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• b - Ministry of Science and Technology

  Steroid and Antihistamin Synergize to Inhibit Rat’s Tracheal Smooth Muscle Contractility and Its Possible Mechanisms

  Wang, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of Cytoplasmic APe1 in Tumor Malignancy, Drug Resistance and Lung Cancer Prognosis

  Lee, H.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigating a key switch between immune-overactivation and tumorigenesis

  Chang, S.

  2/1/16 → 1/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以白色念珠菌 alpha-enolase 為目標的單株抗體的人源化與其可能的應用

  Yang, Y.

  2/1/17 → 1/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation of Long Non-Coding Rna on the Tumorigenesis in Human Colorectal Cancer

  Liang, Y.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Molecular Biological Mechanism of Fish Oil on Preventing Alcoholic Liver Diseases: The Hepatoprotective Effects of EPA and DHA Based on Lipid Metabolism, Autophagy and Inflammatory Responses

  Yang, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• 大腸直腸癌已躍居世界上癌症死亡率第二名，屬於固體型腫瘤，缺氧常見於此類 腫瘤，並誘發HIF-1α 表現而導致抗藥性及預後較差，因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑，可殺死癌 細胞而不影響正常細胞，對小鼠也不具毒性。我們初步結果顯示，Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現，代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性，對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下，經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制；也有研究報導指出，藥物會誘導癌細胞產生autophagy，造成細胞過度吞噬其內容 物而死亡，因此，autophagy在癌細胞為保護或是引發毒殺作用，目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活，但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示，除抑制HIF-1α 表現外，Zeb 也可活化AMPK、UPR/ER stress、以及autophagy， 因此我們推測Zeb 可在缺氧狀態下，促進autophagic cell death。3 年內我們將執行4 項 目標： (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。（第一年） (2) 研究Zeb 抑制HIF-1α表現之分子機轉。（第一年到第二年） (3) 研究Zeb 誘發autophagy之分子機轉。（第二年到第三年） (4) 探討Zeb 對缺氧導致抗藥性之作用。（第三年）

  Yang, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Using the Integrated Hospital Data for Implementing and Evaluating of Early Detection of Influenza Epidemic

  Lo, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Bone-Marrow-Derived Mesenchymal Stem Cells in Prostate Cancer-Induced Bone Remodeling

  Hsieh, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Crystal Structures and Functional Studies of Novel Glycosyltransferases from Staphylococcus aureus(2/3)

  Liu, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以腸-肝-肌肉軸觀點探討腸道健康促進因子對於酒精性肝臟疾病大鼠腸漏症、腸道菌相多樣性及肌少症的影響(3/3)

  Yang, S.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 闡明Hiltonol為主的複合式用藥在肺癌生長，轉移和腫瘤微環境中的作用。

  Chang, S.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of Galectin-1 in Liver Fibrosis-Promoted Stem-Like Cell Properties and Sorafenib-Refractoriness of Hbv-Related Hepatocellular Carcinoma( III )

  Wu, M.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Essential Oils on Smooth Muscle Contraction in Rat Uterus (Gm07)

  Hsia, S.

  8/1/12 → 12/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Huntingtin-Associated Protein-Mediated Vesicular Trafficking Biomarkers in Neurodegenerative Diseases

  Lin, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effectiveness of the Physician-Nurse-Pharmacist Collaboration Model in Medication Reconciliation Using National Health Insurance Pharmacloud in Ambulatory Care

  Hu, S. H.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Carbamylation Modification of Novel Synovial Fluid and Serum Proteins and Its Role of Anti-Carbanylated Protein Autoantibodies in the Clinic Association of Rheumatoid Arthritis Was Investigated

  Lin, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Fibromyalgia: Impacts of Different Phenotypes on Quality of Life and the Effects of Technology-Assisted and Tailored Health Coaching

  Tsai, P.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 抗組織胺藥物ketotifen抑制肝癌細胞生長之機制探討

  Liang, Y.

  7/1/19 → 2/1/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 研究肺氣腫發展中調控細胞老化的分子機轉: 前胸腺素-HuR-SIRT1路徑

  Su, B.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 研究PKLR促進前列腺癌神經內分泌分化之代謝途徑及其治療角色(1/3)

  Liu, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討ARE結合蛋白質與選擇性聚腺甘酸化作用在人類大腸直腸癌上所扮演的角色(3/3)

  Liang, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects and Mechanisms of Pitx2c Modulation for Atrial Electrophysiological and Structural Remodelings in Heart Failure

  Kao, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Primase, DNA, polypeptide 1（PRIM1)參與吸菸所誘發乳癌形成機制及臨床轉譯研究(1/3)

  Chen, L.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Clinical Outcome and Drug Resistant Biomarkers Establish for Hpv Infected Non-Small Cell Lung Cancer

  Hsu, N.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 科普活動：小小AD8失智檢測先鋒—從書寫祖父母的生命故事書串起認知神經科學與失智檢測(主題一)

  Hsu, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 青少年期慢性睡眠剝奪對認知、情緒與壓力調適功能之影響:動物模式與人類世代之整合研究-探討青少年期慢性睡眠剝奪對壓力調適功能之影響--以腸腦軸線功能變化為例(2/3)

  Huang, S.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• An Industry-University Alliance on Pilot-Type Animal Experimental Consultancy and Analytic Platforms(3/3)

  Chang, H.

  2/1/20 → 1/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 昆蟲的親緣基因體學: 昆蟲和其他泛甲殼動物的基因體演化(3/3)

  Chen, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討第一型內皮細胞分子與上皮細胞生長因子受體之相互調控在非小細胞肺癌進程之角色(3/3)

  Chien, M.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 從食安風險暴露之角度探討非營養性甜味劑對女性生殖狀況之影響-非營養甜味劑暴露之評估及其對脂肪組織的影響(1/3)

  Chen, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 治療膠質母細胞瘤之新穎小分子多標靶抗癌藥物之設計合成與開發

  Huang, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 辨認癌化過程中 adenosine至inosine RNA編輯的調控因子

  Chen, C.

  10/1/16 → 10/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 內毒素引發肺迷走感覺神經過度敏感 ：Sigma-1受器的角色

  Hsu, C.

  7/1/19 → 2/1/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Utilizing Artificial Intelligence Vi Rtual Screening Platform to Identify a Small-Molecule Inhibitor of Dna Polymerase Theta and Estimating Its Therapeutic Effectiveness on Metastatic Castration-Resistant Prostate Cancer

  Lin, Y.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• ERK/p65及p300在Pref-1誘導肺部纖維母細胞CTGF表現之研究

  Chen, B.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Prediction of Cancer Metastasis Using SVM-Based Model with Quantification of Pathway Changes between Different Disease Statuses

  Chiu, H. & Chang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of Galectin-1 in Liver Fibrosis-Promoted Stem-Like Cell Properties and Sorafenib-Refractoriness of Hbv-Related Hepatocellular Carcinoma(I)(1/3)

  Wu, M.

  8/1/18 → 8/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Targeting Ovarian Cancers with Chimeric Antigens Receptor (Cars) T-Cells Mediated Immunotherapy(1/3)

  Liu, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Electrophysiological Activity and Functional Correlates in Female Pelvic Floor Muscles(2)

  Yang, J.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• From Hospital to Community: Longitudinal Changes of Participation in Younger Stroke Survivors

  Chang, F.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Randomized Controlled Study of Aquatic Exercise Program for Cognitive Frailty Older People’S Gait, Balance, Cognitive Function and Fall Risk.

  Chiu, H.

  3/1/19 → 2/1/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigate the Molecular Mechanisms Involved in Enhancing Photodynamic Thetapy Using an Old Antibiotic Agent

  Tsai, T.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effect of Long Acting GnRH Agonist Treatment on Mitochondrial Function in

  Tzeng, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Novel Small Molecules Nsc771784 and Nsc772867 for Breast Cancer Therapy with Brain Metastasis

  Lundy, D.

  10/1/19 → 4/30/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effect of Muscle Strength Training on Body Composition and Sarcopenic Obesity among the Female Overweight Elderly

  Liou, T.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies of Interaction Effects between Ketone Metabolism and Mitochondrial Function and Biogenesis

  Hsieh, R.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Molecular and cellular mechanism of adipocyte modulatory effects on pulmonary vein and atrium

  Chen, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 國際產學聯盟計畫III

  Lin, C.

  9/1/19 → 8/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Therapeutic Potentials of Peptide-Based Cytokine Binding Decoy against Sepsis and Its Effects on Modulating Inflammation, Oxidation, Apoptosis, Autophagy and Inflammasome

  Huang, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology