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The Roles of Micrornas in Endothelin-1 and Hypoxia-Induced Ctgf Production

Chen, Y.

8/1/127/31/14

Project: B - Project of TMUh - Other (Funded by TMU)

睡眠困擾是癌症病人最常主訴的問題之一。患有睡眠困擾之癌症病人經常同時伴隨 疲憊、憂鬱等現象發生,形成症狀群集,影響生活品質。雖然目前對於癌症病人睡眠障 礙之量性研究已多有著墨,然而對於癌症病人經歷睡眠障礙之主觀經驗之瞭解,仍相當 有限。瞭解病人經歷睡眠障礙之主觀經驗,將有助於未來睡眠評估工具之修訂。另外, 在評估癌症病人睡眠品質時,若能以簡單工具評估,會更具效率及助益。阿森斯失眠量 表(Athens Insomnia Scale, AIS) 是一個簡單的8 題問卷,廣為使用在一般失眠的病人, 在癌症病人使用上,尚未有豐富的實證資料,若能建立其在癌症病人的信效度,將可作 為一簡單篩檢癌症病人失眠的工具。 睡眠遵行日夜節律規則,日夜節律又需要光作為矯正的線索,光在癌症病人睡眠的 角色,尚未有研究證實,過去研究顯示癌症病人睡眠品質不佳與生物節律有關係。光是 重要日夜節律的線索,光療法透過褪黑激素調節,調整日夜節律週期,可能可以改善睡 眠品質。另外,由於,睡眠障礙、憂鬱、疲憊經常形成一症狀群集,光療法於改善睡眠 障礙之同時,是否亦同時改善憂鬱、疲憊及生活品質。目前,光療法在癌症病人的運用 上,付之闕如,故建立光療法於癌症病人的有效性值得探究。 本研究為三年期研究計畫,目的包括有:1.瞭解癌症個案對於睡眠困擾的主觀經驗 (第一年)。2.建立阿森斯失眠量表中文版的信效度、敏感性、特異性(第一年)。3.瞭 解癌症病人光暴露與生物節率、睡眠障礙的關係(第二年)。4.瞭解光療法對於改善癌 症病人睡眠障礙及相關症狀群集、及生活品質之成效;以及瞭解光療法影響褪黑激素之 程度(第三年)。 本研究擬以癌症住院及門診病人為對象,研究工具包括基本資料、匹茲堡睡眠品質 問卷、阿森斯失眠問卷,簡明疲憊量表,貝克憂鬱量表度、SF-36 生活品質量表、腕動 力器等。資料處理分析方式包括:內容分析、描述性統計、t 檢定、皮爾森相關、GEE (generalized estimating equations)等。 本研究之結果將可瞭解光暴露與生物節率與睡眠障礙之間的關係,並可進一步瞭解 光療法作為改善癌症病人睡眠障礙之護理措施之成效,以期,最終能藉由改善癌症病人 之睡眠品質提昇病人之生活品質。

Lin, C.

8/1/1210/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Epigenetic Regulation of Lps-Induced G-Csf Expression in Macrophages

Chang, S.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Reflex Pelvic Floor Muscle Activities in Women with Urinary Incontinence (Ii)

Yang, J.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Integrated Therapeutic Strategy Using Ginkgo Biloba and Exercise to Improve Muscle Wasting of Different Origin

Peng, C.

8/1/1212/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Role of Sp-Family in Lung Tumorigenesis

Chang, W.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Translational Genomic Approaches in Endometriosis

Tzeng, C.

8/1/1210/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Depression Trajectories in Women – a Developmental-Ecological Approach (Gm03)

Kuo, S.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

A Translational Study to Confirm the Roles of Gata-Dna Binding Proteins in Bone Healing

Chen, R.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

The First Randomized Controlled Clinical Trial for Computerized Decision Support System (II)

Li, Y.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Study of Laser Enhancement of Transdermal Delivery of Nanoparticles

Lee, W.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Avoidable Hospitalizations and Primary Care Manpower in a Universal Health Insurance System: a 15-Year Trend Analysis

Huang, K.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Roles of Central Orexin Activities in the Pathophysiology of Hypertension in Shr

Hwang, L.

8/1/129/30/13

Project: A - Government Institutionb - Ministry of Science and Technology

Studies of Molecular and Cellular Underlying Mechanisms of Ferrous Citrate-Induced Cerebral Vasospasm and Brain Injury

Lee, W.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Combine Anesthesia Information System with Artificial Neural Networks to Develop the Surgical Complication Pre-Warning System

Lin, C.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Pulmonary Effects of Chorioamnionitis and Postnatal Hyperoxia in Rat Offspring

Chen, C.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Simultaneous Delivery of an Antisense Oligonucleotide and a Chemotherapeutic Agent by a Her2-Targeted Liposomal System

Chiu, S.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

NF-kB以及NF-kB repressing factor (NRF) 在慢性阻塞性肺疾病引發系統性發炎之角色探討(3/3)

Lee, K.

8/1/1210/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Genetic Polymorphisms of Calcium Channel in the Risk of Breast Cancer

Chang, W.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Chinese Herbal Compound Extract of Pig Sperm Detection and Activation of the Pharmacokinetic Evaluation and Preparation of R &Amp; D

Lee, C.

8/1/123/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Effects of Glutamine Supplementation on T Cell Homeostasis and Inflammatory Response in Inflammatory Bowel Disease

Yeh, S.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Investigation of the Molecular Mechanisms of a Novel Finger Protein, Znf179, in Neuronal Differentiation

Lee, Y.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

探究腦指蛋白 ZNF179 (Brain Finger Protein) 的分子機制

Huang, C.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Translational Genomic Approaches in Endometriosis

Tzeng, C., Kao, S., Huang, Y., Yang, W., Yang, W., Yeh, C., Li, Y. & Shen, S.

8/1/1210/31/13

Project: B - Project of TMUh - Other (Funded by TMU)

Effects of Maternal Depressive Symptomatology on Pregnancy Outcomes and Newborn Development---How Is Paternal Psychopathology Involved?

Chen, Y.

8/1/129/30/13

Project: A - Government Institutionb - Ministry of Science and Technology

Pharmaceuticals Removal in Hospital Wastwater and Effluent by Electro-Coagulation-Flotation

Hu, C.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Renoprotective Mechanisms of Soy Protein in Rats with Diabetic Nephropathy

Chen, J.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

The Role of Microrna Let-7g in Cytosolic Ca2+ Regulation and Cox-2 Gene Expression

Chang, W.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Lay Health Knowledge Research:Example of Infants and Children Dietary Supplement

Chen, Y. C.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Disjunctivism and Theories of Action

Lin, C.

8/1/127/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

The Role of DDX3 in Human Papillomavirus-Infected Lung Tumorigenesis

Lee, H.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Effects of Essential Oils on Smooth Muscle Contraction in Rat Uterus (Gm07)

Hsia, S.

8/1/1212/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Design and Evaluation of a Novel Drug-Containing Ceramic Hydrogel for the Healing of Alveolar Bone Defect

Lee, S.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

The Role of Cytoplasmic APe1 in Tumor Malignancy, Drug Resistance and Lung Cancer Prognosis

Lee, H.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Integration of Research on Novel Antibacterial Mini-Implant

Lin, C.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Effects of Adlay Hull Extracts on Polycystic Ovary Syndrome (Pcos)

Hsia, S.

8/1/1210/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Studies on the Anti-Islet Hypertrophy and Anti-Osteoporosis Constituents from Formosan Fern

Hsu, F.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Role of Er Stress in Evodiamine-Induced Apoptosis and G2/M Arrest of Human Colorectal Carcinoma Cells

Chen, Y.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology