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• b - Ministry of Science and Technology

  研發新穎性 MAP3K9 抑制劑並探討其對胰臟癌之抗癌機轉

  Pan, S.

  7/1/21 → 2/28/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Pharmacogenomics of Immune Responses during Acute Dengue Virus Infection for Clinical Diagnosis: Focus on T Cell Repertoire and Genetic Variants of the C-Type Lectin Family( III )

  Chang, W.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• 結合活性篩選平台的天然產物自動化分析模組機設計(2/2)

  Lee, C.

  6/1/21 → 5/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Developing New Diagnostic and Therapeutic Strategies for Lung Cancer with ROS1, RET and NTRK1 Mutations in Patients without EGFR, KRAS and ALK Mutations

  Liu, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Therapeutic Potentials of Exosomes from Mesenchymal Stem Cell on Mitigating Cardiac Alterations and Their Effects on Modulating Oxidation, Inflammation, Mitochondrial Dysfunction and Insulin Resistance in Obesity Mice and Obesity Mice with Sepsis

  Huang, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Molecular Basis of Senp2 in Regulating Smad4 Sumoylation and Its Functions in Triple Negative Breast Cancer(2/3)

  Chang, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study on the Roles of Unfolded Protein Response and Ubiquitin-Proteasome System in Radiotherapy Using Nanoparticle Drug Delivery in Triple-Negative Breast Cancer(3/3)

  Chiu, H.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 管理階層政商關係對生物科技公司首次公開募股後辦理首次現金增資期程之影響

  Hsiao, Y.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討TCF7L1對前列腺癌神經內分泌分化之分子機轉與臨床意義

  Wen, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 腦創傷後的神經再生研究(2/5)

  Chuang, J.

  2/1/21 → 1/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 空氣污染與土地利用特性對兒童發展及呼吸道健康之影響：大台北地 區長期追蹤研究(3/3)

  Chao, H. J.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effect of Acceptance and Commitment Therapy (Act) on Internalized Stigma and Low Self-Esteem among Patients with Schizophrenia

  Chung, M.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Logic of Care in Miscarriage and ‘An-Tai’ in Taiwan: Adaptive Practice and Accountability from Medical Professionals, Women and Their Partners (1/2)

  Shih, L.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• Inhibition of IkB Degradation Reduces Collagen Production via Downregulation of Androgen Receptor Expression in Dihydropyridine-Induced Gingival Overgrowth Cells

  Lu, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討HIV-1反轉錄酉每與新穎先導藥物之複合體結構以利優化作為抗HIV候選藥物

  Liu, C.

  8/1/14 → 10/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 大腸直腸癌已躍居世界上癌症死亡率第二名，屬於固體型腫瘤，缺氧常見於此類 腫瘤，並誘發HIF-1α 表現而導致抗藥性及預後較差，因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑，可殺死癌 細胞而不影響正常細胞，對小鼠也不具毒性。我們初步結果顯示，Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現，代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性，對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下，經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制；也有研究報導指出，藥物會誘導癌細胞產生autophagy，造成細胞過度吞噬其內容 物而死亡，因此，autophagy在癌細胞為保護或是引發毒殺作用，目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活，但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示，除抑制HIF-1α 表現外，Zeb 也可活化AMPK、UPR/ER stress、以及autophagy， 因此我們推測Zeb 可在缺氧狀態下，促進autophagic cell death。3 年內我們將執行4 項 目標： (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。（第一年） (2) 研究Zeb 抑制HIF-1α表現之分子機轉。（第一年到第二年） (3) 研究Zeb 誘發autophagy之分子機轉。（第二年到第三年） (4) 探討Zeb 對缺氧導致抗藥性之作用。（第三年）

  Yang, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Mechanistic Investigation of Anticancer Activity of the Site-1 Protease Inhibitor against Hepatocellular Carcinoma (1/3)

  Yang, P.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• Evaluation Studies of Haptoglobin and Its Subunits Applied to the Prevention and Prediction of Restenosis

  Wu, C.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• 台灣中醫醫療利用情形、長期趨勢及其影響因素：一項多樣本的大型研究

  Liao, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Localized Delivery of Radioprotectant to Enhance Salivary Glands Radioprotection Inspired by Sandcastle Worm Adhesive Platform (1/3)

  Wang, C.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• Explore the Pathophysiology Role of Vascular Endothelial Cell and Adam 17 during Blue Light-Induced Retinopathy, and the Therapeutic Strategy.

  Li, C.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• Recovery of Perfluorinated Chemicals by Flotation-Development of New Collectors and New Flotation Process

  Hu, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Study on the Evaluation of Stromal Stem Cells and Stromal Fibroblasts in Human Tissue Regenerative and Cancer Forming Potentials

  Shih, T.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Bicycle Taillights and Reflective/Led Clothing on Motorists’ Overtaking/Tailgating Behaviours: an On-Field Observation Study

  Pai, C.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 肺癌大數據精準醫療人工智慧系統－肺癌大數據精準醫療人工智慧系統( 1/4)

  Chen, C.

  7/1/20 → 6/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Developing an Assessment and Rehabilitation System for Improving Bilateral Ankle Coordination Control and Functional Performances of Lower Limbs Following Chronic Stroke II (2/2)

  Lin, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation of Herbal Medicine Regulate Gut Microbe to Improve Immunotherapy for Colonrectal Cancer

  Tai, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 產學合作計畫－抗藥性白色念珠菌單鏈抗體之研發

  Leu, S.

  11/1/20 → 10/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study the mechanisms of novel benzimidazole derivative in the sorafenib-resistance liver cancer cell

  Liao, Y.

  7/1/18 → 2/28/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 益生菌PS128對重鬱症患者之生理及憂鬱症狀影響：八周之隨機,雙盲,安慰劑控制試驗

  Chen, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 天然物對鉑類抗藥性膀胱癌之治療潛力及其分子作用機轉探討(2/3)

  Chen, M.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 中文版理察斯-坎貝爾睡眠量表於重症病人之測量特性：以古典測試理論與試題反應理論驗證

  Chiu, H.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 非營養性甜味劑對於懷孕母鼠子宮收縮之影響

  Hsia, S.

  7/1/21 → 2/28/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以肝-腸-腦軸之觀點探討抹茶對於Cafeteria飲食誘導大鼠非酒精性脂肪肝疾病脂質代謝、氧化壓力及發炎反應之影響

  Chen, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Elderly Women Caregiver: the Relationship between Their Health Profile and Welfare States

  Chuang, K.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• To Study the Correlation between Serum Markers of Oxidative Stress, Inflammation, and Endocrine-Disrupting Chemicals (Edcs) and Their Impact on the Menstrual Cycle and Reproductive Hormone in Taiwanese Women

  Hsu, M.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 疫苗研發與應用之倫理、法律、社會影響整合型研究計畫－子計畫三-全新與未充分驗證疫苗導入之公共政策與社會認知(1/2)

  Tsai, F.

  1/1/14 → 12/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Ionic Currents and Calcium Homeostasis in Atrial Arrhythmogenesis of Chronic Obstructive Pulmonary Disease Animal Model

  Lin, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Avoidable Hospitalizations and Primary Care Manpower in a Universal Health Insurance System: a 15-Year Trend Analysis

  Huang, K.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• 跨歐洲醫療機構品質與安全提升

  Chang, W.

  12/1/10 → 11/30/11

  Project: A - Government Institution › b - Ministry of Science and Technology

• Prevalence, Risk Factors, and Impacts of Sleep Disturbances in Older Adults Following Traumatic Brain Injury

  Chiu, H.

  7/1/18 → 2/28/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 抑制site-1蛋白酶引發肝癌細胞自我吞噬之研究

  Yang, P.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• The effect of stress and anxiety in actual and virtual blue working environments

  Yen, H.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 低維度奈米材料於智慧感測及微侵入醫療技術之應用(2/5)

  Yang, P.

  11/1/20 → 10/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 混合中位數及平均數之統合分析方法探討--應用於pre-post之研究設計

  Chen, J.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 臺灣乳腺癌術前輔助或術後輔助治療之研究-接受不同類型治療之女性乳癌復發和存活分析之回顧性研究

  Su, E. C.

  7/1/22 → 2/28/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• 大學臨床實習生的睡眠時型與睡眠品質：睡眠應激反應與心理韌性的調節作用

  Tsai, P.

  7/1/22 → 2/28/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigating the Therapeutic Potential and Molecular Mechanism of Natural Products in Pediatric High-Grade Gliomas (2/3)

  Chen, C.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Impact of Bank Relationships on the Speed of Covid-19 Relief Loans

  Hsiao, Y.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Cohort Study of Diverse Environment Exposure for the Association between Arsenic Exposure and Vascular Dementia in Middle Aged and Elders (1/3)

  Chiou, H.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology