Find Research Projects

Search results

• Studies of Molecular and Cellular Underlying Mechanisms of Ferrous Citrate-Induced Cerebral Vasospasm and Brain Injury

  Lee, W.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies the Function and Mechanism of Dnaja3a/Dnaja3b and Interaction Molecules during the Embryonic Satges

  Chow, J.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Influence of Porphyromonas Gingivalis Groel in Vascular Cells

  Lin, F.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of Normoxic Expression of Hypoxia Inducible Factor 1-Α and Endoplasmic Reticulum Stress Associated Protein Grp-78 in the Modulation of Drug-And Radioresistance Acquisition of Human Hepatoma Cell Lines

  Chiou, J.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effect of Pacemaker Current Inhibitor (Ivabradine) on Sinoatrial Node Function and Pulmonary Vein Arrhythmogenesis

  Lin, Y.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies of Cxcl12 in Hypoxia-Induced Pulmonary Fibrosis

  Chen, B. & Chung, C.

  8/1/12 → 7/31/13

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Translational Studies of Mycobacterium Tuberculosis-Induced Lung and Pleural Fibrosis

  Lin, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Involvement of Glycosphingolipids and Toll-Like Receptors in Response to Helicobacter Pylori Infection in Gastric Epithelial Cells

  Lin, H.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Characterization of Molecular and Pathological Role of Hs 1-Associated Protein X-1(Hax-1) in Cisplatin Induced Nephorotoxicity via Hax-1 Conditional Knock out Mice

  Lin, H.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study of Rich Platelets Plasma and Alginate Encapsulated Synovial Fluid Mesenchymal Stem Cells for Repairing the Partial Tear of Cruciate Ligament

  Chen, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Clinical Correlation Study of Dna Methyltransferases Alterations in Breast Cancer and Evaluation of Dna Methyltransferases as a Therapeutic Target in Cell and Animal Models

  Lin, R.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Novel Activities of Gamma-Aminobutyric Acid-Mediated Regulation of Platelet Activation, Apoptosis, and Autophagy: the Non-Genomic Functions of Nf-Kappab Signal in Anucleated Cells

  Sheu, J.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Study of the Relationships among Anti-Obesity Activity, Adipogenesis, and Adipose Angiogenesis of Vegetable Indolic Derivatives – Involvement of the Ah Receptor/Arnt ?

  Chen, Y.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Glutamine Supplementation on T Cell Homeostasis and Inflammatory Response in Inflammatory Bowel Disease

  Yeh, S.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Renoprotective Mechanisms of Soy Protein in Rats with Diabetic Nephropathy

  Chen, J.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Childhood Sleep Deprivation on the Development of Emotional Control and Cognitive Function of Prefrontal Cortex

  Chang, H.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies on the Carcinogenic Mechanisms of Histamine N-Methyltransferase-Mediated Breast Cancer Formation

  Wu, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Indoor Air Quality Improvement on Cardiovascular Health in General Population

  Chuang, K.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Roles of Micrornas in Endothelin-1 and Hypoxia-Induced Ctgf Production

  Chen, Y.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Association of Peroxisome Proliferator-Activated Receptors, Ppar-Mediated Genes and Ischemic Stroke

  Chiou, H.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討完成干擾素治療療程之肝炎病人使用精神相關藥物對治療成效的影響

  Bai, C.

  3/1/12 → 7/31/13

  Project: C - Project of Alliance › s - Shin Kong Wu Ho-Su Memorial Hospital

• Genetic Polymorphisms of Calcium Channel in the Risk of Breast Cancer

  Chang, W.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of Er Stress in Evodiamine-Induced Apoptosis and G2/M Arrest of Human Colorectal Carcinoma Cells

  Chen, Y.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Molecular Mechanisms of Alpha 9-Nicotinic Acetylcholine Receptor (Alpha 9-Nachr)-Mediated Trastuzumab (Herceptinr) Drug Resistance in Breast Cancer Cells

  Ho, Y.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Teledermatology Solutions Though Mobile Phone

  Li, Y.

  9/1/12 → 8/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• 102年癌症篩檢管理中心工作計畫之個管師考題研擬及閱卷

  Chen, L.

  6/13/13 → 8/31/13

  Project: A - Government Institution › c - Ministry of Health and Welfare

• 慢性肝病在台灣是一個極具挑戰性的臨床議題。肝纖維化的多重病原性是造成病患死亡 率增加的原因，而且肝纖維化往往會發展成肝癌。我們最近利用國民營養調查資料庫 (NAHSIT 2005-2008)分析國人血中鐵營養值標與代謝症候群的相關性.在全人口的分析 中，我們發現校正了血清發炎指標以及飲食的營養指標後, serum ferritin (鐵蛋白質) 高於最大三等分位的族群，得到代謝性症候群的危險對比值超過 1.6 倍. 目前並不清楚 過量的鐵蛋白質為何與代謝症候群的發生率有關。肝臟為重要的儲鐵器官但是臨床研究 也顯示過量的鐵質沉積與肝纖維化及肝癌有極大的相關性。血清中鐵蛋白質為反映體內 儲存鐵的生化質標。但是,發炎因子也會造成血清中鐵蛋白質的異常增加。證據顯示發炎 因子可以調控鐵蛋白質的基因表現量。但是慢性發炎如何造成鐵蛋白質代謝異常(組職 內沉積及釋放)? 血清中的鐵蛋白質又有何生理功能? 隨著國人代謝症候群及脂肪肝發生率的年輕化,這次研究的主題是以老鼠初代星狀肝細 胞來分析鐵蛋白質對內質網壓力機轉與肝纖維化的影響: 相關研究的主要目標為: 1. 釐清鐵蛋白質(serum ferritin)過量是否會造成星狀細胞內質網壓力增加與活化? 2. 何種鐵質(ferric, ferrous, ferritin, Apoferritin)較易增加內質網壓力? 3. 找出何種內質網壓力的轉錄因子 (ATF6,ATF4, XBP1 and CHOP)受到鐵質調控? 4. 分析鐵質誘導的內質網壓力機轉與肝臟纖維化的營響

  Chang, J.

  9/1/12 → 8/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以混合羅吉特模型分析機車路口使用兩段式左轉之行為

  Pai, C.

  7/5/12 → 9/3/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Evaluation on prevention for metabolic syndrome and diabetes mellitus through lifestyle modification intervention in pre-diabetic subjects (100-104)

  Chiou, H., Bai, C., Tang, C., Yang, S., Su, C., Liou, T., Wang, S., Chen, J., Hsieh, A. & Huang, C.

  9/13/12 → 9/12/13

  Project: A - Government Institution › c - Ministry of Health and Welfare

• Chemokine Factors Concomitantly Induce Prostate Cancer Organ Specific Bone Metastasis

  Sung, S.

  8/1/12 → 9/30/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Motorcyclist Behavioural Patterns to Pedestrian Green Signal Countdown Device (Pgscd): a Mixed Logit Analysis

  Pai, C.

  8/1/12 → 9/30/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Roles of Central Orexin Activities in the Pathophysiology of Hypertension in Shr

  Hwang, L.

  8/1/12 → 9/30/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study the bacteria species of pneumonia and early detect the pathogen from expired gas by electronic nose

  Shih, C.

  5/1/12 → 9/30/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Detrimental Effects of an Aryl-Hydrocarbon Receptor Agonist, 3mc, on Brain Vascular Integrity and Permeability, and the Therapeutic Intervention by Statin Derivatives.

  Juan, S.

  8/1/12 → 9/30/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Niche Signaling Networks in Self-Renewal and Migration of Pluripotent Germline Stem Cells and Its Implication for Germline Differentiation in Human Pluripotent Stem Cells (II)

  Huang, Y.

  10/1/12 → 9/30/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Maternal Depressive Symptomatology on Pregnancy Outcomes and Newborn Development---How Is Paternal Psychopathology Involved?

  Chen, Y.

  8/1/12 → 9/30/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• 行政院衛生署所屬醫院「102年度滿意度調查評估」勞務委託採購案

  Kuo, N.

  6/18/13 → 10/28/13

  Project: A - Government Institution › f - Other (Funded by Government)

• Role and Use of Blood Protein Fractions in Translational Therapy

  Burnouf, T. P. R.

  11/1/12 → 10/31/13

  Project: B - Project of TMU › i - Other (Funded by TMU)

• The Role of miR-1 in RAS Mutation Prostate Cancer Metastasis

  Liu, Y.

  1/1/13 → 10/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Surgical Decision-Making Process, Providing Information on the Decision-Making Process, the Impact of Physical and Mental Health for Spinal Surgery Patients

  Lin, P.

  8/1/12 → 10/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Biodegradable Poly(Ε-Caprolactone)/Calcium Phosphate Ceramic Composite Screw for Osteofixation Device in Craninoxaxillofical Surgery

  Yang, K.

  11/1/12 → 10/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以彈性工程提升加護病房病人安全之應用研究

  Chuang, S.

  5/1/12 → 10/31/13

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• Study the MicroRNA-128-Mediated Signaling Pathways in Glioblastoma Multiforme Formation

  Chen, K.

  1/1/13 → 10/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Study on Trans-Neuronal Striato-Nigral Degeneration-Induced Movement Disorders after Stroke: Evaluation with Grey Matter Suppression Ir and Diffusion Tensor Imaging( I )

  Chen, C.

  8/1/12 → 10/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Translational Genomic Approaches in Endometriosis

  Tzeng, C., Kao, S., Huang, Y., Yang, W., Yang, W., Yeh, C., Li, Y. & Shen, S.

  8/1/12 → 10/31/13

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Expressing Membrane Antibody Reporter in the Islet Cells of Nonobese Diabetic Mice to Noninvasive Image the Disease Progression of Autoimmune Diabetes and the Therapeutic Effects of Drugs or Transgenes

  Chuang, K.

  11/1/12 → 10/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• 同步輻射X光合成奈米銀修飾複合材料顆粒及其應用

  Lin, C.

  11/1/12 → 10/31/13

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Effects of Adlay Hull Extracts on Polycystic Ovary Syndrome (Pcos)

  Hsia, S.

  8/1/12 → 10/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• 睡眠困擾是癌症病人最常主訴的問題之一。患有睡眠困擾之癌症病人經常同時伴隨 疲憊、憂鬱等現象發生，形成症狀群集，影響生活品質。雖然目前對於癌症病人睡眠障 礙之量性研究已多有著墨，然而對於癌症病人經歷睡眠障礙之主觀經驗之瞭解，仍相當 有限。瞭解病人經歷睡眠障礙之主觀經驗，將有助於未來睡眠評估工具之修訂。另外， 在評估癌症病人睡眠品質時，若能以簡單工具評估，會更具效率及助益。阿森斯失眠量 表(Athens Insomnia Scale, AIS) 是一個簡單的8 題問卷，廣為使用在一般失眠的病人， 在癌症病人使用上，尚未有豐富的實證資料，若能建立其在癌症病人的信效度，將可作 為一簡單篩檢癌症病人失眠的工具。 睡眠遵行日夜節律規則，日夜節律又需要光作為矯正的線索，光在癌症病人睡眠的 角色，尚未有研究證實，過去研究顯示癌症病人睡眠品質不佳與生物節律有關係。光是 重要日夜節律的線索，光療法透過褪黑激素調節，調整日夜節律週期，可能可以改善睡 眠品質。另外，由於，睡眠障礙、憂鬱、疲憊經常形成一症狀群集，光療法於改善睡眠 障礙之同時，是否亦同時改善憂鬱、疲憊及生活品質。目前，光療法在癌症病人的運用 上，付之闕如，故建立光療法於癌症病人的有效性值得探究。 本研究為三年期研究計畫，目的包括有：1.瞭解癌症個案對於睡眠困擾的主觀經驗 （第一年）。2.建立阿森斯失眠量表中文版的信效度、敏感性、特異性（第一年）。3.瞭 解癌症病人光暴露與生物節率、睡眠障礙的關係（第二年）。4.瞭解光療法對於改善癌 症病人睡眠障礙及相關症狀群集、及生活品質之成效；以及瞭解光療法影響褪黑激素之 程度（第三年）。 本研究擬以癌症住院及門診病人為對象，研究工具包括基本資料、匹茲堡睡眠品質 問卷、阿森斯失眠問卷，簡明疲憊量表，貝克憂鬱量表度、SF-36 生活品質量表、腕動 力器等。資料處理分析方式包括：內容分析、描述性統計、t 檢定、皮爾森相關、GEE (generalized estimating equations)等。 本研究之結果將可瞭解光暴露與生物節率與睡眠障礙之間的關係，並可進一步瞭解 光療法作為改善癌症病人睡眠障礙之護理措施之成效，以期，最終能藉由改善癌症病人 之睡眠品質提昇病人之生活品質。

  Lin, C.

  8/1/12 → 10/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Translational Genomic Approaches in Endometriosis

  Tzeng, C.

  8/1/12 → 10/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology