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• b - Ministry of Science and Technology

  Using chemical synthetic lethal screening to identify novel compounds that sensitize acute myeloid leukemia with FLT3-ITD mutations to novel small-molecule FLT3 tyrosine kinase inhibitors, ITRI-260 and overcome microenvironment-mediated drug resistan

  Liu, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study of the Mechanism of HPV Involved Tumorigenesis through Wnt Signaling Pathway Related microRNA Regulation

  Cheng, Y. & Lee, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Essential Oils on Smooth Muscle Contraction in Rat Uterus (Gm07)

  Hsia, S.

  8/1/12 → 12/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Dna Methylation and Genetic Polymorphisms of Inflammatory and Redox Regulation in Periodontal Disease Activities and Treatment Effectiveness

  Huang, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Multifunctionalized Nanoparticles for Delivery of Chemotherapeutic Agents to Triple-Negative Breast Cancer

  Chiu, S.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Evaluation of the Long-Term Effects of Interpersonal and Social Rhythm Therapy on Sleep and Social Functioning in Patients with Bipolar Disorder(3/3)

  Chung, M.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Bridg-Driven Smart Authoring Wizard for Clinical Trial Protocols

  Liou, D.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Roles of Genetic Polymorphisms for Susceptibility and Clinical Outcomes of Colorectal Cancer in Taiwanese Lynch Syndrome Families

  Yeh, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Developing New Diagnostic and Therapeutic Strategies for Lung Cancer with ROS1, RET and NTRK1 Mutations in Patients without EGFR, KRAS and ALK Mutations

  Liu, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 結合奈米診斷治療、影像免疫基因圖譜與人工智慧於原發性與再復發膠質母細胞瘤之研究-以機器學習的方法導入影像基因圖譜用以研究膠質母細胞瘤與免疫相關之基因表現(2/3)

  Chen, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Adaptive Evolution of Pseudomonas Aeruginosa Within Hosts

  Huang, T.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Manipulating Neural Oscillations in Frequency and Phase Shifting Using Transcranial Alternating Current Stimulation: An Investigation into the Oscillatory Neural Mechanisms of Visual Working Memory(2/3)

  Tseng, P.

  12/1/16 → 11/30/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• RAB3C對大腸直腸癌之抗藥性與腫瘤免疫反應影響之探討(2/3)

  Chen, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討使用非維他命K拮抗劑類口服抗凝血劑(NOAC)併用抗憂鬱藥物的出血風險，以及藥物種類選擇與劑量調整之出血風險差異

  Bai, C.

  7/1/22 → 2/28/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• 強化藍光之白光光照法改善纖維肌痛症患者睡眠、憂鬱、神經運動警覺度及症狀嚴重度之成效(3/3)

  Tsai, P.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Environmental Microbiota, Air Pollution and Lifestyle on Allergic Diseases in Preschool Children (Ii)

  Chao, H. J.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• To Evaluate the Pharmacological Mechanisms of Novel Natural Plant Extracts of Coumarins in Suppressing Angiogenesis, Lymphangiogenesis and Inflammation (2/3)

  Hsu, M.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• 脂肪激素內脂素對子宮肌瘤增生及微環境影響:分子機制探討及精準營養應用之研究(1/3)

  Hsia, S.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Preclinical Investigation of Combined Targeting the Immune Signaling Axis Btk/Pd-L1/Pd-L2 for Combating Drug Resistant Glioblastoma Multiforme (1/3)

  Lin, C.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• Pharmacogenomics of Immune Responses during Acute Dengue Virus Infection for Clinical Diagnosis: Focus on T Cell Repertoire and Genetic Variants of the C-Type Lectin Family( III )

  Chang, W.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• From Hospital to Community: Longitudinal Changes of Participation in Younger Stroke Survivors(3/3)

  Chang, F.

  8/1/18 → 10/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Molecular Epidemiological Study of Renal Cell Carcinoma - Arsenic Methylation Capability, 8OHdG and Polymorphism of IRS and RAAS Exploration

  Hsueh, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 研究慢性阻塞性肺疾病患者特異性血紅素結合蛋白表現型對巨噬細胞極化作用和疾病進展的調節作用(2/3)

  Ho, S.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Is proton pump inhibitor a risk factor to bacterial gastroenteritis: A meta-analysis

  Bai, C.

  7/1/19 → 2/1/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Association between Human Endogenous Retrovirus and Cancers Using RNA-Seq Data

  Lee, Y. G.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Simultaneous Delivery of an Antisense Oligonucleotide and a Chemotherapeutic Agent by a Her2-Targeted Liposomal System

  Chiu, S.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• Radiogenomics of Malignant Gliomas by Linking Physiological Mr Imaging, Histopathological Patterns, and Genetic Alternations: a Translational Study from Rat to Man

  Chen, C.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Molecular Mechanisms of Secretory Rab Gtpase 3c in Promoting Colon Cancer Metastasis

  Chen, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 價創計畫：使用人工智慧來建構智慧醫院及健康照護生態圈-從疾病到健康與樂活

  Chen, R.

  5/1/18 → 4/30/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 大學臨床實習生的睡眠時型與睡眠品質：睡眠應激反應與心理韌性的調節作用

  Tsai, P.

  7/1/22 → 2/28/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• Targeting the Adipokines/Batokines Secreted from Afferent Renal Artery Adipocyte Tissue to Explore the Obesity Induced Diabetic Renal Pathophysiology Role under Atf3 Regulation and the Basic and Clinical Therapeutic Application. (1/3)

  Lin, H.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• 「婦女精準健康」大數據應用於女性乳癌及不孕症創新人工智慧檢測模式開發計畫(1/4)

  Lin, C.

  5/1/21 → 4/30/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Establishing a Translational Female Cancer Biomedical Big Data Bank and Developing Precision Medicine Healthcare System( II )

  Chen, T.

  5/1/22 → 4/30/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development and Characterization of Hyaluronan-Based Oral Absorbable Drug Delivery Systems and Its Biomedical Applications

  Sheu, M.

  8/1/10 → 8/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Neuroendocrine-Immune Mechanisms of Physical Activity on Behavioral Symptoms in Lung Cancer Patients---A Comparison of Patients Receiving Active Treatments and Survivors

  Lin, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Epigenetic Editing as a Novel Therapeutics for Gynecological Cancer

  Lai, H.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Plant Metabolomics---1. Agave sisalana; 2. Anoectochilus formosanus; 3. Phalaenopsis spp.

  Lee, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• 補助學者提昇國際影響力─國際合作研究中心：建立全球神經創傷與公共衛生網絡(2-3)

  Chiu, W.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

• Aldose reductase (AR)調控膠原蛋白GPVI及凝血?PAR4所引起血小板活化及細胞凋亡的新角色: Arf-AR在無核細胞中所扮演的訊息傳遞機制 (II)(2/2)

  Sheu, J.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 食品安全相關之信任、風險感知和母親健康行為及孩童發展之間的關係 (II)(2/2)

  Chuang, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 太極對退化性關節炎的高齡者功能性體適能的影響

  Lin, C.

  7/1/17 → 2/28/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 乳癌是目前世界上女性癌症病患中為數最多的癌症之ㄧ。腺病毒蛋白type 5 E1A (E1A)和許多抗腫瘤作用有關，曾於多種癌症如乳癌、卵巢癌及頭頸癌之病患進行臨床基因治療試驗。許多的研究指出E1A具有多項抗腫瘤的功能，包括抑制腫瘤的發生、增加腫瘤細胞對於化療藥物的感受性以及減少腫瘤轉移的現象。腫瘤的轉移對於癌症患者的死亡率有極大的影響當然也包括了乳癌的患者。E1A於抑制腫瘤發展的過程中具有多重生物學上的意義，這也促使我們想要釐清E1A抑制癌症的機制。因此，我們對於了解E1A抑制癌症轉移相關的分子機制感到有興趣，並期望藉以作為未來改進乳癌病人臨床試驗的基石。我們初步的實驗結果顯示，E1A可以有效的抑制Glucose-regulated protein 78 (GRP78)這種已被廣泛報導和腫瘤惡化及轉移相關的蛋白的表現。 提出此研究計劃之目的在於詳細探討E1A所造成的抑制癌轉移作用中，GRP78所扮演的生物功能及其調控的機轉。為了達到此目的，我們將著重於E1A如何調控GRP78表現並進而展現對乳癌轉移的抑制作用。以下為此項研究計畫的四大主要目標： 目標一：探討GRP78在E1A所抑制之癌細胞移行及侵入作用中所扮演的角色 目標二：研究E1A抑制GRP78表現之分子機轉 目標三：於動物模式中驗證GRP78的表現對於E1A抗腫瘤作用的影響 目標四：探討GRP78及其相關分子的表現在乳癌病人的臨床重要性 完成以上的主要目標能夠幫助我們對於E1A之抗腫瘤轉移作用建立更加詳細的分子訊息傳遞機制。另外，藉由此研究計畫的新發現也許可以對未來發展癌症治療上提供更多具有潛力的標的物。

  Wang, W.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Application of Biodegradable Nano-Enabled Drug Delivery in Treatemt of Brain Abscess

  Tseng, Y.

  7/1/13 → 9/30/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Exploring the Effects of an Exercise Program on Female Diabetic Patients' Health

  Liao, Y.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Clinical Study of Hydrophilic Electrospun (ES) Pla/Bioceramic Guided Tissue/Bone Regeneration (GTR/GBR) Membranes

  Lee, S. & Yang, J.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of Sp1-Regulated Neurosteroidogenesis in Glioma Development

  Hsu, T.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies on Combination Chemotherapy of Doxorubicin and Cisplatin Loaded in Thermosensitive Hydrogels as Locally Controlled of Cancer Therapeutics

  Ho, H.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 標靶整合素αvβ3-FAK訊號網絡的膽管癌診療策略開發-基於整合素αvβ3和CEACAM6的訊號網絡建立膽管癌患者的診斷生物標記與治療標靶之臨床連結(1/3)

  Whang-Peng, J.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Design and Verification the Effects of an Innovative Interactive Game on Improving Cognition in Elderly

  Chang, C.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討芳香烴受體核轉位蛋白受器/丙酮酸去氫激?1路徑在與化療相關的頭頸癌進展所扮演的角色(2/3)

  Chang, W.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology