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運用有機金屬偶聯反應於抗癌試劑合成(1/2)

Liou, J.

8/1/177/31/18

Project: A - Government Institutionb - Ministry of Science and Technology

Mechanisms and Clinical Applications of Transcranial Direct Current Stimulation in Treating Patients with Firbomyalgia

Kang, J., Chen, S. & Lee, H.

8/1/117/31/12

Project: A - Government Institutionb - Ministry of Science and Technology

HDAC抑制劑對bleomycin誘發肺纖維化的作用:主要透過stromal cells和stem/progenitor cells交互作用(1/3)

Lin, C.

8/1/177/31/18

Project: A - Government Institutionb - Ministry of Science and Technology

探討早幼粒細胞白血病鋅指蛋白之核轉移對糖化終產物造成血管內皮病變之保護作用及其分子機制(3/3)

Chen, C.

8/1/177/31/18

Project: A - Government Institutionb - Ministry of Science and Technology

探討牙週病與帕金森氏症病理衍生過程之潛在關連:評估血漿製劑為可行之治療策略(2/2)

Chang, H.

8/1/1810/1/19

Project: A - Government Institutionb - Ministry of Science and Technology

鎂表面改質新式骨移植材之開發研究(1/2)

Chang, W.

8/1/177/31/18

Project: A - Government Institutionb - Ministry of Science and Technology

巴金森氏症之新穎療法

Chen, K.

8/1/177/31/18

Project: A - Government Institutionb - Ministry of Science and Technology

亞甲基四氫葉酸脫氫?(MTHFD2)對於肺癌癌幹細胞特性和腫瘤生成的影響及機制之研究(2/2)

Deng, W.

8/1/187/1/19

Project: A - Government Institutionb - Ministry of Science and Technology

助孕酮受器在葉酸抑制腫瘤細胞生長及轉移所扮演的角色(1/3)

Lee, W.

8/1/187/1/19

Project: A - Government Institutionb - Ministry of Science and Technology

細胞外基質蛋白Nephronectin在腎小管細胞形成緊密連結的功能角色探討(1/2)

Cheng, C.

8/1/177/31/18

Project: A - Government Institutionb - Ministry of Science and Technology

利用石墨烯改質去細胞化細胞外基質結合骨髓凝集物於前十字韌帶部分撕裂癒合之應用(2/3)

Chen, C.

8/1/177/31/18

Project: A - Government Institutionb - Ministry of Science and Technology

Research of Wear Resistance and Biocompatibility on Dental Drills Surface with TiAlN Films

Huang, M.

8/1/117/31/12

Project: A - Government Institutionb - Ministry of Science and Technology

鑑定Gαh-連結型的接受器及探討其於三陰性乳癌之轉譯醫學應用

Lin, Y.

8/1/187/1/19

Project: A - Government Institutionb - Ministry of Science and Technology

生命科技相關科技發展計畫規劃、審議及管考諮詢之研究

Chang, W.

1/1/1712/31/17

Project: A - Government Institutionb - Ministry of Science and Technology

未成年期慢性砷暴露對砷代謝基因甲基化程度及癌症罹病風險之相關性研究(3/3)

Chiou, H.

8/1/177/31/18

Project: A - Government Institutionb - Ministry of Science and Technology

Syntheses of Anti-Lung Cancer Agents(1/2)

Liou, J.

6/1/175/31/18

Project: A - Government Institutionb - Ministry of Science and Technology

107大專生計畫獎-蔡伊琳

Tsai, I.

8/1/187/31/19

Project: A - Government Institutionb - Ministry of Science and Technology

組織胺甲基化轉換酵素(HNMT)輔助臨床醫師鑑別乳癌病患作為Herceptin療效評估之新穎分子標記(1/3)

Ho, Y.

8/1/197/31/20

Project: A - Government Institutionb - Ministry of Science and Technology

107大專生計畫獎-陳莉菁

Chen, L.

8/1/187/31/19

Project: A - Government Institutionb - Ministry of Science and Technology

Study on the Preventive Effect and Mechanism of Germinated Brown Rice and Its Components on Colorectal Cancer

Shih, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Translational Studies of Mycobacterium Tuberculosis-Induced Lung and Pleural Fibrosis

Lin, C.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

The Effect and Mechanisms of Chemotherapy in Recruit Inflammatory Cells into Tumor Microenvironment of Lung Cancer Patients

Feng, P. & Lee, K.

8/1/157/31/16

Project: A - Government Institutionb - Ministry of Science and Technology

The Role of SUV39H1 in Control of Inflammatory Genes and in Chronic Inflammation of Copd

Lee, K., Feng, P. & Chuang, H.

8/1/157/31/16

Project: A - Government Institutionb - Ministry of Science and Technology

即時移動污染源自體排放超細懸浮微粒之車載毒性測試平台建立與應用評估

Chuang, H.

9/5/179/4/18

Project: A - Government Institutionb - Ministry of Science and Technology

Effect of Pacemaker Current Inhibitor (Ivabradine) on Sinoatrial Node Function and Pulmonary Vein Arrhythmogenesis

Lin, Y.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Chronic Obstructive Pulmonary Disease Modulate Electrophysiological Properties and Arrhythmogenesis of Pulmonary Vein and Atrium

Lin, Y.

8/1/157/31/16

Project: A - Government Institutionb - Ministry of Science and Technology

Macro and Micro Biomechanical Studies of Soft Tissue Remodeling under Tissue Expansion

Chen, H.

8/1/1111/30/12

Project: A - Government Institutionb - Ministry of Science and Technology

Studies of Anti-Cancer Activity of Folic Acid

Lee, W.

8/1/147/31/15

Project: A - Government Institutionb - Ministry of Science and Technology

探討EGFR基因表現與合併藥物對攝護腺癌治療的影響(3/3)

Liu, Y.

8/1/177/31/18

Project: A - Government Institutionb - Ministry of Science and Technology

多功能活性血漿物質包覆光熱敏感性高分子奈米載體做為抗癌治療技術平台(1/2)

Chuang, E.

8/1/177/31/18

Project: A - Government Institutionb - Ministry of Science and Technology

乳癌是目前世界上女性癌症病患中為數最多的癌症之ㄧ。腺病毒蛋白type 5 E1A (E1A)和許多抗腫瘤作用有關,曾於多種癌症如乳癌、卵巢癌及頭頸癌之病患進行臨床基因治療試驗。許多的研究指出E1A具有多項抗腫瘤的功能,包括抑制腫瘤的發生、增加腫瘤細胞對於化療藥物的感受性以及減少腫瘤轉移的現象。腫瘤的轉移對於癌症患者的死亡率有極大的影響當然也包括了乳癌的患者。E1A於抑制腫瘤發展的過程中具有多重生物學上的意義,這也促使我們想要釐清E1A抑制癌症的機制。因此,我們對於了解E1A抑制癌症轉移相關的分子機制感到有興趣,並期望藉以作為未來改進乳癌病人臨床試驗的基石。我們初步的實驗結果顯示,E1A可以有效的抑制Glucose-regulated protein 78 (GRP78)這種已被廣泛報導和腫瘤惡化及轉移相關的蛋白的表現。 提出此研究計劃之目的在於詳細探討E1A所造成的抑制癌轉移作用中,GRP78所扮演的生物功能及其調控的機轉。為了達到此目的,我們將著重於E1A如何調控GRP78表現並進而展現對乳癌轉移的抑制作用。以下為此項研究計畫的四大主要目標: 目標一:探討GRP78在E1A所抑制之癌細胞移行及侵入作用中所扮演的角色 目標二:研究E1A抑制GRP78表現之分子機轉 目標三:於動物模式中驗證GRP78的表現對於E1A抗腫瘤作用的影響 目標四:探討GRP78及其相關分子的表現在乳癌病人的臨床重要性 完成以上的主要目標能夠幫助我們對於E1A之抗腫瘤轉移作用建立更加詳細的分子訊息傳遞機制。另外,藉由此研究計畫的新發現也許可以對未來發展癌症治療上提供更多具有潛力的標的物。

Wang, W.

8/1/147/31/15

Project: A - Government Institutionb - Ministry of Science and Technology

Effects of Nutrients Supplementation on Damaged Mitochondria and Their Biogenesis and Turnover

Hsieh, R.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Epigenetic Editing as a Novel Therapeutics for Gynecological Cancer

Lai, H.

8/1/167/31/17

Project: A - Government Institutionb - Ministry of Science and Technology

探討神經纖毛蛋白質-1醣基化對半乳糖凝集素-1引發肝臟星狀細胞活化及肝臟纖維化的影響(3/3)

Wu, M.

8/1/169/30/17

Project: A - Government Institutionb - Ministry of Science and Technology

未成年期慢性砷暴露對砷代謝基因甲基化程度及癌症罹病風險之相關性研究(2/3)

Chiou, H.

8/1/167/31/17

Project: A - Government Institutionb - Ministry of Science and Technology

神經動態活動結構的生化相關物 - 一項多模態研究(3/3)

Duncan, N.

8/1/1812/1/19

Project: A - Government Institutionb - Ministry of Science and Technology

核糖核?酸還原?在骨骼肌老化過程中所扮演的角色:RRM2B於修復與再生上的功能分析(3/3)

Chen, Y.

8/1/187/1/19

Project: A - Government Institutionb - Ministry of Science and Technology

探討PCTK1激?蛋白在大腸直腸癌發展的角色及其調控機制(延續計畫)(1/3)

Wei, P.

8/1/187/1/19

Project: A - Government Institutionb - Ministry of Science and Technology

國際產學聯盟計畫III

Lin, C.

9/1/198/31/20

Project: A - Government Institutionb - Ministry of Science and Technology

Sub-Project 1: Mechanisms and Effects of Paired Associative Nerve Stimulation in Spinal Cord Injured Animal Models( I )

Peng, C.

8/1/197/31/20

Project: A - Government Institutionb - Ministry of Science and Technology

以結核分枝桿菌核酸增幅檢驗診斷疑似肺結核患者之研究

Chiang, C.

8/1/197/31/20

Project: A - Government Institutionb - Ministry of Science and Technology