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• b - Ministry of Science and Technology

  The Mechanism and Efficacy Investigation of Using Histone Deacetylase Inhibitors to Enhance the Immune Modulation of Immune Checkpoint Blockade Agent

  Huang, H.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study of Onion and Its S-Containing Components on Ovariectomy-Induced Sarcopenia and Osteoporosis, and the Potential Mechanisms

  Chen, Y.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Application of Regioselective Substitution on 1,4-Benzoquinone Derivatives to Provide Potent Anticancer Agents

  Liou, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • 1,4-benzoquinone 100%
  • Wittig Olefination 54%
  • Intramolecular Cyclization 40%
  • Nucleophilic Substitution 38%
  • Regioselectivity 35%

• Development of Novel Dyrk1a Inhibitors for the Treatment of Alzheimer'S Disease

  HuangFu, W.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Dyrk kinase 100%
  • Alzheimer Disease 43%
  • Neurofibrillary Tangles 17%
  • Amyloid beta-Peptides 15%
  • Memory 10%

• Molecular Mechanisms of Anti-Angiogenic Effects of 3-Methylcholanthrene, an Aryl-Hydrocarbon Receptor Agonist, in Relation to Cell Proliferation, Adhesion and Migration of Endothelial Cells, and Its Therapeutic Intervention Using Resveratrol

  Juan, S.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Methylcholanthrene 100%
  • Aryl Hydrocarbon Receptors 79%
  • Resveratrol 26%
  • Xenobiotics 24%
  • PTEN Phosphohydrolase 16%

• Electroacupunture Relieves Pelvic Pain by Antagonizing MeCP2-Dependent Epigenic Modification of BDNF Mediates Estrogen-Fasciliated Uterus-Colon Crosstalk in Rats(2/3)

  Lin, T.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Methyl-CpG-Binding Protein 2 100%
  • Brain-Derived Neurotrophic Factor 60%
  • Urethra 56%
  • Colon 46%
  • Histones 37%

• Effects of indoor air quality improvement on cardiovascular health in general population

  Chuang, K.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Indoor Air Pollution 100%
  • Air Pollution 15%
  • Taiwan 13%
  • Cardiovascular System 13%
  • Quality Improvement 13%

• The Role and Molecular Mechanism of Pparα in Acute Kidney Injury: Focus on the Protective Effect in Renal Tubular Cell

  Hsu, Y.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • MicroRNAs 100%
  • Type C Phospholipases 73%
  • Kidney 56%
  • Acute Kidney Injury 37%
  • Gentamicins 27%

• Transgenerational Epigenetic Reprogramming of Neuronal Maturation by Early-Life Maternal Sleep Deprivation( II )

  Yang, C. H.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Functional Materials Using Atomic Layer Deposition and Their Applications in Green Energy Technology: Solar Cells, Hydrogen Production via Water Splitting, and Supercapacitors

  Chang, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Atomic Layer Epitaxy 100%
  • Green 37%
  • Energy 30%
  • Solar Cell 18%
  • Nanorod 18%

• Plasma Folate and Selenium Concentrations and Gene Polymorphisms of Selenoprotein, One Carbon Metabolism Related Enzymes and Arsenic Methylation Related Enzymes and Developmental Delay in Preschool Children

  Hsueh, Y.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Arsenic 100%
  • Preschool Children 76%
  • Selenoproteins 69%
  • Selenium 61%
  • Folic Acid 48%

• Innate Immune Modulator---Molecular Characterization of Bupleurum kaoi Polysaccharide Fraction and Assessment of Its Immunomodulatory and Antiviral Effects

  Lin, L. T.

  11/1/12 → 10/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Polysaccharides 100%
  • Antiviral Agents 81%
  • Bupleurum 79%
  • Innate Immunity 32%
  • Hepacivirus 21%

• The Influences and Underlying Mechanisms of Differentiation and Proliferation in Ox-Ldl and Hdl-Stimulated Human Late-Outgrowth Endothelial Progenitor Cells.

  Huang, C., Lin, F., Lin, F. & Shyu, K.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Endothelial Progenitor Cells 100%
  • erucylphosphocholine 98%
  • Endothelium 28%
  • HDL Lipoproteins 25%
  • Dyslipidemias 23%

• Effects of N-3 Polyunsaturated Fatty Acids on the Gut Microbiota in Depressive Disorder

  Huang, S.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of Secretogranin 3 in Autophagy, Insulin Receptor Internalization, and the Regulation of Insulin Sensitivity

  Wu, H.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討短鏈脂肪酸抑制造成過敏作用之免疫細胞的調控機制及其對過敏性氣喘疾病之治療特性評估(3/3)

  Lee, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Volatile Fatty Acids 100%
  • Phenylbutyrates 29%
  • Mast Cells 27%
  • Immunoglobulin E 20%
  • Asthma 17%

• Cell Penetrating Peptide Derived from Human Eosinophil Cationic Protein in Allergic Inflammation Modulation- Enhancing Delivery and Effect of Anti-Sense Rna Targeting Stat-6

  Hou, T. & Lee, Y.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• To Study the Role of Multidrug Resistance Protein 4 on Induction of Aspirin Resistance in Type 2 Diabetes Mellitus

  Lu, W.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Subfamily B ATP Binding Cassette Transporter 100%
  • Aldehyde Reductase 68%
  • Aspirin 64%
  • Platelet Activation 25%
  • Blood Platelets 25%

• 同時抗碳青黴烯類和抗粘菌素的不動桿菌屬菌株之特性分析：抗藥機轉、毒力及適應力

  Huang, T.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 多體學量測平台探討微環境動態變化：以調控脂肪細胞可塑性為例

  Chang, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study the Effect of Dietary Tryptophan Supplementation Strategies in Parkinson’S Disease Progression and Tryptophan Metabolism with Plag6 Knockin Mice

  Huang, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

  • tryptophan 100%
  • disease progression 45%
  • metabolism 34%
  • long term effects 34%
  • intestinal microorganisms 23%

• Ionic Currents and Calcium Homeostasis in Atrial Arrhythmogenesis of Chronic Obstructive Pulmonary Disease Animal Model

  Lin, Y.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Chronic Obstructive Pulmonary Disease 100%
  • Atrial Fibrillation 70%
  • Calcium 18%
  • difebarbamate, febarbamate, phenobarbital drug combination 13%
  • Homeostasis 9%

• 應用脂質體學策略探討食用油對於摘除卵巢小鼠誘導代謝疾病之影響

  Tung, Y.

  7/1/19 → 2/1/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effect of Chronic Sleep Deprivation on Stress Adaptation in Adolescent: a Gut-Brain Axis Study( I )

  Huang, S.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• CAAT/enhancer binding protein beta訊息路徑參與thrombin誘導人類肺部上皮細胞IL-8/CXCL8表現之研究

  Chen, B.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of Renin-Angiotensin System in Hyperoxia-Induced Lung Fibrosis

  Chen, C., Chou, H. & Wang, L.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Hyperoxia 100%
  • Fibrosis 65%
  • Renin-Angiotensin System 60%
  • Connective Tissue Growth Factor 58%
  • Bronchopulmonary Dysplasia 45%

• A Multidisciplinary Study of the Pathophysiology of Blast-Induced Mild Traumatic Brain Injury

  Chiang, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Wounds and Injuries 100%
  • Dizziness 86%
  • N-nitrosoiminodiacetic acid 71%
  • Headache 70%
  • Animal Models 59%

• Studies of Folic Acid-Induced Anti-Tumor Growth Activity---Anti-Angiogensis and Anti-Cancer Cell Growth

  Lee, W.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Folic Acid 100%
  • Antiangiogenic 47%
  • Gonadal Steroid Hormone 12%
  • Antisense Oligonucleotide 11%
  • Protein 10%

• Novel Roles of Aryl-Hydrocarbon Receptor ((AhR) on Epigenetic and Post-Translational Modification of Cell-Cycle Regulatory Genes and Enos in Vascular Endothelial Cells---The Therapeutic Potential of Resveratrol/Statins

  Juan, S. & Hwang, L.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Aryl Hydrocarbon Receptors 100%
  • Phosphatidylinositol 3-Kinases 25%
  • cdc Genes 24%
  • Epigenomics 22%
  • Umbilical Cord 22%

• Study on the Mechanism of Cross-Talk between Ahr and Autophagy, and Autophagy-Associated Physiological or Pathological Phenomenon on Vascular and Airway Systems (II)

  Li, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• To Investigate the Role of SPNS2 in Determining Individual Susceptibility to Hypoxic Challenge

  Yang, C. H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Phenotype 100%
  • Pharmacology 55%
  • Physiological Adaptation 54%
  • Middle Cerebral Artery Infarction 45%
  • Neurodegenerative Diseases 36%

• Role of Normoxic Expression of Hypoxia Inducible Factor 1-Α and Endoplasmic Reticulum Stress Associated Protein Grp-78 in the Modulation of Drug-And Radioresistance Acquisition of Human Hepatoma Cell Lines

  Chiou, J.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • 1-phenyl-3,3-dimethyltriazene 100%
  • Reticulum 60%
  • Hypoxia-Inducible Factor 1 59%
  • Research Design 56%
  • Paclitaxel 47%

• Studies of Anti-Cancer Activity of Folic Acid

  Lee, W.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Folic Acid 100%
  • Gonadal Steroid Hormone 7%
  • Antiangiogenic 7%

• An Investigation of the Combined Administration of Cholesterol-Lowering Agents and Anti-Diabetic Drugs on Cell Migration Inhibition of Anaplastic Thyroid Cancer Cells

  Hsu, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Anaplastic Thyroid Carcinoma 100%
  • Drug Combinations 32%
  • Troglitazone 22%
  • Lovastatin 20%
  • Neoplasms 12%

• he Effects of the APOE4 Allele on cerebral Structural and Functional Connectivity- A Diffusion Tensor Imaging and Resting-state MRI study

  Chen, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Alleles 100%
  • Apolipoproteins E 93%
  • Brain 47%
  • Short-Term Memory 37%
  • Magnetic Resonance Imaging 31%

• The Measure of Palliative Care Spiritual Care Competency and the Effectiveness of an Educational Program for Palliative Spiritual Care Providers

  Chiou, J.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Palliative Care 100%
  • Program Evaluation 46%
  • Education 32%
  • Research Design 24%
  • Learning 15%

• Effects of Resveratrol Supplementation on Endurance Performance, Oxidative Stress and Inflammation

  Hsu, C.

  8/1/11 → 12/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

  • resveratrol 100%
  • placebos 45%
  • exercise 38%
  • antioxidants 26%
  • inflammation 25%

• Study of Mechanosensitive Transduction Channel on Hair Cell of Zebrafish

  Horng, J.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Zebrafish 100%
  • Transient Receptor Potential Channels 63%
  • FM1 43 59%
  • Inner Ear 53%
  • Morpholinos 48%

• When Cognitive Meets Forensic Neuroscience: towards an Integrative Approach to Investigating Deception and Human Social Cognition

  Tseng, P.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討纖連蛋白誘導牙齦上皮細胞間質轉化現象中α5β1整合素調節SHP2的角色

  Lin, C.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 進展性胰臟癌新穎增進免疫療法的治療策略與生物指標-對免疫療法併用方案節拍式化療或射頻燒灼療法之胰臟癌患者進行基因標記和免疫基因組庫之鑑定與分析(2/3)

  Chang, W.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation of Mechanisms of SSRI Antidepressants and GABAAR Modulators Inhibit High-Grade Glioma Invasion

  Shen, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Glioma 100%
  • Ions 24%
  • Ion Channels 23%
  • Hydrodynamics 20%
  • GABA Receptors 14%

• Self, Consciousness, and Neurophilosophy

  Lane, T. J.

  1/1/14 → 12/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Molecular Model 100%
  • Neurophilosophy 96%
  • Applied Ethics 80%
  • Self-consciousness 68%
  • Philosophy of Science 60%

• Whole Organ Decellularizationtrachea Scaffold Tissue Engineering for Whole Segment Tracheal Transplantation/Replacement

  Hung, S., Lee, F. & Tseng, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • trachea (vertebrates) 100%
  • cartilage 77%
  • sonication 70%
  • tissues 27%
  • skeleton 25%

• Chemo-Sensitizer Conjugated Carbon Nanotubes as a Novel Cancer Therapeutical Delivery System

  Cho, E.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Carbon Nanotube 100%
  • Radiation Sensitizing Agent 38%
  • Ribonucleotide 28%
  • Water Soluble 17%
  • Drug 12%

• To Explore the Influence of Chlamydia Pneumoniae Groel in Endothelial Progenitor Cells.

  Lin, F.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Chlamydophila pneumoniae 100%
  • Endothelial Progenitor Cells 46%
  • Pneumonia 30%

• Modulation of Cell Reprogramming to Pluripotency by Complex Surface Nanotopographies

  Wang, P.

  11/1/16 → 10/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • induced pluripotent stem cells 100%
  • stem cells 32%
  • embryonic stem cells 20%
  • new family 18%
  • biocompatible materials 18%

• Develop the Novel Small Molecular Inhibitor to Target Angiogenesis and the Tumor Microenvironment for Primary and Recurrent Gbm Patient( I )

  Huang, S.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Implantable Artificial Kidney Utilizing Nano-Porous Micro Tube Array Membrane Proof of Concept Study

  Wu, M.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Overcoming Chemo-Resistance in Glioma-Bearing Rats by Using Sequential and Biodegradable Multidrug-Loaded Nanofibrous Membranes(2/2)

  Tseng, Y.

  8/1/18 → 10/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Nanofibers 100%
  • Carmustine 85%
  • Temozolomide 63%
  • Glioblastoma 50%
  • Membranes 30%