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• b - Ministry of Science and Technology

  Research of Carbon Nanomaterials Conjugated with Raf Kinase Inhibitors as Multifunctional Delivery System for Kras Mutated Colorectal Cancer Treatment

  Cho, E.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Genetic Studies of Multiple System Atrophy-Cerebellar Type in Taiwan(2/2)

  Soong, B.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 粒線體介入經由代謝調控於糖尿病心肌病變的治療

  Lee, T.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Microarray Investigation of Global Regulation by speG in Salmonella typhimurium, Human Intestinal Epithelium, and B Lymphocytes in an in vitro M-Cell Model

  Fang, S.

  4/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Tumor Necrosis Factor-Alpha Induces Airway Hypersensitivity: Role of Ceramide

  Hsu, C.

  8/1/18 → 10/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• ≫Combination of E1a Gene Therapy and Egfr Tyrosine Kinase Inhibitors in Tnbc: Preclinical Studies May Light up the New Therapeutic Strategy

  Su, C.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Empowerment of Civil Society and Reform of Government Administrative: a Study on the Promotion of Participatory Budget in Taichung City

  Shih, S.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Exploring the Potential Impacts of Maternal Early-Life Sleep Deprivation on Metabolic Function of the Offspring( II )

  Chang, H.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Ways of Seeing, Remembering, and Forgetting in the 21st Century: Unreliable Narrators and Narrative Parodox in Julian Barnes’ and Ian McEwan’s Novels

  Tseng, C.

  5/1/17 → 4/30/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Aldose reductase (AR)調控膠原蛋白GPVI及凝血?PAR4所引起血小板活化及細胞凋亡的新角色: Arf-AR在無核細胞中所扮演的訊息傳遞機制 (II)(2/2)

  Sheu, J.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Series of Study in Lifestyle Analysis and Exploration of the Effect of Cognitive-Behavioral Intervention among High Risk Subjects with Family History of Colorectal Cancer

  Jeng, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 乳癌是目前世界上女性癌症病患中為數最多的癌症之ㄧ。腺病毒蛋白type 5 E1A (E1A)和許多抗腫瘤作用有關，曾於多種癌症如乳癌、卵巢癌及頭頸癌之病患進行臨床基因治療試驗。許多的研究指出E1A具有多項抗腫瘤的功能，包括抑制腫瘤的發生、增加腫瘤細胞對於化療藥物的感受性以及減少腫瘤轉移的現象。腫瘤的轉移對於癌症患者的死亡率有極大的影響當然也包括了乳癌的患者。E1A於抑制腫瘤發展的過程中具有多重生物學上的意義，這也促使我們想要釐清E1A抑制癌症的機制。因此，我們對於了解E1A抑制癌症轉移相關的分子機制感到有興趣，並期望藉以作為未來改進乳癌病人臨床試驗的基石。我們初步的實驗結果顯示，E1A可以有效的抑制Glucose-regulated protein 78 (GRP78)這種已被廣泛報導和腫瘤惡化及轉移相關的蛋白的表現。 提出此研究計劃之目的在於詳細探討E1A所造成的抑制癌轉移作用中，GRP78所扮演的生物功能及其調控的機轉。為了達到此目的，我們將著重於E1A如何調控GRP78表現並進而展現對乳癌轉移的抑制作用。以下為此項研究計畫的四大主要目標： 目標一：探討GRP78在E1A所抑制之癌細胞移行及侵入作用中所扮演的角色 目標二：研究E1A抑制GRP78表現之分子機轉 目標三：於動物模式中驗證GRP78的表現對於E1A抗腫瘤作用的影響 目標四：探討GRP78及其相關分子的表現在乳癌病人的臨床重要性 完成以上的主要目標能夠幫助我們對於E1A之抗腫瘤轉移作用建立更加詳細的分子訊息傳遞機制。另外，藉由此研究計畫的新發現也許可以對未來發展癌症治療上提供更多具有潛力的標的物。

  Wang, W.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of Ribonucleotide Reductase (Rnr) in Skeletal Muscle with Age: the Functionality of Rrm2b in Repair and Regeneration

  Chen, Y.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of Neuropilin-1 Glycosylation in Galectin-1 Induced Activation of Hepatic Stellate Cells and Liver Fibrosis(3/3)

  Wu, M.

  8/1/16 → 9/30/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Quantitative Diagnosis of Rotator Cuff Lesions Using Supraspinatus Ultrasound

  Lo, C.

  9/1/15 → 8/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study on Oseto Tissue Regeneration of Bio-Medical Material Scaffolds Using Anodic Aluminum Oxide with Curved Surface Combined Micro/Nanostructure

  Shen, Y.

  8/1/11 → 10/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study on the Mechanism of Cross-Talk between Ahr and Autophagy, and Autophagy---Associated Physiological or Pathological Phenomenon on Vascular and Airway Systems (I)

  Li, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討臺灣牛樟芝對多型性神經膠質瘤治療的角色、調控基因與開發新穎治療策略

  Lin, J.

  6/1/18 → 12/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Using Machine Learning Technique to Evaluate the Impact of Curcumin on the Brain-Gut Interaction in Patients with Tuberous Sclerosis Complex Comorbid to Autism Spectrum Disorders(2/3)

  Lo, Y.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Research of Core Course for Bio-Energy in TMU

  Shen, Y.

  11/1/10 → 6/30/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Onion and Allium Vegetables Cultivated in Taiwan and Mongolia on Osteoporosis

  Chen, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• To Investigate the Role of Rbm3 in Therapeutic Hypothermia Mediated Neuroprotection in Ischemia Stroke(2/3)

  Yang, C. H.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Changes of Brain Structural Connectivity and Behaviors in Typical Autism after Teacch Intervention

  Lo, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• A series of studies analyzing exercise behavior and exploring the effects of interventions among pre-diabetes, type 1, and type 2 diabetes

  Jeng, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Neural mechanism of distractor induced attentional orienting and suppression

  Hsu, T.

  12/1/16 → 11/30/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討Homer Scaffolding Protein3 (Homer3)蛋白在乳癌病程進展，治療反應的角色和機制

  Hung, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Roles of Central OX2R Activities in the Pathophysiology of Hypertension in SHR

  Hwang, L.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of an Optimal Electrical Stimulation System for Lower Urinary Tract Disorders after Spinal Cord Injury(1/2)

  Chen, S.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation of Inflammatory Microenvironment-Regulated Stemess in Glioblastoma

  Ko, C.

  10/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 蔣介石對美國總統大選的認知、態度與應對—1948至1972(1/2)

  Chang, K.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Dissected the Role of Thrombomodulin in the Clinical Diagnostic and Therapeutic Impacts for Breast Cancer and the Regulation Mechanisms

  Hung, C.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Oxidative Damage in Retinal Pigment Epithelium---The Role Played by Mitochondria and the Protecting Effect of Mitochondria-Targeted Peptide Antioxidants

  Ho, J. & Hsieh, R.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

• Disease Trajectories and Its Association with Metabolic Dysfunction of Prostate Cancer Men Following Androgen Deprivation Therapy and the Potential of Pharmacological Medication in Preventing Metastatic Diseases.

  Shao, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• 抑制NADPH Oxidase可能是 Pomalidomide對創傷性腦損傷之神經保護作用的機制之一

  Wang, J.

  7/1/17 → 2/28/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigating Influences of Neuronal State in Local and Large-Scale Cortical Networks during Rest and Task on Subsequent Neuronal Activity and Behavioral Performance: a Multi-Model Approach

  Hsu, T.

  8/1/18 → 12/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Physiological Indicators of Early Cardiac Dysfunction in Patients with Schizophrenia

  Chen, P.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation of Astrocytic Cebpd-Regulated Mirnas and Their Effects on Angiogenesis during Neuroinflammation (Ii)

  Ko, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Taste of Colonization: the Production and Consumption of Skipjack Tuna in Postwar Taiwan (1945-1995) (1/2)

  Tseng, L.

  8/1/20 → 7/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 融入問題導向學習法與設計思考法於醫學院非資訊領域學生程式學習成效之評估

  Liu, I.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigated the Role of Mir-200 Family in the Prognostic and Therapeutic of Hcc and Dissected the Possible Mechanism

  Wang, W.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• In Vivo Early Neuroimage Profiles of Injurious and Protective Responses in Neonatal Hypoxic-Ischemic Models Using 7t Mri( I )

  Kao, Y. J.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Implication of Plasminogen Activator Inhibitor-1 in the Regulation of Thrombin-Induced Fibrogenesis in Inflammatory Pleural Effusions.

  Chung, C.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Protease-Activated Receptor 4 Antagonists as Novel Antithrombotic Drugs

  Lu, W.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Indole Derivatives from Vegetable on Lipid Metabolism and Adipogenesis – Involvement of the Ah Receptor?

  Chen, Y.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of the Balance Tele-Rehabilitation System with Virtual Reality and Functional Electrical Stimulation

  Chen, S.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• Calcitriol Modulates Cardiac Fibroblasts through Noncanonical Pathway of Receptor for Advanced Glycation End Products and Fibroblast Growth Factor Receptor Signaling: Implicated in Cardiac Fibrosis in Diabetes(1/3)

  Lee, T.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探究腦指蛋白 ZNF179 (Brain Finger Protein) 的分子機制

  Huang, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of a Cognitive Behavioral Self-Help Intervention on Immigrant Life Stress for Immigrant Women Who Are Divorced

  Kuo, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Developing Smart Voice-Control Interfaces and Establishing Smart Living and Work Environments: Based on the Unmet Needs of the Spinal Quadriplegics(Focusing Topic: A6)( I )

  Chen, S.

  1/1/17 → 12/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 建立研發用台灣電子病歷資料庫之先期研究－建立研發用台灣電子病歷資料庫之先期研究

  Yang, C.

  4/1/15 → 12/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology