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• b - Ministry of Science and Technology

  Study on the Regulation of Txnip in Nicotine-Induced Inflammatory C-Reactive Protein Expression in Macrophages and Its Pathological Effects

  Chen, C.

  2/1/16 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• 開發液相層析-質譜儀方法定量血清中IgG subclass: 應用於IgG4 純化流程建立

  Tsai, I.

  7/1/17 → 2/28/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study on the Roles of Unfolded Protein Response and Ubiquitin-Proteasome System in Radiotherapy Using Nanoparticle Drug Delivery in Triple-Negative Breast Cancer

  Chiu, H.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 結合深度學習及數據非依賴採集質譜法以偵測膜蛋白體突變與癌症新生抗原(1/3)

  Han, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討HMGB1對於DCLK1調控急性呼吸窘迫症候群之第二型肺泡上皮細胞老化之角色

  Lee, K.

  7/1/21 → 2/28/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 裝載GM-CSF及標靶奈米粒子疫苗之水膠複合系統用於原位募集並活化樹突細胞以增強腫瘤特異性免疫反應達到抑制癌症轉移之功效(1/3)

  Pan, W.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 藉由整合多重組學的資料解析與判定人體中未知細菌的基因表現及該細菌在環境中伴演的角色(1/2)

  Wu, Y.

  3/1/17 → 2/28/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以光譜與光譜影像技術檢測稻米避免遭受黃麴毒素污染之研究

  Chuang, Y.

  5/1/17 → 4/30/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Efficient Immunoglobulin G Analytical Method for Investigating Autoantibody Biomarkers for Pancreatic Disease (Continuous Research)

  Tsai, I.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Impacts of Particulate Air Pollution on Repair and Abnormal Inflammation in Copd: the Role of Itih4 and the Regeneration Pathways

  Lee, K.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Mechanistic Investigation of Linc00963 on Promoting Lymph Node Metastasis and Drug Resistance through Abcb5 Regulation and Its Potential Theranostic Value during Oral Carcinogenesis

  Tsai, L.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Proteogenomics Platform for Multiplexed Screening of Membrane Protein Mutations

  Han, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation of the Role of Gut Microbiota in Antipsychoticinduced Metabolic Dysfunction in Patient with Schizophrenia

  Liu, Y.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Formation of Glycidyl Esters during Processes of Interesterified Edible Oil Products

  Lee, W.

  6/1/18 → 5/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 認知功能缺損長者的平衡控制與動作策略：三維動作分析以及穿戴式雙重任務訓練裝置之開發及其於居家介入之成效(第二、三期)(1/2)

  Kuan, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Establish the Research Platform for Studying Triple-Negative Breast Tumor Microenvironment Regulation: the Hyaluronan Synthase-3 Mediated Antitumor Effects as an Example.

  Ho, Y. & Wu, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Application of Functional Electrical Stimulation on the Study of Nerve Regeneration in the Rat with Diabetic Neuropathy

  Peng, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Neuroendocrine-Immune Mechanisms of Physical Activity on Behavioral Symptoms in Lung Cancer Patients---A Comparison of Patients Receiving Active Treatments and Survivors

  Lin, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effectiveness of Mindfulness-Based Cognitive Therapy (MBCT) for Patients with Depressive Disorders

  Chang, H. & Chiou, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation of the Feasibility of Functional Electrical Stimulation in the Treatment of Bladder Dysfunction under a Diabetic Rat Model

  Peng, C. & Chen, S.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Central Neuromodulation with Functional Electrical Stimulation on Bladder Functions in Traumatic Brain Injured Rats

  Peng, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 慢性肝病在台灣是一個極具挑戰性的臨床議題。肝纖維化的多重病原性是造成病患死亡 率增加的原因，而且肝纖維化往往會發展成肝癌。我們最近利用國民營養調查資料庫 (NAHSIT 2005-2008)分析國人血中鐵營養值標與代謝症候群的相關性.在全人口的分析 中，我們發現校正了血清發炎指標以及飲食的營養指標後, serum ferritin (鐵蛋白質) 高於最大三等分位的族群，得到代謝性症候群的危險對比值超過 1.6 倍. 目前並不清楚 過量的鐵蛋白質為何與代謝症候群的發生率有關。肝臟為重要的儲鐵器官但是臨床研究 也顯示過量的鐵質沉積與肝纖維化及肝癌有極大的相關性。血清中鐵蛋白質為反映體內 儲存鐵的生化質標。但是,發炎因子也會造成血清中鐵蛋白質的異常增加。證據顯示發炎 因子可以調控鐵蛋白質的基因表現量。但是慢性發炎如何造成鐵蛋白質代謝異常(組職 內沉積及釋放)? 血清中的鐵蛋白質又有何生理功能? 隨著國人代謝症候群及脂肪肝發生率的年輕化,這次研究的主題是以老鼠初代星狀肝細 胞來分析鐵蛋白質對內質網壓力機轉與肝纖維化的影響: 相關研究的主要目標為: 1. 釐清鐵蛋白質(serum ferritin)過量是否會造成星狀細胞內質網壓力增加與活化? 2. 何種鐵質(ferric, ferrous, ferritin, Apoferritin)較易增加內質網壓力? 3. 找出何種內質網壓力的轉錄因子 (ATF6,ATF4, XBP1 and CHOP)受到鐵質調控? 4. 分析鐵質誘導的內質網壓力機轉與肝臟纖維化的營響

  Chang, J.

  9/1/12 → 8/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Impact of Functional Connectivity MR Imaging Study in the Correlation of the Surgical Outcome Validations and Neuroplasticity of Lumbar Spinal Stenosis with Neurogenic Intermittent Claudication

  Huang, T.

  8/1/14 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Investigation of Anti-Neuroinflammatory Constituents from Fungal Species and Their Protective Profiles in the Retinal Diseases(2/3)

  Hsiao, G.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Trajectory of Psychological Distress among Infertility Women: Efficacy and Mechanism of Mind-Body Intervention with Heart Rate Variability Biofeedback(2/3)

  Kuo, S.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Sub-Project 1: Mechanisms and Effects of Paired Associative Nerve Stimulation in Spinal Cord Injured Animal Models( I )

  Peng, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Nucleic Acid Amplification as the Initial Diagnostic Test in Patients Suspected of Having Pulmonary Tuberculosis

  Chiang, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Targeting Kdm4a in Prostate Cancer(III)(3/3)

  Kung, H.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 青少年期慢性睡眠剝奪對認知、情緒與壓力調適功能之影響:動物模式與人類世代之整合研究-青少年期慢性睡眠剝奪對認知、情緒與壓力調適功能之影響:健康青少年族群之觀察追蹤與介入研究(2/3)

  Lee, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Social Medicine Discipline Research Planning and Promotion Project

  Chiou, H.

  1/1/15 → 12/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 台灣乳癌患者自付醫療費用及其對家庭財務的衝擊和生活品質的關聯性之研究

  Tang, C.

  7/1/21 → 2/28/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Growth Factors-Rich Evs-Functionalized Graphene-On-Hydrogel Based Skin Bioactive Regeneration Scaffolds( I )

  Burnouf, T. P. R.

  1/1/22 → 12/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Causes and Courses of Insomnia---Case-Control and Follow-up Study

  Lee, H., Hsu, R. & Kang, J.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• Mechanisms and Clinical Applications of Transcranial Direct Current Stimulation in Treating Patients with Firbomyalgia

  Kang, J., Chen, S. & Lee, H.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• 中風後丘腦神經網路調節機制之轉譯影像研究(3/3)

  Chen, C.

  8/1/18 → 10/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Studies of Cxcl12 on Mycobacterium Tuberculosis-Induced Fibrocyte Activation and Pulmonary Fibrosis

  Lin, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Pharmaceuticals Removal in Hospital wastwater and effluent by Electro-coagulation-flotation

  Hu, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Short-Chain Fatty Acids Act as Anti-Allergic Regulators on Immune Effector Cells and Exert Immune-Modulatory Effects on Ovalbumin-Induced Allergic Diseases in Mice

  Lee, Y. & Hsiao, G.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Expressing Membrane Antibody Reporter in the Islet Cells of Nonobese Diabetic Mice to Noninvasive Assess the Therapeutic Effects of Drugs or Transgenes for Autoimmune Diabetes

  Chuang, K.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study the Therapeutic Effects and Novel Molecular Mechanisms of Resveratrol in Human Osteosarcoma---The Treatment of Metastatic Cancer

  Chien, M.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studied the Roles of Grp94 in the Progression and Metastasis of Esophageal Squamous Carcinoma, Mechanism Dissection, and Drug Development

  Chang, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies on the Carcinogenic Mechanisms of Glucose Transporters in Gastrointestinal Cancer Cells and Its Clinical Therapeutic Applications

  Chen, L. & Wu, C.

  9/1/15 → 8/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• 肺纖維化之轉譯研究－組蛋白去乙醯酉每2的SUMO化修飾貢獻於慢性阻塞性氣喘的結締組織生長因子表現與肺部纖維化反應(2/3)

  Lin, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study on the Mechanism for the Beneficial Effects of Soy Protein on Alcoholic Liver Diseases

  Chen, J.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• 改質活性碳添加於新型微管陣列薄膜應用於中分子蛋白質吸附之高效率 血液淨化器研究

  Wu, M.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Insights into the Molecular Mechanisms of Lithium on Cardioprotection in Social Stress(2/2)

  Chen, P.

  8/1/20 → 7/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Tactile Massage in Improving Older Residents' Psychological Health and Related Indicators in Long-Term Care Facilities

  Chuang, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 102 年東南亞區域共同研究暨培訓型國際合作計畫—亞洲 15 國衛生識能國際合作比較研究與研習教育計畫

  Chang, W.

  6/1/13 → 12/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Plasmon-Activated Water on the Microbiota of Inflammatory Bowel Disease, Crohn’S Disease and Ulcerative Colitis, by Drug-Induced and Transgenic Mouse Models

  Chang, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Translational Relevance and Mechanism of Glucose Transporter 3 in Colon Cancer Metastasis: Focus on Tumor Microenvironment and Developing Therapeutics

  Lin, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology