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  Assessing Risk and Progression of Knee Osteoarthritis via Loading Rate and T2 Mapping of Cartilage

  Chan, W. P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effect of pacemaker current inhibitor (Ivabradine) on sinoatrial node function and pulmonary vein arrhythmogenesis

  Lin, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation of the transcriptional and epigenetic mechanisms for the Nm23-H1 expression: An nm23-H1-promoter screening platform for novel metastasis-suppressing anticancer drugs

  Wang, L.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Belongingness: The Mental Ownership Theory and Research Program

  Lane, T. J.

  8/1/13 → 9/30/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 大腸直腸癌已躍居世界上癌症死亡率第二名，屬於固體型腫瘤，缺氧常見於此類 腫瘤，並誘發HIF-1α 表現而導致抗藥性及預後較差，因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑，可殺死癌 細胞而不影響正常細胞，對小鼠也不具毒性。我們初步結果顯示，Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現，代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性，對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下，經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制；也有研究報導指出，藥物會誘導癌細胞產生autophagy，造成細胞過度吞噬其內容 物而死亡，因此，autophagy在癌細胞為保護或是引發毒殺作用，目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活，但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示，除抑制HIF-1α 表現外，Zeb 也可活化AMPK、UPR/ER stress、以及autophagy， 因此我們推測Zeb 可在缺氧狀態下，促進autophagic cell death。3 年內我們將執行4 項 目標： (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。（第一年） (2) 研究Zeb 抑制HIF-1α表現之分子機轉。（第一年到第二年） (3) 研究Zeb 誘發autophagy之分子機轉。（第二年到第三年） (4) 探討Zeb 對缺氧導致抗藥性之作用。（第三年）

  Yang, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Mobile Phone Use and Walking: A Observational Field Study of Pedestrians' Risky Behaviours and Inattentional Blindness

  Pai, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Trends in Surgical Litigation and Media Coverage of Medical Malpractice: Implications for Medical Education

  Lyu, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• TMU101-AE1-B66

  Lin, J. A.

  8/1/13 → 12/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• Effects and Mechanisms of Pitx2c Modulation for Atrial Electrophysiological and Structural Remodelings in Heart Failure

  Kao, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The association of early-onset ischemic stroke and the aging of vascular system using the telomere length related genes

  Hsieh, F.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Molecular Epidemiological Study of Renal Cell Carcinoma - Arsenic Methylation Capability, 8OHdG and Polymorphism of IRS and RAAS Exploration

  Hsueh, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Emerging Role That Splicing Factor Plays in the Adipose Development

  Lin, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Functional Characterization of Niemann-Pick Type C2 Protein in Hepatocellular Carcinoma

  Liao, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 抽菸、α9-型尼古丁乙醯膽鹼受體、表皮生長因子受體及動情激素相關基因與乳癌之分子流行病學研究

  Chiou, H.

  8/1/13 → 7/31/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Development of Novel Therapeutic Agents for Herceptin Resistance Breast Cancer Cells through Targeting Nicotinic Acetylcholine Receptors

  Lee, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Molecular mechanisms of alpha9-nicotinic acetylcholine receptor (alpha 9-nAChR)-mediated Trastuzumab (HerceptinR) drug resistance in breast cancer cells

  Ho, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Application of clinical anti-arthralgia formulas of traditional Chinese medicine to arthritis

  Wang, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Evaluation on Cervical Cancer Prevention and Treatment Policy in Taiwan

  Tang, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 102年度臺北市輻射屋居民健康照護需求評估工具建立

  Chiu, C.

  7/16/13 → 12/31/13

  Project: A - Government Institution › f - Other (Funded by Government)

• 健康促進國際政策及學術資料建置計畫

  Chang, W.

  7/3/13 → 12/31/13

  Project: A - Government Institution › c - Ministry of Health and Welfare

• TMU101-AE1-B61

  Cheng, P.

  7/1/13 → 6/30/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• The Application of Biodegradable Nano-Enabled Drug Delivery in Treatemt of Brain Abscess

  Tseng, Y.

  7/1/13 → 9/30/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• TMU101-AE1-B62

  Chuang, T.

  7/1/13 → 9/30/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• 奈米金屬微粒暴露引發勞工心血管效應之細胞毒理評估

  Chuang, K.

  6/27/13 → 12/20/13

  Project: A - Government Institution › f - Other (Funded by Government)

• 行政院衛生署所屬醫院「102年度滿意度調查評估」勞務委託採購案

  Kuo, N.

  6/18/13 → 10/28/13

  Project: A - Government Institution › f - Other (Funded by Government)

• 102年癌症篩檢管理中心工作計畫之個管師考題研擬及閱卷

  Chen, L.

  6/13/13 → 8/31/13

  Project: A - Government Institution › c - Ministry of Health and Welfare

• 職場生物氣膠暴露及建議值調查評估研究

  Chao, H. J.

  6/11/13 → 12/13/13

  Project: A - Government Institution › f - Other (Funded by Government)

• 建置健保法學知識數位平台

  Yang, C.

  6/7/13 → 12/6/13

  Project: A - Government Institution › c - Ministry of Health and Welfare

• 牙科根管治療顯影材料之溶凝膠製備與改質研究

  Lin, C.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 香菸特異亞硝胺與代謝基因多形性於牙周炎個案治療成效

  Huang, Y.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 子宮內膜異位症中乙式轉形生長因子在調控OCT4表現及上皮細胞/間葉細胞間轉型之角色探討

  Huang, Y.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• TMU101-AE1-B56

  Wu, C.

  6/1/13 → 5/31/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• 人類乳突病毒導致肺腫瘤化之可能機轉

  Cheng, Y.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 鈦坦銀合金應用於生醫植體之研究

  Huang, C.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 102 年東南亞區域共同研究暨培訓型國際合作計畫—社區精神復健合作研究平台與專業人員培訓工作坊

  Tsai, D.

  6/1/13 → 12/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以系統生物資訊方法分析策略發展頭頸癌治療藥物

  Chen, Y.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• TMU101-AE1-B57

  Chien, L.

  6/1/13 → 5/31/15

  Project: B - Project of TMU › i - Other (Funded by TMU)

• 探討SCUBE1在腎臟上皮間質化及癌症發展的角色

  Lin, H.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 高純度具表面增強拉曼活性奈米貴金屬顆粒之製備與其生醫檢測策略

  Liu, Y.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• TMU101-AE1-B54

  Kao, Y.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › t - Taipei Municipal Wanfang Hospital

• 血小板微粒特性及功能之體外研究

  Burnouf, T. P. R.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 新型醫用鈦鍺合金材料之研究

  Peng, P.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 102 年東南亞區域共同研究暨培訓型國際合作計畫—亞洲 15 國衛生識能國際合作比較研究與研習教育計畫

  Chang, W.

  6/1/13 → 12/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• 晶體性關節炎侵蝕骨頭(蝕骨細胞分化)的分子機制

  Liang, Y.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• TMU101-AE1-B59

  Liao, C.

  6/1/13 → 12/31/15

  Project: B - Project of TMU › i - Other (Funded by TMU)

• 奈米金鍵結標靶藥物afatinib用於治療HER2大量表現之癌症

  Chang, J.

  6/1/13 → 5/31/15

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 探討 GRP78 作為攝護腺癌化學治療之癒後因子之潛能

  Chang, Y.

  6/1/13 → 7/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• TMU101-AE1-B58

  Liu, W.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › u - Taipei Medical University Shuang Ho Hospital

• MEKK1/JNK依賴SMAD3活化媒介CXCL12誘導肺部纖維母細胞CTGF表現之探討

  Chen, B.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• TMU101-AE1-B60

  Lane, T. J.

  6/1/13 → 5/31/14

  Project: B - Project of TMU › i - Other (Funded by TMU)