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Research Output 1994 2019

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Article
2016
7 Citations (Scopus)

The Impact of dUTPase on Ribonucleotide Reductase-Induced Genome Instability in Cancer Cells

Chen, C. W., Tsao, N., Huang, L. Y., Yen, Y., Liu, X., Lehman, C., Wang, Y. H., Tseng, M. C., Chen, Y. J., Ho, Y. C., Chen, C. F. & Chang, Z. F., Aug 2 2016, In : Cell Reports. 16, 5, p. 1287-1299 13 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Genomic Instability
Genes
Cells
Genome
6 Citations (Scopus)
Urinary Bladder Neoplasms
Autophagy
G1 Phase Cell Cycle Checkpoints
cdc Genes
Cyclin E
2015

Correction: HP1β is a biomarker for breast cancer prognosis and PARP inhibitor therapy(PLoS ONE (2015) 10:3 (e0121207) 10.1371/journal.pone.0121207)

Lee, Y. H., Liu, X., Qiu, F., O'Connor, T. R., Yen, Y. & Ann, D. K., Apr 13 2015, In : PLoS One. 10, 4, 0124853.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Detection and phenotyping of circulating tumor cells in high-risk localized prostate cancer

Pal, S. K., He, M., Wilson, T., Liu, X., Zhang, K., Carmichael, C., Torres, A., Hernandez, S., Lau, C., Agarwal, N., Kawachi, M., Yen, Y. & Jones, J. O., Apr 1 2015, In : Clinical Genitourinary Cancer. 13, 2, p. 130-136 7 p.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Prostatic Neoplasms
Epithelial-Mesenchymal Transition
Cadherins
Recurrence
6 Citations (Scopus)

Detection of lysyl oxidase-like 2 (LOXL2), a biomarker of metastasis from breast cancers using human blood samples

Janyasupab, M., Lee, Y. H., Zhang, Y., Liu, C. W., Cai, J., Popa, A., Samia, A. C., Wang, K. W., Xu, J., Hu, C. C., Wendt, M. K., Schiemann, B. J., Thompson, C. L., Yen, Y., Schiemann, W. P. & Liu, C. C., Aug 1 2015, In : Recent Patents on Biomarkers. 5, 2, p. 93-100 8 p.

Research output: Contribution to journalArticle

Protein-Lysine 6-Oxidase
Biomarkers
Blood
Breast Neoplasms
Neoplasm Metastasis
33 Citations (Scopus)

Fibronectin promotes cell proliferation and invasion through mTOR signaling pathway activation in gallbladder cancer

Cao, Y., Liu, X., Lu, W., Chen, Y., Wu, X., Li, M., Wang, X. A., Zhang, F., Jiang, L., Zhang, Y., Hu, Y., Xiang, S., Shu, Y., Bao, R., Li, H., Wu, W., Weng, H., Yen, Y. & Liu, Y., May 1 2015, In : Cancer Letters. 360, 2, p. 141-150 10 p.

Research output: Contribution to journalArticle

Gallbladder Neoplasms
Fibronectins
Cell Proliferation
Phosphorylation
Sirolimus
16 Citations (Scopus)

HP1 β is a biomarker for breast cancer prognosis and PARP inhibitor therapy

Lee, Y. H., Liu, X., Qiu, F., O'Connor, T. R., Yen, Y. & Ann, D. K., Mar 13 2015, In : PLoS One. 10, 3, e0121207.

Research output: Contribution to journalArticle

Biomarkers
breast neoplasms
prognosis
biomarkers
Breast Neoplasms

HP1 βis α biomarker for breast cancer prognosis and PARP inhibitor therapy

Lee, Y. H., Liu, X., Qiu, F., O'Connor, T. R., Yen, Y. & Ann, D. K., Mar 13 2015, In : PLoS One. 10, 3, e0121207.

Research output: Contribution to journalArticle

Biomarkers
breast neoplasms
prognosis
biomarkers
Breast Neoplasms
22 Citations (Scopus)

Is long-term use of benzodiazepine a risk for cancer?

Usman, I., Nguyen, P. A., Syed-Abdul, S., Yang, H. C., Huang, C. W., Jian, W. S., Hsu, M. H., Yen, Y. & Li, Y. C., Feb 1 2015, In : Medicine (United States). 94, 6, p. e483

Research output: Contribution to journalArticle

Benzodiazepines
Neoplasms
Medazepam
Nitrazepam
Oxazepam
14 Citations (Scopus)

KLHL39 suppresses colon cancer metastasis by blocking KLHL20-mediated PML and DAPK ubiquitination

Chen, H. Y., Hu, J. Y., Chen, T. H., Lin, Y. C., Liu, X., Lin, M. Y., Lang, Y. D., Yen, Y. & Chen, R. H., Oct 1 2015, In : Oncogene. 34, 40, p. 5141-5151 11 p.

Research output: Contribution to journalArticle

Death-Associated Protein Kinases
Cullin Proteins
Ubiquitination
Colonic Neoplasms
Neoplasm Metastasis
11 Citations (Scopus)

Lovastatin overcomes gefitinib resistance through TNF-a signaling in human cholangiocarcinomas with different LKB1 statuses in vitro and in vivo

Yang, S. H., Lin, H. Y., Chang, V. H. S., Chen, C. C., Liu, Y. R., Wang, J., Zhang, K., Jiang, X. & Yen, Y., 2015, In : Oncotarget. 6, 27, p. 23857-23873 17 p.

Research output: Contribution to journalArticle

Lovastatin
Cholangiocarcinoma
Heterografts
In Vitro Techniques
gefitinib
18 Citations (Scopus)

Lowered circulating aspartate is a metabolic feature of human breast cancer

Xie, G., Zhou, B., Zhao, A., Qiu, Y., Zhao, X., Garmire, L., Shvetsov, Y. B., Yu, H., Yen, Y. & Jia, W., Jan 1 2015, In : Oncotarget. 6, 32, p. 33369-33381 13 p.

Research output: Contribution to journalArticle

Aspartic Acid
Breast Neoplasms
Neoplasms
Cell Line
Metabolomics
13 Citations (Scopus)

Molecular Properties, Functional Mechanisms, and Applications of Sliced siRNA

Sun, G., Yeh, S. Y., Yuan, C. W. Y., Chiu, M. J. Y., Yung, B. S. H. & Yen, Y., Jan 27 2015, In : Molecular Therapy - Nucleic Acids. 4, 1, p. e221 e221.

Research output: Contribution to journalArticle

Small Interfering RNA
RNA Interference
Colonic Neoplasms
Cell Proliferation
Genes
8 Citations (Scopus)

Non-enzymatic action of RRM1 protein upregulates PTEN leading to inhibition of colorectal cancer metastasis

Qi, H., Lou, M., Chen, Y., Liu, X., Chen, N., Shan, J., Ling, Z., Shen, J., Zhu, L., Yen, Y., Zheng, S. & Shao, J., Feb 1 2015, In : Tumor Biology. 36, 6, p. 4833-4842 10 p.

Research output: Contribution to journalArticle

PTEN Phosphohydrolase
Ribonucleotide Reductases
Protein Subunits
Colorectal Neoplasms
Up-Regulation
36 Citations (Scopus)

PHY906(KD018), an adjuvant based on a 1800-year-old Chinese medicine, enhanced the anti-tumor activity of Sorafenib by changing the tumor microenvironment

Lam, W., Jiang, Z., Guan, F., Huang, X., Hu, R., Wang, J., Bussom, S., Liu, S. H., Zhao, H., Yen, Y. & Cheng, Y. C., Mar 31 2015, In : Scientific Reports. 5, 9384.

Research output: Contribution to journalArticle

Tumor Microenvironment
Medicine
Neoplasms
Macrophages
Scutellaria baicalensis
4 Citations (Scopus)

Primary Cutaneous Anaplastic Large Cell Lymphoma With Positive ALK Expression and a Rapidly Progressive Cutaneous Nodule

Xue, D., Li, X., Ren, Y., Liu, Q., Yen, Y. & Xue, L., Jun 3 2015, In : International Journal of Surgical Pathology. 23, 4, p. 333-335 3 p.

Research output: Contribution to journalArticle

Primary Cutaneous Anaplastic Large Cell Lymphoma
Mucin-1
Skin
Young Adult
anaplastic lymphoma kinase
6 Citations (Scopus)

RRM2B-mediated regulation of mitochondrial activity and inflammation under oxidative stress

Cho, E. C., Kuo, M. L., Cheng, J. H., Cheng, Y. C., Hsieh, Y. C., Liu, Y. R., Hsieh, R. H. & Yen, Y., 2015, In : Mediators of Inflammation. 2015, 287345.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Oxidative Stress
Inflammation
Mitochondrial Genes
DNA Damage
11 Citations (Scopus)

The novel ribonucleotide reductase inhibitor COH29 inhibits DNA repair in vitros

Chen, M. C., Zhou, B., Zhang, K., Yuan, Y. C., Un, F., Hu, S., Chou, C. M., Chen, C. H., Wu, J., Wang, Y., Liu, X., Smith, D. L., Li, H., Liu, Z., Warden, C. D., Su, L., Malkas, L. H., Chung, Y. M., Hu, M. C. T. & Yen, Y., Jun 1 2015, In : Molecular Pharmacology. 87, 6, p. 996-1005 10 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
DNA Repair
DNA Damage
gemcitabine
Deoxyribonucleotides
19 Citations (Scopus)

The pan-PI3K inhibitor GDC-0941 activates canonical WNT signaling to confer resistance in TNBC cells: Resistance reversal with WNT inhibitor

Tzeng, H. E., Yang, L., Chen, K., Wang, Y., Liu, Y. R., Pan, S. L., Gaur, S., Hu, S. & Yen, Y., 2015, In : Oncotarget. 6, 13, p. 11061-11073 13 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Phosphatidylinositol 3-Kinases
beta Catenin
MCF-7 Cells
2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine
22 Citations (Scopus)

Underexpression of LKB1 tumor suppressor is associated with enhanced Wnt signaling and malignant characteristics of human intrahepatic cholangiocarcinoma

Wang, J., Zhang, K., Wang, J., Wu, X., Liu, X., Li, B., Zhu, Y., Yu, Y., Cheng, Q., Hu, Z., Guo, C., Hu, S., Mu, B., Tsai, C. H., Li, J., Smith, L., Yang, L., Liu, Q., Chu, P., Chang, V. & 4 others, Zhang, B., Wu, M., Jiang, X. & Yen, Y., 2015, In : Oncotarget. 6, 22, p. 18905-18920 16 p.

Research output: Contribution to journalArticle

Cholangiocarcinoma
Phosphotransferases
Liver
Catenins
Neoplasms
2014
64 Citations (Scopus)

A distinct metabolic signature of human colorectal cancer with prognostic potential

Qiu, Y., Cai, G., Zhou, B., Li, D., Zhao, A., Xie, G., Li, H., Cai, S., Xie, D., Huang, C., Ge, W., Zhou, Z., Xu, L. X., Jia, W., Zheng, S., Yen, Y. & Jia, W., Apr 15 2014, In : Clinical Cancer Research. 20, 8, p. 2136-2146 11 p.

Research output: Contribution to journalArticle

Metabolomics
Colorectal Neoplasms
Biomarkers
Geographic Locations
Neoplasms
12 Citations (Scopus)

A germline missense mutation in COQ6 is associated with susceptibility to familial schwannomatosis

Zhang, K., Lin, J. W., Wang, J., Wu, X., Gao, H., Hsieh, Y. C., Hwu, P., Liu, Y. R., Su, L., Chiou, H. Y., Wang, D., Yuan, Y. C., Whang-Peng, J., Chiu, W. T. & Yen, Y., Oct 1 2014, In : Genetics in Medicine. 16, 10, p. 787-792 6 p.

Research output: Contribution to journalArticle

Germ-Line Mutation
Missense Mutation
coenzyme Q10
Genome
Exome
39 Citations (Scopus)

Anti-proliferative and gene expression actions of resveratrol in breast cancer cells in vitro

Chin, Y. T., Hsieh, M. T., Yang, S. H., Tsai, P. W., Wang, S. H., Wang, C. C., Lee, Y. S., Cheng, G. Y., HuangFu, W. C., London, D., Tang, H. Y., Fu, E., Yen, Y., Liu, L. F., Lin, H. Y. & Davis, P. J., 2014, In : Oncotarget. 5, 24, p. 12891-12907 17 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Gene Expression
Stilbenes
Cell Proliferation
Perfusion
50 Citations (Scopus)

Arginine starvation-associated atypical cellular death involves mitochondrial dysfunction, nuclear DNA leakage, and chromatin autophagy

Changou, C. A., Chen, Y. R., Xing, L., Yen, Y., Chuang, F. Y. S., Cheng, R. H., Bold, R. J., Ann, D. K. & Kung, H. J., Sep 30 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 39, p. 14147-14152 6 p.

Research output: Contribution to journalArticle

Autophagy
Starvation
Chromatin
Arginine
DNA
24 Citations (Scopus)

Bcl2 induces DNA replication stress by inhibiting ribonucleotide reductase

Xie, M., Yen, Y., Owonikoko, T. K., Ramalingam, S. S., Khuri, F. R., Curran, W. J., Doetsch, P. W. & Deng, X., Jan 1 2014, In : Cancer Research. 74, 1, p. 212-223 12 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
DNA Replication
Diphosphates
DNA
Deoxyribonucleotides
61 Citations (Scopus)

Cancer: Arginine starvation impairs mitochondrial respiratory function in ASS1-deficient breast cancer cells

Qiu, F., Chen, Y. R., Liu, X., Chu, C. Y., Shen, L. J., Xu, J., Gaur, S., Forman, H. J., Zhang, H., Zheng, S., Yen, Y., Huang, J., Kung, H. J. & Ann, D. K., Apr 1 2014, In : Science Signaling. 7, 319

Research output: Contribution to journalArticle

Argininosuccinate Synthase
Starvation
Arginine
Cells
Breast Neoplasms
471 Citations (Scopus)

Cancer-Secreted miR-105 destroys vascular endothelial barriers to promote metastasis

Zhou, W., Fong, M. Y., Min, Y., Somlo, G., Liu, L., Palomares, M. R., Yu, Y., Chow, A., O'Connor, S. T. F., Chin, A. R., Yen, Y., Wang, Y., Marcusson, E. G., Chu, P., Wu, J., Wu, X., Li, A. X., Li, Z., Gao, H., Ren, X. & 3 others, Boldin, M. P., Lin, P. C. & Wang, S. E., Apr 14 2014, In : Cancer Cell. 25, 4, p. 501-515 15 p.

Research output: Contribution to journalArticle

Blood Vessels
Neoplasm Metastasis
Neoplasms
Zonula Occludens-1 Protein
Breast Neoplasms
2 Citations (Scopus)

Clinical research of mortality in emergency air medical transport

Chen, W. L., Ma, H. P., Wu, C. H., Chiou, H. Y., Yen, Y., Chiu, W. T. & Tsai, S. H., 2014, In : BioMed Research International. 2014, 767402.

Research output: Contribution to journalArticle

Health care
Emergencies
Air
Mortality
Taiwan
152 Citations (Scopus)

Correlating animal and human phase Ia/Ib clinical data with CALAA-01, a targeted, polymer-based nanoparticle containing siRNA

Zuckerman, J. E., Gritli, I., Tolcher, A., Heidel, J. D., Lim, D., Morgan, R., Chmielowski, B., Ribas, A., Davis, M. E. & Yen, Y., Aug 5 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 31, p. 11449-11454 6 p.

Research output: Contribution to journalArticle

Nanoparticles
Small Interfering RNA
Polymers
Clinical Trials, Phase I
RNA Interference

Curative use of forequarter amputation for recurrent breast cancer over an axillary area: a case report and literature review

Tsai, C. H., Tzeng, H. E., Juang, W. K., Chu, P. G., Fann, P., Fong, Y. C., Hsu, H. C. & Yen, Y., 2014, In : World Journal of Surgical Oncology. 12, p. 346 1 p.

Research output: Contribution to journalArticle

Amputation
Breast Neoplasms
Recurrence
Neoplasm Metastasis
Upper Extremity
20 Citations (Scopus)

Dovitinib synergizes with oxaliplatin in suppressing cell proliferation and inducing apoptosis in colorectal cancer cells regardless of RAS-RAF mutation status

Gaur, S., Chen, L., Ann, V., Lin, W. C., Wang, Y., Chang, V. H. S., Hsu, N. Y., Shia, H. S. & Yen, Y., Feb 4 2014, In : Molecular Cancer. 13, 1, 21.

Research output: Contribution to journalArticle

oxaliplatin
Colorectal Neoplasms
Cell Proliferation
Heterografts
Colonic Neoplasms
14 Citations (Scopus)

Expression of glypican 3 enriches hepatocellular carcinoma development-related genes and associates with carcinogenesis in cirrhotic livers

Liu, X., Wang, S. K., Zhang, K., Zhang, H., Pan, Q., Liu, Z., Pan, H., Xue, L., Yen, Y. & Chu, P. G., Aug 20 2014, In : Carcinogenesis. 36, 2, p. 232-242 11 p.

Research output: Contribution to journalArticle

Glypicans
Hepatocellular Carcinoma
Carcinogenesis
Liver
Genes
22 Citations (Scopus)

Frequent overexpression of HMGA2 in human atypical teratoid/rhabdoid tumor and its correlation with let-7a3/let-7b miRNA

Zhang, K., Gao, H., Wu, X., Wang, J., Zhou, W., Sun, G., Wang, J., Wang, Y., Mu, B., Kim, C., Chu, P., Ho, D. M., Ann, D. K., Wong, T. T. & Yen, Y., 2014, In : Clinical Cancer Research. 20, 5, p. 1179-1189 11 p.

Research output: Contribution to journalArticle

AT-Hook Motifs
MicroRNAs
Oncogene Proteins
Immunohistochemistry
Typical Teratoid Rhabdoid Tumor
8 Citations (Scopus)

Identification of a distinct small cell population from human bone marrow reveals its multipotency in vivo and in vitro

Wang, J., Guo, X., Lui, M., Chu, P. J., Yoo, J., Chang, M. & Yen, Y., Jan 17 2014, In : PLoS One. 9, 1, e85112.

Research output: Contribution to journalArticle

Stem cells
bone marrow
Bone
Bone Marrow
Cells

Jejunal Cancer with WRN Mutation Identified from Next-Generation Sequencing: A Case Study and Minireview

Chang, C., Shiah, H-S., Hsu, N-Y., Huang, H. Y., Chu, J-S. & Yen, Y., 2014, In : Case Reports in Surgery.

Research output: Contribution to journalArticle

Jejunal Neoplasms
Jejunum
Mutation
Small Intestine
Exome
69 Citations (Scopus)

MiR-26a enhances miRNA biogenesis by targeting Lin28B and Zcchc11 to suppress tumor growth and metastasis

Fu, X., Meng, Z., Liang, W., Tian, Y., Wang, X., Han, W., Lou, G., Wang, X., Lou, F., Yen, Y., Yu, H., Jove, R. & Huang, W., Aug 21 2014, In : Oncogene. 33, 34, p. 4296-4306 11 p.

Research output: Contribution to journalArticle

MicroRNAs
Neoplasm Metastasis
Growth
Neoplasms
Liver Neoplasms
23 Citations (Scopus)

Mutants TP53 p.R273H and p.R273C but not p.R273G Enhance Cancer Cell Malignancy

Li, J., Yang, L., Gaur, S., Zhang, K., Wu, X., Yuan, Y. C., Li, H., Hu, S., Weng, Y. & Yen, Y., Jan 1 2014, In : Human Mutation. 35, 5, p. 575-584 10 p.

Research output: Contribution to journalArticle

Mutation
Neoplasms
BRCA1 Protein
p53 Genes
Molecular Dynamics Simulation
13 Citations (Scopus)

p53MVA therapy in patients with refractory gastrointestinal malignancies elevates p53-specific CD8+ T-cell responses

Hardwick, N. R., Carroll, M., Kaltcheva, T., Qian, D., Lim, D., Leong, L., Chu, P., Kim, J., Chao, J., Fakih, M., Yen, Y., Espenschied, J., Ellenhorn, J. D. I., Diamond, D. J. & Chung, V., Sep 1 2014, In : Clinical cancer research : an official journal of the American Association for Cancer Research. 20, 17, p. 4459-4470 12 p.

Research output: Contribution to journalArticle

Immunization
T-Lymphocytes
Vaccinia
Neoplasms
Therapeutics
35 Citations (Scopus)

Pharmacodynamic and pharmacogenomic study of the nanoparticle conjugate of camptothecin CRLX101 for the treatment of cancer

Gaur, S., Wang, Y., Kretzner, L., Chen, L., Yen, T., Wu, X., Yuan, Y. C., Davis, M. & Yen, Y., Oct 1 2014, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 10, 7, p. 1477-1486 10 p.

Research output: Contribution to journalArticle

Pharmacodynamics
Camptothecin
Nanoparticles
Tumors
Neoplasms
19 Citations (Scopus)

Prognostic and therapeutic significance of ribonucleotide reductase small subunit M2 in estrogen-negative breast cancers

Zhang, H., Liu, X., Warden, C. D., Huang, Y., Loera, S., Xue, L., Zhang, S., Chu, P., Zheng, S. & Yen, Y., Sep 11 2014, In : BMC Cancer. 14, 1, 664.

Research output: Contribution to journalArticle

Estrogen Receptors
Estrogens
Breast Neoplasms
Ribonucleotide Reductases
Biomarkers
20 Citations (Scopus)

Reciprocal regulation of autophagy and dNTP pools in human cancer cells

Chen, W., Zhang, L., Zhang, K., Zhou, B., Kuo, M. L., Hu, S., Chen, L., Tang, M., Chen, Y. R., Yang, L., Ann, D. K. & Yen, Y., Jan 1 2014, In : Autophagy. 10, 7, p. 1272-1284 13 p.

Research output: Contribution to journalArticle

Deoxyribonucleosides
Autophagy
Ribonucleotide Reductases
Neoplasms
Sirolimus
9 Citations (Scopus)

The prognostic value of ribonucleotide reductase small subunit M2 in predicting recurrence for prostate cancers

Huang, Y., Liu, X., Wang, Y. H., Yeh, S. D., Chen, C. L., Nelson, R. A., Chu, P., Wilson, T. & Yen, Y., Jan 2014, In : Urologic Oncology: Seminars and Original Investigations. 32, 1

Research output: Contribution to journalArticle

Prostatic Neoplasms
Recurrence
Capsules
Neoplasm Grading
Metalloproteases
16 Citations (Scopus)

The role of peroxiredoxin II in chemoresistance of breast cancer cells

Wang, T., Diaz, A. J. G. & Yen, Y., 2014, In : Breast Cancer: Targets and Therapy. 6, p. 73-80 8 p.

Research output: Contribution to journalArticle

Peroxiredoxins
Breast Neoplasms
Oxidation-Reduction
Radiotherapy
Radiation
21 Citations (Scopus)

Tumor suppressor FOXO3 regulates ribonucleotide reductase subunit RRM2B and impacts on survival of cancer patients

Cho, E. C., Kuo, M. L., Liu, X., Yang, L., Hsieh, Y. C., Wang, J., Cheng, Y. & Yen, Y., 2014, In : Oncotarget. 5, 13, p. 4834-4844 11 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Survival
Neoplasms
DNA Replication
Tumor Biomarkers
27 Citations (Scopus)

Wnt modulates MCL1 to control cell survival in triple negative breast cancer

Yang, L., Perez, A. A., Fujie, S., Warden, C., Li, J., Wang, Y., Yung, B., Chen, Y. R., Liu, X., Zhang, H., Zheng, S., Liu, Z., Ann, D. & Yen, Y., Feb 24 2014, In : BMC Cancer. 14, 1, 124.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Cell Survival
Microarray Analysis
Ligands
Immunohistochemistry
2013
45 Citations (Scopus)

Amplification of FRS2 and activation of FGFR/FRS2 signaling pathway in high-grade liposarcoma

Zhang, K., Chu, K., Wu, X., Gao, H., Wang, J., Yuan, Y. C., Loera, S., Ho, K., Wang, Y., Chow, W., Un, F., Chu, P. & Yen, Y., Jan 15 2013, In : Cancer Research. 73, 4, p. 1298-1307 10 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor Receptors
Liposarcoma
Sarcoma
Proteins
Receptor, Fibroblast Growth Factor, Type 2

A phase II study of hydroxyurea combined with gemcitabine in patients with head and neck squamous carcinoma and gene expression profiles correlated to poor response

Zhang, K., Kim, C., Wu, X., Loera, S., Wang, Y., Chu, P., Lim, D., Shibata, S. & Yen, Y., Feb 27 2013, In : Head and Neck Oncology. 5, 3, 3.

Research output: Contribution to journalArticle

gemcitabine
Hydroxyurea
Transcriptome
Squamous Cell Carcinoma
Neck
15 Citations (Scopus)

A phase i study of prolonged infusion of triapine in combination with fixed dose rate gemcitabine in patients with advanced solid tumors

Mortazavi, A., Ling, Y., Martin, L. K., Wei, L., Phelps, M. A., Liu, Z., Harper, E. J., Ivy, S. P., Wu, X., Zhou, B. S., Liu, X., Deam, D., Monk, J. P., Hicks, W. J., Yen, Y., Otterson, G. A., Grever, M. R. & Bekaii-Saab, T., Jun 1 2013, In : Investigational New Drugs. 31, 3, p. 685-695 11 p.

Research output: Contribution to journalArticle

gemcitabine
Neoplasms
Maximum Tolerated Dose
Pharmacokinetics
Ribonucleotide Reductases
28 Citations (Scopus)

A small-molecule blocking ribonucleotide reductase holoenzyme formation inhibits cancer cell growth and overcomes drug resistance

Zhou, B., Su, L., Hu, S., Hu, W., Yip, M. L. R., Wu, J., Gaur, S., Smith, D. L., Yuan, Y. C., Synold, T. W., Horne, D. & Yen, Y., Nov 1 2013, In : Cancer Research. 73, 21, p. 6484-6493 10 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Holoenzymes
Drug Resistance
Growth
Neoplasms
32 Citations (Scopus)

Berbamine inhibits the growth of liver cancer cells and cancer-initiating cells by targeting Ca2+/calmodulin- dependent protein kinase II

Meng, Z., Li, T., Ma, X., Wang, X., Ness, C. V., Gan, Y., Zhou, H., Tang, J., Lou, G., Wang, Y., Wu, J., Yen, Y., Xu, R. & Huang, W., Oct 1 2013, In : Molecular Cancer Therapeutics. 12, 10, p. 2067-2077 11 p.

Research output: Contribution to journalArticle

Calcium-Calmodulin-Dependent Protein Kinase Type 2
Liver Neoplasms
Growth
Neoplasms
berbamine