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2016

Prognostic and therapeutic value of mitochondrial serine hydroxyl-methyltransferase 2 as a breast cancer biomarker

Zhang, L., Chen, Z., Xue, D., Zhang, Q., Liu, X., Luh, F., Hong, L., Zhang, H., Pan, F., Liu, Y., Chu, P., Zheng, S., Lou, G. & Yen, Y., Nov 1 2016, In : Oncology Reports. 36, 5, p. 2489-2500 12 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Proton pump inhibitors and risk of periampullary cancers - A nested case-control study

Chien, L-N., Huang, Y. J., Shao, Y-H., Chang, C. J., Chuang, M. T., Chiou, H-Y. & Yen, Y., Mar 15 2016, In : International Journal of Cancer. 138, 6, p. 1401-1409 9 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Pu-erh Tea Extract Attenuates Nicotine-Induced Foam Cell Formation in Primary Cultured Monocytes: An in Vitro Mechanistic Study

Tu, S. H., Chen, M. Y., Chen, L. C., Mao, Y. T., Ho, C. H., Lee, W. J., Lin, Y-K., Pan, M. H., Lo, C. Y., Chen, C. L., Yen, Y., Whang-Peng, J., Ho, C. T., Wu, C. H. & Ho, Y. S., Apr 27 2016, In : Journal of Agricultural and Food Chemistry. 64, 16, p. 3186-3195 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

PYCR1 and PYCR2 Interact and Collaborate with RRM2B to Protect Cells from Overt Oxidative Stress

Kuo, M. L., Lee, M. B. E., Tang, M., Den Besten, W., Hu, S., Sweredoski, M. J., Hess, S., Chou, C. M., Changou, C. A., Su, M., Jia, W., Su, L. & Yen, Y., Jan 6 2016, In : Scientific Reports. 6, 18846.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Research of StemBios cell therapy on dental implants containing nanostructured surfaces: Biomechanical behaviors, microstructural characteristics, and clinical trial

Ou, K. L., Weng, C. C., Wu, C. C., Lin, Y. H., Chiang, H. J., Yang, T. S., Wang, J., Yen, Y., Cheng, H. Y. & Sugiatno, E., Feb 1 2016, In : Implant Dentistry. 25, 1, p. 63-73 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Signature miRNAs in colorectal cancers were revealed using a bias reduction small RNA deep sequencing protocol

Sun, G., Cheng, Y. W., Lai, L., Huang, T. C., Wang, J., Wu, X., Wang, Y., Huang, Y., Wang, J., Zhang, K., Hu, S., Yang, J. R. & Yen, Y., 2016, In : Oncotarget. 7, 4, p. 3857-3872 16 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

The Impact of dUTPase on Ribonucleotide Reductase-Induced Genome Instability in Cancer Cells

Chen, C. W., Tsao, N., Huang, L. Y., Yen, Y., Liu, X., Lehman, C., Wang, Y. H., Tseng, M. C., Chen, Y. J., Ho, Y. C., Chen, C. F. & Chang, Z. F., Aug 2 2016, In : Cell Reports. 16, 5, p. 1287-1299 13 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
11 Citations (Scopus)
2015

Correction: HP1β is a biomarker for breast cancer prognosis and PARP inhibitor therapy(PLoS ONE (2015) 10:3 (e0121207) 10.1371/journal.pone.0121207)

Lee, Y. H., Liu, X., Qiu, F., O'Connor, T. R., Yen, Y. & Ann, D. K., Apr 13 2015, In : PLoS One. 10, 4, 0124853.

Research output: Contribution to journalArticle

Detection and phenotyping of circulating tumor cells in high-risk localized prostate cancer

Pal, S. K., He, M., Wilson, T., Liu, X., Zhang, K., Carmichael, C., Torres, A., Hernandez, S., Lau, C., Agarwal, N., Kawachi, M., Yen, Y. & Jones, J. O., Apr 1 2015, In : Clinical Genitourinary Cancer. 13, 2, p. 130-136 7 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Detection of lysyl oxidase-like 2 (LOXL2), a biomarker of metastasis from breast cancers using human blood samples

Janyasupab, M., Lee, Y. H., Zhang, Y., Liu, C. W., Cai, J., Popa, A., Samia, A. C., Wang, K. W., Xu, J., Hu, C. C., Wendt, M. K., Schiemann, B. J., Thompson, C. L., Yen, Y., Schiemann, W. P. & Liu, C. C., Aug 1 2015, In : Recent Patents on Biomarkers. 5, 2, p. 93-100 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Fibronectin promotes cell proliferation and invasion through mTOR signaling pathway activation in gallbladder cancer

Cao, Y., Liu, X., Lu, W., Chen, Y., Wu, X., Li, M., Wang, X. A., Zhang, F., Jiang, L., Zhang, Y., Hu, Y., Xiang, S., Shu, Y., Bao, R., Li, H., Wu, W., Weng, H., Yen, Y. & Liu, Y., May 1 2015, In : Cancer Letters. 360, 2, p. 141-150 10 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

HP1 β is a biomarker for breast cancer prognosis and PARP inhibitor therapy

Lee, Y. H., Liu, X., Qiu, F., O'Connor, T. R., Yen, Y. & Ann, D. K., Mar 13 2015, In : PLoS One. 10, 3, e0121207.

Research output: Contribution to journalArticle

20 Citations (Scopus)

HP1 βis α biomarker for breast cancer prognosis and PARP inhibitor therapy

Lee, Y. H., Liu, X., Qiu, F., O'Connor, T. R., Yen, Y. & Ann, D. K., Mar 13 2015, In : PLoS One. 10, 3, e0121207.

Research output: Contribution to journalArticle

Is long-term use of benzodiazepine a risk for cancer?

Usman, I., Nguyen, P. A., Syed-Abdul, S., Yang, H. C., Huang, C. W., Jian, W. S., Hsu, M. H., Yen, Y. & Li, Y. C., Feb 1 2015, In : Medicine (United States). 94, 6, p. e483

Research output: Contribution to journalArticle

27 Citations (Scopus)

KLHL39 suppresses colon cancer metastasis by blocking KLHL20-mediated PML and DAPK ubiquitination

Chen, H. Y., Hu, J. Y., Chen, T. H., Lin, Y. C., Liu, X., Lin, M. Y., Lang, Y. D., Yen, Y. & Chen, R. H., Oct 1 2015, In : Oncogene. 34, 40, p. 5141-5151 11 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Lovastatin overcomes gefitinib resistance through TNF-a signaling in human cholangiocarcinomas with different LKB1 statuses in vitro and in vivo

Yang, S. H., Lin, H. Y., Chang, V. H. S., Chen, C. C., Liu, Y. R., Wang, J., Zhang, K., Jiang, X. & Yen, Y., 2015, In : Oncotarget. 6, 27, p. 23857-23873 17 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Lowered circulating aspartate is a metabolic feature of human breast cancer

Xie, G., Zhou, B., Zhao, A., Qiu, Y., Zhao, X., Garmire, L., Shvetsov, Y. B., Yu, H., Yen, Y. & Jia, W., Jan 1 2015, In : Oncotarget. 6, 32, p. 33369-33381 13 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Molecular Properties, Functional Mechanisms, and Applications of Sliced siRNA

Sun, G., Yeh, S. Y., Yuan, C. W. Y., Chiu, M. J. Y., Yung, B. S. H. & Yen, Y., Jan 27 2015, In : Molecular Therapy - Nucleic Acids. 4, 1, p. e221 e221.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Non-enzymatic action of RRM1 protein upregulates PTEN leading to inhibition of colorectal cancer metastasis

Qi, H., Lou, M., Chen, Y., Liu, X., Chen, N., Shan, J., Ling, Z., Shen, J., Zhu, L., Yen, Y., Zheng, S. & Shao, J., Feb 1 2015, In : Tumor Biology. 36, 6, p. 4833-4842 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

PHY906(KD018), an adjuvant based on a 1800-year-old Chinese medicine, enhanced the anti-tumor activity of Sorafenib by changing the tumor microenvironment

Lam, W., Jiang, Z., Guan, F., Huang, X., Hu, R., Wang, J., Bussom, S., Liu, S. H., Zhao, H., Yen, Y. & Cheng, Y. C., Mar 31 2015, In : Scientific Reports. 5, 9384.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Primary Cutaneous Anaplastic Large Cell Lymphoma With Positive ALK Expression and a Rapidly Progressive Cutaneous Nodule

Xue, D., Li, X., Ren, Y., Liu, Q., Yen, Y. & Xue, L., Jun 3 2015, In : International Journal of Surgical Pathology. 23, 4, p. 333-335 3 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

RRM2B-mediated regulation of mitochondrial activity and inflammation under oxidative stress

Cho, E. C., Kuo, M. L., Cheng, J. H., Cheng, Y. C., Hsieh, Y. C., Liu, Y. R., Hsieh, R. H. & Yen, Y., 2015, In : Mediators of Inflammation. 2015, 287345.

Research output: Contribution to journalArticle

8 Citations (Scopus)

The novel ribonucleotide reductase inhibitor COH29 inhibits DNA repair in vitros

Chen, M. C., Zhou, B., Zhang, K., Yuan, Y. C., Un, F., Hu, S., Chou, C. M., Chen, C. H., Wu, J., Wang, Y., Liu, X., Smith, D. L., Li, H., Liu, Z., Warden, C. D., Su, L., Malkas, L. H., Chung, Y. M., Hu, M. C. T. & Yen, Y., Jun 1 2015, In : Molecular Pharmacology. 87, 6, p. 996-1005 10 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

The pan-PI3K inhibitor GDC-0941 activates canonical WNT signaling to confer resistance in TNBC cells: Resistance reversal with WNT inhibitor

Tzeng, H. E., Yang, L., Chen, K., Wang, Y., Liu, Y. R., Pan, S. L., Gaur, S., Hu, S. & Yen, Y., 2015, In : Oncotarget. 6, 13, p. 11061-11073 13 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Underexpression of LKB1 tumor suppressor is associated with enhanced Wnt signaling and malignant characteristics of human intrahepatic cholangiocarcinoma

Wang, J., Zhang, K., Wang, J., Wu, X., Liu, X., Li, B., Zhu, Y., Yu, Y., Cheng, Q., Hu, Z., Guo, C., Hu, S., Mu, B., Tsai, C. H., Li, J., Smith, L., Yang, L., Liu, Q., Chu, P., Chang, V. & 4 others, Zhang, B., Wu, M., Jiang, X. & Yen, Y., 2015, In : Oncotarget. 6, 22, p. 18905-18920 16 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2014

A distinct metabolic signature of human colorectal cancer with prognostic potential

Qiu, Y., Cai, G., Zhou, B., Li, D., Zhao, A., Xie, G., Li, H., Cai, S., Xie, D., Huang, C., Ge, W., Zhou, Z., Xu, L. X., Jia, W., Zheng, S., Yen, Y. & Jia, W., Apr 15 2014, In : Clinical Cancer Research. 20, 8, p. 2136-2146 11 p.

Research output: Contribution to journalArticle

76 Citations (Scopus)

A germline missense mutation in COQ6 is associated with susceptibility to familial schwannomatosis

Zhang, K., Lin, J. W., Wang, J., Wu, X., Gao, H., Hsieh, Y. C., Hwu, P., Liu, Y. R., Su, L., Chiou, H. Y., Wang, D., Yuan, Y. C., Whang-Peng, J., Chiu, W. T. & Yen, Y., Oct 1 2014, In : Genetics in Medicine. 16, 10, p. 787-792 6 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Anti-proliferative and gene expression actions of resveratrol in breast cancer cells in vitro

Chin, Y. T., Hsieh, M. T., Yang, S. H., Tsai, P. W., Wang, S. H., Wang, C. C., Lee, Y. S., Cheng, G. Y., HuangFu, W. C., London, D., Tang, H. Y., Fu, E., Yen, Y., Liu, L. F., Lin, H. Y. & Davis, P. J., 2014, In : Oncotarget. 5, 24, p. 12891-12907 17 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Arginine starvation-associated atypical cellular death involves mitochondrial dysfunction, nuclear DNA leakage, and chromatin autophagy

Changou, C. A., Chen, Y. R., Xing, L., Yen, Y., Chuang, F. Y. S., Cheng, R. H., Bold, R. J., Ann, D. K. & Kung, H. J., Sep 30 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 39, p. 14147-14152 6 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

Bcl2 induces DNA replication stress by inhibiting ribonucleotide reductase

Xie, M., Yen, Y., Owonikoko, T. K., Ramalingam, S. S., Khuri, F. R., Curran, W. J., Doetsch, P. W. & Deng, X., Jan 1 2014, In : Cancer Research. 74, 1, p. 212-223 12 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Cancer: Arginine starvation impairs mitochondrial respiratory function in ASS1-deficient breast cancer cells

Qiu, F., Chen, Y. R., Liu, X., Chu, C. Y., Shen, L. J., Xu, J., Gaur, S., Forman, H. J., Zhang, H., Zheng, S., Yen, Y., Huang, J., Kung, H. J. & Ann, D. K., Apr 1 2014, In : Science Signaling. 7, 319

Research output: Contribution to journalArticle

69 Citations (Scopus)

Cancer-Secreted miR-105 destroys vascular endothelial barriers to promote metastasis

Zhou, W., Fong, M. Y., Min, Y., Somlo, G., Liu, L., Palomares, M. R., Yu, Y., Chow, A., O'Connor, S. T. F., Chin, A. R., Yen, Y., Wang, Y., Marcusson, E. G., Chu, P., Wu, J., Wu, X., Li, A. X., Li, Z., Gao, H., Ren, X. & 3 others, Boldin, M. P., Lin, P. C. & Wang, S. E., Apr 14 2014, In : Cancer Cell. 25, 4, p. 501-515 15 p.

Research output: Contribution to journalArticle

567 Citations (Scopus)

Clinical research of mortality in emergency air medical transport

Chen, W. L., Ma, H. P., Wu, C. H., Chiou, H. Y., Yen, Y., Chiu, W. T. & Tsai, S. H., 2014, In : BioMed Research International. 2014, 767402.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Correlating animal and human phase Ia/Ib clinical data with CALAA-01, a targeted, polymer-based nanoparticle containing siRNA

Zuckerman, J. E., Gritli, I., Tolcher, A., Heidel, J. D., Lim, D., Morgan, R., Chmielowski, B., Ribas, A., Davis, M. E. & Yen, Y., Aug 5 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 31, p. 11449-11454 6 p.

Research output: Contribution to journalArticle

172 Citations (Scopus)

Curative use of forequarter amputation for recurrent breast cancer over an axillary area: a case report and literature review

Tsai, C. H., Tzeng, H. E., Juang, W. K., Chu, P. G., Fann, P., Fong, Y. C., Hsu, H. C. & Yen, Y., 2014, In : World Journal of Surgical Oncology. 12, p. 346 1 p.

Research output: Contribution to journalArticle

Dovitinib synergizes with oxaliplatin in suppressing cell proliferation and inducing apoptosis in colorectal cancer cells regardless of RAS-RAF mutation status

Gaur, S., Chen, L., Ann, V., Lin, W. C., Wang, Y., Chang, V. H. S., Hsu, N. Y., Shia, H. S. & Yen, Y., Feb 4 2014, In : Molecular Cancer. 13, 1, 21.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Expression of glypican 3 enriches hepatocellular carcinoma development-related genes and associates with carcinogenesis in cirrhotic livers

Liu, X., Wang, S. K., Zhang, K., Zhang, H., Pan, Q., Liu, Z., Pan, H., Xue, L., Yen, Y. & Chu, P. G., Aug 20 2014, In : Carcinogenesis. 36, 2, p. 232-242 11 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Frequent overexpression of HMGA2 in human atypical teratoid/rhabdoid tumor and its correlation with let-7a3/let-7b miRNA

Zhang, K., Gao, H., Wu, X., Wang, J., Zhou, W., Sun, G., Wang, J., Wang, Y., Mu, B., Kim, C., Chu, P., Ho, D. M., Ann, D. K., Wong, T. T. & Yen, Y., 2014, In : Clinical Cancer Research. 20, 5, p. 1179-1189 11 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Identification of a distinct small cell population from human bone marrow reveals its multipotency in vivo and in vitro

Wang, J., Guo, X., Lui, M., Chu, P. J., Yoo, J., Chang, M. & Yen, Y., Jan 17 2014, In : PLoS One. 9, 1, e85112.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Jejunal Cancer with WRN Mutation Identified from Next-Generation Sequencing: A Case Study and Minireview

Chang, C., Shiah, H-S., Hsu, N-Y., Huang, H. Y., Chu, J-S. & Yen, Y., 2014, In : Case Reports in Surgery.

Research output: Contribution to journalArticle

MiR-26a enhances miRNA biogenesis by targeting Lin28B and Zcchc11 to suppress tumor growth and metastasis

Fu, X., Meng, Z., Liang, W., Tian, Y., Wang, X., Han, W., Lou, G., Wang, X., Lou, F., Yen, Y., Yu, H., Jove, R. & Huang, W., Aug 21 2014, In : Oncogene. 33, 34, p. 4296-4306 11 p.

Research output: Contribution to journalArticle

77 Citations (Scopus)

Mutants TP53 p.R273H and p.R273C but not p.R273G Enhance Cancer Cell Malignancy

Li, J., Yang, L., Gaur, S., Zhang, K., Wu, X., Yuan, Y. C., Li, H., Hu, S., Weng, Y. & Yen, Y., Jan 1 2014, In : Human Mutation. 35, 5, p. 575-584 10 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

p53MVA therapy in patients with refractory gastrointestinal malignancies elevates p53-specific CD8+ T-cell responses

Hardwick, N. R., Carroll, M., Kaltcheva, T., Qian, D., Lim, D., Leong, L., Chu, P., Kim, J., Chao, J., Fakih, M., Yen, Y., Espenschied, J., Ellenhorn, J. D. I., Diamond, D. J. & Chung, V., Sep 1 2014, In : Clinical cancer research : an official journal of the American Association for Cancer Research. 20, 17, p. 4459-4470 12 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Pharmacodynamic and pharmacogenomic study of the nanoparticle conjugate of camptothecin CRLX101 for the treatment of cancer

Gaur, S., Wang, Y., Kretzner, L., Chen, L., Yen, T., Wu, X., Yuan, Y. C., Davis, M. & Yen, Y., Oct 1 2014, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 10, 7, p. 1477-1486 10 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Prognostic and therapeutic significance of ribonucleotide reductase small subunit M2 in estrogen-negative breast cancers

Zhang, H., Liu, X., Warden, C. D., Huang, Y., Loera, S., Xue, L., Zhang, S., Chu, P., Zheng, S. & Yen, Y., Sep 11 2014, In : BMC Cancer. 14, 1, 664.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Reciprocal regulation of autophagy and dNTP pools in human cancer cells

Chen, W., Zhang, L., Zhang, K., Zhou, B., Kuo, M. L., Hu, S., Chen, L., Tang, M., Chen, Y. R., Yang, L., Ann, D. K. & Yen, Y., Jan 1 2014, In : Autophagy. 10, 7, p. 1272-1284 13 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

The prognostic value of ribonucleotide reductase small subunit M2 in predicting recurrence for prostate cancers

Huang, Y., Liu, X., Wang, Y. H., Yeh, S. D., Chen, C. L., Nelson, R. A., Chu, P., Wilson, T. & Yen, Y., Jan 2014, In : Urologic Oncology: Seminars and Original Investigations. 32, 1

Research output: Contribution to journalArticle

12 Citations (Scopus)

The role of peroxiredoxin II in chemoresistance of breast cancer cells

Wang, T., Diaz, A. J. G. & Yen, Y., 2014, In : Breast Cancer: Targets and Therapy. 6, p. 73-80 8 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Tumor suppressor FOXO3 regulates ribonucleotide reductase subunit RRM2B and impacts on survival of cancer patients

Cho, E. C., Kuo, M. L., Liu, X., Yang, L., Hsieh, Y. C., Wang, J., Cheng, Y. & Yen, Y., 2014, In : Oncotarget. 5, 13, p. 4834-4844 11 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)