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• Haplo-Insufficiency of TSGs on Chromosome 2 for Paclitaxel-Resistant Phenotype of OCCA Cells

  Chang, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Translational Investigation for Tea Attenuate Smoking-Induced Disease---Breast Cancer and Atherosclerosis as a Mechanistic Study

  Ho, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Assessing Trends and Influencing Factors of Medical Services Utilization and Expenditures and the Likelihood of Employment Status Change among Women with Postpartum Depression—A Ten-Year Retrospective Matched Case-Control Study with National Claims

  Huang, K.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of a Computerized Adaptive Testing of the Health Literacy in Stroke Rehabilitation

  Hou, W.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation on Developing Novel Biomarkers and Treatments in the Patients with Fibromyalgia

  Kang, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of a Cognitive Behavioral Self-Help Intervention on Immigrant Life Stress for Immigrant Women Who Are Divorced

  Kuo, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Evaluating the Effect of Migration Stimulating Factor on Wound Healing Behavior at the Cellular Level Using Nano-Biomedical Technologies

  Yang, T.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Developing New Diagnostic and Therapeutic Strategies for Lung Cancer with ROS1, RET and NTRK1 Mutations in Patients without EGFR, KRAS and ALK Mutations

  Liu, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Does Neural Activity during Reward Predict Self-relatedness?

  Lane, T. J.

  1/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Home-Based Exercise Training on Fatigue, Sleep Disturbance, Symptom Distress and Quality of Life in End-Stage Renal Disease Patients

  Lin, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Developing Evidenced-Based, User-Friendly, Self-Directed, and Effective-Driven Nursing Assessment Decision-Assistive System---An Example of Fall Assessment for Hospital Inpatients

  Chang, W.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 周產期尼古丁及新生兒高氧暴露對仔鼠心臟及腎臟的影響

  Chen, C.

  3/1/14 → 7/31/15

  Project: C - Project of Alliance › s - Shin Kong Wu Ho-Su Memorial Hospital

• The Effects of Neurofeedback and RSA Biofeedback on Quality of Sleep in Patients in the Chronic Phase of Traumatic Brain Injury(2/3)

  Tsai, P.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effects of Adipose-Derived Stem Cells on Denervated Rat Skeletal Muscle Atrophy

  Tsai, F.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Characterization of 5-Hydroxymethylcytosine and Ten-to-Eleven Translocation Gene (TET) in Cervical Cancer

  Lai, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Evaluation of the Mechanism of Post-Traumatic Immunosuppression---The Role of TLR4 Trafficking and microRNA

  Lin, J. A.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effect of Long Acting GnRH Agonist Treatment on Mitochondrial Function in

  Tzeng, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Evaluation on Cervical Cancer Prevention and Treatment Policy in Taiwan

  Tang, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• CXCL5/CXCR2/JNK Axis Is the Shared Pathway of Neuroinflammation and Microvascular Damage That Contributes to White Matter Injury in the Immature Brain

  Huang, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation of the Oncogenic Role of Prohibitin in Breast Cancer Progression

  Huang, T.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Genomic and Non-Genomic Estrogen Effects on the Spinal NR2B-Related Uterus-Colon Crosstalk in Rats

  Lin, T.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Relationships of One-Carbon Cycle Pathways with Psychopathology and Metabolic Abnormalities in Patients with Schizophrenia and Potential Intervention Strategy with 5-Methyltetrahydrofolate and Vitamin B12

  Chen, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討精神分裂症治療藥物Chlorpromazine促進大腸直腸癌細胞凋亡及SIRT1-P53的調控機制

  Lin, C.

  3/1/14 → 7/31/15

  Project: C - Project of Alliance › o - Chi Mei Medical Center

• 氧化還原作用調控蛋白質去磷酸酉每羰基化和去羰基化反應對動脈血管內膜增生之影響(1/2)

  Hsieh, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 臨床醫學與生命倫理研究組織與參與設計人才培育計劃

  Tsai, D.

  8/1/14 → 7/31/15

  Project: A - Government Institution › d - Ministry of Education

• Studies of Anti-Cancer Activity of Folic Acid

  Lee, W.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Design and Characterization of Multifunctional Self-Assembling Lecithin/Amphiphilic Polymers Mixed Micellar Delivery Systems

  Sheu, M.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Study of Therapeutic Effects for Stroke with Phenserine, an Amyloid Precursor Protein Inhibitor, in Rodent Focal Cerebral Ischemia Model(2/3)

  Chang, C. & Chiang, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › a - National Health Research Institutes

• Anticancer Drug Discovery of New Tegafur-Derivatives for Colorectal Cancer Therapy

  Chen, M.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Determined the Role and the Mechanims of GRP94 in Mediating the Progression and Therapeutic Responses of HCC

  Huang, M.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 油症患者健康照護服務條例之辦法擬訂工作計畫

  Lee, C.

  3/4/15 → 7/31/15

  Project: A - Government Institution › c - Ministry of Health and Welfare

• The Issues and Rules in Public-Private Partnership for Vaccines Innovation

  Lee, C.

  1/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Evaluate the Molecluar Mechanims and Clinical Application on Atf3 Regulated microRNAs

  Lin, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討不同選擇作用之組織蛋白去乙醯?調節成分抑制神經發炎之機制及其對腦內出血與腦炎之治療特性評估(2/3)

  Hsiao, G.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study of the Mechanism of HPV Involved Tumorigenesis through Wnt Signaling Pathway Related microRNA Regulation

  Cheng, Y. & Lee, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 乳癌是目前世界上女性癌症病患中為數最多的癌症之ㄧ。腺病毒蛋白type 5 E1A (E1A)和許多抗腫瘤作用有關，曾於多種癌症如乳癌、卵巢癌及頭頸癌之病患進行臨床基因治療試驗。許多的研究指出E1A具有多項抗腫瘤的功能，包括抑制腫瘤的發生、增加腫瘤細胞對於化療藥物的感受性以及減少腫瘤轉移的現象。腫瘤的轉移對於癌症患者的死亡率有極大的影響當然也包括了乳癌的患者。E1A於抑制腫瘤發展的過程中具有多重生物學上的意義，這也促使我們想要釐清E1A抑制癌症的機制。因此，我們對於了解E1A抑制癌症轉移相關的分子機制感到有興趣，並期望藉以作為未來改進乳癌病人臨床試驗的基石。我們初步的實驗結果顯示，E1A可以有效的抑制Glucose-regulated protein 78 (GRP78)這種已被廣泛報導和腫瘤惡化及轉移相關的蛋白的表現。 提出此研究計劃之目的在於詳細探討E1A所造成的抑制癌轉移作用中，GRP78所扮演的生物功能及其調控的機轉。為了達到此目的，我們將著重於E1A如何調控GRP78表現並進而展現對乳癌轉移的抑制作用。以下為此項研究計畫的四大主要目標： 目標一：探討GRP78在E1A所抑制之癌細胞移行及侵入作用中所扮演的角色 目標二：研究E1A抑制GRP78表現之分子機轉 目標三：於動物模式中驗證GRP78的表現對於E1A抗腫瘤作用的影響 目標四：探討GRP78及其相關分子的表現在乳癌病人的臨床重要性 完成以上的主要目標能夠幫助我們對於E1A之抗腫瘤轉移作用建立更加詳細的分子訊息傳遞機制。另外，藉由此研究計畫的新發現也許可以對未來發展癌症治療上提供更多具有潛力的標的物。

  Wang, W.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Expressing Membrane Antibody Reporter in the Islet Cells of Nonobese Diabetic Mice to Noninvasive Assess the Therapeutic Effects of Drugs or Transgenes for Autoimmune Diabetes

  Chuang, K.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Cocaine Induces Sig-1R Nuclear Envelope Localization to Regulate MAOB Expression by Interacting with Emerin-HDACs Co-Repressor Complex

  Chuang, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Dissected the Role of Glucosed-Regulated Portein 78 in the Progression, Metastasis and Therapy of Colorectal Cancer

  Wei, P.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study the Function and Regulation of miRNAs in Pancreatic Cancer Progression (I)

  Huang, M.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Genetic Polymorphisms of Calcium Channel in the Risk of Breast Cancer

  Chang, W.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Drug Discovery and Pharmacological Study of Novel pan-HDAC Inhibitors as Anti-Angiogenic Drugs

  Pan, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Application of Regioselective Substitution on 1,4-Benzoquinone Derivatives to Provide Potent Anticancer Agents

  Liou, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Natural Product Hybrid and Ortho-Biaryl N-Hydroxycinnamide as Leads for Anticancer Agent Development

  Huang, W.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effects of the APOE4 Allele on Cerebral Structural and Functional Connectivity---A Diffusion Tensor Imaging and Resting-State MRI Study

  Chen, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Functional Investigation of Heat Shock Protein in Esophageal Squamous Cell Cancer with Implications in Prognostic Prediction and Therapeutic Targeting

  Tzao, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of CISD2 in the Female Reproductive System of Mammal

  Chang, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Multidisciplinary Study of the Pathophysiology of Blast-Induced Mild Traumatic Brain Injury

  Chiang, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Kidney Injury and Heat Shock Protein Modulate the Atrial Electrophysiological Characterisitcs

  Hsieh, M.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Evaluate the Radio-Biological Roles of miR-17-5P in Oral Cancer Cell Line OC3

  Wu, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology