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The Roles of Micrornas in Endothelin-1 and Hypoxia-Induced Ctgf Production

Chen, Y.

8/1/12 → 7/31/14

Project: B - Project of TMU › h - Other (Funded by TMU)

睡眠困擾是癌症病人最常主訴的問題之一。患有睡眠困擾之癌症病人經常同時伴隨 疲憊、憂鬱等現象發生，形成症狀群集，影響生活品質。雖然目前對於癌症病人睡眠障 礙之量性研究已多有著墨，然而對於癌症病人經歷睡眠障礙之主觀經驗之瞭解，仍相當 有限。瞭解病人經歷睡眠障礙之主觀經驗，將有助於未來睡眠評估工具之修訂。另外， 在評估癌症病人睡眠品質時，若能以簡單工具評估，會更具效率及助益。阿森斯失眠量 表(Athens Insomnia Scale, AIS) 是一個簡單的8 題問卷，廣為使用在一般失眠的病人， 在癌症病人使用上，尚未有豐富的實證資料，若能建立其在癌症病人的信效度，將可作 為一簡單篩檢癌症病人失眠的工具。 睡眠遵行日夜節律規則，日夜節律又需要光作為矯正的線索，光在癌症病人睡眠的 角色，尚未有研究證實，過去研究顯示癌症病人睡眠品質不佳與生物節律有關係。光是 重要日夜節律的線索，光療法透過褪黑激素調節，調整日夜節律週期，可能可以改善睡 眠品質。另外，由於，睡眠障礙、憂鬱、疲憊經常形成一症狀群集，光療法於改善睡眠 障礙之同時，是否亦同時改善憂鬱、疲憊及生活品質。目前，光療法在癌症病人的運用 上，付之闕如，故建立光療法於癌症病人的有效性值得探究。 本研究為三年期研究計畫，目的包括有：1.瞭解癌症個案對於睡眠困擾的主觀經驗 （第一年）。2.建立阿森斯失眠量表中文版的信效度、敏感性、特異性（第一年）。3.瞭 解癌症病人光暴露與生物節率、睡眠障礙的關係（第二年）。4.瞭解光療法對於改善癌 症病人睡眠障礙及相關症狀群集、及生活品質之成效；以及瞭解光療法影響褪黑激素之 程度（第三年）。 本研究擬以癌症住院及門診病人為對象，研究工具包括基本資料、匹茲堡睡眠品質 問卷、阿森斯失眠問卷，簡明疲憊量表，貝克憂鬱量表度、SF-36 生活品質量表、腕動 力器等。資料處理分析方式包括：內容分析、描述性統計、t 檢定、皮爾森相關、GEE (generalized estimating equations)等。 本研究之結果將可瞭解光暴露與生物節率與睡眠障礙之間的關係，並可進一步瞭解 光療法作為改善癌症病人睡眠障礙之護理措施之成效，以期，最終能藉由改善癌症病人 之睡眠品質提昇病人之生活品質。

Lin, C.

8/1/12 → 10/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Molecular Mechanisms of Alpha 9-Nicotinic Acetylcholine Receptor (Alpha 9-Nachr)-Mediated Trastuzumab (Herceptinr) Drug Resistance in Breast Cancer Cells

Ho, Y.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Epigenetic Regulation of Lps-Induced G-Csf Expression in Macrophages

Chang, S.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Reflex Pelvic Floor Muscle Activities in Women with Urinary Incontinence (Ii)

Yang, J.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Integrated Therapeutic Strategy Using Ginkgo Biloba and Exercise to Improve Muscle Wasting of Different Origin

Peng, C.

8/1/12 → 12/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Role of Sp-Family in Lung Tumorigenesis

Chang, W.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Translational Genomic Approaches in Endometriosis

Tzeng, C.

8/1/12 → 10/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Depression Trajectories in Women – a Developmental-Ecological Approach (Gm03)

Kuo, S.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

A Translational Study to Confirm the Roles of Gata-Dna Binding Proteins in Bone Healing

Chen, R.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

The First Randomized Controlled Clinical Trial for Computerized Decision Support System (II)

Li, Y.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Study of Laser Enhancement of Transdermal Delivery of Nanoparticles

Lee, W.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Avoidable Hospitalizations and Primary Care Manpower in a Universal Health Insurance System: a 15-Year Trend Analysis

Huang, K.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Roles of Central Orexin Activities in the Pathophysiology of Hypertension in Shr

Hwang, L.

8/1/12 → 9/30/13

Project: A - Government Institution › b - Ministry of Science and Technology

The Build of Functional Protein Molecular Shuttles by Using a Genetically Engineered Kinesin and Nucleic Acid Aptamers - with the Integration of the Cost-Effective Microscopic Imaging System and Micro Fluidic Channel Chips

Kuo, T.

8/1/12 → 10/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Analysis the Role of Satellite Cell during Denervation Induced Muscular Atrophy and a Trail of Transplantation of Adipocyte Derived Myogenic Stem Cells.

Chang, H.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Studies of Molecular and Cellular Underlying Mechanisms of Ferrous Citrate-Induced Cerebral Vasospasm and Brain Injury

Lee, W.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Combine Anesthesia Information System with Artificial Neural Networks to Develop the Surgical Complication Pre-Warning System

Lin, C.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Pulmonary Effects of Chorioamnionitis and Postnatal Hyperoxia in Rat Offspring

Chen, C.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

The Integrated Theraptic Effect of the Major Components of Psidium Guajava L. Aqueous Extracts (Pe) (Gallic Acid, Quercetin, Egcg, and Rutin) Combining with Medical Trials and Control Diets on the Chronic Kidney Disease

Chen, K.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Simultaneous Delivery of an Antisense Oligonucleotide and a Chemotherapeutic Agent by a Her2-Targeted Liposomal System

Chiu, S.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

NF-kB以及NF-kB repressing factor (NRF) 在慢性阻塞性肺疾病引發系統性發炎之角色探討(3/3)

Lee, K.

8/1/12 → 10/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Study the Role of the Endoplasmic Reticulum Stress Related Proteins, Glycoprotein 96(Gp96), in Liver Cancer Progression and Metastasis and the Clinically Therapeutic Implication

Huang, M.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Chinese Herbal Compound Extract of Pig Sperm Detection and Activation of the Pharmacokinetic Evaluation and Preparation of R &Amp; D

Lee, C.

8/1/12 → 12/31/13

Project: B - Project of TMU › h - Other (Funded by TMU)

Genetic Polymorphisms of Calcium Channel in the Risk of Breast Cancer

Chang, W.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Chinese Herbal Compound Extract of Pig Sperm Detection and Activation of the Pharmacokinetic Evaluation and Preparation of R &Amp; D

Lee, C.

8/1/12 → 3/31/14

Project: A - Government Institution › b - Ministry of Science and Technology

The Study of the Relationships among Anti-Obesity Activity, Adipogenesis, and Adipose Angiogenesis of Vegetable Indolic Derivatives – Involvement of the Ah Receptor/Arnt ?

Chen, Y.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Effects of Glutamine Supplementation on T Cell Homeostasis and Inflammatory Response in Inflammatory Bowel Disease

Yeh, S.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Investigation of the Molecular Mechanisms of a Novel Finger Protein, Znf179, in Neuronal Differentiation

Lee, Y.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

探究腦指蛋白 ZNF179 (Brain Finger Protein) 的分子機制

Huang, C.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Translational Genomic Approaches in Endometriosis

Tzeng, C., Kao, S., Huang, Y., Yang, W., Yang, W., Yeh, C., Li, Y. & Shen, S.

8/1/12 → 10/31/13

Project: B - Project of TMU › h - Other (Funded by TMU)

Effects of Maternal Depressive Symptomatology on Pregnancy Outcomes and Newborn Development---How Is Paternal Psychopathology Involved?

Chen, Y.

8/1/12 → 9/30/13

Project: A - Government Institution › b - Ministry of Science and Technology

Pharmaceuticals Removal in Hospital Wastwater and Effluent by Electro-Coagulation-Flotation

Hu, C.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Renoprotective Mechanisms of Soy Protein in Rats with Diabetic Nephropathy

Chen, J.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

The Role of Microrna Let-7g in Cytosolic Ca2+ Regulation and Cox-2 Gene Expression

Chang, W.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

The Pre-Clinical Assessment of the Anti-Tumor Efficacy of a Protein Vaccine and Mesenchymal Stem Cell Combined Therapy, Using Non-Invasive Molecular Imaging Technology

Wu, T. A.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

A Study on Trans-Neuronal Striato-Nigral Degeneration-Induced Movement Disorders after Stroke: Evaluation with Grey Matter Suppression Ir and Diffusion Tensor Imaging( I )

Chen, C.

8/1/12 → 10/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

「智慧生活跨領域基礎課程與服務學習課程推廣計畫」-可攜式行動保健裝置暨個案健康評估管理資料庫服務學習課群擴散計畫

Chiu, C.

8/1/12 → 7/31/13

Project: A - Government Institution › d - Ministry of Education

Lay Health Knowledge Research:Example of Infants and Children Dietary Supplement

Chen, Y. C.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Disjunctivism and Theories of Action

Lin, C.

8/1/12 → 7/31/14

Project: A - Government Institution › b - Ministry of Science and Technology

Development a Tissue-Like Block by Novel Porous Calcium Phosphate Combined Dental Pulp Stem Cells and Platelets Rich Fibrin for Bone Regeneration in Large Bony Defect

Lee, S.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

The Role of DDX3 in Human Papillomavirus-Infected Lung Tumorigenesis

Lee, H.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Effects of Essential Oils on Smooth Muscle Contraction in Rat Uterus (Gm07)

Hsia, S.

8/1/12 → 12/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Design and Evaluation of a Novel Drug-Containing Ceramic Hydrogel for the Healing of Alveolar Bone Defect

Lee, S.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

The Role of Cytoplasmic APe1 in Tumor Malignancy, Drug Resistance and Lung Cancer Prognosis

Lee, H.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Integration of Research on Novel Antibacterial Mini-Implant

Lin, C.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Effects of Adlay Hull Extracts on Polycystic Ovary Syndrome (Pcos)

Hsia, S.

8/1/12 → 10/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Studies on the Anti-Islet Hypertrophy and Anti-Osteoporosis Constituents from Formosan Fern

Hsu, F.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Role of Er Stress in Evodiamine-Induced Apoptosis and G2/M Arrest of Human Colorectal Carcinoma Cells

Chen, Y.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Investigation of the Transcriptional and Epigenetic Mechanisms for the Nm23-H1 Expression: an Nm23-H1-Promoter Screening Platform for Novel Metastasis-Suppressing Anticancer Drugs

Wang, L.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology