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• b - Ministry of Science and Technology

  Discovering Blood Circulating and Bone Micrornas as Biomarker Signatures for Diagnosis or Therapy of Osteoporosis in Men and Male Osteoporotic Fracture

  Chen, R.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Translational Study to Verify Roles of Circulating Mir-19b and Mir-93 as Biomarker Signatures for Early Diagnosis of Osteoporosis in Men

  Chen, R.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 調節第一型神經衍生孤兒核受體 (Neuron-derived orphan receptor 1, NOR-1)之蛋白質表現可能是 Pomalidomide對創傷性腦損傷之神經保護作用之一

  Chen, R.

  7/1/19 → 2/1/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 轉錄因子Sp1在癌細胞抗藥性所扮演角色-HDACs/Sp1-microRNA-106b~25軸在膠質母細胞瘤抗藥性扮演的角色(2/3)

  Chen, R.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 神經生長因子在人類骨母細胞鈣化扮演的角色研究 (Roles of nerve growth factor in calcification of osteoblasts)

  Chen, R.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Therapeutic Evaluation Etanercept, a Tumor Necrosis Factor Antagonist, in Experimental Heatstroke

  Chang, C.

  6/2/11 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

• Therapeutic Implications of Down-Regulation of Microglia Activation Following Repetitive Traumatic Brain Injury-Induced Chronic Traumatic Encephalopathy

  Chang, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Therapeutic Evaluation Etanercept, a Tumor Necrosis Factor Antagonist, in Experimental Heatstroke

  Chang, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Pathogenic Role of Posttranslational Modification of Plasma N-Linked Glycoprotein to Rheumatoid Arthritis Combined Sjogren$S Syndrome Was Investigated

  Lin, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Human Anti-Citrullinated Inter-Alpha-Trypsin Inhibitor Heavy Chain H3 Peptide Antibody Elisa Kit : in Vi Tro Diagnostics Kit of Autoimmune Rheumatic Diseases Examination

  Lin, C.

  11/1/17 → 10/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Application of Regioselective Substitution on 1,4-Benzoquinone Derivatives to Provide Potent Anticancer Agents

  Liou, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Use the organometal catalytic reaction to synthesize the heterocycle-based anticancer agents

  Liou, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 有機金屬催化反應於合成化學和藥物化學之抗癌表觀遺傳學抑制劑研究(2/2)

  Liou, J.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Copy Number Alterations and Transcriptome Profile Analyses Reveal Genetic Determinants Contributing to Higher Paclitaxel-Resistance of Ovarian Clear Cell Adenocarcinoma

  Chang, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• To Study the Role of Pctk1 in the Progression of Colorectal Cancer and Molecular Mechanism

  Wei, P.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Phase I, First-In-Human, Dose-Seeking Study Evaluating the Safety, Pharmacokinetics, and Pharmacodynamics of Orally Administered MPT0E028 in Subjects with Advanced Solid Malignancies without Standard Treatment (I)

  Liou, J.

  9/1/14 → 9/30/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of HBX and IL-6 in Regulating SENP1/Stemness Properties of HBV-Related Hcc under Hypoxia and Its Clinical Implication

  Huang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of HBX and IL-6 in Regulating SENP1/Stemness Properties of HBV-Related HCC under Hypoxia and Its Clinical Implication

  Huang, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of HBX and IL-6 in Regulating SENP1/Stemness Properties of HBV-Related HCC under Hypoxia and Its Clinical Implication

  Huang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Characterization of the Self-Renewal/Reprogramming Factors of Human/Mouse Germ Line Stem Cells in Serum-Free Culture System and Its Induction Effect on Human Embryonic Stem Cells to Sperm (Extension Proposal) (II)

  Huang, Y.

  12/1/10 → 9/30/11

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of Niche Inflammatory Cytokine and Epigenetic Regulation in Expressions of Pluripotent Transcription Factor Oct4 and Sorafenib Refractoriness in Hbv-Related Hepatocellular Carcinoma and Its Clinical Implication.(I)(1/3)

  Huang, Y.

  8/1/18 → 10/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of high cell density in pIGF1R/EpCAM-induced Sorafenib resistance in HBV-HCC

  Huang, Y.

  7/1/19 → 2/1/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 再生醫學科技發展計畫(4/4)－全身安全性異體移植策略之細胞治療產品開發：標靶醫療未滿足慢性發炎相關疾病—糖尿病/褥瘡/嚴重燒燙傷之傷口癒合與多發性硬化症

  Huang, Y.

  5/1/20 → 4/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies on the Molecular Mechanism of Thrombin-Induced Connective Tissue Growth Factor (CTGF) Expression in Lung Fibroblasts

  Lin, C.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

• Translational Studies of Mycobacterium tuberculosis-Induced Lung and Pleural Fibrosis

  Lin, C.

  8/1/14 → 10/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Translational Studies of Mycobacterium Tuberculosis-Induced Lung and Pleural Fibrosis

  Lin, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effect of Hdac Inhibitor in Bleomycin-Induced Pulmonary Fibrosis: Targeting on Niche Interaction between Stromal Cells and Stem/Progenitor Cells

  Lin, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Involvement of Il-21-Regulated Circulating Fibrocyte Activation in Chronic Obstructive Asthma(I)(1/3)

  Lin, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Molecular Mechanism of Paclitaxel-Resistance in Ovarian Clear Cell Carcinoma – from Dna Copy Number Alteration and Differential Expression of Genes Encoding Abc- and Slc-Transporters to Changes in Energy Demand and Metabolic Pathway

  Chang, S.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• (101NP1003) New Drug Development of MPT0E014 for Ischemic Stroke and Dementia (I)

  Hung, K.

  5/1/12 → 4/30/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effect of Hdac Inhibitor in Bleomycin-Induced Pulmonary Fibrosis: Targeting on Niche Interaction between Stromal Cells and Stem/Progenitor Cells(3/3)

  Lin, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討EZH2在嚴重氣喘中媒介纖維化蛋白表現及呼吸道纖維化之機轉(1/3)

  Lin, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討不同選擇作用之組織蛋白去乙醯酶調節成分抑制神經發炎之機制及其對腦內出血與腦炎之治療特性評估(1/3)

  Hsiao, G.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effect of Endothelin-1 on Myofibroblast Transformation of Pleural Mesothelial Cells and Its Implications for Pleural and Pulmonary Fibrosis

  Chung, C. & Hsiao, G.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Investigation of Anti-Neuroinflammatory Mechanisms of Differential Histone Deacetylase Regulators and Their Therapeutic Profiles in Experimental Intracerebral Haemorrahge and Encephalitis

  Hsiao, G.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Short-Chain Fatty Acids Act as Anti-Allergic Regulators on Immune Effector Cells and Exert Immune-Modulatory Effects on Ovalbumin-Induced Allergic Diseases in Mice

  Lee, Y. & Hsiao, G.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• 芳香烴受體於眼科疾病之治療潛力機制探討-探討芳香烴受體活化在青光眼病程的視網膜保護角色(1/3)

  Hsiao, G.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Natural Product Hybrid and Ortho-Biaryl N-Hydroxycinnamide as Leads for Anticancer Agent Development

  Huang, W.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Natural Product Hybrid and Ortho-Biaryl N-Hydroxycinnamide as Leads for Anticancer Agent Development

  Huang, W.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies on Hydroxamates Incorporated with a Naturally Occurring Cap as Novel Selective-Spectrum Histone Deacetylase Inhibitors

  Huang, W.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• Exploiting Acridine Scaffold to Develop Novel Anticancer Agents Based on a Dual Target Strategy

  Huang, W.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• To Investigate the Functions of Shikonin and Its Derivatives in Applied Age-Related Macular Degeneration and Wound Healining

  Cheng, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Multifunctional Nanoparticles for Cancer Therapy

  Chiu, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Simultaneous Delivery of an Antisense Oligonucleotide and a Chemotherapeutic Agent by a Her2-Targeted Liposomal System

  Chiu, S.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Evaluation of the Effects of Plant Trypsin Inhibitors on Lipoprotein Binding and Metabolism

  Hou, W.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies of Hispolon and Its Structural Analogues on Delaying Aging Process and Neurodegenerative Disorders in Vitro and in Vivo

  Hou, W.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study on the Mechanism Involved in Nanoparticles-Induced Tight Junction and Aquaporins Damages in Endothelial Cells, as Well as the Effects on Physiological Function of Endothelial Barriers

  Li, C. & Cheng, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• 芳香烴受體於眼科疾病之治療潛力機制探討-芳香烴受體於藍光誘發視網膜病變之治療潛力機制探討(1/3)

  Cheng, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Evaluate the Molecluar Mechanims and Clinical Application on ATF3 Regulated microRNA

  Lin, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Evaluate the Molecluar Mechanims and Clinical Application on Atf3 Regulated microRNAs

  Lin, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology