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  A Methodology Study of Integrating Systems Thinking and Bayesian Network in Health Policy

  Chuang, S.

  8/1/14 → 11/30/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Identifying Prostate Cancer Biosignature from Multi-Scale Mixture-Lineage Modeling of Tumor Cell Progression

  Jian, W.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Research on Development of Clound Computing Platform for Decision Support Systems Healthcare by Healthcare Big Data and Analytics

  Chiang, I.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Characterization of 5-Hydroxymethylcytosine and Ten-to-Eleven Translocation Gene (TET) in Cervical Cancer

  Lai, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• To See Is to Believe-Visualization of the Spectrum on Chronic Kidney Disease

  Jian, W.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Optimization of Human Meniscus Imaging and Its Clinical Application for Osteoarthritis (II)

  Tsai, P.

  8/1/14 → 10/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Evaluate the Radio-Biological Roles of miR-17-5P in Oral Cancer Cell Line OC3

  Wu, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Novel Roles of Aldose Reductase (AR) in Collagen GPVI- and Thrombin PAR4-Mediated Platelet Activation and Apoptosis---Regulatory Machinery of Arf-AR Signaling in Anucleate Cells

  Sheu, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Pragmatic Challenges to Contemporary Vi Sions on Professionalism in Taiwan and Western Countries：Proposing and Evaluating a Situational and Relational Learning Paradigm Based upon Community Mental Health

  Tsai, D.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Neurotrophic/Neuroprotective Role of GIP in Cellular and Rodent Models of Mild Traumatic Brain Injury (III)

  Lin, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of Oxidative Stress-triggered Redox Adaptation Mechanism and Genetically Endowed Expression Profile of Antioxidant Enzymes in the modulation of Intrinsic and Acquired Chemoand Radio-resistance of Human Hepatocellular Carcinoma Cells

  Chiou, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Chitosan Nanoparticle as a Macrophage-Targeting Drug Delivery Carrier

  Mi, F.

  8/1/14 → 8/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Influence of Porphyromonas gingivalis Groel in Vascular Cells

  Lin, F.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Central Neuromodulation with Functional Electrical Stimulation on Bladder Functions in Traumatic Brain Injured Rats

  Peng, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role and Molecular Mechanism of PPARα in Acute Kidney Injury---Focus on the Protective Effect in Renal Tubular Cell

  Hsu, Y., Chen, T. & Chen, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of ADAM 17 in Hypoxia-Induced CTGF Expression and Pulmonary Fibrosis (II)

  Chen, B.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study of the Mechanism of HPV Involved Tumorigenesis through Wnt Signaling Pathway Related microRNA Regulation

  Cheng, Y. & Lee, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Anticancer Drug Discovery of New Tegafur-Derivatives for Colorectal Cancer Therapy

  Chen, M.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Application of Clinical Anti-Arthralgia Formulas of Traditional Chinese Medicine to Arthritis

  Wang, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 肺纖維化之轉譯研究－組蛋白去乙醯酉每2的SUMO化修飾貢獻於慢性阻塞性氣喘的結締組織生長因子表現與肺部纖維化反應(2/3)

  Lin, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Preclinical Evaluation of Application of Sclareol for Adjuvant Therapy of Cisplatin-Resistant Non-Small Cell Lung Cancer

  Wu, C.

  8/1/14 → 9/30/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Natural Product Hybrid and Ortho-Biaryl N-Hydroxycinnamide as Leads for Anticancer Agent Development

  Huang, W.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 乳癌是目前世界上女性癌症病患中為數最多的癌症之ㄧ。腺病毒蛋白type 5 E1A (E1A)和許多抗腫瘤作用有關，曾於多種癌症如乳癌、卵巢癌及頭頸癌之病患進行臨床基因治療試驗。許多的研究指出E1A具有多項抗腫瘤的功能，包括抑制腫瘤的發生、增加腫瘤細胞對於化療藥物的感受性以及減少腫瘤轉移的現象。腫瘤的轉移對於癌症患者的死亡率有極大的影響當然也包括了乳癌的患者。E1A於抑制腫瘤發展的過程中具有多重生物學上的意義，這也促使我們想要釐清E1A抑制癌症的機制。因此，我們對於了解E1A抑制癌症轉移相關的分子機制感到有興趣，並期望藉以作為未來改進乳癌病人臨床試驗的基石。我們初步的實驗結果顯示，E1A可以有效的抑制Glucose-regulated protein 78 (GRP78)這種已被廣泛報導和腫瘤惡化及轉移相關的蛋白的表現。 提出此研究計劃之目的在於詳細探討E1A所造成的抑制癌轉移作用中，GRP78所扮演的生物功能及其調控的機轉。為了達到此目的，我們將著重於E1A如何調控GRP78表現並進而展現對乳癌轉移的抑制作用。以下為此項研究計畫的四大主要目標： 目標一：探討GRP78在E1A所抑制之癌細胞移行及侵入作用中所扮演的角色 目標二：研究E1A抑制GRP78表現之分子機轉 目標三：於動物模式中驗證GRP78的表現對於E1A抗腫瘤作用的影響 目標四：探討GRP78及其相關分子的表現在乳癌病人的臨床重要性 完成以上的主要目標能夠幫助我們對於E1A之抗腫瘤轉移作用建立更加詳細的分子訊息傳遞機制。另外，藉由此研究計畫的新發現也許可以對未來發展癌症治療上提供更多具有潛力的標的物。

  Wang, W.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Drug Discovery and Pharmacological Study of Novel pan-HDAC Inhibitors as Anti-Angiogenic Drugs

  Pan, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Relationship between Lumbar Vertebral Perfusion and Fat Marrow Content in Normal Subjects, Osteoporosis and Bone Metastases Using DCE-MRI and Fat-Water Separation

  Chan, W. P.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation of Glioblastoma Cell-Secreted microRNA Signatures and Their Functional Effects on Tumor Angiogenesis

  Chen, K.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Short-Chain Fatty Acids Act as Anti-Allergic Regulators on Immune Effector Cells and Exert Immune-Modulatory Effects on Ovalbumin-Induced Allergic Diseases in Mice

  Lee, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Application and Mechanism of Novel Fluoro-Rutaecarpine on Inhibition of Inflammation Induced Endomt

  Lin, C.

  8/1/14 → 12/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effect of Vasopressin Receptor Agonist and Antagonist on Pulmonary Vein and Atrial Arrhythmogenesis

  Huang, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of Organic Anion Transporter in Renal Tubular Injury---A Gateway to Hurt

  Wu, M.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies on the Role of ORMDL3 in Thrombin-Induced IL-8/CXCL8 Expression and Airway Inflammation

  Chen, B.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Plant Metabolomics---1. Agave sisalana; 2. Anoectochilus formosanus; 3. Phalaenopsis spp.)

  Lee, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Glutamine on the Inflammatory Response and Tissue Injury in a Hindlimb Ischemic Reperfusion Mice Model

  Yeh, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Study of Therapeutic Effects for Stroke with Phenserine, an Amyloid Precursor Protein Inhibitor, in Rodent Focal Cerebral Ischemia Model(2/3)

  Chang, C. & Chiang, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › a - National Health Research Institutes

• Three Steps of Fluorescence Resonance Energy Transfer Observation of Complexation of DNA/Drug/Polymeric Micelles on Cornea Transport

  Liaw, J.

  8/1/14 → 12/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Functional Studies of ZNF179 in Neurons in vitro and in vvo

  Lee, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation on Dental Implant Stability Detection Using Damping Factor as a Parameter

  Huang, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 醫學與影像美學

  Chang, H.

  8/1/14 → 1/31/15

  Project: A - Government Institution › d - Ministry of Education

• The Effect of Endothelin-1 on Myofibroblast Transformation of Pleural Mesothelial Cells and Its Implications for Pleural and Pulmonary Fibrosis

  Chung, C. & Hsiao, G.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Ultrafine Particles on Cardiopulmonary System: a Population-Based Approach

  Chuang, K.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Contribution of ER Stress to Inhibit miR-19a/b and miR-26b-Mediated CTGF Expression in Lung Fibrosis (II)

  Chen, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Vector-Borne Disease Forecasting Models Using Satellite Remote Sensing Techniques

  Chuang, T.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Translational Investigation for Tea Attenuate Smoking-Induced Disease---Breast Cancer and Atherosclerosis as a Mechanistic Study

  Ho, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of ER Stress in Evodiamine-Induced Apoptosis and G2/M Arrest of Human Colorectal Carcinoma Cells

  Chen, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Indoor Air Quality Improvement on Cardiovascular Health in General Population

  Chuang, K.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Association Study of Persistent Metabolic Syndrome, Inflammatory Markers, Adipose Markers and Mild Cognitive Decline

  Bai, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Study on the Influence of Classical Mathematics Reading Course on Medical Students$ Beliefs about Mathematics

  Ying, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies on the Teaching Model to Foster Mindfulness through Arts Performance in Medicine Students

  Lin, W.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 2014台北市立聯合醫院 (仁愛院區)員工體適能檢測暨體適能變化情形分析計畫

  Kan, N.

  8/1/14 → 2/28/15

  Project: A - Government Institution › f - Other (Funded by Government)

• Electrophysiological and Molecular Insights into the Cardiac Regulations of ZFHX3 Gene---Implication in the Pathophysiology of Atrial Fibrillation

  Chen, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology