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Role of HBX and IL-6 in Regulating SENP1/Stemness Properties of HBV-Related Hcc under Hypoxia and Its Clinical Implication

Huang, Y.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

《Understanding International Conflicts:An Introduction to Theory and History》Translation and Annotation Project

Chang, K.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

A Study on the Influence of Classical Mathematics Reading Course on Medical Students Beliefs about Mathematics

Ying, J.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Pharmaceuticals Removal in Hospital wastwater and effluent by Electro-coagulation-flotation

Hu, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

The Association Study of Genetic Polymorphisms of Toll-Like Receptors on Ischemic Stroke (I)

Chiou, H.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Effects of a program of mind-body interventions on psychological resilience, vagal tone, emotional states, and outcomes of heart failure

Tsai, P.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

山藥儲藏性蛋白質功能性月生月太之延緩衰老功能評估與機制探討(1/3)

Hou, W.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

An association study of arsenic exposure, inflammation, oxidative stress and the risk of developing cardiovascular diseases

Hsieh, F.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Motor Vehicle Injuries and Screening Tools of Unsafe Driving in Older Drivers

Lin, M.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

The role of DDX3 in human papillomavirus-infected lung tumorigenesis

Lee, H.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Exploring the effects of an exercise program on female diabetic patients$ health

Liao, Y.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Development of Novel Degradable Biomaterial for Dental Hemostatic Sponge Applications

Lin, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

鼻咽癌細胞Annexin A2誘導樹突狀細胞免疫抑制反應

Chen, C.

5/1/137/31/14

Project: C - Project of Allianceu - Taipei Medical University Shuang Ho Hospital

Exploring Biopathways Related to Cancer Based on Differences of Gene Expression between Cancer and Normal Situation

Chiu, H.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Explore of Toll-Like Receptors Associated Mirna Expression in Ischemic Stroke Patients (I)

Wu, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

The Epigenetic Control of IL-6-STAT3 Targeting Dnas in the Cell of Dihydropyridine-Induced Gingival Overgrowth

Lu, H.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Study the Klf10 alters metabolic pathways in genetic-deficient mice and human pancreatic ductal carcinomas

Chang, H.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Survey and Intervention of Health Literacy among Older Adults

Chi, M.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Association of Epidermal Growth Factor Receptor mutations with HPV16/18 E6 Oncoprotein Expression in Non-Small Cell Lung Cancer

Lee, H.

8/1/137/31/14

Project: C - Project of Alliancer - Tung's Taichung MetroHarbor Hospital

Research of preparation and antibacterial mechanism on metal containing yttria-stabilized zirconia ceramics.

Ou, K.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

In vitro and in vivo evaluation for silk fibroin-coated electrospun resorbable poly(lactic acid) GTR barriers

Yang, J.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Structural and Functional Studies on the Virulence Regulators SaeR/S in Staphylococcus aureus

Liu, C.

12/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Mobile Phone Use and Walking: A Observational Field Study of Pedestrians' Risky Behaviours and Inattentional Blindness

Pai, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

大腸直腸癌已躍居世界上癌症死亡率第二名,屬於固體型腫瘤,缺氧常見於此類 腫瘤,並誘發HIF-1α 表現而導致抗藥性及預後較差,因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑,可殺死癌 細胞而不影響正常細胞,對小鼠也不具毒性。我們初步結果顯示,Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現,代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性,對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下,經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制;也有研究報導指出,藥物會誘導癌細胞產生autophagy,造成細胞過度吞噬其內容 物而死亡,因此,autophagy在癌細胞為保護或是引發毒殺作用,目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活,但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示,除抑制HIF-1α 表現外,Zeb 也可活化AMPK、UPR/ER stress、以及autophagy, 因此我們推測Zeb 可在缺氧狀態下,促進autophagic cell death。3 年內我們將執行4 項 目標: (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。(第一年) (2) 研究Zeb 抑制HIF-1α表現之分子機轉。(第一年到第二年) (3) 研究Zeb 誘發autophagy之分子機轉。(第二年到第三年) (4) 探討Zeb 對缺氧導致抗藥性之作用。(第三年)

Yang, P.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Explore of Toll-Like Receptors Associated Mirna Expression in Ischemic Stroke Patients (I)

Wu, C.

8/1/137/31/14

Project: B - Project of TMUi - Other (Funded by TMU)

Potential of Capsaicin against Advanced Glycation Endproducts Formation

Wu, C.

12/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Gender Analysis of Workplace Violence among Medical Care Personnel

Chen, R.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Hospital Patient Safety Culture-Comparison of Major Measurement Tools, Promotion Methods and Their Evaluation

Kuo, N.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Contribution of Er Stress to Inhibit miR-19a/b and miR-26b-Mediated CTGF Expression in Lung Fibrosis (I)

Chen, Y.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Dissected the role of alpha-7 nicotinic receptor in the prognosis and clinical therapy on gastric cancers

Chang, Y.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

The Effects and Molecular Mechanisms of Phthalates (DEHP and DBP) and Primary Metabolite(MEHP and MEP) on Embryonic Development

Tzeng, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Enhancement of immuno-modulatory capacity by shear stress in mesenchymal stem cells

Ho, J.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

The Roles of Micrornas in Endothelin-1 and Hypoxia-Induced Ctgf Production

Chen, Y.

8/1/127/31/14

Project: B - Project of TMUi - Other (Funded by TMU)

Characterization of 5-Hydroxymethylcytosine and Ten-to-Eleven Translocation Gene (TET) in Cervical Cancer

Lai, H.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

探討 GRP78 作為攝護腺癌化學治療之癒後因子之潛能

Chang, Y.

6/1/137/31/14

Project: C - Project of Alliancep - Taipei Medical University Hospital

Evaluation on Cervical Cancer Prevention and Treatment Policy in Taiwan

Tang, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Role of ER stress in Evodiamine-induced apoptosis and G2/M arrest of human colorectal carcinoma cells

Chen, Y.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Investigating of Transcranial Direct Current Stimulation and Robot-Assisted Gait Training Effects in Subjects with Stroke

Lai, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

TMU101-AE1-B65

Wang, T.

8/1/137/31/14

Project: C - Project of Alliancep - Taipei Medical University Hospital

三陰性乳癌周邊微環境之研究平台建立:以玻尿酸合成酉每Ⅲ抑癌作用為例(1/3)

Ho, Y.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

A Methodology Study of Integrating Systems Thinking and Bayesian Network in Health Policy

Chuang, S.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Mechanism and Functional Study of Sumoylation in Mammalian System

Hwang, J.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Therapeutic Strategies for Traumatic Brain Injury with Novelly Desinged Drugs (II)

Wang, J.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Effects and Mechanisms of Pitx2c Modulation for Atrial Electrophysiological and Structural Remodelings in Heart Failure

Kao, Y.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology