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• b - Ministry of Science and Technology

  以新穎微管陣列膜做為長效性內分泌療法載體對缺氧性器官損傷之修護效能評估(2/4)

  Lundy, D.

  2/1/21 → 1/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Ｄevelop an Interactive Game to Improve Cognition in Elderly

  Chang, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 新神經與疼痛相關蛋白抗體開發-抗酸敏感離子通道3蛋白的抗體製備與定性

  Yang, Y.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 中風後視覺依賴與早期多重感覺平衡復健介入之成效探討(2/3)

  Lee, S.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Linkage with Artificial Intelligence for the Development of Brainwave Music Playback System to Improve Sleep

  Chung, M.

  11/1/19 → 10/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigating Nerve Regeneration Following Traumatic Brain Injury( I )

  Chuang, J.

  2/1/20 → 1/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 產學合作計畫－開發千根草於調控骨頭再塑產品之應用

  Lee, M.

  11/1/20 → 10/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 青銀共融數位體感遊戲對憂鬱傾向高齡者之成效

  Chiu, H.

  7/1/21 → 2/28/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Biomarkers Associated with Toll-Like Receptors and Neuroimage Study in Ischemic Stroke Patients (II)

  Hu, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Emerging Role That Splicing Factor Plays in the Adipose Development

  Lin, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Study of the Trismus Condition of Patients with Head and Neck Cancer Who Have Undergone Concomitant Chemoradiotherapy and the Preventive Effect of Oral Rehabilitation on Trismus

  Jeng, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討大葉樹蘭萃取物Rocaglamide A 對三陰性乳癌的影響及其作用機制

  Huang, T.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 購物中心步行在地方案建立與驗證(1/2)

  Chang, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 新穎癌幹細胞侵犯腳治療標靶之整合性蛋白質體、基因體、小分子與功能篩選：聚焦細胞表面AMFR於侵犯性消化道癌症治療標的(2/3)

  Tsai, K. K.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 開發ㄧ奈米粒子水膠複合系統作為手術後的DNA疫苗以預防癌症之復發

  Pan, W.

  11/1/20 → 10/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 大腸直腸癌已躍居世界上癌症死亡率第二名，屬於固體型腫瘤，缺氧常見於此類 腫瘤，並誘發HIF-1α 表現而導致抗藥性及預後較差，因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑，可殺死癌 細胞而不影響正常細胞，對小鼠也不具毒性。我們初步結果顯示，Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現，代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性，對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下，經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制；也有研究報導指出，藥物會誘導癌細胞產生autophagy，造成細胞過度吞噬其內容 物而死亡，因此，autophagy在癌細胞為保護或是引發毒殺作用，目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活，但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示，除抑制HIF-1α 表現外，Zeb 也可活化AMPK、UPR/ER stress、以及autophagy， 因此我們推測Zeb 可在缺氧狀態下，促進autophagic cell death。3 年內我們將執行4 項 目標： (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。（第一年） (2) 研究Zeb 抑制HIF-1α表現之分子機轉。（第一年到第二年） (3) 研究Zeb 誘發autophagy之分子機轉。（第二年到第三年） (4) 探討Zeb 對缺氧導致抗藥性之作用。（第三年）

  Yang, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Mobile Intelligent Personal Medication Management Platform (III)

  Li, Y.

  11/1/10 → 10/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Taiwan Fall-Risk Screening Tool for Community-Dwelling Older People and a Randomized Controlled Trial of Fall Prevention in the Cognitively Impaired

  Lin, M.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• (100SB205)The Resource Center Project from the Joint Biorepository of Taipei Medical University Affiliated and Alliance Hospitals

  Li, Y.

  12/1/11 → 3/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Bone-Marrow-Derived Mesenchymal Stem Cells in Prostate Cancer-Induced Bone Remodeling

  Hsieh, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of miR-21 in Regulating TET I-Hydroxymethylcytosine and Chemotherapeutic Response in Colorectal Cancer (I)

  Yang, P.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Gender Analysis of Workplace Violence among Medical Care Personnel

  Chen, R.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Infant Feeding Information in the Internet and How the Information Influences the Infant Feeding Behavior

  Chen, Y. C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Fish Oil on Alcoholic Liver Disease in Rats Based on Pathological Mechanisms

  Yang, S.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Publication of Journal of Biomedical Science

  Chang, W.

  1/1/11 → 12/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Publication of Journal of Biomedical Science

  Chang, W.

  1/1/15 → 3/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of Ddx3 in Cetuximab Resistance in Kras-Mutated and -Wild-Type Colorectal Cancer ( I )

  Lee, H.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Associated Factors of Smoking around School-Aged Children and the Intervention Development Using the Theory of Reasoned Action

  Chen, P. & Shiau, F.

  8/1/10 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• Surface Adsorption of Nanomaterials in Applications for Gas Sensor and Catalyst

  Lin, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Community-Based Screening and Prevention Model for Periodontal Disease

  Chen, L.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study the Klf10 Alters Metabolic Pathways in Genetic-Deficient Mice and Human Pancreatic Ductal Carcinomas

  Chang, H.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effectiveness of Hormonal Therapy on Prostate Cancer Bone Metastasis Determined by Klf4

  Liu, Y.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 內毒素引發肺迷走感覺神經過度敏感 ：Sigma-1受器的角色

  Hsu, C.

  7/1/19 → 2/1/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Preparation of Nanocrystalline Dielectric Composite Materials and Electromagnetic Absorbing Characterization (Ii)

  Lin, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of Advanced Glycation End Products on Proliferation of Leiomyoma Cell and Stem Cell: in Vivo and in Vitro Study

  Hsia, S.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Deep Learning-based analysis with Multi-Omics data for prognosis prediction of Prostate Cancer

  Chang, T.

  7/1/19 → 2/1/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 基於深度學習與機器學習混合分析多體學數據於癌症精準醫學治療之應用評估(2/2)

  Chang, T.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• An Industry-University Alliance on Pilot-Type Animal Experimental Consultancy and Analytic Platforms(3/3)

  Chang, H.

  2/1/20 → 1/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 治療膠質母細胞瘤之新穎小分子多標靶抗癌藥物之設計合成與開發

  Huang, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 中台灣跨校整合科研產業化平台計畫I

  Lin, C.

  10/1/20 → 12/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討台灣型式Cafeteria飲食誘導大鼠非酒精性脂肪肝臟疾病肝臟及腸道損傷現象

  Chen, Y.

  7/1/21 → 2/28/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 運用機器學習演算法透過基因體資訊挖掘未知基因的功能與預測細菌抗藥性(2/3)

  Wu, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 腦創傷老人中長期多重功能變化以及整體功能評估工具在輕度腦創傷老人之檢驗(1/3)

  Lin, M.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以腸-肝-肌肉軸觀點探討腸道健康促進因子對於酒精性肝臟疾病大鼠腸漏症、腸道菌相多樣性及肌少症的影響(3/3)

  Yang, S.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 為腎臟替代療法患者建立永續發展的營養照護生態系統

  Yang, S.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 污染場址距離對國小學生重金屬暴露之影響與健康風險評估

  Chien, L.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 應用人工智慧於評估牙體形態優劣之研究

  Shen, Y.

  7/1/19 → 2/1/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Can Sesamin Alone or Cotheapy with Anti-DM Medicines Alleviate the Abnormal Intermediate Metabolites of Glucose and Fatty Acids, the Oxygen Consumption and Renal Fibrotic Progression?

  Peng, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Perceptions towards Evidence-Based Decision-Making among Public Health Teachers and Students: a National Survey in Taiwan

  Chiu, Y.

  8/1/16 → 10/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Alternative Treatments for Parkinson$S Disease

  Chen, K.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology