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• b - Ministry of Science and Technology

  價創計畫：AI重大疾病早覺管理

  Li, Y.

  7/1/20 → 12/1/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 新穎性DYRK1A抑制劑於阿茲海默症之機轉探討(2/3)

  HuangFu, W.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 發展標靶galectin-1的單區域抗體來治療sorafenib抗藥性的肝癌

  Wu, M.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 具韌性的謀生方式：台灣原民部落文化中的生態與土地經營整合研究－社會經濟與原民部落韌性生活方式: 以新竹尖石鄉後山兩個部落為例(2/3)

  Lin, Y.

  1/1/21 → 12/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Using Geographic Information Systems to Evaluate the Association of Air Pollution with Neurodevelopment among Preterm Children in the Greater Taipei Area

  Chao, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• 抗氧化防禦基因標籤單核?酸多形性、氧化壓力生物標記與冠狀動脈心臟病之相關性(2/2)

  Yeh, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The First Randomized Controlled Clinical Trial for Computerized Decision Support System

  Li, Y.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• Construction of Pathway Networks for Biological Processes by Data Mining of Protein-Protein Interactions and Gene Expression

  Chiu, H.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

• Analysis the Role of Adam9 as Novel Biosignature in Prostate Cancer Malignant Progression

  Sung, S.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• An fMRI Study of Moral Judgment: The Modulating Effects of Emotion and Religious Belief(3/3)

  Lane, T. J.

  1/1/17 → 12/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• On Risk Governance and Administrative Law: Judicial Review under the Context of National Health Insurance Healthcare Providers Contract as an Example(1/2)

  Liang, C.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Degradation of Phenol and Chlorophenols by Manganese Dioxide-Chitin Hybrid Material in Ground Wate

  Hu, C.

  11/1/18 → 10/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Biomedicine and Health Innovations: What Role for Law in the Global Bio-economy(2/5)

  Lee, T.

  3/1/20 → 2/28/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以FHIR架構建置齒顎矯正科之個案管理系統

  Chiu, H.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 牙科用鈦植體表面製備具降解性鈣磷化合物並接枝含生長因子之奈米顆粒以促進其骨整合反應

  Sun, Y.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 辨認癌化過程中 adenosine至inosine RNA編輯的調控因子

  Chen, C.

  10/1/16 → 10/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effectiveness of Hormonal Therapy on Prostate Cancer Bone Metastasis Determined by Klf4

  Liu, Y.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Artificial Intelligence Grading of Rotator Cuff Tendinopathy Using Real-Time Elastography

  Lo, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Differentiation of Literati-Gentry Strata and the Construction of Citizenship in the Late Qing Dynasty and the Early Republican Period: a Cultural Pragmatics Approach(2/2)

  Tsai, P.

  8/1/18 → 9/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Construction of a Coronary Computed Tomographic Angiography-Based, Imaging/Physiology Mega-Databank to Develop Artificial Intelligence-Facilitated Automatic Diagnostic/Prediction Systems through a Multi-Center, Cross-Specialty Consortium(3/3)

  Lee, C.

  12/1/19 → 11/30/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探索蝦急性肝胰腺壞死病毒素 PirAvp 與 PirBvp 之活化機制與中和策略(1/3)

  Wang, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 休眠前列腺癌細胞之代謝調節

  Kung, H.

  9/1/20 → 8/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Mixed Pharmceuticals Adsorption, Oxidation and Catalytic Chlorination by Metal Oxides

  Hu, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Combination Treatment of Tetrac- and Cetuximab-Induced Anti-Proliferation in Colorectal Cancer with Different APC Status (I)

  Lin, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Saliva Alkaloids of Areca Nut or Tobacco, Inflammatory and Antioxidants Status and Oral Hygiene in Periodontitis Patients

  Huang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Analyses of ADAM9 on Integrin b4 Turnover to Facilitate Prostate Cancer Migration and Invasion

  Sung, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Computational Analysis of Regulatory Networks of Extracellular Matrix in Endometrial Cancer Development and Discovery of Potential Drugs for Therapy

  Chang, T.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Cultivation‭ ‬Of Mindfulness‭ ‬Via‭ ‬The‭ ‬Intelligent Neurofeedback‭ ‬And‭ ‬Disciplinary‭ ‬ Vi Rtual Reality‭ (‬Mindvr‭)‬‭ ‬Platform‭ ‬On Middle-Aged and Elderly Population

  Wu, C.

  6/1/19 → 5/1/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study a Novel Klf10 (Kruppel-Like Transcription Factor10) Regulated Mechanism in Non-Alcoholic Fatty Liver Disease (Nafld) (Continued Project)

  Chang, H.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Victorian Sanitation: Narratives of Poverty, Filth and Economy of Morality

  Chen, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Enacting Pregnant Women, Enacting the Foetus Prenatal Screening and Testing in Taiwan

  Shih, L.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Applying Stochastic Process Models for the Disease Progression, Implication for Prevention and Cost-Effectiveness Analysis for Periodontal Disease

  Yen, M.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Prediction of Cancer Metastasis Using SVM-Based Model with Quantification of Pathway Changes between Different Disease Statuses

  Chiu, H. & Chang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• 大腸直腸癌已躍居世界上癌症死亡率第二名，屬於固體型腫瘤，缺氧常見於此類 腫瘤，並誘發HIF-1α 表現而導致抗藥性及預後較差，因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑，可殺死癌 細胞而不影響正常細胞，對小鼠也不具毒性。我們初步結果顯示，Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現，代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性，對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下，經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制；也有研究報導指出，藥物會誘導癌細胞產生autophagy，造成細胞過度吞噬其內容 物而死亡，因此，autophagy在癌細胞為保護或是引發毒殺作用，目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活，但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示，除抑制HIF-1α 表現外，Zeb 也可活化AMPK、UPR/ER stress、以及autophagy， 因此我們推測Zeb 可在缺氧狀態下，促進autophagic cell death。3 年內我們將執行4 項 目標： (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。（第一年） (2) 研究Zeb 抑制HIF-1α表現之分子機轉。（第一年到第二年） (3) 研究Zeb 誘發autophagy之分子機轉。（第二年到第三年） (4) 探討Zeb 對缺氧導致抗藥性之作用。（第三年）

  Yang, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Exploring Biopathways Related to Cancer Based on Differences of Gene Expression between Cancer and Normal Situation

  Chiu, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of DDX3 in Human Papillomavirus-Infected Lung Tumorigenesis

  Lee, H.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Mobile Intelligent Personal Medication Management Platform (III)

  Li, Y.

  11/1/10 → 10/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Mechanistic Action of DDX3 in Colorectal Tumor Progression

  Lee, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Application of Diffusion Tensor Imaging to Study the White Matter Integrity and Coherence in Resting Electroencephalography

  Shiu, R. & Wang, H.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• Assessment of Bone Healing Capacity and Osseointegration Potential of Bone Grafting Materials Loaded with Rabbit Mesenchymal Stem Cells Derived from Different Sources: in Vitro and in Vivo Studies

  Feng, S.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Disaster Prevention and Education Needs among Indigenous Community Residents

  Lyu, S.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• 建立內皮系細胞血管新生篩選平台以識別中心新生血管促進及拮抗因子

  Hwang, W.

  7/1/17 → 2/28/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Identification of Human Viral Micrornas and Its Targets by Using Small RNA Sequencing Data Based on RNA Sequence and Structure Features

  Chang, T.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The First Randomized Controlled Clinical Trial for Computerized Decision Support System (II)

  Li, Y.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of Cytoplasmic APe1 in Tumor Malignancy, Drug Resistance and Lung Cancer Prognosis

  Lee, H.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Tmu Spark Taiwan-Anchor University Program

  Yen, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Clinical Outcome and Drug Resistant Biomarkers Establish for Hpv Infected Non-Small Cell Lung Cancer

  Hsu, N.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 不同APC基因狀態大腸直腸癌患者藥物治療之抗藥性機轉研究-探討miR-21調控大腸直腸癌細胞TET1/5-hydroxymethylcytosine表現對其化療反應之關聯(3/3)

  Yang, P.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 國際青年之科技風險認知比較調查與建立雙向風險溝通數位平台

  Chang, W.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigating Influences of Neuronal State in Local and Large-Scale Cortical Networks during Rest and Task on Subsequent Neuronal Activity and Behavioral Performance: a Multi-Model Approach

  Hsu, T.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology