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b - Ministry of Science and Technology

Integrated Bioinformatics Approaches to Study the Mechanisms and Discover Drugs of Hcv-Induced Type 2 Diabetes Mellitus(3/3)

Hsu, K.

8/1/197/31/20

Project: A - Government Institutionb - Ministry of Science and Technology

Liver Kinase B1 Dictates Glutamine Addiction and Gemcitabine Response in Pancreatic Ductal Adenocarcinoma

Chiu, C.

8/1/197/31/20

Project: A - Government Institutionb - Ministry of Science and Technology

Development and Application of Black Soy Bean Koji on Elderly Protein Nourishment( III )

Huang, H.

5/1/195/31/20

Project: A - Government Institutionb - Ministry of Science and Technology

Effect of Bright Light Therapy on Improving Sleep Disburanbce and Its Clustered Symptoms in Cancer Patients

Lin, C., Shiau, F., Lai, Y., Lin, C. & Lee, H.

8/1/117/31/12

Project: A - Government Institutionb - Ministry of Science and Technology

Application of Hyaluronic Acid and Resveratrol Modified Carbon Nanotube Scaffolds for Tissue Engineering

Sheu, S.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Platelets and Platelet-Derived Microparticles For“Trojan Horse” Cancer Therapy (Thct)

Burnouf, T. P. R.

8/1/177/31/18

Project: A - Government Institutionb - Ministry of Science and Technology

Mri Study on Trans-Neuronal Degeneration of the Thalamic Networks after Ischemic Stroke

Chen, C.

8/1/177/31/18

Project: A - Government Institutionb - Ministry of Science and Technology

Development of Electrochemical Sensors for Candida Albicans Diagnos

Fan, Y.

8/1/187/1/19

Project: A - Government Institutionb - Ministry of Science and Technology

Knowledge Translation Research in Evidence-Based Practice Guidelines Methodology Development and Critical Appraisal.

Chen, K.

8/1/197/31/20

Project: A - Government Institutionb - Ministry of Science and Technology

Investigation of Genetic and Cellular Factors in Women with Endometriosis(3/3)

Tzeng, C. & Kao, S.

8/1/197/31/20

Project: A - Government Institutionb - Ministry of Science and Technology

Development and Biomechanical Tests of Poly-L-Lactide Bone Screws with CT Imaging Enhancment and 3D Printing Bifunction

Huang, H.

8/1/157/31/16

Project: A - Government Institutionb - Ministry of Science and Technology

Determined the Role and the Mechanims of GRP94 in Mediating the Progression and Therapeutic Responses of HCC

Huang, M.

8/1/147/31/15

Project: A - Government Institutionb - Ministry of Science and Technology

乳癌是目前世界上女性癌症病患中為數最多的癌症之ㄧ。腺病毒蛋白type 5 E1A (E1A)和許多抗腫瘤作用有關,曾於多種癌症如乳癌、卵巢癌及頭頸癌之病患進行臨床基因治療試驗。許多的研究指出E1A具有多項抗腫瘤的功能,包括抑制腫瘤的發生、增加腫瘤細胞對於化療藥物的感受性以及減少腫瘤轉移的現象。腫瘤的轉移對於癌症患者的死亡率有極大的影響當然也包括了乳癌的患者。E1A於抑制腫瘤發展的過程中具有多重生物學上的意義,這也促使我們想要釐清E1A抑制癌症的機制。因此,我們對於了解E1A抑制癌症轉移相關的分子機制感到有興趣,並期望藉以作為未來改進乳癌病人臨床試驗的基石。我們初步的實驗結果顯示,E1A可以有效的抑制Glucose-regulated protein 78 (GRP78)這種已被廣泛報導和腫瘤惡化及轉移相關的蛋白的表現。 提出此研究計劃之目的在於詳細探討E1A所造成的抑制癌轉移作用中,GRP78所扮演的生物功能及其調控的機轉。為了達到此目的,我們將著重於E1A如何調控GRP78表現並進而展現對乳癌轉移的抑制作用。以下為此項研究計畫的四大主要目標: 目標一:探討GRP78在E1A所抑制之癌細胞移行及侵入作用中所扮演的角色 目標二:研究E1A抑制GRP78表現之分子機轉 目標三:於動物模式中驗證GRP78的表現對於E1A抗腫瘤作用的影響 目標四:探討GRP78及其相關分子的表現在乳癌病人的臨床重要性 完成以上的主要目標能夠幫助我們對於E1A之抗腫瘤轉移作用建立更加詳細的分子訊息傳遞機制。另外,藉由此研究計畫的新發現也許可以對未來發展癌症治療上提供更多具有潛力的標的物。

Wang, W.

8/1/147/31/15

Project: A - Government Institutionb - Ministry of Science and Technology

Studies on the Mechanisms of Apple Polyphenol (Phloretin)-Induced Apoptosis in Human Breast Cancer Cells

Wu, C. & Ho, Y.

8/1/107/31/11

Project: A - Government Institutionb - Ministry of Science and Technology

榖胱甘月太硫轉移酉每參與乳癌致癌之分子機制探討(1/3)

Wu, C.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

The Role of Angiopoietin-Like Protein 1 in Sorafenib Resistance and Cancer Stemness of Hepatocellular Carcinoma Cells

Huang, M.

8/1/167/31/17

Project: A - Government Institutionb - Ministry of Science and Technology

提升臺灣生殖醫學在生育保存領域之國際競爭力及影響力 (1/1)

Tzeng, C.

1/1/1712/31/17

Project: A - Government Institutionb - Ministry of Science and Technology

Remodeling of Neuronal Network after Mild Traumatic Brain Injury: Small Animal Mri

Kao, Y. J.

8/1/177/31/18

Project: A - Government Institutionb - Ministry of Science and Technology

外科系醫學(一)學門規劃研究推動計畫

Wu, C.

1/1/1212/31/12

Project: A - Government Institutionb - Ministry of Science and Technology

榖胱甘月太硫轉移酉每參與乳癌致癌之分子機制探討(3/3)

Wu, C.

8/1/147/31/15

Project: A - Government Institutionb - Ministry of Science and Technology

The Role of Neuropilin-1 Glycosylation in Galectin-1 Induced Activation of Hepatic Stellate Cells and Liver Fibrosis

Wu, M. & Yang, W.

8/1/157/31/16

Project: A - Government Institutionb - Ministry of Science and Technology

Remodeling of Neuronal Network after Mild Traumatic Brain Injury: Small Animal MRI(1/2)

Kao, Y. J.

8/1/167/31/17

Project: A - Government Institutionb - Ministry of Science and Technology

To Study the Role of Pctk1 in the Progression of Colorectal Cancer and Molecular Mechanism

Wei, P.

8/1/177/31/18

Project: A - Government Institutionb - Ministry of Science and Technology

可降解鎂基金屬玻璃做為運動醫學修復手術縫合錨釘之研究開發 (重點主題:A1)(1/3)

Chen, C.

5/1/174/30/18

Project: A - Government Institutionb - Ministry of Science and Technology

New Drug Development Using Dengue VI rus-Infected Mouse Models( III )

Lin, C.

1/1/1812/31/18

Project: A - Government Institutionb - Ministry of Science and Technology

The Role of Angiopoietin-Like Protein 1 in Sorafenib Resistance and Cancer Stemness of Hepatocellular Carcinoma Cells

Huang, M.

8/1/187/1/19

Project: A - Government Institutionb - Ministry of Science and Technology

Study on the Shelf Life and Authenticity of Pressed Oils

Lee, W.

7/1/192/1/20

Project: A - Government Institutionb - Ministry of Science and Technology

國小中年級學生對手部衛生之認知及行為態度的探討

Lin, Y.

7/1/192/1/20

Project: A - Government Institutionb - Ministry of Science and Technology

Developement of Microfluidic-Based Mitochondrial Delivering System for Therapy of Suspending Stem Cell( I )

Fan, Y.

2/1/201/31/21

Project: A - Government Institutionb - Ministry of Science and Technology

Knowledge Translation Research in Evidence-Based Practice Guidelines Methodology Development and Critical Appraisal.

Chen, K.

8/1/187/1/19

Project: A - Government Institutionb - Ministry of Science and Technology

Investigation of Genetic and Cellular Factors in Women with Endometriosis(II)

Tzeng, C.

8/1/187/1/19

Project: A - Government Institutionb - Ministry of Science and Technology

In Vivo Early Neuroimage Profiles of Injurious and Protective Responses in Neonatal Hypoxic-Ischemic Models Using 7t Mri( I )

Kao, Y. J.

8/1/177/31/18

Project: A - Government Institutionb - Ministry of Science and Technology

Biomarkers for the Early Prediction and Prognosis for Colorectal Cancer---Construction of Kinetic

Chang, W. & Wei, P.

8/1/157/31/16

Project: A - Government Institutionb - Ministry of Science and Technology

Study on the Preventive Effect and Mechanism of Germinated Brown Rice and Its Components on Colorectal Cancer

Shih, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

The Role of Angiopoietin-Like Protein 1 in Sorafenib Resistance and Cancer Stemness of Hepatocellular Carcinoma Cells

Huang, M.

8/1/177/31/18

Project: A - Government Institutionb - Ministry of Science and Technology

Application of Foodomics in the Development of an Assay for Food Allergen (Mollusks) On-Site Detection(1/3)

Chen, Y.

8/1/197/31/20

Project: A - Government Institutionb - Ministry of Science and Technology

In Vivo Early Neuroimage Profiles of Injurious and Protective Responses in Neonatal Hypoxic-Ischemic Models Using 7t Mri(3/3)

Kao, Y. J.

8/1/197/31/20

Project: A - Government Institutionb - Ministry of Science and Technology