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• b - Ministry of Science and Technology

  Prevalence, Related Factors and Health Promotion Programs for Sarcopenia among Elderly with Diabetes (1/2)

  Lee, P. & Lee, S.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation the Functional Roles and Molecular Mechanism of Long Non-Coding Rna-Crnde in Autophagy and Oxaliplatin Drug Resistance

  Lee, K.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• ETFDH突變於阿茲海默症之類澱粉前驅蛋白生成和細胞焦亡扮演的角色

  Kao, S.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 醫病共享決策用於高齡心血管病患之治療選擇初探：病患與醫師觀點

  Hsu, Y.

  7/1/21 → 2/28/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以CRISPR/Cas9基因編輯平台發展MYC/BCL2/BCL6作為人類B細胞淋巴癌標靶精準治療模式

  Chen, S.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 乳癌細胞受體專一性RNA適體奈米質粒誘發第三型玻尿酸合成酵素的抗癌機制探討(2/3)

  Tu, S.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effectiveness of Transitional Medication Management on Improving Quality of Life, Medication Adherence, and Reducing Rehospitalization in Older Patients with Heart Failure

  Hu, S. H.

  5/1/14 → 10/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Lncrna Lnchifcar–Hif1a Regulatory Network and Its Clinical Relevance in Oral Cancer Progression(1/2)

  Shih, J.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 胃腸科相關癌症之差異蛋白質體與致病機轉之研究

  Lee, J.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 利用多模式小動物進階磁振造影技術定量膠質母細胞瘤之研究(2/2)

  Liu, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• SEA調控肺部細胞發炎透過STAT 1 蛋白路徑之研究

  Cheng, P.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 臺北醫學大學基礎研究核心設施共同使用服務計畫(1/5)

  Chang, H.

  1/1/21 → 12/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 台灣乳癌患者自付醫療費用及其對家庭財務的衝擊和生活品質的關聯性之研究

  Tang, C.

  7/1/21 → 2/28/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 台灣家族特有肌聯蛋白單?酸位點變異導致肌失養症之病因學研究 (II)

  Kuo, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以循環腫瘤細胞擴增系統預測非小細胞肺癌治療反應

  Chen, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies on Combination Chemotherapy of Doxorubicin and Cisplatin Loaded in Thermosensitive Hydrogels as Locally Controlled of Cancer Therapeutics

  Ho, H.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Molecular Mechanisms of Secretory Rab Gtpase 3c in Promoting Colon Cancer Metastasis(3/3)

  Chen, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Prevalence, Related Factors and Health Promotion Programs for Sarcopenia among Elderly with Diabetes (2/2)

  Lee, P.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 晚期肺癌病患使用免疫療法之生活品質評估

  Hsu, J. C.

  7/1/19 → 3/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 深度學習影像分割技術於黑質燕尾特徵的應用與神經黑色素之磁化率及遲豫時間的相關性分析

  Liu, H.

  7/1/21 → 2/28/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討使用者原創內容對消費者購買意願的影響

  Chang, C.

  7/1/21 → 2/28/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 真實世界數據應用於風險評估設定醫療照護模式以提昇住院照護品質研究-方法建立與導入實施(1/2)

  Chen, T.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Service for Sharing Precious Instruments of Taipei Medical University

  Lin, C.

  1/1/13 → 1/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study on the Expression and Regulatory Mechanism of Tumor Metastasis Suppressor Nm23-H1: Establishing Platforms for Studying and Screening Chemotherapeutic Agents Using Genomic Promoter Approaches

  Wang, L.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• In Vivo and in Vitro Studies of Progesterone-Induced Anti-Angiogenesis

  Lee, W.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• Reactions of NSAIDs (Mefenamic Acid and Diclofenac) by O3/Gac Processes: Intermediates, Pathway and Kinetic Models

  Chang, E.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Use of RIA-Enabled Image Processing Techniques for Constructing Micro-to-Macro Personal Biomedical Atlas

  Chen, C.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以經顱交流電刺激治療思覺失調症的隨機對照試驗(1/3)

  Lu, M.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 從食安風險暴露之角度探討非營養性甜味劑對女性生殖狀況之影響-非營養性甜味劑對青春期早發育的影響及相關機轉探討(2/3)

  Chen, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Regular Exercise on Emotional Control and Cognitive Function of Prefrontal-Limbic Pathway in Sleep-Deprived Rats---An Analysis by Behavior and Neurostructural Correlates(2/2)

  Hsu, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Prevalence and Effect of Potentially Inappropriate Medication of Elderly in Long Term Care Facility

  Hung, Y.

  8/1/14 → 10/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• A High Density and Nano-Sized ReRAM Crossbar Array Using Copper Chemical Displacement and Nanotip Array Techniques (I)

  Wu, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• 奈米生物介面研究：中孔洞氧化矽奈米粒子性質及其蛋白質冠冕於抗聚乙二醇免疫性、腫瘤標靶效率及腎臟排泄的影響(2/2)

  Wu, S.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 尼古丁受體基因叢與認知障礙關聯性的探討

  Yeh, C.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Mobile Phone Use and Walking: A Observational Field Study of Pedestrians' Risky Behaviours and Inattentional Blindness

  Pai, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Therapeutic Implications of Down-Regulation of Microglia Activation Following Repetitive Traumatic Brain Injury-Induced Chronic Traumatic Encephalopathy

  Chang, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 生醫與醫材轉譯加值人才培訓-ANCHOR UNIVERSITY計畫(TMU)

  Wu, C.

  8/1/20 → 7/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 消費者購買保健食品之實證研究

  Chang, C.

  7/1/21 → 2/28/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Technology & Distrust: a Study on Biomed Research & Development Models and Legal Framework( I )

  Chia, W.

  2/1/20 → 1/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Study on Learning and Counselling Strategies of Dental Technology Students for the Dental Technician Examination

  Lin, C. & Huang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• ERK/p65及p300在Pref-1誘導肺部纖維母細胞CTGF表現之研究

  Chen, B.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 智能垂足電刺激器之研發

  Peng, C.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Gender Analysis of Workplace Violence among Medical Care Personnel

  Chen, R.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Characterization of Multiple Functions of Plzf in Brain Development

  Lee, Y.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 闡明Hiltonol為主的複合式用藥在肺癌生長，轉移和腫瘤微環境中的作用。

  Chang, S.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討HIV-1反轉錄酉每與新穎先導藥物之複合體結構以利優化作為抗HIV候選藥物

  Liu, C.

  8/1/14 → 10/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 大腸直腸癌已躍居世界上癌症死亡率第二名，屬於固體型腫瘤，缺氧常見於此類 腫瘤，並誘發HIF-1α 表現而導致抗藥性及預後較差，因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑，可殺死癌 細胞而不影響正常細胞，對小鼠也不具毒性。我們初步結果顯示，Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現，代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性，對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下，經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制；也有研究報導指出，藥物會誘導癌細胞產生autophagy，造成細胞過度吞噬其內容 物而死亡，因此，autophagy在癌細胞為保護或是引發毒殺作用，目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活，但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示，除抑制HIF-1α 表現外，Zeb 也可活化AMPK、UPR/ER stress、以及autophagy， 因此我們推測Zeb 可在缺氧狀態下，促進autophagic cell death。3 年內我們將執行4 項 目標： (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。（第一年） (2) 研究Zeb 抑制HIF-1α表現之分子機轉。（第一年到第二年） (3) 研究Zeb 誘發autophagy之分子機轉。（第二年到第三年） (4) 探討Zeb 對缺氧導致抗藥性之作用。（第三年）

  Yang, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 環境菌相、空氣污染及生活型態對學齡前兒童過敏性疾病之影響

  Chao, H. J.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 具抗纖維化效果之選擇性組蛋白去乙醯酶抑制劑：利用有機金屬耦合反應合成吡啶酮為骨架之系列衍生物

  Liu, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Social Economy and Indigenous Community Resilient Livelihood: A Case Study of Three Communities in Back Mountain of Jienshi District, Hsinchu County (3/3)

  Lin, Y.

  1/1/22 → 12/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology