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  The Neurotrophic/Neuroprotective Role of GIP in Cellular and Rodent Models of Mild Traumatic Brain Injury (II)

  Lin, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Multidisciplinary Study of the Pathophysiology of Blast-Induced Mild Traumatic Brain Injury

  Chiang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation of the Effect of Androgen Receptor Knockout on Pathophysiology of Traumatic Brain Injury

  Yang, L.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of ADAM 17 in Hypoxia-Induced CTGF Expression and Pulmonary Fibrosis (I)

  Chen, B.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Immune Alteration and Immunogenic Cell Death in Advanced Non-Small Cell Lung Cancer Patients

  Feng, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Application of Functional Electrical Stimulation on the Study of Nerve Regeneration in the Rat with Diabetic Neuropathy

  Peng, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Indoxyl Sulfate, Chronic Kidney Disease and Heat Shock Protein Modulate the Atrial Electrophysiological Characteristics

  Hsieh, M.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Glucagon-Like Peptide-1 in the Regulation of PPARs and Calcium Handling in Hyperglycemia or Hypertensive HL-1 Cells

  Huang, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Application of Hyaluronic Acid and Resveratrol Modified Carbon Nanotube Scaffolds for Tissue Engineering

  Sheu, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study of the mechanism of HPV involved tumorigenesis through Wnt signaling pathway related microRNA regulation

  Cheng, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Clinical Correlation study of DNA Methyltransferases Alterations in Breast Cancer and Evaluation of DNA Methyltransferases as a Therapeutic Target in Cell and Animal Models

  Lin, R.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Proteomic Study of Metformin on Kidney Damage in Rats

  Lee, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects and Mechanisms of Massotherapy of Acupoints, Gene Polymorphisms of RRM1 and RRM2 on Relieving Chemotherapy-Induced Myelossupression among Patients with Cervical Cancer

  Tsai, H.

  8/1/13 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Antibody-Mediated Immune Suppression of Fetal and Neonatal Alloimmune Thrombocytopenia (FNAIT)

  Burnouf, T. P. R.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• he Effects of the APOE4 Allele on cerebral Structural and Functional Connectivity- A Diffusion Tensor Imaging and Resting-state MRI study

  Chen, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• α9-型尼古丁乙醯膽鹼受體在乳癌幹細胞的角色與防治藥物的篩選

  Lai, G.

  8/1/13 → 7/31/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Deferasirox Plasma Concentration Analysis and Effects of Potential Iron Chelators on Iron Overload and Safety Evaluation

  Wu, T.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Roles of Novel CCCH Zinc Finger Genes on the Regulation of Cell Proliferation and Inflammation

  Liang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Renoprotective mechanisms of soy protein in rats with diabetic nephropathy 全文電子檔： 全文連結1

  Chen, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Evaluation on Cervical Cancer Prevention and Treatment Policy in Taiwan

  Tang, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Methodology Study of Integrating Systems Thinking and Bayesian Network in Health Policy

  Chuang, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Dissected the role of Glucosed-regulated portein 78 in the progression, metastasis and therapy of colorectal cancer

  Wei, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Use the organometal catalytic reaction to synthesize the heterocycle-based anticancer agents

  Liou, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Model Comparison Within Diagnostic Accuracy Test Model in Meta-Analysis

  Chen, J.

  8/1/13 → 10/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effect of Improved Nutrition Care on the Progress of Hemodialysis Patients

  Yang, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of fish oil on alcoholic liver disease in rats based on pathological mechanisms

  Yang, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Writing for Scholarly Publication in English for Researchers in the Fields of Social Sciences, Natural Sciences, Engineering, and Medicine in Higher Education in Taiwan

  Chien, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Epigenetic Control of IL-6-STAT3 Targeting Dnas in the Cell of Dihydropyridine-Induced Gingival Overgrowth

  Lu, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study of Anti-RRM-2 Antibody Drug Generation and Their Inhibitory Mechanisms

  Yang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of Sp-family in lung tumorigenesis

  Chang, W.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study on the cancer and non-cancer, including cardovascular diseases, risks in cohort population with prolonged low-dose radiation exposure

  Chang, W.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigating the Differential Effects and the Mechanisms of Flavonols on Osteogenic Differentiation of Human Dental Pulp Stem Cells

  Lee, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Modifying the Impact of Maternal Psychopathology on Adverse Infant Health Outcomes---Effects of Paternal Involvement and a Trial on Positive Activity Intervention

  Chen, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Contribution of Er Stress to Inhibit miR-19a/b and miR-26b-Mediated CTGF Expression in Lung Fibrosis (I)

  Chen, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Enhancement of immuno-modulatory capacity by shear stress in mesenchymal stem cells

  Ho, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• TMU101-AE1-B67

  Wang, W.

  8/1/13 → 7/31/16

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Victorian Sanitation: Narratives of Poverty, Filth and Economy of Morality

  Chen, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Lipid Raft Associated Signaling in Regulation of Osteoclast Activation in Inflammatory Arthritis

  Tsai, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Using Cometing Risk Model for Death and Multi-state Stochastic Process for the Behaviour of Betel-quid Chewing and Smoking to Estimate the Potential Years of Life Lost Due to Betel Quid and to Estiamte the Impact of Qutiing Betel-quid chewing

  Yen, M.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies on the anti-islet hypertrophy and anti-osteoporosis constituents from Formosan Fern

  Hsu, F.

  8/1/13 → 12/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Novel Degradable Biomaterial for Dental Hemostatic Sponge Applications

  Lin, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Novel Therapeutic Agents for Herceptin Resistance Breast Cancer Cells through Targeting Nicotinic Acetylcholine Receptors

  Lee, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Explore of Toll-Like Receptors Associated Mirna Expression in Ischemic Stroke Patients (I)

  Wu, C.

  8/1/13 → 7/31/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• The Effect of Muscle Strength Training on Body Composition and Sarcopenic Obesity among the Female Overweight Elderly

  Liou, T.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effects of Sintered Dicalcium Pyrophosphate (SDCP) on Fracture Healing in Ovariectomized Rats

  Kuo, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 大腸直腸癌已躍居世界上癌症死亡率第二名，屬於固體型腫瘤，缺氧常見於此類 腫瘤，並誘發HIF-1α 表現而導致抗藥性及預後較差，因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑，可殺死癌 細胞而不影響正常細胞，對小鼠也不具毒性。我們初步結果顯示，Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現，代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性，對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下，經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制；也有研究報導指出，藥物會誘導癌細胞產生autophagy，造成細胞過度吞噬其內容 物而死亡，因此，autophagy在癌細胞為保護或是引發毒殺作用，目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活，但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示，除抑制HIF-1α 表現外，Zeb 也可活化AMPK、UPR/ER stress、以及autophagy， 因此我們推測Zeb 可在缺氧狀態下，促進autophagic cell death。3 年內我們將執行4 項 目標： (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。（第一年） (2) 研究Zeb 抑制HIF-1α表現之分子機轉。（第一年到第二年） (3) 研究Zeb 誘發autophagy之分子機轉。（第二年到第三年） (4) 探討Zeb 對缺氧導致抗藥性之作用。（第三年）

  Yang, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Cultivation of Young Scholars: Philosophy of Consciousness

  Lane, T. J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Exercise Training on Sleep Disturbances, Anxiety, and Depression among Newly Diagnosed Elderly Lung Cancer Patients

  Lin, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Evaluation of Therapeutic Correlation of Nanomedicine with Tea Polyphenol for Inhibition of Ocular Surface Inflammation in Rabbit Dry Eye Model

  Tseng, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Depression Trajectories in Women – A Developmental-ecological approach (GM03)

  Kuo, S.

  8/1/13 → 9/30/14

  Project: A - Government Institution › b - Ministry of Science and Technology