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• b - Ministry of Science and Technology

  Journey of Professional Identity Building of Young Physicians-- Examining the Impact of Gender, Stress, Duty Hours, and Work Loading.

  Chiu, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Study of the Trismus Condition of Patients with Head and Neck Cancer Who Have Undergone Concomitant Chemoradiotherapy and the Preventive Effect of Oral Rehabilitation on Trismus

  Jeng, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Evaluation of the Discriminative Ability of Multiple Comorbidity Indices

  Huang, K.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Cross-Talk between Endothelial Cell-Specific Molecule-1 (Esm1) and Epidermal Growth Factor Receptor (Egfr) in the Progression of Non-Small-Cell Lung Cancer (Nsclc)

  Chien, M.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 中文版理察斯-坎貝爾睡眠量表於重症病人之測量特性：以古典測試理論與試題反應理論驗證

  Chiu, H.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 台灣創新癌症藥物使用量與費用支出之趨勢分析：回溯觀察性研究

  Tang, C.

  7/1/17 → 2/28/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation the Functional Roles and Molecular Mechanism of Long Non-Coding Rna-Crnde in Autophagy and Oxaliplatin Drug Resistance

  Lee, K.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 不孕症婦女心理困擾變化軌跡：身心療癒措施結合心率變異生理回饋之成效與機轉(3/3)

  Kuo, S.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of Protein Kinase CK1 and The Mechanism of Inhibitors on Glioblastoma Cells

  Pan, S.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effect of a Leader Empowering Behaviors Intervention on Staff Nurse and Resident Well-Being in Long-Term Care Settings—Part Ii

  Chen, I.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 針對PD-L1 表現機制所發展出之口腔癌治療策略(2/3)

  Lin, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 建立新興環境汙染物與藥物毒理預測平台之研究

  Hsu, K.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Enhancement of Immuno-Modulatory Capacity by Shear Stress in Mesenchymal Stem Cells

  Ho, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 核糖核甘酸還原酉每抑制劑在人類乳突瘤病毒感染之非小細胞肺癌治療效果評估

  Hsu, N.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Can Sesamin Alone or Cotheapy with Anti-DM Medicines Alleviate the Abnormal Intermediate Metabolites of Glucose and Fatty Acids, the Oxygen Consumption and Renal Fibrotic Progression?

  Peng, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以重要性－績效分析法探討床邊資訊系統之研究

  Wen, H.

  7/1/19 → 2/1/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 早幼粒細胞白血病鋅指蛋白(PLZF)對腦部發育的多重功能之探討(3/3)

  Lee, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 新穎癌幹細胞侵犯腳治療標靶之整合性蛋白質體、基因體、小分子與功 能篩選：聚焦細胞表面AMFR於侵犯性消化道癌症治療標的(1/3)

  Tsai, K. K.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 輔助學習疾病專業術語之APP設計與評估

  Chang, W. P.

  7/1/17 → 2/28/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Methodology Study of Integrating Systems Thinking and Bayesian Network in Health Policy

  Chuang, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 大腸直腸癌已躍居世界上癌症死亡率第二名，屬於固體型腫瘤，缺氧常見於此類 腫瘤，並誘發HIF-1α 表現而導致抗藥性及預後較差，因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑，可殺死癌 細胞而不影響正常細胞，對小鼠也不具毒性。我們初步結果顯示，Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現，代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性，對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下，經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制；也有研究報導指出，藥物會誘導癌細胞產生autophagy，造成細胞過度吞噬其內容 物而死亡，因此，autophagy在癌細胞為保護或是引發毒殺作用，目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活，但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示，除抑制HIF-1α 表現外，Zeb 也可活化AMPK、UPR/ER stress、以及autophagy， 因此我們推測Zeb 可在缺氧狀態下，促進autophagic cell death。3 年內我們將執行4 項 目標： (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。（第一年） (2) 研究Zeb 抑制HIF-1α表現之分子機轉。（第一年到第二年） (3) 研究Zeb 誘發autophagy之分子機轉。（第二年到第三年） (4) 探討Zeb 對缺氧導致抗藥性之作用。（第三年）

  Yang, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Clinical Outcome and Drug Resistant Biomarkers Establish for Hpv Infected Non-Small Cell Lung Cancer

  Hsu, N.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Fibromyalgia: Impacts of Different Phenotypes on Quality of Life and the Effects of Technology-Assisted and Tailored Health Coaching

  Tsai, P.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 繪本教學介入對學齡期自閉症兒童人際互動之成效探討

  Kuo, S.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討第一型內皮細胞分子與上皮細胞生長因子受體之相互調控在非小細胞肺癌進程之角色(3/3)

  Chien, M.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 抑制site-1蛋白酶引發肝癌細胞自我吞噬之研究

  Yang, P.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討真實與虛擬藍色工作環境對壓力與焦慮之影響

  Yen, H.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Utilizing Artificial Intelligence Vi Rtual Screening Platform to Identify a Small-Molecule Inhibitor of Dna Polymerase Theta and Estimating Its Therapeutic Effectiveness on Metastatic Castration-Resistant Prostate Cancer

  Lin, Y.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies of Roles of SIRT7 in Cancer Biology

  Tsai, Y.

  1/1/14 → 10/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Behaviors of Corneal Endothelial Cells on Biodegradable Biomaterials and the Interaction between Corneal Endothelial Cells and Corneal Keratocytes

  Wang, T.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• SEA調控肺部細胞發炎透過STAT 1 蛋白路徑之研究

  Cheng, P.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects and Mechanisms of Pitx2c Modulation for Atrial Electrophysiological and Structural Remodelings in Heart Failure

  Kao, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Preceptors’ perceptions of training programs and training needs, experienced barriers during precepting, and development and effectiveness evaluation of a preceptor intervention

  Chang, W.

  8/1/13 → 10/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 102 年東南亞區域共同研究暨培訓型國際合作計畫—社區精神復健合作研究平台與專業人員培訓工作坊

  Tsai, D.

  6/1/13 → 12/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effect of Long Acting GnRH Agonist Treatment on Mitochondrial Function in

  Tzeng, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 紫杉醇調控血小板活化、細胞凋亡和自我吞噬之分子機轉探討:體內及體外試驗(1/3)

  Lu, W.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 在國際健康功能與身心障礙分類系統的架構下，探討蛋白質補充合併運動訓練對急慢性機構衰弱老人改善肌少症指數及身體活動功能之成效(2/3)

  Liou, T.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Depression Trajectories in Women – a Developmental-Ecological Approach (Gm03)

  Kuo, S.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Roles of Microrna96 in Tgfβ-Mediated Tumor Progression

  Tsai, Y.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 纖維細胞生長因子與其受體之訊息路徑在急性腎損傷中維持腎臟血管結構能力之角色研究

  Cheng, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• ZFHX3 knockdown調控心房纖維化導致心房顫動病理性結構重塑之機轉探討

  Kao, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation of the Mechanism of Post-Fracture Immune Dysfunction and the Role of Statin in Its Prevention and Treatment Strategy: from Bench to Bedside(2/2)

  Lin, J. A.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development and Validation of On-Line Faculty Training for Milestone-Based Entrustable Professional Activities (Epas): Anesthesiology in Taiwan

  Chen, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of Tripartite Motif Protein 72 in the Regulation of Irs and Pi3k/Akt/Mtor Pathway in Experimental Bronchopulmonary Dysplasia: in Vitro and in Vivo Assessment

  Huang, L.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 藉由調控神經包網結構來改善早期社交孤立所誘發於模棱兩可的資訊下異常恐懼記憶連結的形成(1/3)

  Yang, C. H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development and Validation of On-Line Faculty Training for Milestone-Based Entrustable Professional Activities (Epas): Anesthesiology in Taiwan(2/2)

  Chen, C.

  7/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 利用輸卵管上皮類器官培養技術開發卵巢癌早期偵測之表基因生物標記(1/3)

  Lai, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• To Study the Correlation between Serum Markers of Oxidative Stress, Inflammation, and Endocrine-Disrupting Chemicals (Edcs) and Their Impact on the Menstrual Cycle and Reproductive Hormone in Taiwanese Women

  Hsu, M.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Action Research of the Flipped Classroom for Teaching Undergraduate Calculus Course

  Tang, K. & Ying, J.

  11/1/15 → 10/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Analysis the role of satellite cell during denervation induced muscular atrophy and a trail of transplantation of adipocyte derived myogenic stem cells.

  Chang, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology