra-cranial stenosis in stroke patients
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Association Study of Genetic Polymorphisms of Toll-Like Receptors on Ischemic Stroke (I)
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Association of Epidermal Growth Factor Receptor mutations with HPV16/18 E6 Oncoprotein Expression in Non-Small Cell Lung Cancer
Lee, H.
8/1/13 → 7/31/14
Project: C - Project of Alliance › r - Tung's Taichung MetroHarbor Hospital
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The Effects of Neurofeedback and Rsa Biofeedback on Quality of Sleep in Patients in the Chronic Phase of Traumatic Brain Injury
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Development of Vector-Borne Disease Forecasting Models Using Satellite Remote Sensing Techniques
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Community-based Screening and Prevention Model for Periodontal Disease
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Hospital Patient Safety Culture-Comparison of Major Measurement Tools, Promotion Methods and Their Evaluation
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Deferasirox Plasma Concentration Analysis and Effects of Potential Iron Chelators on Iron Overload and Safety Evaluation
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Study the Therapeutic Effects and Novel Molecular Mechanisms of Resveratrol in Human Osteosarcoma: the Treatment of Metastatic Cancer
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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To Investigate the Functions of Shikonin and Its Derivatives in Applied Age-Related Macular Degeneration and Wound Healining
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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TMU101-AE1-B63
8/1/13 → 7/31/14
Project: C - Project of Alliance › p - Taipei Medical University Hospital
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Roles of Central OX2R Activities in the Pathophysiology of Hypertension in SHR
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Studies on the carcinogenic mechanisms of histamine N-methyltransferase-mediated breast cancer formation
Wu, C.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Functional Characterization of Niemann-Pick Type C2 Protein in Hepatocellular Carcinoma
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Neurotrophic/Neuroprotective Role of GIP in Cellular and Rodent Models of Mild Traumatic Brain Injury (II)
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Plant metabolomics (1. Agave sisalana, 2. Anoectochilus formosanus, 3. phalaenopsis spp.)
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Effects of Music Listening on Pain, Heart Rate Variability and Joint Range of Motion for Patints Receving Total Knee Replacement
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Evaluation of Therapeutic Correlation of Nanomedicine with Tea Polyphenol for Inhibition of Ocular Surface Inflammation in Rabbit Dry Eye Model
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Design and Characterization of Multifunctional Self-Assembling Lecithin/Amphiphilic Polymers Mixed Micellar Delivery Systems
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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An association study of arsenic exposure, inflammation, oxidative stress and the risk of developing cardiovascular diseases
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Explore of Toll-Like Receptors Associated Mirna Expression in Ischemic Stroke Patients (I)
Wu, C.
8/1/13 → 7/31/14
Project: B - Project of TMU › i - Other (Funded by TMU)
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The Effect of Muscle Strength Training on Body Composition and Sarcopenic Obesity among the Female Overweight Elderly
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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大腸直腸癌已躍居世界上癌症死亡率第二名,屬於固體型腫瘤,缺氧常見於此類 腫瘤,並誘發HIF-1α 表現而導致抗藥性及預後較差,因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑,可殺死癌 細胞而不影響正常細胞,對小鼠也不具毒性。我們初步結果顯示,Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現,代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性,對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下,經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制;也有研究報導指出,藥物會誘導癌細胞產生autophagy,造成細胞過度吞噬其內容 物而死亡,因此,autophagy在癌細胞為保護或是引發毒殺作用,目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活,但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示,除抑制HIF-1α 表現外,Zeb 也可活化AMPK、UPR/ER stress、以及autophagy, 因此我們推測Zeb 可在缺氧狀態下,促進autophagic cell death。3 年內我們將執行4 項 目標: (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。(第一年) (2) 研究Zeb 抑制HIF-1α表現之分子機轉。(第一年到第二年) (3) 研究Zeb 誘發autophagy之分子機轉。(第二年到第三年) (4) 探討Zeb 對缺氧導致抗藥性之作用。(第三年)
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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A Clinical Correlation study of DNA Methyltransferases Alterations in Breast Cancer and Evaluation of DNA Methyltransferases as a Therapeutic Target in Cell and Animal Models
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
-
Development of Strontium-Impregnated Bioabsorbable Bone Screw for Fracture Fixation in Osteoporotic Bone
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Effect of Improved Nutrition Care on the Progress of Hemodialysis Patients
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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TMU101-AE1-B65
8/1/13 → 7/31/14
Project: C - Project of Alliance › p - Taipei Medical University Hospital
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Effects of Exercise Training on Sleep Disturbances, Anxiety, and Depression among Newly Diagnosed Elderly Lung Cancer Patients
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Exploratory Study of Self-Identity and Medical Professionalism Among Medical Students
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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α9-型尼古丁乙醯膽鹼受體在乳癌幹細胞的角色與防治藥物的篩選
8/1/13 → 7/31/14
Project: B - Project of TMU › i - Other (Funded by TMU)
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Effects of a program of mind-body interventions on psychological resilience, vagal tone, emotional states, and outcomes of heart failure
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Studies on the anti-islet hypertrophy and anti-osteoporosis constituents from Formosan Fern
Hsu, F.
8/1/13 → 12/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Survey and Intervention of Health Literacy among Older Adults
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Study of the mechanism of HPV involved tumorigenesis through Wnt signaling pathway related microRNA regulation
Cheng, Y.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology