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• Role of Autophagy in Membranous Glomerulonephropathy---From Animal to Human Model

  Lin, Y.

  8/1/13 → 12/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effects of Electroconvulsive Therapy on Health Services Utilization, Positive and Negative Syndrome, and Sleep among Psychiatric Patients

  Chung, M.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Mobile Phone Use and Walking: A Observational Field Study of Pedestrians' Risky Behaviours and Inattentional Blindness

  Pai, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Dissected the role of Glucosed-regulated portein 78 in the progression, metastasis and therapy of colorectal cancer

  Wei, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The role of DDX3 in human papillomavirus-infected lung tumorigenesis

  Lee, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Genomic and non-genomic estrogen effects on the spinal NR2B-related uterus-colon crosstalk in rats

  Lin, T.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Victorian Sanitation: Narratives of Poverty, Filth and Economy of Morality

  Chen, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Sumoylation of Histone Deacetylase 2 Contributes to CTGF Expression and Pulmonary Fibrosis in Chronic Obstructive Asthma (I)

  Lin, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Explore of Toll-Like Receptors Associated Mirna Expression in Ischemic Stroke Patients (I)

  Wu, C.

  8/1/13 → 7/31/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• The exploitation of Taiwan native plants in promoting bone growth and establishment of the system biology platform

  Lee, M.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Optimization of Human Meniscus Imaging and Its Clinical Application for Osteoarthritis

  Tsai, P.

  8/1/13 → 10/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Research of Harmful Substances in Water on Human Reproductive and Neuronal Cells Toxicity Translation Assessment (I)

  Mai, F.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討芳香烴受體(AhR)改變血管內皮細胞功能之新角色：經由表觀基因或後轉譯修飾(細胞週期蛋白/內皮細胞一氧化氮合成?)的調控與白蘆黎醇/史達汀臨床治療及應用(1/3)

  Juan, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Molecular Mechanism Underlying Progesterone-Regulated p27 Gene Expression

  Hsu, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Analysis and Data Mining of Decision Characteristic of Prehospital Emergency Patients Transport

  Hsu, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Trends in Surgical Litigation and Media Coverage of Medical Malpractice: Implications for Medical Education

  Lyu, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation of the Effect of Androgen Receptor Knockout on Pathophysiology of Traumatic Brain Injury

  Yang, L.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Design and Characterization of Multifunctional Self-Assembling Lecithin/Amphiphilic Polymers Mixed Micellar Delivery Systems

  Sheu, M.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 抗氧化防禦基因標籤單核?酸多形性、氧化壓力生物標記與冠狀動脈心臟病之相關性(1/2)

  Yeh, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Immune Alteration and Immunogenic Cell Death in Advanced Non-Small Cell Lung Cancer Patients

  Feng, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Moderating Effect of Welfare States on Health and Service Utilization - Comparison of Taiwan and European Countries

  Chuang, K.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• TMU102-AE1-B20

  Hsieh, C.

  8/1/13 → 7/31/16

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• 大腸直腸癌已躍居世界上癌症死亡率第二名，屬於固體型腫瘤，缺氧常見於此類 腫瘤，並誘發HIF-1α 表現而導致抗藥性及預後較差，因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑，可殺死癌 細胞而不影響正常細胞，對小鼠也不具毒性。我們初步結果顯示，Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現，代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性，對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下，經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制；也有研究報導指出，藥物會誘導癌細胞產生autophagy，造成細胞過度吞噬其內容 物而死亡，因此，autophagy在癌細胞為保護或是引發毒殺作用，目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活，但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示，除抑制HIF-1α 表現外，Zeb 也可活化AMPK、UPR/ER stress、以及autophagy， 因此我們推測Zeb 可在缺氧狀態下，促進autophagic cell death。3 年內我們將執行4 項 目標： (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。（第一年） (2) 研究Zeb 抑制HIF-1α表現之分子機轉。（第一年到第二年） (3) 研究Zeb 誘發autophagy之分子機轉。（第二年到第三年） (4) 探討Zeb 對缺氧導致抗藥性之作用。（第三年）

  Yang, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Plant metabolomics (1. Agave sisalana, 2. Anoectochilus formosanus, 3. phalaenopsis spp.)

  Lee, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Association Study of Genetic Polymorphisms of Toll-Like Receptors on Ischemic Stroke (I)

  Chiou, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Association between lipid, glucose related genes and prognosis of intra- and extra-cranial stenosis in stroke patients

  Chiou, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effects of Sintered Dicalcium Pyrophosphate (SDCP) on Fracture Healing in Ovariectomized Rats

  Kuo, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Huntingtin-Associated Protein-Regulated Biomarkers in Neurodegenerative Diseases

  Lin, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Roles of Novel CCCH Zinc Finger Genes on the Regulation of Cell Proliferation and Inflammation

  Liang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Molecular mechanisms of alpha9-nicotinic acetylcholine receptor (alpha 9-nAChR)-mediated Trastuzumab (HerceptinR) drug resistance in breast cancer cells

  Ho, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 樂活隨身科技-獨居高齡者之周全健康照護計畫

  Chang, C., Tseng, I. J., Chang, C., Liu, M. F. & Hou, W.

  8/1/13 → 7/31/14

  Project: A - Government Institution › d - Ministry of Education

• 抽菸、α9-型尼古丁乙醯膽鹼受體、表皮生長因子受體及動情激素相關基因與乳癌之分子流行病學研究

  Chiou, H.

  8/1/13 → 7/31/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• The Effects and Molecular Mechanisms of Phthalates (DEHP and DBP) and Primary Metabolite(MEHP and MEP) on Embryonic Development

  Tzeng, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Reflex Pelvic Floor Muscle Activities in Women with Urinary Incontinence (II)

  Yang, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• To Study the Correlation between Serum Markers of Oxidative Stress, Inflammation, and Endocrine-Disrupting Chemicals (Edcs) and Their Impact on the Menstrual Cycle and Reproductive Hormone in Taiwanese Women

  Hsu, M.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• TMU101-AE1-B65

  Wang, T.

  8/1/13 → 7/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 《Understanding International Conflicts：An Introduction to Theory and History》Translation and Annotation Project

  Chang, K.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Preclinical Assessment of the Potential Prognostic and Therapeutic Values of Hippo Signaling Cascade in Targeting Therapy-Resistant Cancer Stem Cells in Hepatocellular Carcinoma

  Lee, W.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Roles of toll-like receptor-4 and hif-1 in propofol-involved protection against traumatic brain injury-induced dysfunction of the blood-brain barrier

  Chang, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Roles of Central OX2R Activities in the Pathophysiology of Hypertension in SHR

  Hwang, L.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Expressing Membrane Antibody Reporter in the Islet Cells of Nonobese Diabetic Mice to Noninvasive Assess the Therapeutic Effects of Drugs or Transgenes for Autoimmune Diabetes

  Chuang, K.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of a program of mind-body interventions on psychological resilience, vagal tone, emotional states, and outcomes of heart failure

  Tsai, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effect of Blood Sugar Regulation and Molecular Mechanism by White Potato Extract

  Li, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies of Anti-Cancer Activity of Folic Acid

  Lee, W.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Molecular and Clinical Role of microRNA in Obesity Induced Nephropathy

  Lin, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of the M-Learning Materials for Facilitating Nursing Students’ Basic Nursing Skills Competence and Self-Confidence

  Chuang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study on the Preventive Effect and Mechanism of Germinated Brown Rice and Its Components on Colorectal Cancer

  Shih, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of fish oil on alcoholic liver disease in rats based on pathological mechanisms

  Yang, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Functional Role of Transcription Factor Sp1 in Brain Neuronal Injury (II)

  Chang, W.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Study of the Relationships among Anti-Obesity Activity, Adipogenesis, and Adipose Angiogenesis of Vegetable Indolic Derivatives---Involvement of the Ah Receptor/Arnt ? (II)

  Chen, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology