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b - Ministry of Science and Technology

Personal Traits of Circadian Rhythm and Treatment Efficacy on Emotional Regulation in Insomnia

Wu, C.

1/1/1712/31/17

Project: A - Government Institutionb - Ministry of Science and Technology

Application Study on Niti Shape Memory Alloy Scaffolds

Fan, F.

8/1/197/31/20

Project: A - Government Institutionb - Ministry of Science and Technology

Platform of Digital Oral Industry Alliance( II )

Shen, Y.

2/1/201/31/21

Project: A - Government Institutionb - Ministry of Science and Technology

Deep Learning-based analysis with Multi-Omics data for prognosis prediction of Prostate Cancer

Chang, T.

7/1/192/1/20

Project: A - Government Institutionb - Ministry of Science and Technology

A Investigation of Ccl5(Rantes) in Neurogenesis Mechanism

Chou, S.

2/1/131/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

探討HIV-1反轉錄酉每與新穎先導藥物之複合體結構以利優化作為抗HIV候選藥物

Liu, C.

8/1/1410/31/15

Project: A - Government Institutionb - Ministry of Science and Technology

大腸直腸癌已躍居世界上癌症死亡率第二名,屬於固體型腫瘤,缺氧常見於此類 腫瘤,並誘發HIF-1α 表現而導致抗藥性及預後較差,因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑,可殺死癌 細胞而不影響正常細胞,對小鼠也不具毒性。我們初步結果顯示,Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現,代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性,對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下,經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制;也有研究報導指出,藥物會誘導癌細胞產生autophagy,造成細胞過度吞噬其內容 物而死亡,因此,autophagy在癌細胞為保護或是引發毒殺作用,目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活,但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示,除抑制HIF-1α 表現外,Zeb 也可活化AMPK、UPR/ER stress、以及autophagy, 因此我們推測Zeb 可在缺氧狀態下,促進autophagic cell death。3 年內我們將執行4 項 目標: (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。(第一年) (2) 研究Zeb 抑制HIF-1α表現之分子機轉。(第一年到第二年) (3) 研究Zeb 誘發autophagy之分子機轉。(第二年到第三年) (4) 探討Zeb 對缺氧導致抗藥性之作用。(第三年)

Yang, P.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

以量化感覺神經評量(QST)測試下顎齒槽神經受損後感覺恢復與神經修復的關係

Wu, C.

7/1/172/28/18

Project: A - Government Institutionb - Ministry of Science and Technology

學前幼童行動裝置使用的影響因子:對數位時代兒童之健康發展衝擊為何?

Chen, Y.

7/1/192/1/20

Project: A - Government Institutionb - Ministry of Science and Technology

Motor Signature, Falls Risk, and Home-Based Interventions in Older Adults with Mild Cognitive Impairment(3/3)

Lin, M.

8/1/197/31/20

Project: A - Government Institutionb - Ministry of Science and Technology

The Physical Properties and Biocompatibility of Orthodontic Elastomeric Chain after Nanoimprint Surface Treatment

Cheng, H.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Effects of a Cognitive Behavioral Self-Help Intervention on Immigrant Life Stress for Immigrant Women Who Are Divorced

Kuo, S. & Lin, Y.

8/1/157/31/16

Project: A - Government Institutionb - Ministry of Science and Technology

Medical Humanistic View of Young Physicians: the Comparison of Taiwan and Indonesia

Kao, M.

8/1/1110/31/12

Project: A - Government Institutionb - Ministry of Science and Technology

利用跨顱交流電刺激影響腦波頻率與相位差探討視覺記憶歷程的神經機制(2/3)

Tseng, P.

12/1/1611/30/17

Project: A - Government Institutionb - Ministry of Science and Technology

The exploitation of Taiwan native plants in promoting bone growth and establishment of the system biology platform

Lee, M.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Bone-Marrow-Derived Mesenchymal Stem Cells in Prostate Cancer-Induced Bone Remodeling

Hsieh, C.

8/1/147/31/15

Project: A - Government Institutionb - Ministry of Science and Technology

Design and Evaluation of a Novel Drug-Containing Ceramic Hydrogel for the Healing of Alveolar Bone Defect

Lee, S.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

利用結構生物學探討金黃色葡萄球菌之新穎醣基轉移蛋白質功能與結構之研究(2/3)

Liu, C.

8/1/167/31/17

Project: A - Government Institutionb - Ministry of Science and Technology

Changes in Cognitive Functions in Patients with Recovery Stage of Traumatic Brain Injury: Effects and Mechanism of Neurofeedback(2/3)

Chiu, H.

8/1/187/1/19

Project: A - Government Institutionb - Ministry of Science and Technology

Mental Health and Related Factors among Temporary International Migrant Workers in Taiwan

Chuang, K.

8/1/187/1/19

Project: A - Government Institutionb - Ministry of Science and Technology

The Role of Advanced Glycation End Products on Proliferation of Leiomyoma Cell and Stem Cell: in Vivo and in Vitro Study

Hsia, S.

8/1/187/1/19

Project: A - Government Institutionb - Ministry of Science and Technology

The Promise of Prenatal Genetic Screening and Testing: Noninvasive Prenatal Diagnosis in Taiwan

Shih, L.

8/1/187/1/19

Project: A - Government Institutionb - Ministry of Science and Technology

Involvement of Genes Encoding Apoptosis Regulatory Pathway in the Pathogenesis of Hyperglycemia in Acute Ischemic Stroke

Hsieh, Y.

8/1/187/1/19

Project: A - Government Institutionb - Ministry of Science and Technology

What Is an Insect? Genome Evolution of Insects Relative to Other Pancrustaceans

Chen, C.

8/1/187/1/19

Project: A - Government Institutionb - Ministry of Science and Technology

失調的大腦時鐘?探討老化歷程如何改變大腦網路的晝夜節律

Wu, C.

7/1/192/1/20

Project: A - Government Institutionb - Ministry of Science and Technology

Health Effects of Active Transport

Yen, H.

8/1/197/31/20

Project: A - Government Institutionb - Ministry of Science and Technology

Identification of Rewired APC Mutation Signaling Network in Chemotherapy Resistant Response in Colorectal Cancer (I)

Huang, T.

8/1/1410/31/15

Project: A - Government Institutionb - Ministry of Science and Technology

The First Randomized Controlled Clinical Trial for Computerized Decision Support System (II)

Li, Y.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

The Role of Cytoplasmic APe1 in Tumor Malignancy, Drug Resistance and Lung Cancer Prognosis

Lee, H.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Outcome Evaluation of Self-Reflection Education and Parent-Child Interaction on Screen Activity in Preschool Children

Chen, S.

8/1/167/31/17

Project: A - Government Institutionb - Ministry of Science and Technology

Depression Trajectories in Women – a Developmental-Ecological Approach (Gm03)

Kuo, S.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Studies of Interaction Effects between Ketone Metabolism and Mitochondrial Function and Biogenesis

Hsieh, R.

8/1/187/1/19

Project: A - Government Institutionb - Ministry of Science and Technology

抗組織胺藥物ketotifen抑制肝癌細胞生長之機制探討

Liang, Y.

7/1/192/1/20

Project: A - Government Institutionb - Ministry of Science and Technology

Integrations and Applications of Health and Clinical Big Data

Cheng, K.

4/1/159/30/15

Project: A - Government Institutionb - Ministry of Science and Technology

Hospital Patient Safety Culture-Comparison of Major Measurement Tools, Promotion Methods and Their Evaluation

Kuo, N.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

探討microRNA96在轉化生長因子β導致的癌症演進過程的角色(3/3)

Tsai, Y.

8/1/177/31/18

Project: A - Government Institutionb - Ministry of Science and Technology

國際青年之科技風險認知比較調查與建立雙向風險溝通數位平台

Chang, W.

8/1/167/31/17

Project: A - Government Institutionb - Ministry of Science and Technology

The Effect of Muscle Strength Training on Body Composition and Sarcopenic Obesity among the Female Overweight Elderly

Liou, T.

8/1/157/31/16

Project: A - Government Institutionb - Ministry of Science and Technology

The Effect of Long Acting GnRH Agonist Treatment on Mitochondrial Function in

Tzeng, C.

8/1/147/31/15

Project: A - Government Institutionb - Ministry of Science and Technology