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The Neurotrophic/Neuroprotective Role of GIP in Cellular and Rodent Models of Mild Traumatic Brain Injury (II)
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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A Multidisciplinary Study of the Pathophysiology of Blast-Induced Mild Traumatic Brain Injury
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Investigation of the Effect of Androgen Receptor Knockout on Pathophysiology of Traumatic Brain Injury
Yang, L.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Role of ADAM 17 in Hypoxia-Induced CTGF Expression and Pulmonary Fibrosis (I)
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Immune Alteration and Immunogenic Cell Death in Advanced Non-Small Cell Lung Cancer Patients
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Application of Functional Electrical Stimulation on the Study of Nerve Regeneration in the Rat with Diabetic Neuropathy
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Indoxyl Sulfate, Chronic Kidney Disease and Heat Shock Protein Modulate the Atrial Electrophysiological Characteristics
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Glucagon-Like Peptide-1 in the Regulation of PPARs and Calcium Handling in Hyperglycemia or Hypertensive HL-1 Cells
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Application of Hyaluronic Acid and Resveratrol Modified Carbon Nanotube Scaffolds for Tissue Engineering
Sheu, S.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Study of the mechanism of HPV involved tumorigenesis through Wnt signaling pathway related microRNA regulation
Cheng, Y.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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A Clinical Correlation study of DNA Methyltransferases Alterations in Breast Cancer and Evaluation of DNA Methyltransferases as a Therapeutic Target in Cell and Animal Models
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Proteomic Study of Metformin on Kidney Damage in Rats
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Effects and Mechanisms of Massotherapy of Acupoints, Gene Polymorphisms of RRM1 and RRM2 on Relieving Chemotherapy-Induced Myelossupression among Patients with Cervical Cancer
8/1/13 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Antibody-Mediated Immune Suppression of Fetal and Neonatal Alloimmune Thrombocytopenia (FNAIT)
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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he Effects of the APOE4 Allele on cerebral Structural and Functional Connectivity- A Diffusion Tensor Imaging and Resting-state MRI study
Chen, C.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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α9-型尼古丁乙醯膽鹼受體在乳癌幹細胞的角色與防治藥物的篩選
8/1/13 → 7/31/14
Project: B - Project of TMU › i - Other (Funded by TMU)
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Deferasirox Plasma Concentration Analysis and Effects of Potential Iron Chelators on Iron Overload and Safety Evaluation
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Roles of Novel CCCH Zinc Finger Genes on the Regulation of Cell Proliferation and Inflammation
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Renoprotective mechanisms of soy protein in rats with diabetic nephropathy 全文電子檔: 全文連結1
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Evaluation on Cervical Cancer Prevention and Treatment Policy in Taiwan
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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A Methodology Study of Integrating Systems Thinking and Bayesian Network in Health Policy
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Dissected the role of Glucosed-regulated portein 78 in the progression, metastasis and therapy of colorectal cancer
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Use the organometal catalytic reaction to synthesize the heterocycle-based anticancer agents
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Model Comparison Within Diagnostic Accuracy Test Model in Meta-Analysis
8/1/13 → 10/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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The Effect of Improved Nutrition Care on the Progress of Hemodialysis Patients
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Effects of fish oil on alcoholic liver disease in rats based on pathological mechanisms
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Writing for Scholarly Publication in English for Researchers in the Fields of Social Sciences, Natural Sciences, Engineering, and Medicine in Higher Education in Taiwan
Chien, S.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Epigenetic Control of IL-6-STAT3 Targeting Dnas in the Cell of Dihydropyridine-Induced Gingival Overgrowth
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Study of Anti-RRM-2 Antibody Drug Generation and Their Inhibitory Mechanisms
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Role of Sp-family in lung tumorigenesis
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Study on the cancer and non-cancer, including cardovascular diseases, risks in cohort population with prolonged low-dose radiation exposure
Chang, W.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Investigating the Differential Effects and the Mechanisms of Flavonols on Osteogenic Differentiation of Human Dental Pulp Stem Cells
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Modifying the Impact of Maternal Psychopathology on Adverse Infant Health Outcomes---Effects of Paternal Involvement and a Trial on Positive Activity Intervention
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Contribution of Er Stress to Inhibit miR-19a/b and miR-26b-Mediated CTGF Expression in Lung Fibrosis (I)
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Enhancement of immuno-modulatory capacity by shear stress in mesenchymal stem cells
Ho, J.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Victorian Sanitation: Narratives of Poverty, Filth and Economy of Morality
Chen, C.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Lipid Raft Associated Signaling in Regulation of Osteoclast Activation in Inflammatory Arthritis
Tsai, H.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Using Cometing Risk Model for Death and Multi-state Stochastic Process for the Behaviour of Betel-quid Chewing and Smoking to Estimate the Potential Years of Life Lost Due to Betel Quid and to Estiamte the Impact of Qutiing Betel-quid chewing
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Studies on the anti-islet hypertrophy and anti-osteoporosis constituents from Formosan Fern
Hsu, F.
8/1/13 → 12/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Development of Novel Degradable Biomaterial for Dental Hemostatic Sponge Applications
Lin, C.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Development of Novel Therapeutic Agents for Herceptin Resistance Breast Cancer Cells through Targeting Nicotinic Acetylcholine Receptors
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Explore of Toll-Like Receptors Associated Mirna Expression in Ischemic Stroke Patients (I)
Wu, C.
8/1/13 → 7/31/14
Project: B - Project of TMU › i - Other (Funded by TMU)
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The Effect of Muscle Strength Training on Body Composition and Sarcopenic Obesity among the Female Overweight Elderly
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Effects of Sintered Dicalcium Pyrophosphate (SDCP) on Fracture Healing in Ovariectomized Rats
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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大腸直腸癌已躍居世界上癌症死亡率第二名,屬於固體型腫瘤,缺氧常見於此類 腫瘤,並誘發HIF-1α 表現而導致抗藥性及預後較差,因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑,可殺死癌 細胞而不影響正常細胞,對小鼠也不具毒性。我們初步結果顯示,Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現,代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性,對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下,經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制;也有研究報導指出,藥物會誘導癌細胞產生autophagy,造成細胞過度吞噬其內容 物而死亡,因此,autophagy在癌細胞為保護或是引發毒殺作用,目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活,但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示,除抑制HIF-1α 表現外,Zeb 也可活化AMPK、UPR/ER stress、以及autophagy, 因此我們推測Zeb 可在缺氧狀態下,促進autophagic cell death。3 年內我們將執行4 項 目標: (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。(第一年) (2) 研究Zeb 抑制HIF-1α表現之分子機轉。(第一年到第二年) (3) 研究Zeb 誘發autophagy之分子機轉。(第二年到第三年) (4) 探討Zeb 對缺氧導致抗藥性之作用。(第三年)
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Cultivation of Young Scholars: Philosophy of Consciousness
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Effects of Exercise Training on Sleep Disturbances, Anxiety, and Depression among Newly Diagnosed Elderly Lung Cancer Patients
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Evaluation of Therapeutic Correlation of Nanomedicine with Tea Polyphenol for Inhibition of Ocular Surface Inflammation in Rabbit Dry Eye Model
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Depression Trajectories in Women – A Developmental-ecological approach (GM03)
8/1/13 → 9/30/14
Project: A - Government Institution › b - Ministry of Science and Technology