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• b - Ministry of Science and Technology

  Crystal Structures and Functional Studies of Novel Glycosyltransferases from Staphylococcus Aureus

  Liu, C.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 寶寶玩音樂!音樂環境介入對幼兒神經語言發展的影響

  Lo, Y.

  7/1/19 → 2/1/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of CCR5/RANTES in Neurodegeneration

  Chou, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Mechanisms of Biophysical Effects on Differentiation of Mesenchymal Stem Cells and Real-Time Evaluation of Biophysical Effects with Surface Plasmon Resonance Technique

  Ho, J.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effect of Long Acting GnRH Agonist Treatment on Mitochondrial Function in

  Tzeng, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Cellular and Molecular Mechanisms of Nicotine and Nitrosamines Promote Tumorigenic Behaviors in Renal Cell Carcinoma (II)

  Cheng, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Cellular and Molecular Mechanisms of Nicotine and Nitrosamines Promote Tumorigenic Behaviors in Renal Cell Carcinoma (Ii)

  Cheng, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Characterization of Glioblastoma Using Advanced Multimodal Small Animal Mr Imaging Techniques

  Liu, H.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Molecular and Cellular Mechanism of Adipocyte Modulatory Effects on Pulmonary Vein and Atrium:

  Chen, Y.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Multifunctional Aminated Gelatin Nanoparticles as an Adjuvant Antigen-Carrier for Mucosal Immunization

  Liu, D.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Investigation of CCL5 (Rantes) in Neurogenesis Mechanism

  Chou, S.

  2/1/14 → 10/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Model Construction of the Relationships among Mental Fatigue, Cognitive Functions, and Return to Productive Activity in Patients with Traumatic Brain Injury.

  Chiu, H.

  12/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Roles of Fibronectin Fragments in the Articular Chondrocytes: from Single Nucleotide Polymorphism to Functional Investigation.

  Lee, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• 膠淋巴系統於混合型失智症之角色(1/2)

  Hu, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討腎臟細胞暴露於塑膠微粒和塑膠奈米中誘發自體吞噬作用和增加SREBPs並引起血管內皮細胞滲漏作用之機制(1/3)

  Chiu, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• The effects on mental health, stress, and physical activity from the urban natural environment: A comparison between real and virtual experiences(1/3)

  Yen, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Diabetes and the Risk of Parkinson'S Disease&Quot; Investigate the Association between Insulin Resistance and Parkinson'S Disease-Second Term Project

  Hong, C.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Occupation Choices, Work Characteristics, and Career Success of Medical Technology Undergraduates from Gender and Generational Perspectives (K01)

  Liang, Y.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of Sp1-Regulated Neurosteroidogenesis in Glioma Development(2/2)

  Hsu, T.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Using Machine Learning Technique to Evaluate the Impact of Curcumin on the Brain-Gut Interaction in Patients with Tuberous Sclerosis Complex Comorbid to Autism Spectrum Disorders(2/3)

  Lo, Y.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 自體免疫心肌炎引起心室心律不整及鈣離子調控失衡、粒線體異常與NLRP3/MIF發炎體訊息路徑活化之致病機轉及治療策略探討(1/3)

  Chen, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Evaluation of the Long-Term Effects of Interpersonal and Social Rhythm Therapy on Sleep and Social Functioning in Patients with Bipolar Disorder(3/3)

  Chung, M.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Analysis and Therapy of Post-Tbi Insomnia – Animal Study of Music Therapy as a Remedy

  Chen, K.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 台灣菸商之定價策略與菸品消耗-2011-2019 非菸稅引起的菸價上漲與其影響

  Sanna, M.

  9/1/20 → 7/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 乳癌細胞α9尼古丁受體作為新穎靶向RNA奈米藥物與T細胞療法之臨床轉譯 研究-乳癌細胞α9尼古丁受體/HER2複合體作為RNA奈米藥物治療HerceptinR抗藥 性之機制探討(2/3)

  Ho, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 乳癌細胞α9尼古丁受體作為新穎靶向RNA奈米藥物與T細胞療法之臨床轉譯研究-開發抗α9尼古丁受體/抗CD3雙功能抗體以一步驟建構可高效標靶毒殺乳癌腫瘤之武裝型T細胞免疫療法(2/3)

  Chuang, K.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 選擇性抗癌標靶藥物HDAC6抑制劑臨床前試驗研究(II)

  Pan, S.

  5/1/19 → 1/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 老年人輕度頭部外傷後身體活動與腦震盪症候群變化之相關性

  Chiu, H.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Huntingtin-Associated Protein Related Biomarkers in Neural Survival

  Lin, Y.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以病人為中心的跨領域醫病共享決策模式課程之發展、實施、評量與推展：導入人工智慧營造創新的混成學習環境(1/3)

  Hou, W.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討張口受限患者的牙關緊閉與生活品質之關係

  Huang, T.

  7/1/21 → 2/28/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Evaluation of the Long-Term Effects of Interpersonal and Social Rhythm Therapy on Sleep and Social Functioning in Patients with Bipolar Disorder

  Chung, M.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Anti-Aging Effect with the Associated Mechanism by PRP (Platelet-Rich Plasma) in Cartilage---A Fibronectin Fragment Model

  Lee, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Gender Differences in the Pathway to Power: from Rookie Doctors to Medical Leaders (V08)

  Kao, M.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討新型benzimidazole衍生物抑制肝癌抗藥性細胞生長的角色

  Liao, Y.

  7/1/17 → 2/28/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Investigation of the Effects and Illness Prevention of 1100-Km Tour De Taiwan Ultra-Marathon Race

  Kao, W.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Fibromyalgia: Impacts of Different Phenotypes on Quality of Life and the Effects of Technology-Assisted and Tailored Health Coaching(1/3)

  Tsai, P.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Galectins-Immune Signaling Reprograming in Atrial Remodeling and Arrhythmogenesis: a Novel Therapeutic Strategy for Atrial Fibrillation(2/3)

  Chen, Y.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 中文版理察斯-坎貝爾睡眠量表於重症病人之測量特性：以古典測試理論與試題反應理論驗證

  Chiu, H.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 釐清神經類固醇的代謝在神經膠質瘤的抗藥性中扮演的角色(2/3)

  Hsu, T.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 結構優化苯丙炔醯胺基礎之蛋白質雙硫鍵異構酶抑制劑以作為具潛力之抗多形性神經膠質母細胞瘤試劑(1/3)

  Huang, W.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 實體及多媒體音樂語言介入模式對疑似語言發展遲緩幼兒詞彙量擴充及腦部神經發展之影響

  Lo, Y.

  7/1/21 → 2/28/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation of the Oncogenic Role of Prohibitin in Breast Cancer Progression

  Huang, T.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Home-Based Exercise Training on Fatigue, Sleep Disturbance, Symptom Distress and Quality of Life in End-Stage Renal Disease Patients(3/3)

  Lin, C.

  8/1/16 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Impact of Electron-Transfer-Flavoprotein Dehydrogenase Mutation on Bioenergetic Metabolism and Muscular Differentiation in Vitro

  Kao, S.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Study of Neurotrophic and Neuroplastic Effects of Exercise and Environmental Enrichment in Mild Traumatic Brain Injury

  Chen, K.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Antibody-Mediated Immune Suppression of Fetal and Neonatal Alloimmune Thrombocytopenia (FNAIT)

  Burnouf, T. P. R.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討小泛素蛋白酶Sentrin-specific protease 2 參與轉型生長因子-beta訊息傳遞的作用機制(1/2)

  Chang, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Exploration of RBM4-Regulated Splicing Events in Differentiating Adipocytes by Using Next-Generation Sequencing

  Lin, J.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• 睡眠困擾是癌症病人最常主訴的問題之一。患有睡眠困擾之癌症病人經常同時伴隨 疲憊、憂鬱等現象發生，形成症狀群集，影響生活品質。雖然目前對於癌症病人睡眠障 礙之量性研究已多有著墨，然而對於癌症病人經歷睡眠障礙之主觀經驗之瞭解，仍相當 有限。瞭解病人經歷睡眠障礙之主觀經驗，將有助於未來睡眠評估工具之修訂。另外， 在評估癌症病人睡眠品質時，若能以簡單工具評估，會更具效率及助益。阿森斯失眠量 表(Athens Insomnia Scale, AIS) 是一個簡單的8 題問卷，廣為使用在一般失眠的病人， 在癌症病人使用上，尚未有豐富的實證資料，若能建立其在癌症病人的信效度，將可作 為一簡單篩檢癌症病人失眠的工具。 睡眠遵行日夜節律規則，日夜節律又需要光作為矯正的線索，光在癌症病人睡眠的 角色，尚未有研究證實，過去研究顯示癌症病人睡眠品質不佳與生物節律有關係。光是 重要日夜節律的線索，光療法透過褪黑激素調節，調整日夜節律週期，可能可以改善睡 眠品質。另外，由於，睡眠障礙、憂鬱、疲憊經常形成一症狀群集，光療法於改善睡眠 障礙之同時，是否亦同時改善憂鬱、疲憊及生活品質。目前，光療法在癌症病人的運用 上，付之闕如，故建立光療法於癌症病人的有效性值得探究。 本研究為三年期研究計畫，目的包括有：1.瞭解癌症個案對於睡眠困擾的主觀經驗 （第一年）。2.建立阿森斯失眠量表中文版的信效度、敏感性、特異性（第一年）。3.瞭 解癌症病人光暴露與生物節率、睡眠障礙的關係（第二年）。4.瞭解光療法對於改善癌 症病人睡眠障礙及相關症狀群集、及生活品質之成效；以及瞭解光療法影響褪黑激素之 程度（第三年）。 本研究擬以癌症住院及門診病人為對象，研究工具包括基本資料、匹茲堡睡眠品質 問卷、阿森斯失眠問卷，簡明疲憊量表，貝克憂鬱量表度、SF-36 生活品質量表、腕動 力器等。資料處理分析方式包括：內容分析、描述性統計、t 檢定、皮爾森相關、GEE (generalized estimating equations)等。 本研究之結果將可瞭解光暴露與生物節率與睡眠障礙之間的關係，並可進一步瞭解 光療法作為改善癌症病人睡眠障礙之護理措施之成效，以期，最終能藉由改善癌症病人 之睡眠品質提昇病人之生活品質。

  Lin, C.

  8/1/12 → 10/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology