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• 降解型細胞自噬藉由促進微小RNA miR-449a表現量抑制大腸直腸癌之進程進而發展治療大腸癌之新策略(1/2)

  Wu, S.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討黃腐醇合併降血糖藥是否可調控粒線體失常並經由活化未摺疊蛋白反應所激發之AMPK-NRf2-ARE-Glo1路徑來逆轉雙羰基壓力導致之糖尿病腎脂毒性

  Chen, K.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 芳香烴受體於眼科疾病之治療潛力機制探討-多環芳香烴受體缺陷改變視網膜色素上皮細胞的整合素訊息,促進視網膜發炎環境及損害視網膜功能之分子機轉(1/3)

  Li, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 長散在核元件-1甲基化及DNA甲基化標記5-甲基胞嘧啶與5-甲基-2'-脫氧胞?濃度及尿液總砷濃度與慢性腎臟病的相關性

  Hsueh, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以循環腫瘤細胞預測肝癌治療反應及其機制探討

  Chiou, J.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 建立探討膜蛋白折疊的研究平台(2/3)

  Chang, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 標靶B型肝炎誘發之肝癌腫瘤生成與Sorafenib抗藥性之微環境：聚焦發炎激素與癌幹細胞特性之轉譯精準醫學研究與臨床意義-探討微環境發炎細胞激素與基因後生調節於B型肝炎病毒誘導之肝癌表現多能性幹細胞基因OCT4與Sorafenib抗藥性之調控機制與其臨床意義(3/3)

  Huang, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 開發1,3-二芳基取代之五元雜環作為抗胰臟癌劑(2/3)

  Lee, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 將BTK-ITK途徑作為標靶以克服肺癌治療的抗藥性以及抑制腦轉移的策略(2/3)

  Kuo, K.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Aza-PBHA , 透過調控芳香烴受體於糖尿病視網膜病變治療潛力機制探討(1/3)

  Cheng, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 丙型干擾素抗性於上皮細胞間質轉化對免疫檢查點阻斷療法的影響

  Lin, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 發展具有靶向及溶解血栓功能的奈米藥物治療平台(1/2)

  Mi, F.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 遠紅外線改善線粒體功能對糖尿病小鼠胰島β細胞的保護作用及與SIRT1和PLZF相關機制的研究(3/3)

  Chen, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Etelcalcetide經由調控Nrf2和Klotho-AMPK路徑改善腎性骨病變的骨轉換、血管鈣化和腎臟纖維化

  Zheng, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 改質活性碳添加於新型微管陣列薄膜應用於中分子蛋白質吸附之高效率 血液淨化器研究

  Wu, M.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• CHRNA7-p38MAPKs axis發炎基因網絡在巨噬細胞極化作用及對脂蛋白(a)引發冠狀動脈細胞痙攣的機制探討(2/3)

  Hung, M.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 寡糖經由調節發炎反應來保護急性腎損傷的機制研究

  Chen, T.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討PINK1於肺癌代謝鏈的調控機轉並研發可以調控PINK1活性的藥物(3/3)

  Lin, E. P.

  8/1/20 → 7/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 從食安風險暴露之角度探討非營養性甜味劑對女性生殖狀況之影響-非營養性甜味劑在妊娠期糖尿病發生所扮演的角色(1/3)

  Wu, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 辛伐他汀抗腎細胞癌的作用，經由抑制代謝重編程從mTOR、PPAR到RhoA(2/3)

  Juan, S.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 青少年期慢性睡眠剝奪對認知、情緒與壓力調適功能之影響：動物模式與人類世代之整合研究-青少年期慢性睡眠剝奪對認知與情緒功能之影響：動物模式之行為與神經內分泌功能變化探討(2/3)

  Yang, C. H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 社區民眾血管硬化程度分布，以及血管鈣化硬化粥狀硬化與代謝發炎相關生物標記及其基因多型性關連性研究(3/3)

  Bai, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討以Myc/PD-L1/Akt作為治療惡性腦癌標靶之轉譯研究(3/3)

  Lin, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討生物時鐘所調控之新型態肝細胞分裂模式在肝臟生理功能及相關疾病中所扮演之角色(3/3)

  Chao, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• BSP相似重複序列家族蛋白在草綠色鏈球菌所引起的感染性心內膜炎中細菌逃避免疫攻擊及生物膜形成所扮演的角色及機制探討(2/3)

  Jung, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 結合奈米診斷治療、影像免疫基因圖譜與人工智慧於原發性與再復發膠質母細胞瘤之研究-以機器學習的方法導入影像基因圖譜用以研究膠質母細胞瘤與免疫相關之基因表現(2/3)

  Chen, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 慢性腎臟病之日夜週期失序(1/3)

  Wu, M.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 胃腸科相關癌症之差異蛋白質體與致病機轉之研究

  Lee, J.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以靜磁場刺激臍帶間葉幹細胞所釋放的細胞外囊泡作為促進牙髓幹細胞分化成類牙本質細胞之研究

  Huang, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 進展性胰臟癌新穎增進免疫療法的治療策略與生物指標-對免疫療法併用方案節拍式化療或射頻燒灼療法之胰臟癌患者進行基因標記和免疫基因組庫之鑑定與分析(2/3)

  Chang, W.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 開發尼古丁乙醯膽鹼受體亞型5之單鏈變異片段型抗體及評估此一抗體對於增強口腔癌之放射線敏感度的治療效果

  Lin, C.

  8/1/20 → 7/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 標的蛋白降解技術: 含氮三環化合物為骨架利用有機金屬耦合反應合成系列衍生物

  Liu, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 陶斯松對於腸炎時CD4+ T細胞極化相關訊息路徑之影響(3/3)

  Hou, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 紫色桿菌素之微生物綠色醱酵製程開發與應用

  Lin, S.

  8/1/20 → 7/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 枸杞多醣與辣椒素對潰瘍性結腸炎修復之影響-探討抗氧化、抗發炎、抗細胞凋亡 、止痛、腸通透率、細胞防禦及菌相調節機制(2/3)

  Chao, J. C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Ma Tong Hypothesis of Brain Metabolite Clearance: Circadian Clock Effect on Beta-Amyloid Accumulation

  Myung, J.

  8/1/20 → 7/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Choroid Plexus as a Hub of Immune-Clock Interaction That Connects the Body to the Brain in Prematurity (1/3)

  Myung, J.

  8/1/20 → 7/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 建立無數據交換之健康數據研究聯盟之可行性探討

  Hsu, M.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討孩童肥胖，青春期發育與胰島素阻抗之基因生活型態影響因素(3/3)

  Chen, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 奈米HEVnp於晚期大腸直腸癌患者的治療策略(2/3)

  Whang-Peng, J.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 癲癇精準醫療：基於腦連結體之頑性癲癇術後個體預測

  Peng, S.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 從食安風險暴露之角度探討非營養性甜味劑對女性生殖狀況之影響-非營養性甜味劑對青春期早發育的影響及相關機轉探討(1/3)

  Chen, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討介白質-10對腹腔巨噬細胞的免疫調節作用以抑制腹膜炎及纖維化

  Liao, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討Homer Scaffolding Protein3 (Homer3)蛋白在乳癌病程進展，治療反應的角色和機制

  Hung, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討FCGR3A在肺腺癌中促進癌症惡化的角色和它作為免疫檢查點抑制劑治療效果之預測生物標記的應用

  Zheng, J.

  8/1/20 → 7/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Integrated Study of Clinical, Molecular Analysis, Mr-Based Radiogenomic, and Preclinical Trials for Precision Treatment of Atypical Teratoid/Rhabdoid Tumor (Atrt) in Children(2/3)

  Wong, T.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以社會壓力模型大鼠研究鋰鹽心臟保護作用之分子機轉(2/2)

  Chen, P.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effect of Low-Intensity/High-Repetition Resistance Training and High-Intensity Circuit Training on Peripheral Bdnf Levels, Cognitive Functions and Physical Fitness in Elderly with Different Bdnf Val66met Genotypes

  Chung, Y.

  8/1/20 → 7/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 肌肉感覺神經元在腰椎神經根病變中之角色(3/3)

  Lin, J.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 腦外傷動物經鼻腔注射FGF-21間質幹細胞之治療效果與機制探究

  Wu, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology