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• 發展三功能抗體(EGFR/CD3/mPEG)修飾之聚乙二醇-免疫增敏奈米藥物以主動標靶毒殺大腸癌並同時強化體內T細胞於腫瘤微環境抗癌功效之創新協同療法-開發三功能抗體(EGFR/CD3/mPEG)以協同加成聚乙二醇-免疫增敏奈米藥物及T細胞於大腸癌腫瘤微環境之抗癌功效(1/3)

  Lin, S.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• TXNIP在肺泡巨噬細胞偏向M1/M2極化中的調控：慢性阻塞性肺病致病機轉的研究(3/3)

  Chen, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 胃腸科相關癌症之差異蛋白質體與致病機轉之研究

  Lee, J.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 乳癌細胞α9尼古丁受體作為新穎靶向RNA奈米藥物與T細胞療法之臨床轉譯研究-開發抗α9尼古丁受體/抗CD3雙功能抗體以一步驟建構可高效標靶毒殺乳癌腫瘤之武裝型T細胞免疫療法(1/3)

  Chuang, K.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 建置與評估可擴充式機器學習演算法之重症醫療資訊平台

  Lo, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Aza-PBHA , 透過調控芳香烴受體於糖尿病視網膜病變治療潛力機制探討(1/3)

  Cheng, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 建立可偵測多重膜蛋白突變之蛋白基因體平台（延續計畫）

  Han, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 闡明Hiltonol為主的複合式用藥在肺癌生長，轉移和腫瘤微環境中的作用。

  Chang, S.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 發展三功能抗體(EGFR/CD3/mPEG)修飾之聚乙二醇-免疫增敏奈米藥物以主動標靶毒殺大腸癌並同時強化體內 T 細胞於腫瘤微環境抗癌功效之創新協同療法-發展新型聚乙二醇-免疫增敏奈米藥物載體以毒殺大腸癌並強化腫瘤區域T細胞之抗癌功效(1/3)

  Liu, D.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 整合臨床血液透析高分辨率生物活體脈衝光驅動鹵素鈣鈦礦成像於微觀血管彈性研究與紅外線照射系統

  Liou, J.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 絲氨酸/蘇氨酸蛋白激酶(SIK3)參與乳癌致癌過程的分子機制探討

  Chen, L.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 肺纖維化之分子病理機制探討-探討Sema7A+調節型T細胞在肺部纖維化中第二型免疫反應的調控角色(3/3)

  Chen, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 間質幹細胞之外泌體於減緩肥胖及肥胖併發敗血症於小鼠所致心臟病變之療效與其調控氧化、發炎、粒線體異常及胰島素抵抗之效應探討(3/3)

  Huang, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討腎臟細胞暴露於塑膠微粒和塑膠奈米中誘發自體吞噬作用和增加SREBPs並引起血管內皮細胞滲漏作用之機制(1/3)

  Chiu, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 母親食安風險認知對孩童體內實際鉛、鎘、砷暴露之影響(1/3)

  Chien, L.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 滑世代幼兒期親子睡眠與晝夜節律追蹤研究-整合智慧型資料探討3C產品使用與孕產期相關因子影響效應(2/3)

  Chen, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 研發整合互動式擴增實境與電刺激神經調控系統以改善腦中風者神經可塑性和肢體功能(II)

  Lai, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• The molecular pathogenesis of pulmonary fibrosis-Warburg effect在肺纖維化之角色(3/3)

  Chen, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Transforming growth factor beta引發呼吸道過度敏感：肺迷走C纖維感覺神經的角色(2/3)

  Hsu, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• ASPM-PAR-PCP訊息軸於侵犯性癌幹細胞造成癌轉移的角色與其標靶治療(2/3)

  Tsai, K. K.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討粒線體因子C20orf7在大腸癌進程中對化療藥物抗藥性及上皮細胞間質轉化作用EMT之調控機轉及大腸癌合併治療策略研究

  Cho, E.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 白朮及其藥對與方劑之成分與功效關係機制探討(3/3)

  Wang, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 印尼瑪琅地區HIV個案接受ART治療，憂鬱傾向，跟生活品質之長期追蹤研究: 社會歧視，個人韌力，與社會支持之角色

  Chuang, K.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 建構定量系統生理基礎藥動模型以評估腸道菌叢對口服藥物代謝影響及協助奈米膠體處方之開發(1/3)

  Hsieh, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 利用藥物基因體發展急性登革熱病毒感染期間免疫反應之臨床診斷：探討T細胞組庫和C-型凝集素基因家族之遺傳變異(1/3)

  Chang, W.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 新穎性DYRK1A抑制劑於阿茲海默症之機轉探討(2/3)

  HuangFu, W.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 【玩轉生技-巾幗傳奇II】生技女企業家經營管理智慧傳承之科學活動與 出版計畫

  Hsu, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 評估糖稅課徵政策對肥胖相關疾病負擔之影響：微觀模擬預測模型之研 究(1/2)

  Lo, W.

  8/1/20 → 7/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探索衰老新穎性標的與神經退化性疾病相互作用並以衰老作為開發神經保護潛力藥物之新策略

  Lee, M.

  8/1/20 → 7/31/21

  Project: B - Project of TMU › i - Other (Funded by TMU)

• 股市變動與心理健康：醫院急診入院的實證研究

  Hsiao, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探索蝦急性肝胰腺壞死病毒素 PirAvp 與 PirBvp 之活化機制與中和策略(1/3)

  Wang, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 攝護腺癌之精準代謝治療(3/3)

  Kung, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 針對IL-33/ST2訊息路徑調控鈣平衡、內質網壓力與粒線體功能作為心房與肺靜脈心律不整活性與心房顫動致病機轉及治療策略探討(1/3)

  Chen, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 天然物實驗室的自動化設計(3/3)

  Lee, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 發展干擾染色質複製時期基因體穩定性之藥劑 (第二至四年)

  Lee, S.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 開發透明質酸基奈米藥物以增強後眼部藥物遞送效能及應用於藍光誘導損傷之視網膜病變治療

  Tseng, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 桑黃天然物hispolon及其結構衍生物延緩老化與神經退化疾病的研究:從體外試驗到體內動物模式(3/3)

  Hou, W.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 科普活動：小小AD8失智檢測先鋒—從書寫祖父母的生命故事書串起認知神經科學與失智檢測(主題一)

  Hsu, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討 CWH43 大腸直腸癌發展的角色及其調控機制

  Chang, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 研究慢性阻塞性肺疾病患者特異性血紅素結合蛋白表現型對巨噬細胞極化作用和疾病進展的調節作用(2/3)

  Ho, S.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• ZFHX3 knockdown調控心房纖維化導致心房顫動病理性結構重塑之機轉探討

  Kao, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 昆蟲的親緣基因體學: 昆蟲和其他泛甲殼動物的基因體演化(3/3)

  Chen, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 運用馬桶理論探討腦內代謝物清除：日夜週期對 β類澱粉蛋白質堆積的影響

  Myung, J.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以機器學習和自然語言理解技術探勘社群互動關係及商業智慧之應用(1/2)

  Chang, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• (教學實踐) 經典閱讀、反思寫作與知識創新─立基知識建構理論的反思教學設計與學生學習經驗探索

  Lin, W.

  8/1/20 → 7/1/21

  Project: A - Government Institution › d - Ministry of Education

• 死亡體驗教育對醫護學生之生死態度影響探究

  Han, D.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 方志中的財政書寫與歷史記憶：以明代嚴州府方志為中心(1/2)

  Tseng, M.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 低強度高反覆阻力訓練及高強度循環訓練對不同BDNF Val66Met基因型老年人BDNF、認知功能及體能表現之影響

  Chung, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• (教學實踐) AR 技術置入歷史課程教學對學生學習興趣之影響

  Tseng, M.

  8/1/20 → 7/1/21

  Project: A - Government Institution › d - Ministry of Education

• 利用電子病歷與個人健康資訊建構慢性腎臟病人之紅血球生成刺激劑智慧給藥模型(第二、三年延續案)

  Huang, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology