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• b - Ministry of Science and Technology

  The Effectiveness of Mindfulness-Based Cognitive Therapy (Mbct) for Patients with Depressive Disorders

  Chang, H.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• A series of studies analyzing exercise behavior and exploring the effects of interventions among pre-diabetes, type 1, and type 2 diabetes

  Jeng, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Study of the Trismus Condition of Patients with Head and Neck Cancer Who Have Undergone Concomitant Chemoradiotherapy and the Preventive Effect of Oral Rehabilitation on Trismus

  Jeng, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studying on the Mechanism and Translational Application of Blocking the Protein-Protein Interaction between Galpha-h and PLC-delta1 in Combating Drug-Resistance and Metastasis of Triple-Negative Breast Cancer

  Lin, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• 睡眠困擾是癌症病人最常主訴的問題之一。患有睡眠困擾之癌症病人經常同時伴隨 疲憊、憂鬱等現象發生，形成症狀群集，影響生活品質。雖然目前對於癌症病人睡眠障 礙之量性研究已多有著墨，然而對於癌症病人經歷睡眠障礙之主觀經驗之瞭解，仍相當 有限。瞭解病人經歷睡眠障礙之主觀經驗，將有助於未來睡眠評估工具之修訂。另外， 在評估癌症病人睡眠品質時，若能以簡單工具評估，會更具效率及助益。阿森斯失眠量 表(Athens Insomnia Scale, AIS) 是一個簡單的8 題問卷，廣為使用在一般失眠的病人， 在癌症病人使用上，尚未有豐富的實證資料，若能建立其在癌症病人的信效度，將可作 為一簡單篩檢癌症病人失眠的工具。 睡眠遵行日夜節律規則，日夜節律又需要光作為矯正的線索，光在癌症病人睡眠的 角色，尚未有研究證實，過去研究顯示癌症病人睡眠品質不佳與生物節律有關係。光是 重要日夜節律的線索，光療法透過褪黑激素調節，調整日夜節律週期，可能可以改善睡 眠品質。另外，由於，睡眠障礙、憂鬱、疲憊經常形成一症狀群集，光療法於改善睡眠 障礙之同時，是否亦同時改善憂鬱、疲憊及生活品質。目前，光療法在癌症病人的運用 上，付之闕如，故建立光療法於癌症病人的有效性值得探究。 本研究為三年期研究計畫，目的包括有：1.瞭解癌症個案對於睡眠困擾的主觀經驗 （第一年）。2.建立阿森斯失眠量表中文版的信效度、敏感性、特異性（第一年）。3.瞭 解癌症病人光暴露與生物節率、睡眠障礙的關係（第二年）。4.瞭解光療法對於改善癌 症病人睡眠障礙及相關症狀群集、及生活品質之成效；以及瞭解光療法影響褪黑激素之 程度（第三年）。 本研究擬以癌症住院及門診病人為對象，研究工具包括基本資料、匹茲堡睡眠品質 問卷、阿森斯失眠問卷，簡明疲憊量表，貝克憂鬱量表度、SF-36 生活品質量表、腕動 力器等。資料處理分析方式包括：內容分析、描述性統計、t 檢定、皮爾森相關、GEE (generalized estimating equations)等。 本研究之結果將可瞭解光暴露與生物節率與睡眠障礙之間的關係，並可進一步瞭解 光療法作為改善癌症病人睡眠障礙之護理措施之成效，以期，最終能藉由改善癌症病人 之睡眠品質提昇病人之生活品質。

  Lin, C.

  8/1/12 → 10/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effectiveness of the Physician-Nurse-Pharmacist Collaboration Model in Medication Reconciliation Using National Health Insurance Pharmacloud in Ambulatory Care(2/3)

  Hu, S. H.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Mind-Body Approach to Study Irritable Bowel Syndrome: Role of Psychological Distress, Effectiveness and Mechanisms of Mindfulness Training

  Tsai, P.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effects of Music Therapy on Psychological Distress and Functional Recovery in Patients with Stroke

  Chang, H.

  8/1/14 → 10/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Neuroendocrine-Immune Mechanisms of Physical Activity on Behavioral Symptoms in Lung Cancer Patients---A Comparison of Patients Receiving Active Treatments and Survivors

  Lin, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Islide - a Global Community E-Learning Online

  Li, Y. & Jian, W.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• Exploring the Effects of an Exercise Program on Female Diabetic Patients' Health

  Liao, Y.

  8/1/14 → 8/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Risk of Attempted and Completed Suicide among Patients with Major Physical Disorders: an Instrumental Variable Analysis

  Huang, K.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 罹患重大精神與生理疾病的病人之自殺風險性以及超額死亡的探討：嵌入型病例對照研究設計

  Huang, K.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Establishment of a Biophysical Effect-Based Platform for Rapid Expansion of Functional Mesenchymal Stem Cells

  Ho, J.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effect of Hdac Inhibitor in Bleomycin-Induced Pulmonary Fibrosis: Targeting on Niche Interaction between Stromal Cells and Stem/Progenitor Cells(3/3)

  Lin, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Developing an Assessment and Rehabilitation System for Improving Bilateral Ankle Coordination Control and Functional Performances of Lower Limbs Following Chronic Stroke

  Lin, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 新穎性DYRK1A抑制劑於阿茲海默症之機轉探討(2/3)

  HuangFu, W.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 肺纖維化之分子病理機制探討-ADAM17/preadipocyte factor-1在缺氧誘導CTGF表現及呼吸道纖維化角色探討(3/3)

  Chen, B.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation of Inflammatory Microenvironment-Regulated Stemess in Glioblastoma

  Ko, C.

  10/1/16 → 9/30/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Epigenetic Targeting for Potential Tumor Suppressor Genes, Poldip2 and Sox1, with Investigations of Prognostic and Therapeutic Implications in Non-Small Cell Lung Cancer(3/3)

  Tzao, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討桌遊對獨居長者的生活滿意、憂鬱及幸福感的影響

  Lin, C.

  7/1/19 → 2/1/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討以網絡平台及個人化為基礎的認知行為治療方案 (Deprexis) 在台灣憂鬱症個案的成效: 隨機對照試驗(1/3)

  Chang, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 菸品廣告對於大學生吸菸媒介素養、吸菸態度與行為之影響

  Liu, F.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of CD24 in TNF-Alpha-Inhibited Erythroid Differentiation

  Huang, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Taiwan R＆D Survey Design and Development ─ Enterprise Questionnaire

  Shia, B.

  4/1/15 → 12/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Molecular and cellular mechanism of adipocyte modulatory effects on pulmonary vein and atrium

  Chen, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Clinical Outcome and Drug Resistant Biomarkers Establish for Hpv Infected Non-Small Cell Lung Cancer

  Hsu, N.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development and Effectiveness Research of Rhythm Light Regulating Physiological Index, Sleep and Emotion

  Chung, M.

  11/1/18 → 10/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Fibromyalgia: Impacts of Different Phenotypes on Quality of Life and the Effects of Technology-Assisted and Tailored Health Coaching

  Tsai, P.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 繪本教學介入對學齡期自閉症兒童人際互動之成效探討

  Kuo, S.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討第一型內皮細胞分子與上皮細胞生長因子受體之相互調控在非小細胞肺癌進程之角色(3/3)

  Chien, M.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 抑制site-1蛋白酶引發肝癌細胞自我吞噬之研究

  Yang, P.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討真實與虛擬藍色工作環境對壓力與焦慮之影響

  Yen, H.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects and Mechanisms of Pitx2c Modulation for Atrial Electrophysiological and Structural Remodelings in Heart Failure

  Kao, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 腦創傷後的神經再生研究(2/5)

  Chuang, J.

  2/1/21 → 1/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Methodology Study of Integrating Systems Thinking and Bayesian Network in Health Policy

  Chuang, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 大腸直腸癌已躍居世界上癌症死亡率第二名，屬於固體型腫瘤，缺氧常見於此類 腫瘤，並誘發HIF-1α 表現而導致抗藥性及預後較差，因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑，可殺死癌 細胞而不影響正常細胞，對小鼠也不具毒性。我們初步結果顯示，Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現，代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性，對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下，經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制；也有研究報導指出，藥物會誘導癌細胞產生autophagy，造成細胞過度吞噬其內容 物而死亡，因此，autophagy在癌細胞為保護或是引發毒殺作用，目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活，但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示，除抑制HIF-1α 表現外，Zeb 也可活化AMPK、UPR/ER stress、以及autophagy， 因此我們推測Zeb 可在缺氧狀態下，促進autophagic cell death。3 年內我們將執行4 項 目標： (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。（第一年） (2) 研究Zeb 抑制HIF-1α表現之分子機轉。（第一年到第二年） (3) 研究Zeb 誘發autophagy之分子機轉。（第二年到第三年） (4) 探討Zeb 對缺氧導致抗藥性之作用。（第三年）

  Yang, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Dissection of Synergistic Involvement among Different Guidance Families in Spinal Motor Neuron Development

  Kao, T.

  12/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effect of Smart Care Model on the Improvement of Physical and Psychological Adaptation among Patients with Liver Cirrhosis

  Huang, H.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 內毒素引發肺迷走感覺神經過度敏感 ：Sigma-1受器的角色

  Hsu, C.

  7/1/19 → 2/1/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Changes in Cognitive Functions in Patients with Recovery Stage of Traumatic Brain Injury: Effects and Mechanism of Neurofeedback(2/3)

  Chiu, H.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Changes in Cognitive Functions in Patients with Recovery Stage of Traumatic Brain Injury: Effects and Mechanism of Neurofeedback(3/3)

  Chiu, H.

  8/1/19 → 10/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Utilizing Artificial Intelligence Vi Rtual Screening Platform to Identify a Small-Molecule Inhibitor of Dna Polymerase Theta and Estimating Its Therapeutic Effectiveness on Metastatic Castration-Resistant Prostate Cancer

  Lin, Y.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Sarcopenia in Patients with Liver Cirrhosis: Validation of Screening Methods and Evaluation of Exercise and Nutritional Supplementation( I )

  Huang, H.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Molecular Basis of Senp2 in Regulating Smad4 Sumoylation and Its Functions in Triple Negative Breast Cancer(2/3)

  Chang, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以重要性－績效分析法探討床邊資訊系統之研究

  Wen, H.

  7/1/19 → 2/1/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation of the Transcriptional and Epigenetic Mechanisms for the Nm23-H1 Expression---An Nm23-H1-Promoter Screening Platform for Novel Metastasis-Suppressing Anticancer Drugs

  Wang, L.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討病原感染之共同激活分子脾酪氨酸蛋白激?Syk調節NLRP3、NLRC4及AIM2發炎小體活化的分子作用機制(1/3)

  Lin, W.

  1/1/15 → 12/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 輔助學習疾病專業術語之APP設計與評估

  Chang, W. P.

  7/1/17 → 2/28/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies of Roles of SIRT7 in Cancer Biology

  Tsai, Y.

  1/1/14 → 10/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology